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Gene: Gcm2 (glial cells missing transcription factor 2) Rattus norvegicus

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Symbol:

Gcm2

Name:

glial cells missing transcription factor 2

RGD ID:

1311127

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including intracellular calcium ion homeostasis; intracellular phosphate ion homeostasis; and transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including magnesium ion homeostasis; parathyroid gland development; and phosphate ion homeostasis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; trichloroethene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

chorion-specific transcription factor GCMb; glial cells missing homolog 2; glial cells missing homolog 2 (Drosophila); LOC291047

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GCM2 (glial cells missing transcription factor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gcm2 (glial cells missing homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gcm2 (glial cells missing transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GCM2 (glial cells missing transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GCM2 (glial cells missing transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gcm2 (glial cells missing transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GCM2 (glial cells missing transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GCM2 (glial cells missing transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gcm2 (glial cells missing transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gcm2 (glial cells missing transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GCM2 (glial cells missing transcription factor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gcm2 (glial cells missing homolog 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gcm2 (glial cells missing transcription factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	gcm	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	gcm	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	gcm2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gcm2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	23,858,379 - 23,867,495 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	23,858,379 - 23,867,495 (+)	Ensembl				GRCr8
mRatBN7.2	17	23,652,637 - 23,661,754 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	23,652,637 - 23,661,754 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	23,521,943 - 23,531,028 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	25,125,406 - 25,134,497 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	23,462,908 - 23,471,996 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	21,490,402 - 21,499,516 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	21,490,402 - 21,499,516 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	23,472,659 - 23,481,773 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	29,603,541 - 29,612,656 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	23,323,562 - 23,332,669 (+)	NCBI		Celera
RGSC_v3.1	17	29,604,108 - 29,613,827 (+)	NCBI
Cytogenetic Map	17	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Desbuquois dysplasia (ISO)

familial isolated hypoparathyroidism (ISO)

familial isolated hypoparathyroidism 2 (ISO)

genetic disease (ISO)

Hyperparathyroidism 4 (ISO)

hypoparathyroidism (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

folic acid (ISO)

methylisothiazolinone (ISO)

N-ethyl-N-nitrosourea (ISO)

paracetamol (ISO)

resveratrol (ISO)

sirolimus (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cell differentiation (ISO)

gliogenesis (IBA)

intracellular calcium ion homeostasis (IEA,ISO)

intracellular phosphate ion homeostasis (IEA,ISO)

negative regulation of apoptotic process (ISO)

parathyroid gland development (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

transcription by RNA polymerase II (IEA,ISO)

Cellular Component

nucleus (IBA,IEA,ISO)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Familial isolated hypoparathyroidism caused by a mutation in the gene for the transcription factor GCMB.	Ding C, etal., J Clin Invest. 2001 Oct;108(8):1215-20.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9770492	PMID:14573516	PMID:15728199	PMID:15863676	PMID:17382312	PMID:19968565	PMID:20190276	PMID:20484821	PMID:22871113	PMID:27745835

Genomics

Comparative Map Data

Gcm2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	23,858,379 - 23,867,495 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	23,858,379 - 23,867,495 (+)	Ensembl				GRCr8
mRatBN7.2	17	23,652,637 - 23,661,754 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	23,652,637 - 23,661,754 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	23,521,943 - 23,531,028 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	25,125,406 - 25,134,497 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	23,462,908 - 23,471,996 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	21,490,402 - 21,499,516 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	21,490,402 - 21,499,516 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	23,472,659 - 23,481,773 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	29,603,541 - 29,612,656 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	23,323,562 - 23,332,669 (+)	NCBI		Celera
RGSC_v3.1	17	29,604,108 - 29,613,827 (+)	NCBI
Cytogenetic Map	17	p12	NCBI

GCM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	10,873,223 - 10,882,041 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	10,873,223 - 10,882,041 (-)	Ensembl			hg38	GRCh38
GRCh37	6	10,873,456 - 10,882,274 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	10,981,450 - 10,990,084 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	10,981,449 - 10,990,084	NCBI
Celera	6	12,101,899 - 12,110,544 (-)	NCBI		Celera
Cytogenetic Map	6	p24.2	NCBI
HuRef	6	10,749,238 - 10,757,883 (-)	NCBI		HuRef
CHM1_1	6	10,875,550 - 10,884,190 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	10,740,840 - 10,749,654 (-)	NCBI		T2T-CHM13v2.0

Gcm2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	41,254,903 - 41,264,511 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	41,254,903 - 41,264,511 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	41,101,427 - 41,111,035 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	41,101,427 - 41,111,035 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	41,196,796 - 41,205,357 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	41,112,402 - 41,121,157 (-)	NCBI		MGSCv36	mm8
Celera	13	42,183,278 - 42,191,831 (-)	NCBI		Celera
Cytogenetic Map	13	A3.3	NCBI
cM Map	13	20.31	NCBI

Gcm2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	3,523,029 - 3,530,342 (+)	Ensembl
ChiLan1.0	NW_004955465	3,523,029 - 3,530,342 (+)	NCBI	ChiLan1.0	ChiLan1.0

GCM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	25,515,392 - 25,530,455 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	21,503,414 - 21,520,596 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	10,712,428 - 10,722,056 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	10,990,928 - 10,999,554 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	10,990,928 - 10,999,554 (-)	Ensembl			panPan2	panpan1.1

GCM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	10,561,245 - 10,568,351 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	10,561,514 - 10,568,106 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	10,509,436 - 10,517,862 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	10,664,433 - 10,672,863 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	10,666,045 - 10,672,637 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	10,493,352 - 10,501,771 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	10,540,441 - 10,548,864 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	11,861,899 - 11,870,330 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gcm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	13,866,641 - 13,873,635 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936534	2,135,627 - 2,142,621 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936534	2,135,627 - 2,142,621 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GCM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	7,564,252 - 7,570,523 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	7,563,880 - 7,570,628 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	7,925,756 - 7,928,086 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GCM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	61,256,063 - 61,264,688 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	61,256,611 - 61,264,390 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	10,911,392 - 10,919,500 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gcm2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	15,090,428 - 15,095,121 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624756	15,087,045 - 15,095,049 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gcm2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	60,096,883 - 60,104,212 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gcm2
107 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	210
Count of miRNA genes:	146
Interacting mature miRNAs:	171
Transcripts:	ENSRNOT00000020244
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9266755	40968173	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
8552966	Pigfal18	Plasma insulin-like growth factor 1 level QTL 18	8.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	12860942	57860942	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9206505	23859062	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22660799	55604694	Rat
9589151	Insul30	Insulin level QTL 30	8.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	12860942	57860942	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21498994	50592236	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23286322	64246472	Rat
9589057	Scfw6	Subcutaneous fat weight QTL 6	8.62	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	17	12860942	57860942	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9206505	23859062	Rat
9590154	Scort9	Serum corticosterone level QTL 9	23.57	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	12860942	57860942	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	22019705	67019705	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
9590088	Insglur7	Insulin/glucose ratio QTL 7	20.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	17	12860942	57860942	Rat
1331720	Rf43	Renal function QTL 43	2.881		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	17	15537025	28637951	Rat
2317053	Aia25	Adjuvant induced arthritis QTL 25	2.69		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	10604694	55604694	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15537025	60531414	Rat
7411666	Foco31	Food consumption QTL 31	11.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	17	12860942	57860942	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23858926	68858926	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	8574342	32199534	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23858926	68858926	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23858926	68858926	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23858926	68858926	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9206505	23859062	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23858926	68858926	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat

Markers in Region

D17Rat84

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	17	23,858,926 - 23,859,062 (+)	Marker Load Pipeline
mRatBN7.2	17	23,653,184 - 23,653,323 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	21,490,950 - 21,491,085	NCBI	Rnor6.0
Rnor_5.0	17	23,473,207 - 23,473,342	UniSTS	Rnor5.0
RGSC_v3.4	17	29,603,712 - 29,604,237	RGD	RGSC3.4
RGSC_v3.4	17	29,604,089 - 29,604,224	UniSTS	RGSC3.4
Celera	17	23,324,112 - 23,324,238	UniSTS
RGSC_v3.1	17	29,606,930 - 29,607,065	RGD
RH 3.4 Map	17	280.1	RGD
RH 3.4 Map	17	280.1	UniSTS
RH 2.0 Map	17	199.7	RGD
SHRSP x BN Map	17	17.2899	RGD
FHH x ACI Map	17	22.3299	RGD
Cytogenetic Map	17	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	19	46	54	53	22	25	22	6	124	67	26	18	46	31	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020244 ⟹ ENSRNOP00000020244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	23,858,379 - 23,867,495 (+)	Ensembl
mRatBN7.2 Ensembl	17	23,652,637 - 23,661,754 (+)	Ensembl
Rnor_6.0 Ensembl	17	21,490,402 - 21,499,516 (+)	Ensembl

RefSeq Acc Id:

NM_001106105 ⟹ NP_001099575

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	23,858,379 - 23,867,495 (+)	NCBI
mRatBN7.2	17	23,652,637 - 23,661,754 (+)	NCBI
Rnor_6.0	17	21,490,402 - 21,499,516 (+)	NCBI
Rnor_5.0	17	23,472,659 - 23,481,773 (+)	NCBI
RGSC_v3.4	17	29,603,541 - 29,612,656 (+)	RGD
Celera	17	23,323,562 - 23,332,669 (+)	RGD

Sequence:

show sequence

TGCATCTCTCTGTTTCTCTCTGTGTCTGTGTGTCTCTCTTTCTGTCTCCCTCTGTCTCTGTCTC
TGTCCCCTCCCTCCTCTTCCTCCTCCTCCTTTCACTCACCTCTCGCCCTACATCTCATTTGGGA
AAAAGTCACCCTGTGCGCTCCTTGCTTTTATTTCTCTTTCAGGCCCCTCCAGATGCCAGCAGAC
AGCATGCAGGACCCCGATCCTGTGCTTTCCTACGGGATGAAACTCACATGGGACATCAATGACC
CGCAGATGCCTCAGGAACCAGCTCACTTCGACCACTTCCGGGAGTGGCCTGATGGCTACGTGCG
CTTCATCTACAGCAGTCAGGAGAAGAAAGCTCAGCGCCACCTGAGCGGCTGGGCCATGCGCAAC
ACCAACAACCACAATGGCCACATCCTCAAAAAGTCCTGCCTGGGCGTGGTGGTGTGCGCACGCG
CCTGCGCCCTGAAGGATGGCTCGCACCTGCAGCTGAGGCCAGCCATCTGCGACAAGGCTCGTCT
GAAGCAACAAAAGAAAGCTTGCCCCAACTGTCATTCAGCTTTGGAGCTGGTCCCTTGCCGAGGA
CACAGTGGATACCCTGTCACCAACTTCTGGAGACTTGATGGCAATGCAATATTTTTTCAGGCCA
AAGGAGTTCATGATCATCCCAGACCAGAGAGCAAGTCAGAGACAGAAGGCAGAAGAAGTGCCCT
CAAGAGACAGATGGCCTCTTTCTACCAACCCCAGAAAAGGAGATCAGAGGAGCCTGAGGCAGGA
AGCACTCAGGACACCAGGGGACACTCCAATAGCACGCCTGTCCCAGAACCCTCAGAACTGTTTG
CTATGCCTGCTGACACCAGCTTCCCTATTTCAGGGCATTCTTCCCTTTCCTTCCCAAACTCTGA
TGTCCACAGAGTTACCTGTGACCTGCCCACCTTTCCAGGAGATGTAATACTTCCCTTTCAGAAA
TATTCAAATCCAAGCATTTATTTCCCTGGGCCACCTTGGAGCTATGAATTGGCAAGTCCTGGAG
TTACGGGTTCAAGTCCATATCCTACCCTGTATAAAGACCCCTCCATTGTCCCCGATGACCCTGA
CTGGATCCATCTAAACTCACTACAATATAATGTGAGTTCATACGGCAGCTATGAGAGAAGCTTG
GATCTCACAGCTAGATATCATGGCTGGAAACCTACACATGGGAAAGCTGGCCTTGAGGAGAAGG
TTGACTGTAGGCCATGCCAGGCTGTGCCCACATCGCCTTATTACAACCTAGAGCTGCCCTGCAG
GTACCTGCCAGTGGCCCCGGCAGGTACCCAGGCCCTGCAGACAGTGATCACCACCACAGTGGCT
TATCAGGCTTACCAGCACCCTGCTCTGAAACACGGCGACAGCGTGCAGGAGGTTAGCAGCCTTG
CCAGTTGCACCTACGCTTCTGAAAACCTCCCAATGCCCATCTATCCGCAAGCCTTAGACCCTCA
AGAGGGAGCCATCCAGGCAGCCTCCCCTTCAGGGAGAGCCCCTGGGATAGTCCCTGGAGATTGC
CAGGCAGCCAGACCTACTCTGGCTTTCCCTCAAGAAACAGATCCCTCCAGGACAGCTGGAGCAG
ATGTGTGGGATGTGTGTCTGTCTGGGGTGGGCTCTGTGATGGCTTACTTGGATAGGACAGGGCA
ACCCTTTAACCTCGACAATGAGGACTTTTAGGAGGGTCCCAGGATACACACACCATGACAATGA
AGTACATGCTAGATAACCCATGCCCAGGGGCAACGACTTGCTTGGGTGGTTCATACACATACAG
GACTGGAGTTGAGTGTAAAGGCACCTGGGGAGTTATAAGTTGGGAATGATAGGTGCTGGAAGTT
AGCACAGCACTTTGAAACCTGCCACACCGCATAGGCTAGTAGCAGTGCGAGCATCCCAGATGAA
CAAATAAAGGAGCGGGAGGGACCTGCAATGCCCTGGCCTGCCCTTCCTTAGCTTGCCTGCTAAG
GATGCTAGTTCCATTCTTAACCTTTGCCCTTTAGACTTTTAGAGAATTTCACACAGCTGTGAAT
AGCATCAAGAGGCTATGTAAGCAGCATGGGTGTGGAAGCCTGGAGAGAAACATATGAAACGTAT
GAAATGTAGCAAGTGTTTTATTGCCCTGCAGGCTTTTCCATTCATCAGCTGAAAATTCTGTAAG
CCAAGAGGAACCCTACATAACTTGGGGTGCTATGACATCTGTGAACTGAAGCTCCCCCCACCCT
GGGGGGGAGCCTCCTCTGTGTTAAAGATTCCTCAATGTGGACTGATTGGCAAGAATTTCTGTGA
TGTTGAGAGCTGGAATGTTGCAGGTCTGAGGCCAGATCTGTGACTTTAACCCTTTAATAGCCAT
GTCTCACCTATTAAGTGATTAAGTGGATCCCTTTGGGATGCACAAACAAACCCCAAGTTTCTAT
TTCCCCCAAAGGCTAAAAATGTCATCAAGTAGCATCTTAGGCTACTATATGGAAAAAGAAAATA
TATATATATATTTATATATATAATCCTGTCTTCCTGGTTTTACCACTAATGAATTTTTCACATA
CCTTGATTTATGAGTTCCTTTGTTCTATTACTATAAAAACGTTATGAACTTGCTCCCTCCATGT
TTGAACATGTTTTCAAATCTATGTTCCCTACTCCGTGATCAACTAATGTTCAGCTCCATAATAA
AATCTCTCGTTTCCTTTGAGGTAAGAGCTATGGTTCTTGTGTCCACACACCTCAGTAATCCCAG
CACTCTGAAGGCTAAGGCAGGAGGATTTGCCTATGGCACTTGCTGTAGATGGCTTTTCAAATAT
CAATTTCTACCAGACAGTTTCTGTGTCTCGTGAGTCACTGAGGACAGTTCAGGCCTGTTACTTG
CTGGTGAGACACAACTCAGTATATGAACACTTTAAAACTGTCACCAATTTAGACACAATTTAAC
TAACCTAGCCTTACTGGTTTCTATGCTGACAAAACTGAACTTAATCTATATTTTATGGCTTTTT
TTAAACTTTTTATTATATATTTCTTTACTTACATTTCAAAGGTTACTCCCCTTCCTGGTTTCCT
GTCCATAAGCCCCCATTCCCTCCCCTCCCTCTCCCCCATACAGGTATTCCCCCTATACATCTGC
CTTATTGCCCTCCCCCATATTCCCTTGCACTGGGGGTCCAACCTTGGCAAGACCAAGGGCTTTC
CCTTCCATTGGTGCCCAACAAGGCTATTCTCTGCTACATATCCAGTTGGAGCCCTGGGTCAGTC
CGTGTATAGTCTTTCGGTAGTGGTTTAGTCCCTGGAAGCTCTGATTGGTTGGCATTGTTGTTTT
CTATATTTTAATAAAAGACAATTGATATTGTTCTATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099575	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98221	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020244
	ENSRNOP00000020244.4

RefSeq Acc Id:

NP_001099575 ⟸ NM_001106105

- UniProtKB:

D3ZXW4 (UniProtKB/TrEMBL), A6J771 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPADSMQDPDPVLSYGMKLTWDINDPQMPQEPAHFDHFREWPDGYVRFIYSSQEKKAQRHLSGW
AMRNTNNHNGHILKKSCLGVVVCARACALKDGSHLQLRPAICDKARLKQQKKACPNCHSALELV
PCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEGRRSALKRQMASFYQPQKRRSEE
PEAGSTQDTRGHSNSTPVPEPSELFAMPADTSFPISGHSSLSFPNSDVHRVTCDLPTFPGDVIL
PFQKYSNPSIYFPGPPWSYELASPGVTGSSPYPTLYKDPSIVPDDPDWIHLNSLQYNVSSYGSY
ERSLDLTARYHGWKPTHGKAGLEEKVDCRPCQAVPTSPYYNLELPCRYLPVAPAGTQALQTVIT
TTVAYQAYQHPALKHGDSVQEVSSLASCTYASENLPMPIYPQALDPQEGAIQAASPSGRAPGIV
PGDCQAARPTLAFPQETDPSRTAGADVWDVCLSGVGSVMAYLDRTGQPFNLDNEDF

hide sequence

Ensembl Acc Id:

ENSRNOP00000020244 ⟸ ENSRNOT00000020244

Protein Domains

GCM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZXW4-F1-model_v2	AlphaFold	D3ZXW4	1-504	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311127	AgrOrtholog
BioCyc Gene	G2FUF-9731	BioCyc
Ensembl Genes	ENSRNOG00000015008	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020244	ENTREZGENE
	ENSRNOT00000020244.7	UniProtKB/TrEMBL
Gene3D-CATH	2.20.25.670	UniProtKB/TrEMBL
	3.30.70.3530	UniProtKB/TrEMBL
InterPro	GCM	UniProtKB/TrEMBL
	GCM_dom_sf	UniProtKB/TrEMBL
	GCM_large	UniProtKB/TrEMBL
	GCM_small	UniProtKB/TrEMBL
	Tscrpt_reg_GCM_motif	UniProtKB/TrEMBL
KEGG Report	rno:291047	UniProtKB/TrEMBL
NCBI Gene	291047	ENTREZGENE
PANTHER	CHORION-SPECIFIC TRANSCRIPTION FACTOR GCMB	UniProtKB/TrEMBL
	PTHR12414	UniProtKB/TrEMBL
Pfam	GCM	UniProtKB/TrEMBL
PhenoGen	Gcm2	PhenoGen
PROSITE	GCM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015008	RatGTEx
Superfamily-SCOP	GCM_motif	UniProtKB/TrEMBL
UniProt	A6J771	ENTREZGENE, UniProtKB/TrEMBL
	D3ZXW4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-12-04	Gcm2	glial cells missing transcription factor 2	Gcm2	glial cells missing homolog 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-03	Gcm2	glial cells missing homolog 2	Gcm2	glial cells missing homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Gcm2	glial cells missing homolog 2 (Drosophila)	Gcm2_predicted	glial cells missing homolog 2 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gcm2_predicted	glial cells missing homolog 2 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM