Ptgir (prostaglandin I2 receptor) - Rat Genome Database

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Gene: Ptgir (prostaglandin I2 receptor) Rattus norvegicus
Analyze
Symbol: Ptgir
Name: prostaglandin I2 receptor
RGD ID: 1310890
Description: Predicted to enable prostacyclin receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of platelet-derived growth factor receptor signaling pathway; and negative regulation of smooth muscle cell proliferation. Predicted to act upstream of or within response to lipopolysaccharide. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human PTGIR (prostaglandin I2 receptor); PARTICIPATES IN eicosanoid signaling pathway; prostaglandin I2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC292661; PGI receptor; PGI2 receptor; prostacyclin receptor; prostaglandin I receptor (IP); prostaglandin I2 (prostacyclin) receptor; prostaglandin I2 (prostacyclin) receptor (IP); prostanoid IP receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,707,690 - 86,710,073 (+)NCBIGRCr8
mRatBN7.2177,579,596 - 77,581,979 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,579,596 - 77,581,979 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,959,574 - 82,961,958 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,523,619 - 91,526,003 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,714,664 - 84,717,048 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,833,449 - 78,835,832 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,833,157 - 78,837,623 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0180,080,854 - 80,083,237 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,234,538 - 77,236,921 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,312,476 - 77,315,005 (+)NCBI
Celera172,064,851 - 72,067,234 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtgirRatlong QT syndrome 1  ISOPTGIR (Homo sapiens)8554872ClinVar Annotator: match by term: Long QT syndrome 1ClinVarPMID:28492532
PtgirRatWalker-Warburg syndrome  ISOPTGIR (Homo sapiens)8554872ClinVar Annotator: match by term: Walker-Warburg congenital muscular dystrophyClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtgirRataspirin-induced respiratory disease  ISOPTGIR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20485159
PtgirRatheart disease  ISOPTGIR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16154102

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtgirRat1,2-dimethylhydrazine increases expressionISOPtgir (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PTGIR mRNACTDPMID:22206623
PtgirRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PTGIR mRNACTDPMID:32387183 and PMID:34747641
PtgirRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PTGIR mRNACTDPMID:33387578
PtgirRat2,4,6-trinitrobenzenesulfonic acid increases expressionEXP 6480464Trinitrobenzenesulfonic Acid results in increased expression of PTGIR mRNACTDPMID:25526689
PtgirRat3',5'-cyclic AMP multiple interactionsISOPTGIR (Homo sapiens)6480464[cicaprost results in increased activity of PTGIR protein] which results in increased abundance of Cyclic AMP and GNAS protein promotes the reaction [[cicaprost results in increased activity of PTGIR protein] which results in increased abundance of Cyclic AMP]CTDPMID:11895442
PtgirRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOPTGIR (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTGIR mRNA more ...CTDPMID:28628672
PtgirRat4,4'-sulfonyldiphenol multiple interactionsISOPTGIR (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PTGIR mRNACTDPMID:28628672
PtgirRatacetylsalicylic acid affects response to substanceISOPTGIR (Homo sapiens)6480464PTGIR gene SNP affects the susceptibility to AspirinCTDPMID:20485159
PtgirRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of PTGIR mRNACTDPMID:16483693
PtgirRatantirheumatic drug decreases expressionISOPTGIR (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of PTGIR mRNACTDPMID:24449571
PtgirRatasbestos increases expressionISOPTGIR (Homo sapiens)6480464Asbestos results in increased expression of PTGIR mRNACTDPMID:22398240
PtgirRatAzoxymethane multiple interactionsISOPtgir (Mus musculus)6480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PTGIR mRNACTDPMID:29950665
PtgirRatbenzo[a]pyrene increases expressionISOPtgir (Mus musculus)6480464Benzo(a)pyrene results in increased expression of PTGIR mRNACTDPMID:22228805
PtgirRatberaprost multiple interactionsISOPTGIR (Homo sapiens)6480464beraprost binds to and results in increased activity of PTGIR protein and Endocannabinoids inhibits the reaction [beraprost binds to and results in increased activity of PTGIR protein]CTDPMID:30102254
PtgirRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of PTGIR mRNACTDPMID:25181051
PtgirRatbisphenol F multiple interactionsISOPTGIR (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTGIR mRNACTDPMID:28628672
PtgirRatbuta-1,3-diene decreases expressionISOPtgir (Mus musculus)64804641 and 3-butadiene results in decreased expression of PTGIR mRNACTDPMID:29038090
PtgirRatbutanal increases expressionISOPTGIR (Homo sapiens)6480464butyraldehyde results in increased expression of PTGIR mRNACTDPMID:26079696
PtgirRatcalcium atom multiple interactionsISOPTGIR (Homo sapiens)6480464[cicaprost results in increased activity of PTGIR protein] which results in increased abundance of CalciumCTDPMID:11895442
PtgirRatcalcium(0) multiple interactionsISOPTGIR (Homo sapiens)6480464[cicaprost results in increased activity of PTGIR protein] which results in increased abundance of CalciumCTDPMID:11895442

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Biological Process
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
PtgirRatadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOPTGIR (Homo sapiens)1624291 PMID:20622039RGDPMID:20622039
PtgirRatadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIEAUniProtKB:P43119 and ensembl:ENSP000002912941600115GO_REF:0000107EnsemblGO_REF:0000107
PtgirRatadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIEAUniProtKB:P43252 and ensembl:ENSMUSP000001220801600115GO_REF:0000107EnsemblGO_REF:0000107
PtgirRatadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOPtgir (Mus musculus)1624291 PMID:20622039RGDPMID:20622039
PtgirRatadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIBAMGI:97793 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtgirRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
PtgirRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
PtgirRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000370 and InterPro:IPR0083651600115GO_REF:0000002InterProGO_REF:0000002
PtgirRatinflammatory response involved_inIBAMGI:102966 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtgirRatnegative regulation of platelet-derived growth factor receptor signaling pathway involved_inISOPtgir (Mus musculus)1624291 PMID:20622039RGDPMID:20622039
PtgirRatnegative regulation of platelet-derived growth factor receptor signaling pathway involved_inIEAUniProtKB:P43252 and ensembl:ENSMUSP000001220801600115GO_REF:0000107EnsemblGO_REF:0000107
PtgirRatnegative regulation of smooth muscle cell proliferation involved_inISOPTGIR (Homo sapiens)1624291 PMID:20622039RGDPMID:20622039
PtgirRatnegative regulation of smooth muscle cell proliferation involved_inIEAUniProtKB:P43252 and ensembl:ENSMUSP000001220801600115GO_REF:0000107EnsemblGO_REF:0000107
PtgirRatnegative regulation of smooth muscle cell proliferation involved_inIEAUniProtKB:P43119 and ensembl:ENSP000002912941600115GO_REF:0000107EnsemblGO_REF:0000107
PtgirRatnegative regulation of smooth muscle cell proliferation involved_inISOPtgir (Mus musculus)1624291 PMID:20622039RGDPMID:20622039
PtgirRatnegative regulation of smooth muscle cell proliferation involved_inIBAMGI:99535 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtgirRatpositive regulation of cytosolic calcium ion concentration involved_inIBAMGI:97795 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtgirRatresponse to lipopolysaccharide acts_upstream_of_or_withinISOPtgir (Mus musculus)1624291MGI:2137832 PMID:15834430RGDPMID:15834430
PtgirRatresponse to lipopolysaccharide acts_upstream_of_or_withinIEAUniProtKB:P43252 and ensembl:ENSMUSP000001220801600115GO_REF:0000107EnsemblGO_REF:0000107
PtgirRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtgirRatcytosol located_inISOPTGIR (Homo sapiens)1624291 PMID:20622039RGDPMID:20622039
PtgirRatcytosol located_inIEAUniProtKB:P43119 and ensembl:ENSP000002912941600115GO_REF:0000107EnsemblGO_REF:0000107
PtgirRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
PtgirRatmembrane located_inIEAInterPro:IPR000370 and InterPro:IPR0083651600115GO_REF:0000002InterProGO_REF:0000002
PtgirRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
PtgirRatplasma membrane located_inISOPTGIR (Homo sapiens)1624291 PMID:20622039RGDPMID:20622039
PtgirRatplasma membrane located_inIEAUniProtKB:P43119 and ensembl:ENSP000002912941600115GO_REF:0000107EnsemblGO_REF:0000107
PtgirRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
PtgirRatplasma membrane is_active_inIBAMGI:102966 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PtgirRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function

  
Object Symbol
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Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
PtgirRatG protein-coupled receptor activity enablesIEAARBA:ARBA000291511600115GO_REF:0000117UniProtGO_REF:0000117
PtgirRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
PtgirRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
PtgirRatprostacyclin receptor activity enablesIBAPANTHER:PTN002627486 and ZFIN:ZDB-GENE-120511-11600115GO_REF:0000033GO_CentralGO_REF:0000033
PtgirRatprostanoid receptor activity enablesIEAARBA:ARBA000291131600115GO_REF:0000117UniProtGO_REF:0000117

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtgirRatprostaglandin I2 signaling pathway  ISOPTGIR (Homo sapiens)10402751 SMPDBSMP:00354

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PtgirRateicosanoid signaling pathway  ISOPTGIR (Homo sapiens)6484113 PIDPID:200082

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:7803522   PMID:15834430   PMID:19696359   PMID:20622039   PMID:20622163   PMID:21549696   PMID:21749934  



Ptgir
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,707,690 - 86,710,073 (+)NCBIGRCr8
mRatBN7.2177,579,596 - 77,581,979 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,579,596 - 77,581,979 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,959,574 - 82,961,958 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,523,619 - 91,526,003 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,714,664 - 84,717,048 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,833,449 - 78,835,832 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,833,157 - 78,837,623 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0180,080,854 - 80,083,237 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,234,538 - 77,236,921 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,312,476 - 77,315,005 (+)NCBI
Celera172,064,851 - 72,067,234 (+)NCBICelera
Cytogenetic Map1q21NCBI
PTGIR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,610,687 - 46,625,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,618,550 - 46,625,089 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,123,725 - 47,128,346 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,815,565 - 51,820,194 (-)NCBINCBI36Build 36hg18NCBI36
Build 341951,815,565 - 51,820,194NCBI
Celera1943,927,252 - 43,931,881 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,548,741 - 43,553,370 (-)NCBIHuRef
CHM1_11947,125,572 - 47,130,201 (-)NCBICHM1_1
T2T-CHM13v2.01949,436,301 - 49,450,683 (-)NCBIT2T-CHM13v2.0
Ptgir
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,640,442 - 16,644,828 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,640,415 - 16,644,830 (+)EnsemblGRCm39 Ensembl
GRCm38716,906,490 - 16,910,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,906,490 - 16,910,905 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,491,839 - 17,496,254 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36716,065,012 - 16,069,427 (+)NCBIMGSCv36mm8
Celera714,112,908 - 14,117,323 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Ptgir
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574687,583 - 689,750 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574686,156 - 690,126 (-)NCBIChiLan1.0ChiLan1.0
PTGIR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,770,490 - 52,775,153 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,641,304 - 54,645,928 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,613,065 - 43,617,700 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,141,822 - 52,146,473 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,141,822 - 52,146,473 (-)Ensemblpanpan1.1panPan2
PTGIR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,275,198 - 109,279,463 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,274,988 - 109,277,584 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,754,493 - 108,758,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,801,203 - 109,805,465 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,801,007 - 109,805,132 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,478,359 - 109,480,898 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,112,477 - 109,116,738 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,981,209 - 109,985,471 (+)NCBIUU_Cfam_GSD_1.0
Ptgir
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934918,866,264 - 18,871,516 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664487,125 - 489,414 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936664487,069 - 489,328 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGIR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,522,638 - 52,527,345 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,522,639 - 52,527,338 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,842,083 - 47,847,155 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGIR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,977,057 - 39,983,592 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,977,864 - 39,980,860 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607319,689,063 - 19,693,721 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgir
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,948,572 - 6,952,719 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,948,638 - 6,952,664 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ptgir
10 total Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 78833700 78833701 T G snv ACI/EurMcwi (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:94
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000022461
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 47 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat

1 to 10 of 47 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 57 31



Ensembl Acc Id: ENSRNOT00000022461   ⟹   ENSRNOP00000022461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,579,596 - 77,581,979 (+)Ensembl
Rnor_6.0 Ensembl178,833,157 - 78,837,623 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100532   ⟹   ENSRNOP00000089168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,579,678 - 77,581,979 (+)Ensembl
RefSeq Acc Id: NM_001077644   ⟹   NP_001071112
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,707,690 - 86,710,073 (+)NCBI
mRatBN7.2177,579,596 - 77,581,979 (+)NCBI
Rnor_6.0178,833,449 - 78,835,832 (+)NCBI
Rnor_5.0180,080,854 - 80,083,237 (+)NCBI
RGSC_v3.4177,234,538 - 77,236,921 (+)RGD
Celera172,064,851 - 72,067,234 (+)RGD
Sequence:
Protein RefSeqs NP_001071112 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA06091 (Get FASTA)   NCBI Sequence Viewer  
  EDM08294 (Get FASTA)   NCBI Sequence Viewer  
  EDM08295 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022461
  ENSRNOP00000022461.2
GenBank Protein P43253 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001071112   ⟸   NM_001077644
- UniProtKB: P43253 (UniProtKB/Swiss-Prot),   A6J8D9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022461   ⟸   ENSRNOT00000022461
Ensembl Acc Id: ENSRNOP00000089168   ⟸   ENSRNOT00000100532
Name Modeler Protein Id AA Range Protein Structure
AF-P43253-F1-model_v2 AlphaFold P43253 1-416 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689744
Promoter ID:EPDNEW_R268
Type:initiation region
Name:Ptgir_1
Description:prostaglandin I2 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,833,234 - 78,833,294EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-60588 BioCyc
Ensembl Genes ENSRNOG00000016756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022461 ENTREZGENE
  ENSRNOT00000022461.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot
  Prostglndn_IP_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:292661 UniProtKB/Swiss-Prot
NCBI Gene 292661 ENTREZGENE
PANTHER PTHR11866 UniProtKB/Swiss-Prot
  PTHR11866:SF7 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ptgir PhenoGen
PRINTS PROSTANOIDR UniProtKB/Swiss-Prot
  PRSTNOIDIPR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016756 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A8I6AC54_RAT UniProtKB/TrEMBL
  A6J8D9 ENTREZGENE, UniProtKB/TrEMBL
  P43253 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Ptgir  prostaglandin I2 receptor  Ptgir  prostaglandin I2 (prostacyclin) receptor (IP)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Ptgir  prostaglandin I2 (prostacyclin) receptor (IP)  Ptgir  prostaglandin I2 (prostacyclin) receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Ptgir  prostaglandin I2 (prostacyclin) receptor  Ptgir  prostaglandin I receptor (IP)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ptgir  prostaglandin I receptor (IP)   Ptgir_predicted  prostaglandin I receptor (IP) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ptgir_predicted  prostaglandin I receptor (IP) (predicted)      Symbol and Name status set to approved 70820 APPROVED