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Gene: Ssr1 (signal sequence receptor subunit 1) Rattus norvegicus

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Symbol:

Ssr1

Name:

signal sequence receptor subunit 1

RGD ID:

1310961

Description:

Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SSR1 (signal sequence receptor subunit 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 3,3',5,5'-tetrabromobisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Ac2-238; liver regeneration-related protein LRRG137; LOC361233; signal sequence receptor subunit alpha; signal sequence receptor, alpha; SSR-alpha; translocon-associated protein subunit alpha; TRAP-alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SSR1 (signal sequence receptor subunit 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Ssr1 (signal sequence receptor, alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ssr1 (signal sequence receptor subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SSR1 (signal sequence receptor subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SSR1 (signal sequence receptor subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ssr1 (signal sequence receptor subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SSR1 (signal sequence receptor subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SSR1 (signal sequence receptor subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ssr1 (signal sequence receptor subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ssr1 (signal sequence receptor subunit 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AEBP1 (AE binding protein 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SSR1 (signal sequence receptor subunit 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ssr1 (signal sequence receptor, alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ssr1 (signal sequence receptor, alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	trap-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	l(1)G0320	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ssr1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	27,039,203 - 27,067,352 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	27,039,269 - 27,067,348 (+)	Ensembl				GRCr8
mRatBN7.2	17	26,833,720 - 26,861,821 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	26,833,741 - 26,861,821 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	26,692,010 - 26,707,862 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	28,295,585 - 28,311,437 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	26,640,642 - 26,656,477 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	27,496,369 - 27,512,781 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	27,492,220 - 27,523,912 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	29,410,597 - 29,430,911 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	33,061,975 - 33,077,827 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	26,465,484 - 26,481,337 (+)	NCBI		Celera
RGSC_v3.1	17	33,060,629 - 33,111,917 (+)	NCBI
Cytogenetic Map	17	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

buspirone (EXP)

cadmium dichloride (EXP)

calciol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (EXP,ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

deguelin (ISO)

diuron (ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

eugenol (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

genistein (ISO)

glafenine (EXP)

hydralazine (ISO)

iron atom (ISO)

iron(0) (ISO)

ivermectin (ISO)

ketamine (EXP)

methimazole (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

nimesulide (EXP)

Nivalenol (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

resveratrol (ISO)

Salinomycin (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP)

sodium fluoride (ISO)

Soman (EXP)

succimer (ISO)

sulfadimethoxine (EXP)

tamibarotene (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

theophylline (ISO)

titanium dioxide (ISO)

tolcapone (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

endoplasmic reticulum (IBA,IEA,ISO)

endoplasmic reticulum membrane (IEA)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:21795745

Genomics

Comparative Map Data

Ssr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	27,039,203 - 27,067,352 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	27,039,269 - 27,067,348 (+)	Ensembl				GRCr8
mRatBN7.2	17	26,833,720 - 26,861,821 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	26,833,741 - 26,861,821 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	26,692,010 - 26,707,862 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	28,295,585 - 28,311,437 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	26,640,642 - 26,656,477 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	27,496,369 - 27,512,781 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	27,492,220 - 27,523,912 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	29,410,597 - 29,430,911 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	33,061,975 - 33,077,827 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	26,465,484 - 26,481,337 (+)	NCBI		Celera
RGSC_v3.1	17	33,060,629 - 33,111,917 (+)	NCBI
Cytogenetic Map	17	p12	NCBI

SSR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	7,281,143 - 7,313,199 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	7,268,306 - 7,347,446 (-)	Ensembl			hg38	GRCh38
GRCh37	6	7,281,376 - 7,313,432 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	7,232,803 - 7,258,434 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	7,232,802 - 7,258,434	NCBI
Celera	6	8,511,044 - 8,543,304 (-)	NCBI		Celera
Cytogenetic Map	6	p24.3	NCBI
HuRef	6	7,157,612 - 7,189,870 (-)	NCBI		HuRef
CHM1_1	6	7,283,386 - 7,315,638 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	7,150,204 - 7,182,261 (-)	NCBI		T2T-CHM13v2.0

Ssr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	38,155,377 - 38,178,184 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	38,150,581 - 38,178,193 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	37,971,401 - 37,994,208 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	37,966,605 - 37,994,217 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	38,063,270 - 38,086,059 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	37,985,476 - 38,001,623 (-)	NCBI		MGSCv36	mm8
MGSCv36	13	37,369,878 - 37,386,025 (-)	NCBI		MGSCv36	mm8
Celera	13	39,093,049 - 39,114,041 (-)	NCBI		Celera
Cytogenetic Map	13	A3.3	NCBI
cM Map	13	17.86	NCBI

Ssr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955465	6,540,509 - 6,557,402 (+)	Ensembl
ChiLan1.0	NW_004955465	6,540,509 - 6,557,402 (+)	NCBI	ChiLan1.0	ChiLan1.0

SSR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	21,908,087 - 21,953,252 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	17,904,511 - 17,950,147 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	7,105,729 - 7,151,072 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	7,392,565 - 7,418,260 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	7,373,460 - 7,418,260 (-)	Ensembl			panPan2	panpan1.1

SSR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	7,276,697 - 7,303,223 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	7,264,171 - 7,303,201 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	7,281,918 - 7,306,242 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	7,358,147 - 7,384,700 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	7,345,926 - 7,384,710 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	7,213,481 - 7,237,847 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	7,240,417 - 7,264,763 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	8,572,724 - 8,597,108 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ssr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	17,000,234 - 17,036,788 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936534	5,269,259 - 5,293,697 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936534	5,269,263 - 5,305,771 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SSR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	4,652,921 - 4,685,901 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	4,662,949 - 4,685,892 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	4,675,472 - 4,698,116 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SSR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	64,879,447 - 64,905,046 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	64,879,249 - 64,922,885 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	7,228,653 - 7,272,150 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ssr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624756	18,229,189 - 18,247,902 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624756	18,229,623 - 18,247,898 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ssr1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	57,017,742 - 57,034,807 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ssr1
204 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	403
Count of miRNA genes:	224
Interacting mature miRNAs:	277
Transcripts:	ENSRNOT00000019040
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9266755	40968173	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
8552966	Pigfal18	Plasma insulin-like growth factor 1 level QTL 18	8.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	12860942	57860942	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22660799	55604694	Rat
9589151	Insul30	Insulin level QTL 30	8.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	12860942	57860942	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21498994	50592236	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23286322	64246472	Rat
9589057	Scfw6	Subcutaneous fat weight QTL 6	8.62	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	17	12860942	57860942	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	26522051	71522051	Rat
9590154	Scort9	Serum corticosterone level QTL 9	23.57	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	12860942	57860942	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	22019705	67019705	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
9590088	Insglur7	Insulin/glucose ratio QTL 7	20.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	17	12860942	57860942	Rat
1331720	Rf43	Renal function QTL 43	2.881		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	17	15537025	28637951	Rat
2317053	Aia25	Adjuvant induced arthritis QTL 25	2.69		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	10604694	55604694	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15537025	60531414	Rat
7411666	Foco31	Food consumption QTL 31	11.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	17	12860942	57860942	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23858926	68858926	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	8574342	32199534	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23858926	68858926	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23858926	68858926	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23858926	68858926	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23858926	68858926	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat

Markers in Region

RH133246

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	26,849,888 - 26,850,092 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	27,512,484 - 27,512,687	NCBI	Rnor6.0
Rnor_5.0	17	29,426,713 - 29,426,916	UniSTS	Rnor5.0
RGSC_v3.4	17	33,078,102 - 33,078,305	UniSTS	RGSC3.4
Celera	17	26,481,612 - 26,481,815	UniSTS
RH 3.4 Map	17	341.4	UniSTS
Cytogenetic Map	17	p12	UniSTS

RH143561

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	26,849,776 - 26,849,934 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	27,512,372 - 27,512,529	NCBI	Rnor6.0
Rnor_5.0	17	29,426,601 - 29,426,758	UniSTS	Rnor5.0
RGSC_v3.4	17	33,077,990 - 33,078,147	UniSTS	RGSC3.4
Celera	17	26,481,500 - 26,481,657	UniSTS
RH 3.4 Map	17	341.4	UniSTS
Cytogenetic Map	17	p12	UniSTS

RH141249

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	26,849,387 - 26,849,570 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	27,511,983 - 27,512,165	NCBI	Rnor6.0
Rnor_5.0	17	29,426,212 - 29,426,394	UniSTS	Rnor5.0
RGSC_v3.4	17	33,077,601 - 33,077,783	UniSTS	RGSC3.4
Celera	17	26,481,111 - 26,481,293	UniSTS
RH 3.4 Map	4	420.62	UniSTS
Cytogenetic Map	17	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY321345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019040 ⟹ ENSRNOP00000019040

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	27,039,273 - 27,054,658 (+)	Ensembl
mRatBN7.2 Ensembl	17	26,833,741 - 26,849,701 (+)	Ensembl
Rnor_6.0 Ensembl	17	27,496,406 - 27,512,207 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077994 ⟹ ENSRNOP00000071334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	27,039,273 - 27,067,348 (+)	Ensembl
mRatBN7.2 Ensembl	17	26,833,741 - 26,861,821 (+)	Ensembl
Rnor_6.0 Ensembl	17	27,496,353 - 27,510,918 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084090 ⟹ ENSRNOP00000070389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	27,039,269 - 27,055,845 (+)	Ensembl
mRatBN7.2 Ensembl	17	26,833,741 - 26,851,035 (+)	Ensembl
Rnor_6.0 Ensembl	17	27,492,220 - 27,523,912 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000089736 ⟹ ENSRNOP00000070167

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	27,039,269 - 27,066,747 (+)	Ensembl
mRatBN7.2 Ensembl	17	26,833,741 - 26,861,216 (+)	Ensembl
Rnor_6.0 Ensembl	17	27,496,472 - 27,523,912 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098549 ⟹ ENSRNOP00000093163

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	26,835,438 - 26,851,035 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109967 ⟹ ENSRNOP00000083441

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	27,040,972 - 27,054,658 (+)	Ensembl
mRatBN7.2 Ensembl	17	26,835,013 - 26,850,057 (+)	Ensembl

RefSeq Acc Id:

NM_001008891 ⟹ NP_001008891

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	27,039,293 - 27,055,146 (+)	NCBI
mRatBN7.2	17	26,833,759 - 26,849,614 (+)	NCBI
Rnor_6.0	17	27,496,406 - 27,512,209 (+)	NCBI
Rnor_5.0	17	29,410,597 - 29,430,911 (+)	NCBI
RGSC_v3.4	17	33,061,975 - 33,077,827 (+)	RGD
Celera	17	26,465,484 - 26,481,337 (+)	RGD

Sequence:

show sequence

CGCCATTACCGCCAAGAGCCGCCGAGAGCCCTAGCGGACGCGCACTGGACGCTGACCGGCCGCA
CCATGAGACTCCTCCCCCGCCTGCTGCTGCTTTTCCTGCTGGCCTTCCCCGCCGCCGTGCTGCT
ACGAGGCGGCCCCGGAGGGTCATTAGCTGTGGCTCAAGATCTTACAGAAGATGAAGAAACCGTA
GAAGATCCAATAATCGAGGATGAGGATGATGAGGCTGAAGTAGAAGAAGACGAACCCACAGACT
TGGCAGAAGAGAAAGAAGAAGAAGAAGATGTGTCTAGTGAACCAGAAGCTTCACCGAGTGCAGA
CACAACCATTCTATTTGTAAAAGGAGAAGATTTTCCAGCAAACAACATTGTGAAGTTCCTGGTT
GGCTTTACAAACAAGGGGACAGAAGATTTTATTGTTGAGTCACTAGATGCCTCCTTCCGTTATC
CTCAGGACTACCAGTTTTACATCCAGAATTTCACGGCTCTTCCTCTAAACACCATAGTGCCGCC
CCAGAGACAGGCGACTTTTGAGTATTCCTTCATTCCTGCAGAGCCTATGGGGGGACGACCCTTT
GGTCTGGTCATCAATCTGAACTACAAAGATTTGAATGGCAACGTATTCCAAGATGCTGTCTTCA
ATCAGACGGTCACAGTCATTGAAAGAGAGGACGGGTTAGATGGAGAAACAATTTTTATGTACAT
GTTCCTTGCCGGCCTTGGACTTCTAGTTGTTGTTGGCCTTCATCAACTTCTTGAATCTAGAAAG
CGCAAGAGACCCATACAGAAGGTAGAAATGGGTACCTCAAGTCAAAATGATGTTGACATGAGTT
GGATTCCTCAGGAAACTTTGAATCAGATCAATAAAGCTTCTCCGAGAAGGCTGCCCAGGAAGCG
GGCACAGAAGAGATCGGTGGGATCTGATGAGTAAATGTTGTTTGTGCAACAGTCCAGTCTGTGC
TCCCCTGCCCTCATGTTCTCCGCCTCGTGGGAATTAGTGCAGAGAACGTGTCACCACAGAAGGC
AGCTTCTGCTTATGTGTGGACTGAGCAGTCGGAATCTGTGGCCATAAGATTGCTGAAAATGCAC
TGCATTTGTTTTCTAAAGTAACAAATTTGGGTTTTTTTTAAAACCATTAAACTGTATGGGTGTG
AATGTCTGTGAGCAGTTGTCTTACCAGAATCATTGTTGAACTACCTGAAACACGCCTTTAGAAT
GCTCAGCAAAACGCTCTTGCCGCTTCCCTTGTGATGTTTTCCATTTTGCACCCAAATTCAATTA
ATATTTTTTCCCAGTGTGGTTTTAGGTGGATTGTTTGGATGAAATAATTTGCTTATTTCTTGGA
GTCGATCAAATCCAAACTGATGGCACAAACCAGCCCTTGGCTTGCTGTCTGTCACAGCTTGTAT
TTTAACTGCACAGCACGGTGGCTGCTGGGTGAGCATCAGAGGCATGCTGGGTAGTTTGCTGCTG
TTTGCTGTGTGCACCCCTTCAGAAACTTAGCAATAGAGTCAAAGAATTTTGGAATCACTAGCAA
CAAAATTGTGAAGCCTGACAGTTCTACTGACACCGGTTTATAAATCCTAATTCTATGCCTGTTT
TTTGTTTTGTTTGTTTTTAACCAAGTATAGTATGTCTGTGCAAACTGGGCTGTTGTGTTGTCCA
TTGTTCCGGGTGGCCTGGGAGCCTCCTTTCTTTGTTTGTTGTTGGTTTTAAGCAGAGCATTTTG
TTCTTAGTAGAAATAATCTTAAGAAAAAATTGTCATGGTCTATAGTCCAAAGAGATCACATTTT
AGGGGCAGGAATACATTTATATTAATCCTAATCTTTATAGAAATCTTAATTGGAAAGTTTTAAA
GTAGTTATGAGGTTATCTTTTAACCCTGTATTTAGGAGTTTTGATTGTTGACCTACCTTCTTAT
TAATGTGAAAAATCCCTAAACTCCAAGCACTTAAGATTTGAAGACCAAAATTAAGTTGGGTTTG
ATAAAATGACTCTAGTTATTCCTGCCTGACCTAATGAATTAAGTTTGGCATTATTGTCATACTT
ACTAGAAATTAATGTTGAGTGTGACTGGATAAGAGGCTTCCCTCTGTCTTTGAAGCCATATTCT
CCCTGCTTGTATTATAAGGAAGTGGTAATTTCAGTAACACTTTTATTCCTGACCTTTTTTATTC
TTATTTTCTTGTGGTCCAATCCCTTCCACATACACCTAAAGGAAAGCAACAAAACGAAACACAC
ACAGAAACAGAACTTAGAAGCTGTTTAACATGTAAGCCAAAACCAATGATTGAAGGTCTTCTGT
GTCCTCTGTAATTGTTAATCACTTACAAAAGGGGCTGAAATGTCAAATTGCCTGTATTTGCATA
TCTGGACTGTAAACTCTGTATGCCTGTAATACAATGTGTGTGGTTTTTAAAAAAAAAAAAAAAA
AAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039095878 ⟹ XP_038951806

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	27,039,203 - 27,067,352 (+)	NCBI
mRatBN7.2	17	26,833,721 - 26,861,821 (+)	NCBI

RefSeq Acc Id:

XM_063276579 ⟹ XP_063132649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	27,039,203 - 27,053,324 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008891	(Get FASTA)	NCBI Sequence Viewer
	XP_038951806	(Get FASTA)	NCBI Sequence Viewer
	XP_063132649	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98008	(Get FASTA)	NCBI Sequence Viewer
	AAP86277	(Get FASTA)	NCBI Sequence Viewer
	EDL98266	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070167.2
	ENSRNOP00000070389
	ENSRNOP00000071334
GenBank Protein	Q7TPJ0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001008891 ⟸ NM_001008891
- Peptide Label:	precursor
- UniProtKB:	Q4V7D1 (UniProtKB/TrEMBL), F7F9K1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLLPRLLLLFLLAFPAAVLLRGGPGGSLAVAQDLTEDEETVEDPIIEDEDDEAEVEEDEPTDL AEEKEEEEDVSSEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYP QDYQFYIQNFTALPLNTIVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFN QTVTVIEREDGLDGETIFMYMFLAGLGLLVVVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSW IPQETLNQINKASPRRLPRKRAQKRSVGSDE hide sequence

Ensembl Acc Id:

ENSRNOP00000071334 ⟸ ENSRNOT00000077994

Ensembl Acc Id:

ENSRNOP00000070167 ⟸ ENSRNOT00000089736

Ensembl Acc Id:

ENSRNOP00000019040 ⟸ ENSRNOT00000019040

Ensembl Acc Id:

ENSRNOP00000070389 ⟸ ENSRNOT00000084090

RefSeq Acc Id:	XP_038951806 ⟸ XM_039095878
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K075 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000093163 ⟸ ENSRNOT00000098549

Ensembl Acc Id:

ENSRNOP00000083441 ⟸ ENSRNOT00000109967

RefSeq Acc Id:	XP_063132649 ⟸ XM_063276579
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2K075 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TPJ0-F1-model_v2	AlphaFold	Q7TPJ0	1-319	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700397

Promoter ID:

EPDNEW_R10920

Type:

initiation region

Name:

Ssr1_1

Description:

signal sequence receptor subunit 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	27,496,419 - 27,496,479	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310961	AgrOrtholog
BioCyc Gene	G2FUF-9671	BioCyc
Ensembl Genes	ENSRNOG00000014165	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000077994	ENTREZGENE
	ENSRNOT00000084090	ENTREZGENE
	ENSRNOT00000089736.2	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7454159	IMAGE-MGC_LOAD
InterPro	TRAP_alpha	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116155	IMAGE-MGC_LOAD
NCBI Gene	361233	ENTREZGENE
PANTHER	TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA	UniProtKB/Swiss-Prot
	TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT	UniProtKB/Swiss-Prot
Pfam	TRAP_alpha	UniProtKB/Swiss-Prot
PhenoGen	Ssr1	PhenoGen
RatGTEx	ENSRNOG00000014165	RatGTEx
UniProt	A0A0G2JX79_RAT	UniProtKB/TrEMBL
	A0A0G2JXS8_RAT	UniProtKB/TrEMBL
	A0A0G2K075	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZVE2_RAT	UniProtKB/TrEMBL
	F7F9K1	ENTREZGENE, UniProtKB/TrEMBL
	Q4V7D1	ENTREZGENE, UniProtKB/TrEMBL
	Q7TPJ0	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-11	Ssr1	signal sequence receptor subunit 1	Ssr1	signal sequence receptor, alpha	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Ssr1	signal sequence receptor, alpha	Ssr1_predicted	signal sequence receptor, alpha (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ssr1_predicted	signal sequence receptor, alpha (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)