Smg7 (SMG7 nonsense mediated mRNA decay factor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Smg7 (SMG7 nonsense mediated mRNA decay factor) Rattus norvegicus
Analyze
Symbol: Smg7
Name: SMG7 nonsense mediated mRNA decay factor
RGD ID: 1310761
Description: Predicted to enable protein phosphatase 2A binding activity; telomerase RNA binding activity; and telomeric DNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be located in cytosol and nucleus. Predicted to be part of telomerase holoenzyme complex. Orthologous to human SMG7 (SMG7 nonsense mediated mRNA decay factor); PARTICIPATES IN mRNA decay pathway; INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360855; nonsense-mediated mRNA decay factor SMG7; RGD1310761; similar to chromosome 1 open reading frame 16; Smg-7 homolog, nonsense mediated mRNA decay factor; Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,536,016 - 67,600,624 (-)NCBIGRCr8
mRatBN7.21364,986,145 - 65,050,698 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1364,987,434 - 65,050,582 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1367,588,905 - 67,629,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01368,875,892 - 68,916,950 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,126,955 - 66,168,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,258,919 - 70,321,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,258,915 - 70,321,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,229,500 - 75,292,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41367,835,448 - 67,900,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11367,849,527 - 67,951,670 (-)NCBI
Celera1364,891,810 - 64,932,829 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14636577   PMID:17916692  


Genomics

Comparative Map Data
Smg7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,536,016 - 67,600,624 (-)NCBIGRCr8
mRatBN7.21364,986,145 - 65,050,698 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1364,987,434 - 65,050,582 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1367,588,905 - 67,629,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01368,875,892 - 68,916,950 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,126,955 - 66,168,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,258,919 - 70,321,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,258,915 - 70,321,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,229,500 - 75,292,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41367,835,448 - 67,900,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11367,849,527 - 67,951,670 (-)NCBI
Celera1364,891,810 - 64,932,829 (-)NCBICelera
Cytogenetic Map13q21NCBI
SMG7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381183,472,499 - 183,554,191 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1183,472,216 - 183,598,246 (+)EnsemblGRCh38hg38GRCh38
GRCh371183,441,634 - 183,523,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,708,257 - 181,789,949 (+)NCBINCBI36Build 36hg18NCBI36
Build 341180,173,290 - 180,254,982NCBI
Celera1156,552,563 - 156,634,375 (+)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1154,677,519 - 154,759,191 (+)NCBIHuRef
CHM1_11184,864,494 - 184,946,346 (+)NCBICHM1_1
T2T-CHM13v2.01182,831,784 - 182,913,482 (+)NCBIT2T-CHM13v2.0
Smg7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,712,746 - 152,783,212 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,712,746 - 152,778,397 (-)EnsemblGRCm39 Ensembl
GRCm381152,836,995 - 152,903,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,836,995 - 152,902,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv371154,684,125 - 154,749,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,599,213 - 154,664,840 (-)NCBIMGSCv36mm8
Celera1155,258,082 - 155,323,736 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.07NCBI
Smg7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540622,273,298 - 22,352,782 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540622,273,298 - 22,352,782 (+)NCBIChiLan1.0ChiLan1.0
SMG7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,163,481 - 66,245,785 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,846,613 - 65,928,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,002,363 - 159,084,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,159,294 - 163,242,285 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,159,362 - 163,242,285 (+)Ensemblpanpan1.1panPan2
SMG7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,820,938 - 16,913,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,820,882 - 16,911,377 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha716,406,152 - 16,499,070 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0716,552,548 - 16,645,376 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl716,551,996 - 16,645,376 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1716,460,693 - 16,553,547 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0716,570,275 - 16,662,968 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,701,145 - 16,793,905 (+)NCBIUU_Cfam_GSD_1.0
Smg7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934488,481,369 - 88,558,329 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,326,010 - 6,405,074 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,326,211 - 6,405,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMG7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,697,093 - 124,775,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19124,696,432 - 124,775,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29137,052,343 - 137,105,730 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMG7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12545,808,384 - 45,895,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2545,805,689 - 45,866,852 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605547,025,227 - 47,114,190 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smg7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,137,548 - 10,224,825 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481410,135,733 - 10,224,991 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smg7
130 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:970
Count of miRNA genes:329
Interacting mature miRNAs:459
Transcripts:ENSRNOT00000044235
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat

Markers in Region
D13Rat102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,043,980 - 65,044,107 (+)MAPPERmRatBN7.2
Rnor_6.01370,315,160 - 70,315,286NCBIRnor6.0
Rnor_5.01375,285,741 - 75,285,867UniSTSRnor5.0
RGSC_v3.41367,893,709 - 67,893,836RGDRGSC3.4
RGSC_v3.41367,893,710 - 67,893,836UniSTSRGSC3.4
RGSC_v3.11367,907,762 - 67,908,135RGD
Celera1364,948,288 - 64,948,414UniSTS
FHH x ACI Map1324.89RGD
FHH x ACI Map1324.89UniSTS
Cytogenetic Map13q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 42 26 19 26 6 9 74 35 41 11 6
Low 15 15 15 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044235   ⟹   ENSRNOP00000048900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1364,987,434 - 65,050,582 (-)Ensembl
Rnor_6.0 Ensembl1370,258,920 - 70,299,733 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092269   ⟹   ENSRNOP00000075882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1364,987,434 - 65,018,126 (-)Ensembl
Rnor_6.0 Ensembl1370,260,865 - 70,321,752 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092336   ⟹   ENSRNOP00000075818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1364,987,434 - 65,050,582 (-)Ensembl
Rnor_6.0 Ensembl1370,261,003 - 70,321,746 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092397   ⟹   ENSRNOP00000075794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1364,987,587 - 65,050,578 (-)Ensembl
Rnor_6.0 Ensembl1370,258,915 - 70,321,722 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092649   ⟹   ENSRNOP00000075847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1364,987,434 - 65,019,597 (-)Ensembl
Rnor_6.0 Ensembl1370,266,013 - 70,321,750 (-)Ensembl
RefSeq Acc Id: NM_001191549   ⟹   NP_001178478
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,536,016 - 67,600,437 (-)NCBI
mRatBN7.21364,986,145 - 65,050,567 (-)NCBI
Rnor_6.01370,258,919 - 70,299,657 (-)NCBI
Rnor_5.01375,229,500 - 75,292,318 (-)NCBI
Celera1364,891,810 - 64,932,829 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001415738   ⟹   NP_001402667
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,536,016 - 67,600,437 (-)NCBI
mRatBN7.21364,986,145 - 65,050,567 (-)NCBI
RefSeq Acc Id: NM_001415740   ⟹   NP_001402669
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,536,016 - 67,600,437 (-)NCBI
mRatBN7.21364,986,145 - 65,050,567 (-)NCBI
RefSeq Acc Id: NM_001415741   ⟹   NP_001402670
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,536,016 - 67,600,437 (-)NCBI
mRatBN7.21364,986,145 - 65,050,567 (-)NCBI
RefSeq Acc Id: NM_001415742   ⟹   NP_001402671
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,536,016 - 67,600,437 (-)NCBI
mRatBN7.21364,986,145 - 65,050,567 (-)NCBI
RefSeq Acc Id: XM_039090906   ⟹   XP_038946834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,537,304 - 67,600,604 (-)NCBI
mRatBN7.21364,986,145 - 65,050,698 (-)NCBI
RefSeq Acc Id: XM_063272474   ⟹   XP_063128544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,537,304 - 67,600,624 (-)NCBI
RefSeq Acc Id: XM_063272475   ⟹   XP_063128545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,537,304 - 67,600,542 (-)NCBI
RefSeq Acc Id: XM_063272476   ⟹   XP_063128546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,537,304 - 67,600,624 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178478   ⟸   NM_001191549
- Peptide Label: isoform 1
- UniProtKB: D4ACJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075882   ⟸   ENSRNOT00000092269
RefSeq Acc Id: ENSRNOP00000075794   ⟸   ENSRNOT00000092397
RefSeq Acc Id: ENSRNOP00000075818   ⟸   ENSRNOT00000092336
RefSeq Acc Id: ENSRNOP00000075847   ⟸   ENSRNOT00000092649
RefSeq Acc Id: ENSRNOP00000048900   ⟸   ENSRNOT00000044235
RefSeq Acc Id: XP_038946834   ⟸   XM_039090906
- Peptide Label: isoform X3
- UniProtKB: A0A0U1RS03 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402667   ⟸   NM_001415738
- Peptide Label: isoform 2
- UniProtKB: A0A0U1RRS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402671   ⟸   NM_001415742
- Peptide Label: isoform 5
- UniProtKB: A0A0U1RRU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402670   ⟸   NM_001415741
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001402669   ⟸   NM_001415740
- Peptide Label: isoform 3
RefSeq Acc Id: XP_063128546   ⟸   XM_063272476
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128544   ⟸   XM_063272474
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128545   ⟸   XM_063272475
- Peptide Label: isoform X2
Protein Domains
DNA/RNA-binding   Telomerase activating protein Est1-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACJ3-F1-model_v2 AlphaFold D4ACJ3 1-1166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698894
Promoter ID:EPDNEW_R9417
Type:multiple initiation site
Name:Smg7_1
Description:SMG7 nonsense mediated mRNA decay factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01370,321,745 - 70,321,805EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310761 AgrOrtholog
BioCyc Gene G2FUF-17897 BioCyc
Ensembl Genes ENSRNOG00000027962 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044235 ENTREZGENE
  ENSRNOT00000044235.6 UniProtKB/TrEMBL
  ENSRNOT00000092269.2 UniProtKB/TrEMBL
  ENSRNOT00000092336 ENTREZGENE
  ENSRNOT00000092336.2 UniProtKB/TrEMBL
  ENSRNOT00000092397 ENTREZGENE
  ENSRNOT00000092397.2 UniProtKB/TrEMBL
  ENSRNOT00000092649.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro DNA/RNA-bd_Est1-type UniProtKB/TrEMBL
  EST1 UniProtKB/TrEMBL
  Est1/Ebs1-like UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
NCBI Gene 360855 ENTREZGENE
PANTHER PROTEIN SMG7 UniProtKB/TrEMBL
  PTHR15696 UniProtKB/TrEMBL
Pfam EST1 UniProtKB/TrEMBL
  EST1_DNA_bind UniProtKB/TrEMBL
PhenoGen Smg7 PhenoGen
RatGTEx ENSRNOG00000027962 RatGTEx
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
UniProt A0A0U1RRS5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0U1RRU7 ENTREZGENE, UniProtKB/TrEMBL
  A0A0U1RRX2_RAT UniProtKB/TrEMBL
  A0A0U1RS03 ENTREZGENE, UniProtKB/TrEMBL
  D4ACJ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-12 Smg7  SMG7 nonsense mediated mRNA decay factor  Smg7  Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Smg7  Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)   Smg7_predicted  Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Smg7_predicted  Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) (predicted)  RGD1310761_predicted  similar to chromosome 1 open reading frame 16 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310761_predicted  similar to chromosome 1 open reading frame 16 (predicted)  LOC360855_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360855_predicted  similar to chromosome 1 open reading frame 16 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL