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Gene: Zfand2a (zinc finger AN1-type containing 2A) Rattus norvegicus

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Symbol:

Zfand2a

Name:

zinc finger AN1-type containing 2A

RGD ID:

1310991

Description:

Predicted to enable zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein targeting to ER. Predicted to act upstream of or within cellular response to arsenic-containing substance and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome complex. Predicted to be active in endoplasmic reticulum. Orthologous to human ZFAND2A (zinc finger AN1-type containing 2A); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

AN1-type zinc finger protein 2A; LOC360772; MGC94876; RGD1310991; similar to arsenite inducible RNA associated protein; zinc finger, AN1-type domain 2A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	20,275,435 - 20,286,513 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	20,275,450 - 20,286,513 (+)	Ensembl				GRCr8
mRatBN7.2	12	15,161,601 - 15,172,679 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	15,161,639 - 15,172,677 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	15,971,815 - 15,982,797 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	16,595,558 - 16,606,540 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	15,621,909 - 15,632,883 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	17,252,093 - 17,263,477 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	17,252,093 - 17,263,477 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	19,239,057 - 19,250,441 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	15,661,609 - 15,672,672 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	16,915,504 - 16,926,567 (+)	NCBI		Celera
RGSC_v3.1	12	15,691,536 - 15,702,600 (+)	NCBI
Cytogenetic Map	12	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2-palmitoylglycerol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

andrographolide (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

arotinoid acid (ISO)

arsenite(3-) (ISO)

azathioprine (ISO)

azoxystrobin (ISO)

Bardoxolone methyl (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bilirubin IXalpha (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (EXP,ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carfilzomib (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

CHIR 99021 (ISO)

chloropicrin (ISO)

choline (ISO)

cisplatin (ISO)

cobalt atom (ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cortisol (ISO)

coumestrol (ISO)

crotonaldehyde (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dexamethasone (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diethyl maleate (ISO)

dioxygen (EXP)

diquat (ISO)

disulfiram (ISO)

diuron (ISO)

doxorubicin (ISO)

elesclomol (ISO)

endosulfan (EXP)

Enterolactone (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

fenpyroximate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

ixazomib (ISO)

ketamine (EXP)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

L-methionine (ISO)

Licochalcone B (ISO)

manganese(II) chloride (EXP)

menadione (ISO)

metacetamol (ISO)

methamphetamine (EXP)

methimazole (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (ISO)

N-acetyl-L-cysteine (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nefazodone (EXP)

nickel dichloride (EXP)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

phorone (EXP)

picoxystrobin (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

propiconazole (EXP,ISO)

pyrimidifen (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (EXP,ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

sulforaphane (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

Triptolide (ISO)

triptonide (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

Tungsten carbide (ISO)

tunicamycin (ISO)

valdecoxib (EXP)

valproic acid (ISO)

XAV939 (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to arsenic-containing substance (ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)

protein targeting to ER (IBA)

Cellular Component

cytoplasm (IBA,IEA)

endoplasmic reticulum (IBA)

nucleus (IEA)

proteasome complex (IEA,ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16973439

Genomics

Comparative Map Data

Zfand2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	20,275,435 - 20,286,513 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	20,275,450 - 20,286,513 (+)	Ensembl				GRCr8
mRatBN7.2	12	15,161,601 - 15,172,679 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	15,161,639 - 15,172,677 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	15,971,815 - 15,982,797 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	16,595,558 - 16,606,540 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	15,621,909 - 15,632,883 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	17,252,093 - 17,263,477 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	17,252,093 - 17,263,477 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	19,239,057 - 19,250,441 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	15,661,609 - 15,672,672 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	16,915,504 - 16,926,567 (+)	NCBI		Celera
RGSC_v3.1	12	15,691,536 - 15,702,600 (+)	NCBI
Cytogenetic Map	12	q11	NCBI

ZFAND2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	1,148,850 - 1,160,196 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	1,151,903 - 1,160,771 (-)	Ensembl			hg38	GRCh38
GRCh37	7	1,188,486 - 1,199,832 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	1,159,070 - 1,166,324 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	1,156,001 - 1,163,022 (-)	NCBI		Celera
Cytogenetic Map	7	p22.3	NCBI
HuRef	7	1,103,329 - 1,110,234 (-)	NCBI		HuRef
CHM1_1	7	1,192,155 - 1,199,130 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	1,248,817 - 1,259,769 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	1,245,778 - 1,252,683 (-)	NCBI

Zfand2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	139,456,971 - 139,470,246 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	139,456,966 - 139,470,304 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	139,471,216 - 139,484,491 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	139,471,211 - 139,484,549 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	139,947,170 - 139,960,445 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	139,724,858 - 139,738,059 (-)	NCBI		MGSCv36	mm8
Celera	5	136,525,556 - 136,538,829 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	78.68	NCBI

Zfand2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	8,881,981 - 8,892,404 (-)	Ensembl
ChiLan1.0	NW_004955460	8,881,981 - 8,892,404 (-)	NCBI	ChiLan1.0	ChiLan1.0

ZFAND2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	6,089,860 - 6,102,600 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	54,414,533 - 54,427,280 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	1,392,979 - 1,401,283 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	1,519,583 - 1,526,107 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	1,518,912 - 1,526,107 (-)	Ensembl			panPan2	panpan1.1

ZFAND2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	15,725,903 - 15,736,450 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	15,726,076 - 15,883,451 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	17,199,161 - 17,209,608 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	15,857,290 - 15,867,446 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	15,857,296 - 15,867,452 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	15,659,726 - 15,669,861 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	15,586,692 - 15,596,870 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	15,874,002 - 15,884,148 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Zfand2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	143,646,682 - 143,656,872 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936754	1,353,342 - 1,363,720 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936754	1,353,482 - 1,363,651 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZFAND2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	756,429 - 775,983 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	756,427 - 776,028 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	873,586 - 894,043 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZFAND2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	20,434,434 - 20,441,641 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	20,434,495 - 20,442,322 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666090	1,255,751 - 1,264,882 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Zfand2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	26,727,557 - 26,741,411 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	26,730,499 - 26,741,426 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Zfand2a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	13,716,365 - 13,725,198 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Zfand2a
74 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	621
Count of miRNA genes:	274
Interacting mature miRNAs:	359
Transcripts:	ENSRNOT00000047634
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	20139028	26430640	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

RH131214

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	15,172,462 - 15,172,612 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	17,263,261 - 17,263,410	NCBI	Rnor6.0
Rnor_5.0	12	19,250,225 - 19,250,374	UniSTS	Rnor5.0
RGSC_v3.4	12	15,672,456 - 15,672,605	UniSTS	RGSC3.4
Celera	12	16,926,351 - 16,926,500	UniSTS
RH 3.4 Map	12	235.3	UniSTS
Cytogenetic Map	12	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089558	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC085928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000047634 ⟹ ENSRNOP00000043105

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	20,275,450 - 20,286,513 (+)	Ensembl
mRatBN7.2 Ensembl	12	15,161,639 - 15,172,675 (+)	Ensembl
Rnor_6.0 Ensembl	12	17,252,093 - 17,263,477 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083814 ⟹ ENSRNOP00000069561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	20,275,485 - 20,286,513 (+)	Ensembl
mRatBN7.2 Ensembl	12	15,161,692 - 15,172,677 (+)	Ensembl
Rnor_6.0 Ensembl	12	17,253,791 - 17,261,049 (+)	Ensembl

RefSeq Acc Id:

NM_001008363 ⟹ NP_001008364

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	20,275,450 - 20,286,513 (+)	NCBI
mRatBN7.2	12	15,161,616 - 15,172,679 (+)	NCBI
Rnor_6.0	12	17,252,093 - 17,263,477 (+)	NCBI
Rnor_5.0	12	19,239,057 - 19,250,441 (+)	NCBI
RGSC_v3.4	12	15,661,609 - 15,672,672 (+)	RGD
Celera	12	16,915,504 - 16,926,567 (+)	RGD

Sequence:

show sequence

CGCCGGGAACGCCCAGGATGTATGACTCTGGATCTGTCGGCTGCGGATAAATGGCCAGGGCTGC
TGTAGGCGCAATGCTACGTTTCCCGGCCTTGCGAGAAGTCGGGTGCCTCGCGGCGATTGGAGCT
GCAGTTTCTATTGCAGTGTCACCGGGCTGACCACGAAGGACTCTGCCAGGCGAGTGGGACTCCG
ACTACCCGTGAATGCCAGGCGATACTTAAATACCTGTGTGGTTTGGCCACCATTCGCAATGGAG
TTTCCTGACCTGGGGAAGCACTGTTCAGAACCGACTTGCAAACAACTAGATTTTCTGCCAATCA
CGTGTGATGCCTGCAAACAAGATTTCTGTAAAGACCATTTTTCCTACTCGGGTCATAAGTGTCC
CTTTGCATTCAAGAAGGATGTGCAGGTGCCTGTGTGTCCACTCTGTAATGCCCCCATCCCAGTG
AGGAGAGGTGACATCCCAGATGTGGTGGTCGGCGAGCACATGGACAGAGATTGCACCTTTCACC
CCGGGAGGAACAGAAACAAGGTTTTCACACACCGCTGCTCCAAAGAGGGATGCAGGAAGAAGGA
GATGCTGCAGCTGGCTTGTGCCCAGTGCCATGGCAACTTCTGCATTCAGCACAGGCATCCTCTG
GACCACAACTGCCAAGCTGGGAGCAGCTCAGTCAGCAGAGGGAGGTCTTCCGCATCCAGAGCTG
CTGAGCAGAAGCCATCGGGAGTCAGTTGGCTGGCCCAGCGACTCAGGCGGACAGTGAAATGACG
GGGAGGCTCCTGTCAGTGCTGCACCCCAGCTCCTTTCTGTTGACTTTTAATCTTGGTGACGTGG
CCTCCGGCACTTTCCTGCTTCTCTGGAGTCTGGGTCTTTATGGAAGAGTCTCCCATTGACTGCT
CAAGTTAGGATGAGGAGATGGCTCAGTGGGTAAAGCGTTTGCCTCACAAGCATGAAGACCTGAT
AGCATCTCCAGAACTGAATGTTGTAGTCTCAGCACTTGGGAGGTGAGGAGATGACGCTCCGGGG
CTCTCTGACCAGCAACCTTGCCTTATTGGAGAGTTCCAGGCCAGAAAGATGCTGCCTCAAAAAC
CAAGGTGCACACTTCCTGCGGAAGGACATCAGAAACTTACGTCTGGCCTCACACACACAAACAC
ATGGTATATAATTTATTTGGTAAAGTAAACGAGGCTGTTGAGCCACTTACTGAGATGGGTTAGG
TTACCATAGCCAAAGCTGGGGACTTGTGTCAACCTCCTTAGTGGTTGGTTTGGTCTGTGCTAAA
CCACTCCAGGACTTGGTATTCTGGAAAAGTCTGTCCTTTAACAGATAAGATCCACCTCTGCTCT
CTATTCTCCCCTACATGACTTTTGTAATGAGGTGCCTTTGGGGCACAGTCTGCTCATGGTCCCC
AAGAACAAGAGTTGGTGTGGCACCCTTTCCTGACCTCTGGCTGGGGCACTGTAGAGGGAGGGTA
CATACCCTGCCCGCAGTGATGTCTCCAAGGTTGATTTAAGCAACCAGCTCCTCCCTGCCACGGC
TCCAGGCTCCACATGCCTGGGTTAAGGCTGGGTTTGTTTTTTGAGACAGTGTCTTAACTATGGA
GCGCTGACTGTTCTGGAACTCACTCTGTAGACCAGTCTGGCCTTGAACTCAGTGATCCCCCTGA
CTCTGTCTCCAGAATGTGGATTCTCCCAAGAAAAGCAGCAAGACCTGGGCGCCATTTCAGAGCT
GTCTAATTTTGCAATGGAAGCTTCTCATGTCGGAGCACCATGGCAGCAGGCCGAGGGTGTCCTT
GGGCACTTTGCAGAGCAGAAACCCAGACAGAAGAAGAGCAGTGGCTCTGGGCCTCTGGGTGCAG
CCACAGTCGCTCCTGTGCTACCTGTGTGGCCTGACCACATCTACCACCATGACAGTGTTGGGGA
AGATGCTTGGAGGTACTCTGGTGACCTCCATGTAAGGGTTTACCCTCACTTTCCAGGAGCTTGA
GTATCAGGGATGACATGGGACAAACCACCCGAGCTGCGTTAGACCTTTACCCTTCGTTCAGACA
GCCTTTAGGACAGTTGACTGCATGAATTCCATACAGAGCAGCATTGTGCAGATTTTGTGACCTC
TGGCTGTCATGGACAGGCAGGGGTGGGTTCCGCTCTGTTCTCTAAAGACTTGACTCTGTCCTAA
GCCAGTGCCTCTGGTCACATCAGTGCACCAGCCTGCTTTAGTCCAGCTCTAGGCCCATCAGTGC
CTCCTTCTGTCCCCAGTGTTTGGCTAGATCTGGGGCCTGGGGACTTGGGTTCTTAGAACAAGGT
CTCTGCAGTGGTGCTATGTGGGGACACAGACAAACCATTCTATTGTACTTGCACTCCCAGGTGA
CAGCCACTCACCCTCATATAGTAGACACTTGAGATGTAACCTGCATAACAAAGCTTTTAATTCC
ACTTAAGTTTTTTTTTTTAAAGAATTTATTTTATGTATATGAGTGCACTGTAGCTGCCTTCAGA
CTCACCAGATCCCATTACAGATGGTTGTGAGCCACCATGTGGTTCCTGGGGATTGAACTCAGGA
CCTCTGGAAGAAGAATCGGTGCTCTTGACCTTGGAGCCATCTCTCCAGCCCCCTTGACTTAAAT
TTTAAAATAGGTGGGCTCAGTAATTAGTCAATGTTTAAATAAGGACTTAGAGTCTACCCCCTAA
CCATTTTATGCAGTAATGTTTCCACTGAGATGACTCTAAATTGGGAATTAAAAGCACATAGCGT
GGGCTGGGGGAACGGCCCAGTGATTAAGAGCTTGTACCTCTCTTGCAGAGGACCAAGTTTGGTT
CCCAGCACCACCCATATTAGATGGCTCCAGGATCTGATGCCACTGAACTCTGGGCCCTGGCACT
CACATGCACATGTTCTTAAACATAAATGTGGAAGTACACTGAGAAAGGTTAGAGTCTAGGATAG
TGGGCTGAACCTCACCTAGAGCCTACCACTGAGGAGCTGTGGCCATGTTTCAATAGGAGAGCAC
TTGCCTAGAACCCCTCGGGTCTGGGGCATAGTTTAGTAGTGGAGGACCTGCCTGTCATGTCTGA
GGCCTCAGATTCTATCCCAACTATTGCAAGGAAACAGTCACCAGACTGAAGACAATATCAAATG
TAAGACATTGTGTGTTGAAATATTTTATACTGATCAATAAAAATTTATTTCACCTGTCAAAAAA
AAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039089558 ⟹ XP_038945486

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	20,275,435 - 20,286,513 (+)	NCBI
mRatBN7.2	12	15,161,601 - 15,172,679 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008364	(Get FASTA)	NCBI Sequence Viewer
	XP_038945486	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85928	(Get FASTA)	NCBI Sequence Viewer
	EDL89762	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000043105
	ENSRNOP00000069561.1
GenBank Protein	Q5U2P3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001008364 ⟸ NM_001008363
- UniProtKB:	Q5U2P3 (UniProtKB/Swiss-Prot), A6K1V4 (UniProtKB/TrEMBL), A0A8L2QLB5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEFPDLGKHCSEPTCKQLDFLPITCDACKQDFCKDHFSYSGHKCPFAFKKDVQVPVCPLCNAPI PVRRGDIPDVVVGEHMDRDCTFHPGRNRNKVFTHRCSKEGCRKKEMLQLACAQCHGNFCIQHRH PLDHNCQAGSSSVSRGRSSASRAAEQKPSGVSWLAQRLRRTVK hide sequence

Ensembl Acc Id:

ENSRNOP00000043105 ⟸ ENSRNOT00000047634

Ensembl Acc Id:

ENSRNOP00000069561 ⟸ ENSRNOT00000083814

RefSeq Acc Id:	XP_038945486 ⟸ XM_039089558
- Peptide Label:	isoform X1
- UniProtKB:	Q5U2P3 (UniProtKB/Swiss-Prot), A6K1V4 (UniProtKB/TrEMBL), A0A8L2QLB5 (UniProtKB/TrEMBL)

Protein Domains

AN1-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U2P3-F1-model_v2	AlphaFold	Q5U2P3	1-171	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698465

Promoter ID:

EPDNEW_R8989

Type:

initiation region

Name:

Zfand2a_1

Description:

zinc finger AN1-type containing 2A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	17,252,169 - 17,252,229	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310991	AgrOrtholog
BioCyc Gene	G2FUF-19897	BioCyc
Ensembl Genes	ENSRNOG00000032917	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000047634	ENTREZGENE
	ENSRNOT00000083814.2	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.1110.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7110398	IMAGE-MGC_LOAD
InterPro	AN1-like_Znf	UniProtKB/Swiss-Prot
	Znf_AN1	UniProtKB/Swiss-Prot
KEGG Report	rno:360772	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94876	IMAGE-MGC_LOAD
NCBI Gene	360772	ENTREZGENE
PANTHER	AN1-TYPE ZINC FINGER PROTEIN 2A	UniProtKB/Swiss-Prot
	ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED	UniProtKB/Swiss-Prot
Pfam	zf-AN1	UniProtKB/Swiss-Prot
	zf-C2H2_ZFAND2	UniProtKB/Swiss-Prot
PhenoGen	Zfand2a	PhenoGen
PROSITE	ZF_AN1	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000032917	RatGTEx
SMART	ZnF_AN1	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF118310	UniProtKB/Swiss-Prot
UniProt	A0A8L2QLB5	ENTREZGENE, UniProtKB/TrEMBL
	A6K1V4	ENTREZGENE, UniProtKB/TrEMBL
	Q5U2P3	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Zfand2a	zinc finger AN1-type containing 2A	Zfand2a	zinc finger, AN1-type domain 2A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Zfand2a	zinc finger, AN1-type domain 2A	RGD1310991	similar to arsenite inducible RNA associated protein	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1310991	similar to arsenite inducible RNA associated protein	RGD1310991_predicted	similar to arsenite inducible RNA associated protein (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1310991_predicted	similar to arsenite inducible RNA associated protein (predicted)	LOC360772_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC360772_predicted	similar to arsenite inducible RNA associated protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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