Cda (cytidine deaminase) - Rat Genome Database

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Gene: Cda (cytidine deaminase) Rattus norvegicus
Analyze
Symbol: Cda
Name: cytidine deaminase
RGD ID: 1311101
Description: Enables cytidine deaminase activity. Involved in cellular response to external biotic stimulus; cytidine deamination; and response to cycloheximide. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase); PARTICIPATES IN beta-ureidopropionase deficiency pathway; capecitabine pharmacodynamics pathway; capecitabine pharmacokinetics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; 5-fluorouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytidine deaminase-like; LOC100909857; LOC362638
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,839,929 - 155,866,541 (-)NCBIGRCr8
mRatBN7.25150,556,615 - 150,583,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,556,615 - 150,583,231 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,252,247 - 153,279,877 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,026,533 - 155,054,163 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,008,554 - 155,036,184 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,703,579 - 156,734,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,703,579 - 156,734,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,757,044 - 156,781,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05160,452,101 - 160,482,729 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,117,303 - 157,143,989 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,127,441 - 157,153,991 (-)NCBI
Celera5148,950,060 - 148,976,672 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdaRatDrug-Related Side Effects and Adverse Reactions  ISOCDA (Homo sapiens)152995291DNA:SNP:cds:rs1048977 more ...RGD 
CdaRatlung non-small cell carcinoma  ISOCDA (Homo sapiens)2316365DNA:snp:cds:p.K27Q (human)RGD 
CdaRatstomach cancer  ISOCDA (Homo sapiens)152995290protein:increased expression:stomach:RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdaRat3-hydroxy-3-methylglutaryl-CoA lyase deficiency  ISOCDA (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of hydroxymethylglutaryl-CoA lyaseClinVarPMID:28492532
CdaRatcongenital disorder of glycosylation Ir  ISOCDA (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type IrClinVarPMID:28492532
CdaRathyperprolinemia type 2  ISOCDA (Homo sapiens)8554872ClinVar Annotator: match by term: Hyperprolinemia type 2ClinVarPMID:28492532
CdaRatParkinson's disease 6  ISOCDA (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive early-onset Parkinson disease 6ClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdaRatBreast Neoplasms  ISOCDA (Homo sapiens)11554173CTD more ...CTDPMID:10811482 and PMID:25330770

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdaRat(1->4)-beta-D-glucan multiple interactionsISOCda (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CDA mRNACTDPMID:36331819
CdaRat1,1-dichloroethene decreases expressionISOCda (Mus musculus)6480464vinylidene chloride results in decreased expression of CDA mRNACTDPMID:26682919
CdaRat1,2-dichloroethane increases expressionISOCda (Mus musculus)6480464ethylene dichloride results in increased expression of CDA mRNACTDPMID:28960355
CdaRat1,2-dimethylhydrazine decreases expressionISOCda (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CDA mRNACTDPMID:22206623
CdaRat17beta-estradiol multiple interactionsISOCDA (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of CDA mRNA and [Progesterone co-treated with Estradiol] affects the expression of CDA mRNACTDPMID:17404688 and PMID:30165855
CdaRat17beta-estradiol increases expressionISOCda (Mus musculus)6480464Estradiol results in increased expression of CDA mRNACTDPMID:39298647
CdaRat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOCda (Mus musculus)64804642 more ...CTDPMID:30294300
CdaRat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOCda (Mus musculus)64804642 more ...CTDPMID:31388691
CdaRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCDA (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of CDA mRNACTDPMID:20106945 and PMID:21632981
CdaRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CDA mRNACTDPMID:33387578
CdaRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCda (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CDA mRNACTDPMID:19933214
CdaRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOCda (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of CDA mRNACTDPMID:21354282 and PMID:28922406
CdaRat2,4-diaminotoluene increases expressionISOCda (Mus musculus)64804642 and 4-diaminotoluene results in increased expression of CDA mRNACTDPMID:20713471
CdaRat2-hydroxypropanoic acid decreases expressionISOCDA (Homo sapiens)6480464Lactic Acid results in decreased expression of CDA mRNACTDPMID:30851411
CdaRat3,3',5,5'-tetrabromobisphenol A decreases expressionEXP 6480464tetrabromobisphenol A results in decreased expression of CDA mRNACTDPMID:27914987
CdaRat3-methylcholanthrene increases expressionISOCda (Mus musculus)6480464Methylcholanthrene results in increased expression of CDA mRNACTDPMID:20713471
CdaRat4-hydroxyphenyl retinamide increases expressionISOCda (Mus musculus)6480464Fenretinide results in increased expression of CDA mRNACTDPMID:28973697
CdaRat4-tert-Octylphenol increases expressionISOCda (Mus musculus)64804644-tert-octylphenol results in increased expression of CDA mRNA and 4-tert-octylphenol results in increased expression of CDA proteinCTDPMID:30487447
CdaRat5'-Deoxy-5-fluorocytidine increases metabolic processingISOCda (Mus musculus)6480464CDA protein results in increased metabolism of 5'-deoxy-5-fluorocytidineCTDPMID:18077151
CdaRat5-aza-2'-deoxycytidine increases degradationISOCDA (Homo sapiens)6480464CDA protein results in increased degradation of DecitabineCTDPMID:17616700

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Biological Process
1 to 16 of 16 rows

  
Object Symbol
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Term
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Reference
Notes
Source
Original Reference(s)
CdaRatcarbohydrate derivative metabolic process involved_inIEAARBA:ARBA000262971600115GO_REF:0000117UniProtGO_REF:0000117
CdaRatcellular response to external biotic stimulus  IEP 2316359K-selection - confluent cultureRGD 
CdaRatcytidine deamination  IDA 2316616 RGD 
CdaRatcytidine deamination involved_inIEAUniProtKB:P32320 and ensembl:ENSP000003642121600115GO_REF:0000107EnsemblGO_REF:0000107
CdaRatcytidine deamination involved_inIEAInterPro:IPR0062621600115GO_REF:0000002InterProGO_REF:0000002
CdaRatcytidine deamination involved_inIBAPANTHER:PTN000182087 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
CdaRatcytidine deamination involved_inISOCDA (Homo sapiens)1624291 PMID:9596658RGDPMID:9596658
CdaRatnegative regulation of cell growth involved_inISOCDA (Homo sapiens)1624291 PMID:9596658RGDPMID:9596658
CdaRatnegative regulation of cell growth involved_inIEAUniProtKB:P32320 and ensembl:ENSP000003642121600115GO_REF:0000107EnsemblGO_REF:0000107
CdaRatnegative regulation of nucleotide metabolic process involved_inISOCDA (Homo sapiens)1624291 PMID:9596658RGDPMID:9596658
CdaRatnegative regulation of nucleotide metabolic process involved_inIEAUniProtKB:P32320 and ensembl:ENSP000003642121600115GO_REF:0000107EnsemblGO_REF:0000107
CdaRatnucleobase-containing small molecule metabolic process involved_inIEAARBA:ARBA000276811600115GO_REF:0000117UniProtGO_REF:0000117
CdaRatpyrimidine-containing compound metabolic process involved_inIEAARBA:ARBA000268591600115GO_REF:0000117UniProtGO_REF:0000117
CdaRatresponse to cycloheximide  IEP 2316616 RGD 
CdaRatUMP salvage involved_inISOCda (Mus musculus)1624291 PMID:6498945RGDPMID:6498945
CdaRatUMP salvage involved_inIEAUniProtKB:P56389 and ensembl:ENSMUSP000000305351600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 16 of 16 rows

Cellular Component

  
Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
CdaRatcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
CdaRatcytosol located_inISOCDA (Homo sapiens)1624291 PMID:9596658RGDPMID:9596658
CdaRatcytosol is_active_inISOCda (Mus musculus)1624291 PMID:5651639RGDPMID:5651639
CdaRatcytosol is_active_inIBAMGI:1919519 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
CdaRatcytosol located_inIEAUniProtKB:P32320 and ensembl:ENSP000003642121600115GO_REF:0000107EnsemblGO_REF:0000107
CdaRatcytosol is_active_inIEAUniProtKB:P56389 and ensembl:ENSMUSP000000305351600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function
1 to 20 of 29 rows

  
Object Symbol
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Term
Qualifier
Evidence
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Reference
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Original Reference(s)
CdaRatcatalytic activity enablesIEAInterPro:IPR0161931600115GO_REF:0000002InterProGO_REF:0000002
CdaRatcytidine deaminase activity  IDA 2316616 RGD 
CdaRatcytidine deaminase activity enablesIEAUniProtKB:P56389 and ensembl:ENSMUSP000000305351600115GO_REF:0000107EnsemblGO_REF:0000107
CdaRatcytidine deaminase activity enablesIEAARBA:ARBA000433841600115GO_REF:0000117UniProtGO_REF:0000117
CdaRatcytidine deaminase activity enablesIEAEC:3.5.4.51600115GO_REF:0000003UniProtGO_REF:0000003
CdaRatcytidine deaminase activity enablesIEAUniRule:UR0004357911600115GO_REF:0000104UniProtGO_REF:0000104
CdaRatcytidine deaminase activity enablesISOCda (Mus musculus)1624291 PMID:16784234 and PMID:5651639RGDPMID:16784234 and PMID:5651639
CdaRatcytidine deaminase activity enablesIEAUniProtKB:P32320 and ensembl:ENSP000003642121600115GO_REF:0000107EnsemblGO_REF:0000107
CdaRatcytidine deaminase activity enablesIEAInterPro:IPR0062621600115GO_REF:0000002InterProGO_REF:0000002
CdaRatcytidine deaminase activity enablesIBAMGI:1919519 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
CdaRatcytidine deaminase activity enablesISOCDA (Homo sapiens)1624291 PMID:7923172 and PMID:9596658RGDPMID:7923172 and PMID:9596658
CdaRathydrolase activity enablesIEAInterPro:IPR0161921600115GO_REF:0000002InterProGO_REF:0000002
CdaRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
CdaRatidentical protein binding enablesISOCDA (Homo sapiens)1624291UniProtKB:P32320 more ...RGDPMID:31515488 more ...
CdaRatidentical protein binding enablesIEAUniProtKB:P56389 and ensembl:ENSMUSP000000305351600115GO_REF:0000107EnsemblGO_REF:0000107
CdaRatidentical protein binding enablesIEAARBA:ARBA000279301600115GO_REF:0000117UniProtGO_REF:0000117
CdaRatidentical protein binding enablesISOCda (Mus musculus)1624291PR:P56389 PMID:11591653RGDPMID:11591653
CdaRatidentical protein binding enablesIEAUniProtKB:P32320 and ensembl:ENSP000003642121600115GO_REF:0000107EnsemblGO_REF:0000107
CdaRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
CdaRatnucleoside binding enablesISOCDA (Homo sapiens)1624291 PMID:15689149RGDPMID:15689149
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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CdaRatpyrimidine metabolic pathway  IEA 6907045 KEGGrno:00240

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#
Reference Title
Reference Citation
1. Adenosine deaminase, 5'-nucleotidase, guanase and cytidine deaminase activities in gastric tissues from patients with gastric cancer. Durak I, etal., Cancer Lett. 1994 Sep 15;84(2):199-202. doi: 10.1016/0304-3835(94)90376-x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation. Nakamura Y, etal., Int J Cancer. 2006 May 15;118(10):2448-54.
6. Identification of new SNPs associated with severe toxicity to capecitabine. Pellicer M, etal., Pharmacol Res. 2017 Jun;120:133-137. doi: 10.1016/j.phrs.2017.03.021. Epub 2017 Mar 27.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Pyrimidine nucleotide synthesis in rat liver after the administration of cycloheximide. Seifert J and Vacha J, Toxicology. 1978 May;10(1):29-38.
12. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. Sugiyama E, etal., J Clin Oncol. 2007 Jan 1;25(1):32-42.
13. Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients. Tibaldi C, etal., Clin Cancer Res. 2008 Mar 15;14(6):1797-803.
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PMID:7923172   PMID:9596658   PMID:11591653   PMID:15689149   PMID:31515488  



Cda
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,839,929 - 155,866,541 (-)NCBIGRCr8
mRatBN7.25150,556,615 - 150,583,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,556,615 - 150,583,231 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,252,247 - 153,279,877 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,026,533 - 155,054,163 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,008,554 - 155,036,184 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,703,579 - 156,734,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,703,579 - 156,734,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,757,044 - 156,781,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05160,452,101 - 160,482,729 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,117,303 - 157,143,989 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,127,441 - 157,153,991 (-)NCBI
Celera5148,950,060 - 148,976,672 (-)NCBICelera
Cytogenetic Map5q36NCBI
CDA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,589,097 - 20,618,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,589,086 - 20,618,903 (+)EnsemblGRCh38hg38GRCh38
GRCh37120,915,590 - 20,945,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,788,031 - 20,817,988 (+)NCBINCBI36Build 36hg18NCBI36
Build 34120,660,836 - 20,690,702NCBI
Celera119,239,772 - 19,269,752 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef119,161,467 - 19,190,528 (+)NCBIHuRef
CHM1_1121,025,824 - 21,055,781 (+)NCBICHM1_1
T2T-CHM13v2.0120,414,048 - 20,443,922 (+)NCBIT2T-CHM13v2.0
Cda
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,065,839 - 138,095,623 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,065,735 - 138,095,303 (-)EnsemblGRCm39 Ensembl
GRCm384138,338,528 - 138,368,311 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,338,424 - 138,367,992 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,894,443 - 137,923,870 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,610,604 - 137,640,031 (-)NCBIMGSCv36mm8
Celera4140,122,623 - 140,152,350 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.17NCBI
Cda
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,132,049 - 1,156,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,131,968 - 1,156,777 (+)NCBIChiLan1.0ChiLan1.0
CDA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21206,506,028 - 206,535,363 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11205,618,335 - 205,647,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,538,696 - 19,568,008 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1120,583,441 - 20,612,711 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,583,441 - 20,612,711 (+)Ensemblpanpan1.1panPan2
CDA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,305,328 - 78,327,229 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,304,726 - 78,327,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,819,639 - 74,841,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,872,416 - 78,894,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,870,359 - 78,894,541 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,690,869 - 75,712,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,702,707 - 76,724,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,706,391 - 77,728,271 (-)NCBIUU_Cfam_GSD_1.0
Cda
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,718,495 - 40,739,795 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,543,220 - 6,566,308 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,543,295 - 6,564,575 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,824,270 - 78,849,547 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,824,248 - 78,849,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2673,017,555 - 73,042,459 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,931,365 - 111,960,172 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,931,364 - 111,960,036 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660334,270,608 - 4,299,725 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cda
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,621,899 - 5,645,850 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,621,888 - 5,645,055 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cda
196 total Variants

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:88
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000021036, ENSRNOT00000075128
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat

1 to 10 of 38 rows
RH141036  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,556,910 - 150,557,109 (+)MAPPERmRatBN7.2
Rnor_6.05156,756,874 - 156,757,072NCBIRnor6.0
Rnor_6.05156,703,875 - 156,704,073NCBIRnor6.0
Rnor_5.05160,505,087 - 160,505,285UniSTSRnor5.0
Rnor_5.05160,452,397 - 160,452,595UniSTSRnor5.0
RGSC_v3.45157,117,599 - 157,117,797UniSTSRGSC3.4
Celera5148,950,356 - 148,950,554UniSTS
RH 3.4 Map51032.4UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 10 43 67 20 26 17 3 17 101 49 66 24 39 9



Ensembl Acc Id: ENSRNOT00000021036   ⟹   ENSRNOP00000021036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,556,615 - 150,583,231 (-)Ensembl
Rnor_6.0 Ensembl5156,703,579 - 156,734,541 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075128   ⟹   ENSRNOP00000065378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5156,757,044 - 156,781,291 (-)Ensembl
RefSeq Acc Id: NM_001108688   ⟹   NP_001102158
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,839,929 - 155,866,541 (-)NCBI
mRatBN7.25150,556,615 - 150,583,231 (-)NCBI
Rnor_6.05156,703,579 - 156,734,541 (-)NCBI
Rnor_5.05160,452,101 - 160,482,729 (-)NCBI
RGSC_v3.45157,117,303 - 157,143,989 (-)RGD
Celera5148,950,060 - 148,976,672 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110422   ⟹   XP_038966350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,840,029 - 155,859,562 (-)NCBI
mRatBN7.25150,556,715 - 150,576,217 (-)NCBI
Protein RefSeqs NP_001102158 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966350 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80875 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021036
  ENSRNOP00000021036.4
RefSeq Acc Id: NP_001102158   ⟸   NM_001108688
- UniProtKB: D4AC20 (UniProtKB/TrEMBL),   A6ITH4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021036   ⟸   ENSRNOT00000021036
RefSeq Acc Id: XP_038966350   ⟸   XM_039110422
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000065378   ⟸   ENSRNOT00000075128
CMP/dCMP-type deaminase

Name Modeler Protein Id AA Range Protein Structure
AF-D4AC20-F1-model_v2 AlphaFold D4AC20 1-146 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-39456 BioCyc
BioCyc Pathway PWY-7181 [pyrimidine deoxyribonucleosides degradation] BioCyc
  PWY-7193 [pyrimidine ribonucleosides salvage I] BioCyc
  PWY-7199 [pyrimidine deoxyribonucleosides salvage] BioCyc
  PWY0-1295 [pyrimidine ribonucleosides degradation] BioCyc
BioCyc Pathway Image PWY-7181 BioCyc
  PWY-7193 BioCyc
  PWY-7199 BioCyc
  PWY0-1295 BioCyc
Ensembl Genes ENSRNOG00000015677 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000049700 Ensembl
Ensembl Transcript ENSRNOT00000021036 ENTREZGENE
  ENSRNOT00000021036.5 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
InterPro APOBEC/CMP_deaminase_Zn-bd UniProtKB/TrEMBL
  CMP_dCMP_Zn-bd UniProtKB/TrEMBL
  Cyt/Deoxycyt_deaminase UniProtKB/TrEMBL
  Cyt_deam_tetra UniProtKB/TrEMBL
  Cytidine_deaminase-like UniProtKB/TrEMBL
KEGG Report rno:362638 UniProtKB/TrEMBL
NCBI Gene 362638 ENTREZGENE
PANTHER CYTIDINE DEAMINASE UniProtKB/TrEMBL
  CYTIDINE DEAMINASE UniProtKB/TrEMBL
Pfam dCMP_cyt_deam_1 UniProtKB/TrEMBL
PharmGKB CDA RGD
PhenoGen Cda PhenoGen
PROSITE CYT_DCMP_DEAMINASES UniProtKB/TrEMBL
  CYT_DCMP_DEAMINASES_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015677 RatGTEx
  ENSRNOG00000049700 RatGTEx
Superfamily-SCOP Cytidine_deaminase-like UniProtKB/TrEMBL
UniProt A6ITH4 ENTREZGENE, UniProtKB/TrEMBL
  D4AC20 ENTREZGENE, UniProtKB/TrEMBL
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cda  cytidine deaminase  LOC100909857  cytidine deaminase-like  Data merged from RGD:6501229 737654 PROVISIONAL
2012-07-05 LOC100909857  cytidine deaminase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Cda  cytidine deaminase   Cda_predicted  cytidine deaminase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cda_predicted  cytidine deaminase (predicted)      Symbol and Name status set to approved 70820 APPROVED