Efr3b (EFR3 homolog B) - Rat Genome Database

Name: Efr3b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Efr3b (EFR3 homolog B) Rattus norvegicus

Analyze

Symbol:

Efr3b

Name:

EFR3 homolog B

RGD ID:

1310845

Description:

Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in actin cytoskeleton and cytosol. Predicted to be active in plasma membrane. Orthologous to human EFR3B (EFR3 homolog B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

EFR3 homolog B (S. cerevisiae); LOC313928; protein EFR3 homolog B; RGD1310845; similar to KIAA0953 protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EFR3B (EFR3 homolog B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Efr3b (EFR3 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Efr3b (EFR3 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EFR3B (EFR3 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EFR3B (EFR3 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Efr3b (EFR3 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EFR3B (EFR3 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EFR3B (EFR3 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Efr3b (EFR3 homolog B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EFR3B (EFR3 homolog B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Efr3b (EFR3 homolog B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	efr3bb (EFR3 homolog Bb (S. cerevisiae))	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	efr3ba (EFR3 homolog Ba (S. cerevisiae))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	EFR3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Caenorhabditis elegans (roundworm):	efr-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	stmA	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	efr3b	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	32,664,593 - 32,740,417 (-)	NCBI		GRCr8
mRatBN7.2	6	26,947,436 - 27,021,113 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	26,948,540 - 27,020,933 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	6	28,390,541 - 28,464,174 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	28,393,016 - 28,464,118 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	38,199,581 - 38,273,364 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	26,943,439 - 27,015,602 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	26,946,381 - 27,015,675 (-)	NCBI
Celera	6	26,423,314 - 26,496,653 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Tatton-Brown-Rahman syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

amphotericin B (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

dichloroacetic acid (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

L-methionine (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

propanal (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

phosphatidylinositol phosphate biosynthetic process (ISO)

protein localization to plasma membrane (IBA,ISO)

Cellular Component

actin cytoskeleton (IEA,ISO)

cytosol (IEA,ISO)

plasma membrane (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23229899

Genomics

Comparative Map Data

Efr3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	32,664,593 - 32,740,417 (-)	NCBI		GRCr8
mRatBN7.2	6	26,947,436 - 27,021,113 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	26,948,540 - 27,020,933 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	6	28,390,541 - 28,464,174 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	28,393,016 - 28,464,118 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	38,199,581 - 38,273,364 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	26,943,439 - 27,015,602 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	26,946,381 - 27,015,675 (-)	NCBI
Celera	6	26,423,314 - 26,496,653 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

EFR3B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	25,042,076 - 25,159,135 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	25,042,076 - 25,159,135 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	25,264,945 - 25,382,004 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	25,112,200 - 25,231,747 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	25,105,314 - 25,222,296 (+)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	25,002,615 - 25,119,748 (+)	NCBI		HuRef
CHM1_1	2	25,194,891 - 25,311,889 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	25,076,512 - 25,193,588 (+)	NCBI		T2T-CHM13v2.0

Efr3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	4,012,554 - 4,089,199 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	4,012,554 - 4,088,915 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	3,962,554 - 4,039,103 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	3,962,554 - 4,038,915 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	3,962,554 - 4,038,915 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	3,962,571 - 4,038,931 (-)	NCBI		MGSCv36	mm8
Celera	12	3,890,293 - 3,966,947 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	1.99	NCBI

Efr3b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	7,159,087 - 7,215,627 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	7,159,087 - 7,215,234 (+)	NCBI	ChiLan1.0	ChiLan1.0

EFR3B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	101,359,697 - 101,482,816 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	101,363,662 - 101,486,791 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	25,035,897 - 25,159,074 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	25,100,107 - 25,256,179 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	25,174,016 - 25,251,617 (+)	Ensembl	panpan1.1		panPan2

EFR3B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	19,334,949 - 19,428,888 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	19,334,369 - 19,424,561 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	19,231,650 - 19,321,206 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	19,607,766 - 19,699,773 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	19,607,666 - 19,701,639 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	19,344,359 - 19,433,835 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	19,353,903 - 19,443,527 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	19,400,293 - 19,490,009 (+)	NCBI		UU_Cfam_GSD_1.0

Efr3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	63,668,733 - 63,772,520 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	7,069,019 - 7,148,935 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	7,067,045 - 7,148,929 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EFR3B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	113,670,755 - 113,758,876 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	113,670,750 - 113,758,956 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	120,775,181 - 120,799,573 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EFR3B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	82,501,890 - 82,620,212 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	82,501,889 - 82,570,973 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	29,543,890 - 29,659,579 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Efr3b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	7,357,719 - 7,440,767 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	7,357,656 - 7,440,221 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Efr3b
352 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	100
Count of miRNA genes:	66
Interacting mature miRNAs:	70
Transcripts:	ENSRNOT00000039251, ENSRNOT00000068214
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	16536140	27261739	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat

Markers in Region

BE107959

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	27,007,657 - 27,007,824 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	28,450,757 - 28,450,923	NCBI	Rnor6.0
Rnor_5.0	6	38,259,644 - 38,259,810	UniSTS	Rnor5.0
RGSC_v3.4	6	26,999,607 - 26,999,773	UniSTS	RGSC3.4
Celera	6	26,483,510 - 26,483,676	UniSTS
RH 3.4 Map	6	117.59	UniSTS
Cytogenetic Map	6	q14	UniSTS

BF404957

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	27,008,396 - 27,008,494 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	28,451,498 - 28,451,595	NCBI	Rnor6.0
Rnor_5.0	6	38,260,385 - 38,260,482	UniSTS	Rnor5.0
RGSC_v3.4	6	27,000,347 - 27,000,444	UniSTS	RGSC3.4
Celera	6	26,484,250 - 26,484,347	UniSTS
RH 3.4 Map	6	93.9	UniSTS
Cytogenetic Map	6	q14	UniSTS

BF390574

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	27,004,691 - 27,004,860 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	28,447,711 - 28,447,879	NCBI	Rnor6.0
Rnor_5.0	6	38,256,751 - 38,256,919	UniSTS	Rnor5.0
RGSC_v3.4	6	26,996,755 - 26,996,923	UniSTS	RGSC3.4
Celera	6	26,480,568 - 26,480,736	UniSTS
RH 3.4 Map	6	117.8	UniSTS
Cytogenetic Map	6	q14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									72		1
Low	2	43	23	12	14	12	8	11	2	35	40	11	8
Below cutoff	1		32	27	5	27

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006225717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039113097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000068214 ⟹ ENSRNOP00000062505

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	26,948,540 - 27,020,933 (-)	Ensembl
Rnor_6.0 Ensembl	6	28,393,016 - 28,464,118 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097849 ⟹ ENSRNOP00000078976

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	26,951,328 - 26,983,538 (-)	Ensembl

RefSeq Acc Id:

NM_001427261 ⟹ NP_001414190

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	32,666,945 - 32,740,417 (-)	NCBI

RefSeq Acc Id:

XM_039113097 ⟹ XP_038969025

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	32,664,593 - 32,703,035 (-)	NCBI
mRatBN7.2	6	26,947,436 - 27,021,113 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414190	(Get FASTA)	NCBI Sequence Viewer
	XP_038969025	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM03024	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062505.2
	ENSRNOP00000078976.1

RefSeq Acc Id:

ENSRNOP00000062505 ⟸ ENSRNOT00000068214

RefSeq Acc Id:	XP_038969025 ⟸ XM_039113097
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000078976 ⟸ ENSRNOT00000097849

RefSeq Acc Id:	NP_001414190 ⟸ NM_001427261
- UniProtKB:	F1LTW9 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LTW9-F1-model_v2	AlphaFold	F1LTW9	1-817	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310845	AgrOrtholog
BioCyc Gene	G2FUF-38284	BioCyc
Ensembl Genes	ENSRNOG00000012950	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000068214.5	UniProtKB/TrEMBL
	ENSRNOT00000097849.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	EFR3-like_ARM	UniProtKB/TrEMBL
KEGG Report	rno:313928	UniProtKB/TrEMBL
NCBI Gene	313928	ENTREZGENE
PANTHER	PROTEIN EFR3 HOMOLOG B	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
Pfam	EFR3_ARM	UniProtKB/TrEMBL
PhenoGen	Efr3b	PhenoGen
RatGTEx	ENSRNOG00000012950	RatGTEx
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
UniProt	A0A8I5ZM57_RAT	UniProtKB/TrEMBL
	F1LTW9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-09	Efr3b	EFR3 homolog B	Efr3b	EFR3 homolog B (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-04-23	Efr3b	EFR3 homolog B (S. cerevisiae)	RGD1310845	similar to KIAA0953 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1310845	similar to KIAA0953 protein	RGD1310845_predicted	similar to KIAA0953 protein (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1310845_predicted	similar to KIAA0953 protein (predicted)	LOC313928_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313928_predicted	similar to KIAA0953 protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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