CDA (cytidine deaminase) - Rat Genome Database

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Gene: CDA (cytidine deaminase) Canis lupus familiaris
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Symbol: CDA
Name: cytidine deaminase
RGD ID: 12162392
Description: ENCODES a protein that exhibits cytidine deaminase activity (ortholog); INVOLVED IN cellular response to external biotic stimulus (ortholog); cytidine deamination (ortholog); response to cycloheximide (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; capecitabine pharmacodynamics pathway; capecitabine pharmacokinetics pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); Breast Neoplasms (ortholog); congenital disorder of glycosylation Ir (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,305,328 - 78,327,229 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,304,726 - 78,327,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,819,639 - 74,841,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,872,416 - 78,894,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,870,359 - 78,894,541 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,690,869 - 75,712,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,702,707 - 76,724,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,706,391 - 77,728,271 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CDA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,305,328 - 78,327,229 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,304,726 - 78,327,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,819,639 - 74,841,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,872,416 - 78,894,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,870,359 - 78,894,541 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,690,869 - 75,712,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,702,707 - 76,724,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,706,391 - 77,728,271 (-)NCBIUU_Cfam_GSD_1.0
CDA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,589,097 - 20,618,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,589,086 - 20,618,903 (+)EnsemblGRCh38hg38GRCh38
GRCh37120,915,590 - 20,945,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,788,031 - 20,817,988 (+)NCBINCBI36Build 36hg18NCBI36
Build 34120,660,836 - 20,690,702NCBI
Celera119,239,772 - 19,269,752 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef119,161,467 - 19,190,528 (+)NCBIHuRef
CHM1_1121,025,824 - 21,055,781 (+)NCBICHM1_1
T2T-CHM13v2.0120,414,048 - 20,443,922 (+)NCBIT2T-CHM13v2.0
Cda
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,065,839 - 138,095,623 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,065,735 - 138,095,303 (-)EnsemblGRCm39 Ensembl
GRCm384138,338,528 - 138,368,311 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,338,424 - 138,367,992 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,894,443 - 137,923,870 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,610,604 - 137,640,031 (-)NCBIMGSCv36mm8
Celera4140,122,623 - 140,152,350 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.17NCBI
Cda
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,839,929 - 155,866,541 (-)NCBIGRCr8
mRatBN7.25150,556,615 - 150,583,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,556,615 - 150,583,231 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,252,247 - 153,279,877 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,026,533 - 155,054,163 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,008,554 - 155,036,184 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,703,579 - 156,734,541 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,703,579 - 156,734,541 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,757,044 - 156,781,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05160,452,101 - 160,482,729 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,117,303 - 157,143,989 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,127,441 - 157,153,991 (-)NCBI
Celera5148,950,060 - 148,976,672 (-)NCBICelera
Cytogenetic Map5q36NCBI
Cda
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,132,049 - 1,156,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,131,968 - 1,156,777 (+)NCBIChiLan1.0ChiLan1.0
CDA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21206,506,028 - 206,535,363 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11205,618,335 - 205,647,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,538,696 - 19,568,008 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1120,583,441 - 20,612,711 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,583,441 - 20,612,711 (+)Ensemblpanpan1.1panPan2
Cda
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,718,495 - 40,739,795 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,543,220 - 6,566,308 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,543,295 - 6,564,575 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,824,270 - 78,849,547 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,824,248 - 78,849,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2673,017,555 - 73,042,459 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,931,365 - 111,960,172 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,931,364 - 111,960,036 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660334,270,608 - 4,299,725 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cda
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,621,899 - 5,645,850 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,621,888 - 5,645,055 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CDA
244 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 13 6 5 6 1 12 5 1
Low 5 5 9 1 5 1 8 5 5
Below cutoff 4

Sequence


RefSeq Acc Id: ENSCAFT00000023893   ⟹   ENSCAFP00000022181
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl278,304,726 - 78,327,247 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004629   ⟹   ENSCAFP00845003700
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl278,870,359 - 78,894,541 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845004637   ⟹   ENSCAFP00845003705
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl278,870,359 - 78,894,541 (-)Ensembl
RefSeq Acc Id: XM_038470876   ⟹   XP_038326804
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1275,690,869 - 75,712,919 (-)NCBI
RefSeq Acc Id: XM_038531753   ⟹   XP_038387681
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0277,706,391 - 77,728,271 (-)NCBI
RefSeq Acc Id: XM_038595992   ⟹   XP_038451920
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0276,702,707 - 76,724,560 (-)NCBI
RefSeq Acc Id: XM_038660083   ⟹   XP_038516011
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0278,872,416 - 78,894,283 (-)NCBI
RefSeq Acc Id: XM_544519   ⟹   XP_544519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1278,305,328 - 78,327,229 (-)NCBI
Dog10K_Boxer_Tasha274,819,639 - 74,841,500 (-)NCBI
Sequence:
RefSeq Acc Id: XP_544519   ⟸   XM_544519
- UniProtKB: A0A8C0K6L8 (UniProtKB/TrEMBL),   A0A8C0MP51 (UniProtKB/TrEMBL),   A0A8I3MFS9 (UniProtKB/TrEMBL),   A0A8I3N2Q2 (UniProtKB/TrEMBL),   A0A8P0PQS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000022181   ⟸   ENSCAFT00000023893
RefSeq Acc Id: XP_038326804   ⟸   XM_038470876
RefSeq Acc Id: XP_038451920   ⟸   XM_038595992
RefSeq Acc Id: XP_038516011   ⟸   XM_038660083
- UniProtKB: A0A8C0K6L8 (UniProtKB/TrEMBL),   A0A8C0MP51 (UniProtKB/TrEMBL),   A0A8I3MFS9 (UniProtKB/TrEMBL),   A0A8I3N2Q2 (UniProtKB/TrEMBL),   A0A8P0PQS0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387681   ⟸   XM_038531753
- UniProtKB: A0A8C0K6L8 (UniProtKB/TrEMBL),   A0A8C0MP51 (UniProtKB/TrEMBL),   A0A8I3MFS9 (UniProtKB/TrEMBL),   A0A8I3N2Q2 (UniProtKB/TrEMBL),   A0A8P0PQS0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003705   ⟸   ENSCAFT00845004637
RefSeq Acc Id: ENSCAFP00845003700   ⟸   ENSCAFT00845004629
Protein Domains
CMP/dCMP-type deaminase

Promoters
RGD ID:13682622
Promoter ID:EPDNEW_C689
Type:initiation region
Name:CDA_1
Description:cytidine deaminase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1278,327,181 - 78,327,241EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015049 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006962 UniProtKB/TrEMBL
  ENSCAFG00845002612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023893.4 UniProtKB/TrEMBL
  ENSCAFT00000095989.1 UniProtKB/TrEMBL
  ENSCAFT00030012825.1 UniProtKB/TrEMBL
  ENSCAFT00845004629.1 UniProtKB/TrEMBL
  ENSCAFT00845004637 ENTREZGENE
  ENSCAFT00845004637.1 UniProtKB/TrEMBL
Gene3D-CATH Cytidine Deaminase, domain 2 UniProtKB/TrEMBL
InterPro APOBEC/CMP_deaminase_Zn-bd UniProtKB/TrEMBL
  CMP_dCMP_dom UniProtKB/TrEMBL
  Cyt_deam_tetra UniProtKB/TrEMBL
  Cytidine_deaminase-like UniProtKB/TrEMBL
KEGG Report cfa:487393 UniProtKB/TrEMBL
NCBI Gene CDA ENTREZGENE
PANTHER CYTIDINE DEAMINASE UniProtKB/TrEMBL
  CYTIDINE DEAMINASE UniProtKB/TrEMBL
Pfam dCMP_cyt_deam_1 UniProtKB/TrEMBL
PROSITE CYT_DCMP_DEAMINASES_1 UniProtKB/TrEMBL
  CYT_DCMP_DEAMINASES_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53927 UniProtKB/TrEMBL
UniProt A0A8C0K6L8 ENTREZGENE
  A0A8C0MP51 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MFS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2Q2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PQS0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38983 ENTREZGENE