Spsb2 (splA/ryanodine receptor domain and SOCS box containing 2) - Rat Genome Database

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Gene: Spsb2 (splA/ryanodine receptor domain and SOCS box containing 2) Rattus norvegicus
Analyze
Symbol: Spsb2
Name: splA/ryanodine receptor domain and SOCS box containing 2
RGD ID: 1310854
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2); INTERACTS WITH 2,6-dinitrotoluene; all-trans-retinoic acid; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gene rich cluster, C9 gene; Grcc9; LOC100911548; LOC297592; MGC108858; SPRY domain-containing SOCS box protein 2; SPRY domain-containing SOCS box protein 2-like; SPRY domain-containing SOCS box protein SSB-2; SSB-2
RGD Orthologs
Human
Mouse
Dog
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: LOC100911548 (GeneID: 100911548) appears to be a duplicate placement of Spsb2 (GeneID: 297592) on Rnor_6.0 (Annot. Release 105) that is absent from Rn_Celera and is not supported by syntenic regions in mouse and human. BLAST analysis of the underlying component AABR07066868.1 against the rat genome shows 88% coverage and 99% identity with NC_005103.4, at the location where Spsb2 is annotated. Annotation of Spsb2 (GeneID: 297592) at this location on Rnor_6.0 is supported by annotation on Rn_Celera and synteny with mouse and human. This apparent duplication could be explained by misassembly of several underlying components on Rnor_6.0. LOC100911548 is bracketed by two genes, Gpr116 and Gpr110, which serve as a useful frame of reference, on the rat reference assembly. The region between these two genes also includes several other genes with names beginning with "LOC". However, on the Celera assembly as well as at the syntenic region in the mouse genome, these "LOC" genes are not annotated between Gpr116 and Gpr110. This suggests that the underlying components for these "LOC" genes could be misassembled in Rnor_6.0, including AABR07066868.1, AABR07066869.1, and AABR07066870.1. [14 Apr 2021]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,298,362 - 159,301,568 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,299,159 - 159,309,021 (+)EnsemblGRCr8
mRatBN7.24157,613,404 - 157,615,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,613,401 - 157,615,284 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,841,571 - 163,843,460 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,624,481 - 159,626,370 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,260,087 - 158,261,976 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,325,980 - 157,328,380 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,326,727 - 157,328,379 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl920,217,278 - 20,219,209 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,343,582 - 224,346,314 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,931,693 - 160,933,346 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,351,625 - 146,353,278 (+)NCBICelera
RGSC_v3.14161,176,628 - 161,178,281 (+)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO,ISS)
SCF ubiquitin ligase complex  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:20603330   PMID:21199876  


Genomics

Comparative Map Data
Spsb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,298,362 - 159,301,568 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,299,159 - 159,309,021 (+)EnsemblGRCr8
mRatBN7.24157,613,404 - 157,615,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,613,401 - 157,615,284 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,841,571 - 163,843,460 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,624,481 - 159,626,370 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,260,087 - 158,261,976 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,325,980 - 157,328,380 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,326,727 - 157,328,379 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl920,217,278 - 20,219,209 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,343,582 - 224,346,314 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,931,693 - 160,933,346 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,351,625 - 146,353,278 (+)NCBICelera
RGSC_v3.14161,176,628 - 161,178,281 (+)NCBI
Cytogenetic Map4q42NCBI
SPSB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,870,935 - 6,873,303 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,870,934 - 6,889,358 (-)Ensemblhg38GRCh38
GRCh37126,980,099 - 6,982,467 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12p13.31NCBI
HuRef126,833,828 - 6,836,250 (-)NCBIHuRef
CHM1_1126,979,098 - 6,981,520 (-)NCBICHM1_1
T2T-CHM13v2.0126,880,233 - 6,882,601 (-)NCBIT2T-CHM13v2.0
Spsb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,785,640 - 124,787,582 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,785,624 - 124,787,582 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386124,808,604 - 124,810,619 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,808,661 - 124,810,619 (+)Ensemblmm10GRCm38
MGSCv376124,758,959 - 124,760,632 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366124,774,560 - 124,776,233 (+)NCBIMGSCv36mm8
Celera6126,485,070 - 126,486,743 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
SPSB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,134,855 - 38,154,520 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,151,906 - 38,154,529 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,462,222 - 8,472,440 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02738,496,970 - 38,507,413 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,505,309 - 38,507,417 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,371,292 - 38,381,487 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,412,320 - 38,422,514 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,940,955 - 7,951,171 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spsb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1623,081,585 - 23,084,001 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spsb2
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:120
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000020493
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
RH143034  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,613,045 - 157,613,296 (-)MAPPERmRatBN7.2
mRatBN7.24157,613,045 - 157,613,296 (+)MAPPERmRatBN7.2
Rnor_6.04157,326,138 - 157,326,388NCBIRnor6.0
Rnor_6.0920,219,269 - 20,219,519NCBIRnor6.0
Rnor_5.04224,343,734 - 224,343,984UniSTSRnor5.0
Rnor_5.0919,095,245 - 19,095,495UniSTSRnor5.0
RGSC_v3.44160,931,104 - 160,931,354UniSTSRGSC3.4
Celera4146,351,036 - 146,351,286UniSTS
RH 3.4 Map41002.8UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 23 57 135 60 66 36 94 36 320 180 11 121 75 88 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020493   ⟹   ENSRNOP00000020493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,299,874 - 159,301,568 (+)Ensembl
mRatBN7.2 Ensembl4157,613,622 - 157,615,284 (+)Ensembl
Rnor_6.0 Ensembl4157,326,727 - 157,328,379 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072086   ⟹   ENSRNOP00000064453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,613,401 - 157,615,277 (+)Ensembl
Rnor_6.0 Ensembl920,217,278 - 20,219,209 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114293   ⟹   ENSRNOP00000084808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,613,730 - 157,615,283 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136731   ⟹   ENSRNOP00000100710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,299,159 - 159,309,021 (+)Ensembl
RefSeq Acc Id: NM_001009660   ⟹   NP_001009660
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,299,874 - 159,301,568 (+)NCBI
mRatBN7.24157,613,599 - 157,615,293 (+)NCBI
Rnor_6.04157,326,727 - 157,328,380 (+)NCBI
Rnor_5.04224,343,582 - 224,346,314 (+)NCBI
RGSC_v3.44160,931,693 - 160,933,346 (+)RGD
Celera4146,351,625 - 146,353,278 (+)RGD
Sequence:
RefSeq Acc Id: NM_001394356   ⟹   NP_001381285
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,299,679 - 159,301,568 (+)NCBI
mRatBN7.24157,613,404 - 157,615,293 (+)NCBI
RefSeq Acc Id: NM_001394357   ⟹   NP_001381286
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,299,874 - 159,301,568 (+)NCBI
mRatBN7.24157,613,599 - 157,615,293 (+)NCBI
RefSeq Acc Id: XM_063285904   ⟹   XP_063141974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,299,815 - 159,301,565 (+)NCBI
RefSeq Acc Id: XM_063285905   ⟹   XP_063141975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,298,362 - 159,301,565 (+)NCBI
RefSeq Acc Id: XM_063285906   ⟹   XP_063141976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,299,843 - 159,301,565 (+)NCBI
RefSeq Acc Id: NP_001009660   ⟸   NM_001009660
- UniProtKB: Q5M877 (UniProtKB/Swiss-Prot),   A6ILL1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020493   ⟸   ENSRNOT00000020493
Ensembl Acc Id: ENSRNOP00000064453   ⟸   ENSRNOT00000072086
Ensembl Acc Id: ENSRNOP00000084808   ⟸   ENSRNOT00000114293
RefSeq Acc Id: NP_001381285   ⟸   NM_001394356
- UniProtKB: Q5M877 (UniProtKB/Swiss-Prot),   A6ILL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381286   ⟸   NM_001394357
- UniProtKB: Q5M877 (UniProtKB/Swiss-Prot),   A6ILL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141975   ⟸   XM_063285905
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141974   ⟸   XM_063285904
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141976   ⟸   XM_063285906
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYR0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100710   ⟸   ENSRNOT00000136731
Protein Domains
B30.2/SPRY   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M877-F1-model_v2 AlphaFold Q5M877 1-264 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693389
Promoter ID:EPDNEW_R3914
Type:initiation region
Name:LOC100911548_1
Description:SPRY domain-containing SOCS box protein 2-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,326,698 - 157,326,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310854 AgrOrtholog
BioCyc Gene G2FUF-43067 BioCyc
Ensembl Genes ENSRNOG00000015125 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000047113 Ensembl
Ensembl Transcript ENSRNOT00000020493 ENTREZGENE
  ENSRNOT00000020493.6 UniProtKB/Swiss-Prot
  ENSRNOT00000136731 ENTREZGENE
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot
  SOCS box UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7371446 IMAGE-MGC_LOAD
InterPro B30.2/SPRY UniProtKB/Swiss-Prot
  B30.2/SPRY_sf UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  FBXO45-Fsn/SPSB_families UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
  SPRY_dom UniProtKB/Swiss-Prot
  SSB2_SOCS UniProtKB/Swiss-Prot
KEGG Report rno:297592 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108858 IMAGE-MGC_LOAD
NCBI Gene 297592 ENTREZGENE
PANTHER SPRY DOMAIN CONTAINING SOCS BOX PROTEIN UniProtKB/Swiss-Prot
  SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 2 UniProtKB/Swiss-Prot
Pfam SOCS_box UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
PhenoGen Spsb2 PhenoGen
PROSITE B302_SPRY UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015125 RatGTEx
  ENSRNOG00000047113 RatGTEx
SMART SOCS UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
UniProt A0A8I5ZYR0 ENTREZGENE, UniProtKB/TrEMBL
  A6ILL1 ENTREZGENE, UniProtKB/TrEMBL
  Q5M877 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Spsb2  splA/ryanodine receptor domain and SOCS box containing 2  LOC100911548  SPRY domain-containing SOCS box protein 2-like  Data merged from RGD:6492498 737654 PROVISIONAL
2012-07-05 LOC100911548  SPRY domain-containing SOCS box protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Spsb2  splA/ryanodine receptor domain and SOCS box containing 2  Grcc9  gene rich cluster, C9 gene  Symbol and Name updated 1299863 APPROVED
2005-12-06 Grcc9  gene rich cluster, C9 gene  Grcc9_predicted  gene rich cluster, C9 gene (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Grcc9_predicted  gene rich cluster, C9 gene (predicted)      Symbol and Name status set to approved 70820 APPROVED