Hoxb3 (homeo box B3) - Rat Genome Database

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Gene: Hoxb3 (homeo box B3) Rattus norvegicus
Analyze
Symbol: Hoxb3
Name: homeo box B3
RGD ID: 1310780
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including angiogenesis; embryonic skeletal system morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including hemopoiesis; nervous system development; and thyroid gland development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human HOXB3 (homeobox B3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein Hox-B3; LOC303488
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,786,001 - 81,810,655 (+)NCBIGRCr8
mRatBN7.21081,258,739 - 81,314,134 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1081,299,357 - 81,313,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1086,259,007 - 86,261,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,757,056 - 85,759,744 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,149,531 - 81,152,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01084,170,629 - 84,196,823 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1084,182,118 - 84,195,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,984,855 - 83,999,476 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,076,528 - 85,079,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11085,090,910 - 85,093,586 (+)NCBI
Celera1080,076,118 - 80,078,806 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7913891   PMID:9441667   PMID:9520319   PMID:9556594   PMID:10885747   PMID:12477932   PMID:17761289   PMID:17972163   PMID:21320481   PMID:24029230   PMID:37652291  


Genomics

Comparative Map Data
Hoxb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,786,001 - 81,810,655 (+)NCBIGRCr8
mRatBN7.21081,258,739 - 81,314,134 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1081,299,357 - 81,313,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1086,259,007 - 86,261,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,757,056 - 85,759,744 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,149,531 - 81,152,219 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01084,170,629 - 84,196,823 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1084,182,118 - 84,195,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,984,855 - 83,999,476 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,076,528 - 85,079,216 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11085,090,910 - 85,093,586 (+)NCBI
Celera1080,076,118 - 80,078,806 (+)NCBICelera
Cytogenetic Map10q26NCBI
HOXB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,548,870 - 48,590,241 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,548,870 - 48,604,912 (-)EnsemblGRCh38hg38GRCh38
GRCh371746,626,232 - 46,667,603 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,981,231 - 44,006,809 (-)NCBINCBI36Build 36hg18NCBI36
Build 341743,982,245 - 44,006,809NCBI
Celera1743,080,373 - 43,105,963 (-)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,995,516 - 42,020,616 (-)NCBIHuRef
CHM1_11746,692,172 - 46,717,774 (-)NCBICHM1_1
T2T-CHM13v2.01749,412,447 - 49,453,831 (-)NCBIT2T-CHM13v2.0
Hoxb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391196,197,927 - 96,238,756 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1196,214,152 - 96,238,756 (+)EnsemblGRCm39 Ensembl
GRCm381196,307,101 - 96,347,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,323,326 - 96,347,930 (+)EnsemblGRCm38mm10GRCm38
MGSCv371196,184,440 - 96,209,244 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,159,859 - 96,162,597 (+)NCBIMGSCv36mm8
Celera11105,973,984 - 105,998,796 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.84NCBI
Hoxb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,687,364 - 12,689,511 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,651,229 - 12,690,941 (+)NCBIChiLan1.0ChiLan1.0
HOXB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21916,512,202 - 16,553,798 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11718,515,733 - 18,518,314 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,946,441 - 8,987,876 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,131,587 - 9,172,501 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,147,784 - 9,171,021 (+)Ensemblpanpan1.1panPan2
HOXB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,810,299 - 24,837,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,809,739 - 24,836,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,274,578 - 24,331,200 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,605,021 - 25,661,765 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,605,623 - 25,630,630 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1924,373,225 - 24,429,868 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,633,869 - 24,690,451 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0924,762,003 - 24,818,731 (-)NCBIUU_Cfam_GSD_1.0
Hoxb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,237,247 - 24,240,922 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,834,240 - 12,836,398 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,834,240 - 12,836,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOXB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1224,804,647 - 24,809,937 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11224,803,119 - 24,827,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,760,577 - 24,786,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HOXB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,961,877 - 69,003,718 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1668,963,358 - 68,965,498 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,016,393 - 40,042,720 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hoxb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,048,920 - 5,068,708 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,050,272 - 5,072,614 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hoxb3
263 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:47
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000011027
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
AW524089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,301,917 - 81,302,110 (+)MAPPERmRatBN7.2
Rnor_6.01084,184,678 - 84,184,870NCBIRnor6.0
Rnor_5.01083,987,410 - 83,987,602UniSTSRnor5.0
RGSC_v3.41085,068,042 - 85,068,234UniSTSRGSC3.4
Celera1080,068,060 - 80,068,252UniSTS
RH 3.4 Map10769.3UniSTS
Cytogenetic Map10q31UniSTS
BF397575  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,302,676 - 81,302,853 (+)MAPPERmRatBN7.2
Rnor_6.01084,185,437 - 84,185,613NCBIRnor6.0
Rnor_5.01083,988,169 - 83,988,345UniSTSRnor5.0
RGSC_v3.41085,068,801 - 85,068,977UniSTSRGSC3.4
Celera1080,068,819 - 80,068,995UniSTS
RH 3.4 Map10745.4UniSTS
Cytogenetic Map10q31UniSTS
BE117971  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,312,894 - 81,313,060 (+)MAPPERmRatBN7.2
Rnor_6.01084,195,584 - 84,195,749NCBIRnor6.0
Rnor_5.01083,998,237 - 83,998,402UniSTSRnor5.0
RGSC_v3.41085,079,385 - 85,079,550UniSTSRGSC3.4
Celera1080,078,975 - 80,079,140UniSTS
RH 3.4 Map10747.1UniSTS
Cytogenetic Map10q31UniSTS
Hoxb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,310,512 - 81,310,916 (+)MAPPERmRatBN7.2
Rnor_6.01084,193,202 - 84,193,605NCBIRnor6.0
Rnor_5.01083,995,855 - 83,996,258UniSTSRnor5.0
RGSC_v3.41085,077,003 - 85,077,406UniSTSRGSC3.4
Celera1080,076,593 - 80,076,996UniSTS
Cytogenetic Map10q31UniSTS
Hoxb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,310,640 - 81,310,716 (+)MAPPERmRatBN7.2
Rnor_6.01084,193,330 - 84,193,405NCBIRnor6.0
Rnor_5.01083,995,983 - 83,996,058UniSTSRnor5.0
Celera1080,076,721 - 80,076,796UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 65 91 90 59 25 59 6 218 97 45 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011027   ⟹   ENSRNOP00000011027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1081,299,357 - 81,313,107 (+)Ensembl
Rnor_6.0 Ensembl1084,182,118 - 84,195,796 (+)Ensembl
RefSeq Acc Id: NM_001107042   ⟹   NP_001100512
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,806,559 - 81,809,247 (+)NCBI
mRatBN7.21081,310,038 - 81,312,726 (+)NCBI
Rnor_6.01084,192,727 - 84,195,415 (+)NCBI
Rnor_5.01083,984,855 - 83,999,476 (+)NCBI
RGSC_v3.41085,076,528 - 85,079,216 (+)RGD
Celera1080,076,118 - 80,078,806 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247194   ⟹   XP_006247256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,794,463 - 81,810,655 (+)NCBI
mRatBN7.21081,297,927 - 81,314,134 (+)NCBI
Rnor_6.01084,180,356 - 84,196,823 (+)NCBI
Rnor_5.01083,984,855 - 83,999,476 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597314   ⟹   XP_017452803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,786,001 - 81,810,655 (+)NCBI
mRatBN7.21081,287,861 - 81,314,134 (+)NCBI
Rnor_6.01084,170,629 - 84,196,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597315   ⟹   XP_017452804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,794,463 - 81,810,655 (+)NCBI
mRatBN7.21081,297,928 - 81,314,134 (+)NCBI
Rnor_6.01084,180,356 - 84,196,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086074   ⟹   XP_038942002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,797,910 - 81,810,655 (+)NCBI
mRatBN7.21081,301,376 - 81,314,134 (+)NCBI
RefSeq Acc Id: XM_039086075   ⟹   XP_038942003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,803,742 - 81,810,655 (+)NCBI
mRatBN7.21081,307,187 - 81,314,134 (+)NCBI
RefSeq Acc Id: NP_001100512   ⟸   NM_001107042
- UniProtKB: A6HIE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247256   ⟸   XM_006247194
- Peptide Label: isoform X2
- UniProtKB: F7FL39 (UniProtKB/TrEMBL),   B2RYQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452803   ⟸   XM_017597314
- Peptide Label: isoform X1
- UniProtKB: A6HIE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452804   ⟸   XM_017597315
- Peptide Label: isoform X1
- UniProtKB: A6HIE8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011027   ⟸   ENSRNOT00000011027
RefSeq Acc Id: XP_038942002   ⟸   XM_039086074
- Peptide Label: isoform X1
- UniProtKB: A6HIE8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942003   ⟸   XM_039086075
- Peptide Label: isoform X1
- UniProtKB: A6HIE8 (UniProtKB/TrEMBL)
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FL39-F1-model_v2 AlphaFold F7FL39 1-428 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697631
Promoter ID:EPDNEW_R8156
Type:single initiation site
Name:Hoxb3_1
Description:homeo box B3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01084,182,215 - 84,182,275EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310780 AgrOrtholog
BioCyc Gene G2FUF-23504 BioCyc
Ensembl Genes ENSRNOG00000008313 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011027.7 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9100655 IMAGE-MGC_LOAD
InterPro DUF4074 UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
  Homeobox_Antennapedia_CS UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_region UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:303488 UniProtKB/TrEMBL
MGC_CLONE MGC:188766 IMAGE-MGC_LOAD
NCBI Gene 303488 ENTREZGENE
PANTHER HOMEOBOX PROTEIN HOX-B3 UniProtKB/TrEMBL
  PROTEIN ZERKNUELLT 1-RELATED UniProtKB/TrEMBL
Pfam DUF4074 UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
PhenoGen Hoxb3 PhenoGen
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE ANTENNAPEDIA UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008313 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6HIE8 ENTREZGENE, UniProtKB/TrEMBL
  B2RYQ0 ENTREZGENE
  F7FL39 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2RYQ0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Hoxb3  homeo box B3   Hoxb3_predicted  homeo box B3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hoxb3_predicted  homeo box B3 (predicted)      Symbol and Name status set to approved 70820 APPROVED