Herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4) Rattus norvegicus
Analyze
Symbol: Herc4
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 4
RGD ID: 1310971
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of smoothened signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and fibrillar center. Predicted to be active in cytoplasm. Orthologous to human HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HECT domain and RCC1-like domain-containing protein 4; hect domain and RLD 4; HECT-type E3 ubiquitin transferase HERC4; LOC309758; probable E3 ubiquitin-protein ligase HERC4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,329,005 - 25,403,443 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2025,328,822 - 25,403,372 (-)EnsemblGRCr8
mRatBN7.22025,329,972 - 25,404,657 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,330,280 - 25,404,657 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2026,023,208 - 26,097,568 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,376,231 - 25,450,593 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,962,772 - 26,037,143 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,755,948 - 26,831,267 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,755,911 - 26,830,931 (+)Ensemblrn6Rnor6.0
Rnor_5.0208,063,820 - 8,139,150 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42025,591,774 - 25,665,597 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2026,628,361 - 26,702,717 (-)NCBICelera
RGSC_v3.12025,605,573 - 25,679,395 (+)NCBI
Cytogenetic Map20p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility. Rodriguez CI and Stewart CL, Dev Biol. 2007 Dec 15;312(2):501-8. Epub 2007 Oct 4.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:31010679  


Genomics

Comparative Map Data
Herc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,329,005 - 25,403,443 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2025,328,822 - 25,403,372 (-)EnsemblGRCr8
mRatBN7.22025,329,972 - 25,404,657 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,330,280 - 25,404,657 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2026,023,208 - 26,097,568 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,376,231 - 25,450,593 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,962,772 - 26,037,143 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,755,948 - 26,831,267 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,755,911 - 26,830,931 (+)Ensemblrn6Rnor6.0
Rnor_5.0208,063,820 - 8,139,150 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42025,591,774 - 25,665,597 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2026,628,361 - 26,702,717 (-)NCBICelera
RGSC_v3.12025,605,573 - 25,679,395 (+)NCBI
Cytogenetic Map20p11NCBI
HERC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381067,921,905 - 68,075,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1067,921,899 - 68,075,342 (-)Ensemblhg38GRCh38
GRCh371069,681,662 - 69,835,040 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,351,662 - 69,505,109 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341069,352,252 - 69,505,019NCBI
Celera1062,956,525 - 63,109,715 (-)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1063,681,241 - 63,834,644 (-)NCBIHuRef
CHM1_11069,963,663 - 70,116,856 (-)NCBICHM1_1
T2T-CHM13v2.01068,790,646 - 68,944,156 (-)NCBIT2T-CHM13v2.0
Herc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391063,079,122 - 63,153,660 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1063,079,589 - 63,153,657 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381063,243,751 - 63,317,881 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1063,243,810 - 63,317,878 (+)Ensemblmm10GRCm38
MGSCv371062,706,733 - 62,780,625 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361062,639,342 - 62,713,234 (+)NCBIMGSCv36mm8
Celera1064,344,505 - 64,417,884 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.56NCBI
Herc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,309,449 - 20,418,338 (-)Ensembl
ChiLan1.0NW_00495542520,310,264 - 20,418,154 (-)NCBIChiLan1.0ChiLan1.0
HERC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2880,084,224 - 80,238,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11080,090,126 - 80,244,093 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01064,405,164 - 64,559,651 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11066,717,537 - 66,870,774 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1066,716,761 - 66,870,774 (-)EnsemblpanPan2panpan1.1
HERC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,223,525 - 19,352,490 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,210,166 - 19,351,709 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha419,352,188 - 19,484,809 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0419,489,565 - 19,622,141 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl419,489,565 - 19,622,026 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,372,156 - 19,504,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0419,594,124 - 19,726,917 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0419,937,349 - 20,070,205 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Herc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,683,669 - 61,800,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652110,176,132 - 10,292,845 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493652110,176,191 - 10,294,761 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,122,792 - 71,269,424 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11471,126,100 - 71,269,517 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,237,996 - 77,279,396 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HERC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1963,311,619 - 63,460,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl963,311,651 - 63,461,536 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604824,079,840 - 24,229,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Herc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247542,336,163 - 2,466,862 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247542,335,585 - 2,466,955 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Herc4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11823,391,050 - 23,463,174 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Herc4
237 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:25
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000051367
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
AW553563  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82025,329,274 - 25,329,375 (+)Marker Load Pipeline
mRatBN7.22025,330,546 - 25,330,648 (-)MAPPERmRatBN7.2
Rnor_6.02026,830,584 - 26,830,685NCBIRnor6.0
Rnor_5.0208,138,467 - 8,138,568UniSTSRnor5.0
RGSC_v3.42025,665,227 - 25,665,328UniSTSRGSC3.4
Celera2026,628,630 - 26,628,731UniSTS
Cytogenetic Map20p11UniSTS
RH130359  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,330,161 - 25,330,347 (-)MAPPERmRatBN7.2
Rnor_6.02026,830,885 - 26,831,070NCBIRnor6.0
Rnor_5.0208,138,768 - 8,138,953UniSTSRnor5.0
RGSC_v3.42025,665,528 - 25,665,713UniSTSRGSC3.4
Celera2026,628,245 - 26,628,430UniSTS
Cytogenetic Map20p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC087104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000083017   ⟹   ENSRNOP00000072219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2025,328,822 - 25,403,372 (-)Ensembl
mRatBN7.2 Ensembl2025,330,280 - 25,404,657 (-)Ensembl
Rnor_6.0 Ensembl2026,755,911 - 26,830,931 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107240   ⟹   ENSRNOP00000082108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2025,329,007 - 25,396,592 (-)Ensembl
mRatBN7.2 Ensembl2025,330,287 - 25,404,566 (-)Ensembl
RefSeq Acc Id: NM_001012074   ⟹   NP_001012074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,372 (-)NCBI
mRatBN7.22025,330,278 - 25,404,657 (-)NCBI
Rnor_6.02026,755,948 - 26,830,954 (+)NCBI
Rnor_5.0208,063,820 - 8,139,150 (+)NCBI
RGSC_v3.42025,591,774 - 25,665,597 (+)RGD
Celera2026,628,361 - 26,702,717 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256134   ⟹   XP_006256196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,423 (-)NCBI
mRatBN7.22025,330,100 - 25,404,480 (-)NCBI
Rnor_6.02026,756,176 - 26,831,267 (+)NCBI
Rnor_5.0208,063,820 - 8,139,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256135   ⟹   XP_006256197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,433 (-)NCBI
mRatBN7.22025,330,100 - 25,404,544 (-)NCBI
Rnor_6.02026,756,175 - 26,831,267 (+)NCBI
Rnor_5.0208,063,820 - 8,139,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256136   ⟹   XP_006256198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,401,079 (-)NCBI
mRatBN7.22025,329,972 - 25,402,364 (-)NCBI
Rnor_6.02026,763,006 - 26,831,267 (+)NCBI
Rnor_5.0208,063,820 - 8,139,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601656   ⟹   XP_017457145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,026 (-)NCBI
mRatBN7.22025,330,100 - 25,403,369 (-)NCBI
Rnor_6.02026,756,278 - 26,831,267 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098756   ⟹   XP_038954684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,424 (-)NCBI
mRatBN7.22025,330,100 - 25,404,544 (-)NCBI
RefSeq Acc Id: XM_039098757   ⟹   XP_038954685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,424 (-)NCBI
mRatBN7.22025,330,100 - 25,404,544 (-)NCBI
RefSeq Acc Id: XM_039098758   ⟹   XP_038954686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,376,943 (-)NCBI
mRatBN7.22025,329,972 - 25,378,237 (-)NCBI
RefSeq Acc Id: XM_039098759   ⟹   XP_038954687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,366,384 (-)NCBI
mRatBN7.22025,329,972 - 25,367,659 (-)NCBI
RefSeq Acc Id: XM_063279170   ⟹   XP_063135240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,026 (-)NCBI
RefSeq Acc Id: XM_063279171   ⟹   XP_063135241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,443 (-)NCBI
RefSeq Acc Id: XM_063279172   ⟹   XP_063135242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,423 (-)NCBI
RefSeq Acc Id: XR_005497262
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,348,722 - 25,403,425 (-)NCBI
mRatBN7.22025,349,995 - 25,404,544 (-)NCBI
RefSeq Acc Id: NP_001012074   ⟸   NM_001012074
- UniProtKB: Q5PQN1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256197   ⟸   XM_006256135
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWE9 (UniProtKB/TrEMBL),   A6JKY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256196   ⟸   XM_006256134
- Peptide Label: isoform X1
- UniProtKB: Q5PQN1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256198   ⟸   XM_006256136
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017457145   ⟸   XM_017601656
- Peptide Label: isoform X1
- UniProtKB: Q5PQN1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072219   ⟸   ENSRNOT00000083017
RefSeq Acc Id: XP_038954686   ⟸   XM_039098758
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038954687   ⟸   XM_039098759
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038954685   ⟸   XM_039098757
- Peptide Label: isoform X5
- UniProtKB: A6JKY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954684   ⟸   XM_039098756
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000082108   ⟸   ENSRNOT00000107240
RefSeq Acc Id: XP_063135241   ⟸   XM_063279171
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWE9 (UniProtKB/TrEMBL),   A6JKY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135242   ⟸   XM_063279172
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063135240   ⟸   XM_063279170
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWE9 (UniProtKB/TrEMBL),   A6JKY7 (UniProtKB/TrEMBL)
Protein Domains
HECT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQN1-F1-model_v2 AlphaFold Q5PQN1 1-1057 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701566
Promoter ID:EPDNEW_R12090
Type:initiation region
Name:Herc4_1
Description:HECT and RLD domain containing E3 ubiquitin protein ligase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02026,756,026 - 26,756,086EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310971 AgrOrtholog
BioCyc Gene G2FUF-3819 BioCyc
Ensembl Genes ENSRNOG00000061040 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083017 ENTREZGENE
  ENSRNOT00000083017.2 UniProtKB/Swiss-Prot
  ENSRNOT00000107240 ENTREZGENE
Gene3D-CATH 2.130.10.30 UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192894 IMAGE-MGC_LOAD
InterPro HECT_dom UniProtKB/Swiss-Prot
  Hect_E3_ubiquitin_ligase UniProtKB/Swiss-Prot
  RCC1/BLIP-II UniProtKB/Swiss-Prot
  Reg_chr_condens UniProtKB/Swiss-Prot
  Ub-ligase/GTPase-reg UniProtKB/Swiss-Prot
KEGG Report rno:309758 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94698 IMAGE-MGC_LOAD
NCBI Gene 309758 ENTREZGENE
PANTHER REGULATOR OF CHROMOSOME CONDENSATION DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  UBIQUITIN-PROTEIN LIGASE E3A-RELATED UniProtKB/Swiss-Prot
Pfam HECT UniProtKB/Swiss-Prot
  WD40_RLD UniProtKB/Swiss-Prot
PhenoGen Herc4 PhenoGen
PRINTS RCCNDNSATION UniProtKB/Swiss-Prot
PROSITE HECT UniProtKB/Swiss-Prot
  RCC1_2 UniProtKB/Swiss-Prot
  RCC1_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061040 RatGTEx
SMART HECTc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50985 UniProtKB/Swiss-Prot
  SSF56204 UniProtKB/Swiss-Prot
UniProt A0A8I5ZWE9 ENTREZGENE, UniProtKB/TrEMBL
  A6JKY6 ENTREZGENE, UniProtKB/TrEMBL
  A6JKY7 ENTREZGENE, UniProtKB/TrEMBL
  HERC4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-17 Herc4  HECT and RLD domain containing E3 ubiquitin protein ligase 4  Herc4  hect domain and RLD 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Herc4  hect domain and RLD 4  Herc4_predicted  hect domain and RLD 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Herc4_predicted  hect domain and RLD 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED