Arhgdig (Rho GDP dissociation inhibitor gamma) - Rat Genome Database

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Gene: Arhgdig (Rho GDP dissociation inhibitor gamma) Rattus norvegicus
Analyze
Symbol: Arhgdig
Name: Rho GDP dissociation inhibitor gamma
RGD ID: 1310739
Description: Predicted to enable Rho GDP-dissociation inhibitor activity. Predicted to be involved in Rho protein signal transduction. Predicted to act upstream of or within blastocyst hatching and regulation of protein localization. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and membrane. Orthologous to human ARHGDIG (Rho GDP dissociation inhibitor gamma); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; furan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC360500; Rho GDP dissociation inhibitor (GDI) gamma; rho GDP-dissociation inhibitor 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,723,525 - 15,725,719 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,723,525 - 15,725,688 (-)EnsemblGRCr8
mRatBN7.21015,219,049 - 15,221,257 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,219,049 - 15,221,213 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,958,820 - 19,960,982 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,447,699 - 19,449,861 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,946,979 - 14,949,141 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_5.01015,379,685 - 15,381,879 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,466,159 - 15,468,322 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,886,854 - 14,889,018 (-)NCBICelera
RGSC_v3.11015,467,209 - 15,469,243 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)
membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8939998   PMID:20051515   PMID:27869233   PMID:38029612  


Genomics

Comparative Map Data
Arhgdig
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,723,525 - 15,725,719 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,723,525 - 15,725,688 (-)EnsemblGRCr8
mRatBN7.21015,219,049 - 15,221,257 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,219,049 - 15,221,213 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1019,958,820 - 19,960,982 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,447,699 - 19,449,861 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,946,979 - 14,949,141 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_5.01015,379,685 - 15,381,879 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,466,159 - 15,468,322 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,886,854 - 14,889,018 (-)NCBICelera
RGSC_v3.11015,467,209 - 15,469,243 (-)NCBI
Cytogenetic Map10q12NCBI
ARHGDIG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816280,591 - 283,010 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16280,450 - 283,010 (+)Ensemblhg38GRCh38
GRCh3716330,591 - 333,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616270,607 - 273,004 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3416270,627 - 273,701NCBI
Celera16530,508 - 532,906 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16241,938 - 251,249 (+)NCBIHuRef
CHM1_116330,546 - 332,944 (+)NCBICHM1_1
T2T-CHM13v2.016275,429 - 277,879 (+)NCBIT2T-CHM13v2.0
Arhgdig
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,418,157 - 26,420,324 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,418,157 - 26,426,760 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381726,199,183 - 26,201,350 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,199,183 - 26,207,786 (-)Ensemblmm10GRCm38
MGSCv371726,336,128 - 26,338,295 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,926,783 - 25,928,950 (-)NCBIMGSCv36mm8
Celera1726,732,940 - 26,735,160 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.07NCBI
Arhgdig
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,898,552 - 16,903,685 (-)Ensembl
ChiLan1.0NW_00495544216,901,951 - 16,903,147 (-)NCBIChiLan1.0ChiLan1.0
ARHGDIG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218498,860 - 501,189 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,291,760 - 4,294,086 (+)NCBINHGRI_mPanPan1
PanPan1.116271,736 - 273,605 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16271,739 - 273,605 (+)EnsemblpanPan2panpan1.1
ARHGDIG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,222,014 - 40,225,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,221,103 - 40,223,115 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha641,485,622 - 41,488,734 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0640,564,370 - 40,567,486 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,563,460 - 40,566,392 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,252,617 - 40,255,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,213,673 - 40,216,782 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,692,143 - 40,695,255 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgdig
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,539,290 - 112,544,529 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501637,299 - 639,096 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936501637,150 - 640,984 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGDIG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,397,643 - 41,400,241 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1341,397,640 - 41,402,095 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARHGDIG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15226,760 - 229,449 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5227,202 - 229,274 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606830,947,377 - 30,949,964 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgdig
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,133,421 - 1,135,403 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249131,133,381 - 1,135,386 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgdig
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v193,459,398 - 3,461,549 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgdig
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000030114
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 17 37 16 58 43 11 35 8 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000103181   ⟹   ENSRNOP00000080805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,723,525 - 15,725,688 (-)Ensembl
mRatBN7.2 Ensembl1015,219,049 - 15,221,213 (-)Ensembl
RefSeq Acc Id: NM_001108269   ⟹   NP_001101739
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,723,525 - 15,725,688 (-)NCBI
mRatBN7.21015,219,049 - 15,221,213 (-)NCBI
Rnor_5.01015,379,685 - 15,381,879 (-)NCBI
RGSC_v3.41015,466,159 - 15,468,322 (-)RGD
Celera1014,886,854 - 14,889,018 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086280   ⟹   XP_038942208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,723,527 - 15,725,719 (-)NCBI
mRatBN7.21015,219,051 - 15,221,257 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101739 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942208 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03999 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080805
  ENSRNOP00000080805.1
RefSeq Acc Id: NP_001101739   ⟸   NM_001108269
- UniProtKB: A0A8I5ZRJ5 (UniProtKB/TrEMBL),   A6HD94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038942208   ⟸   XM_039086280
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000080805   ⟸   ENSRNOT00000103181

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310739 AgrOrtholog
BioCyc Gene G2FUF-25723 BioCyc
Ensembl Genes ENSRNOG00000068707 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000103181 ENTREZGENE
  ENSRNOT00000103181.2 UniProtKB/TrEMBL
Gene3D-CATH 2.70.50.30 UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/TrEMBL
  Rho_GDI UniProtKB/TrEMBL
  RhoGDI_dom_sf UniProtKB/TrEMBL
KEGG Report rno:360500 UniProtKB/TrEMBL
NCBI Gene 360500 ENTREZGENE
PANTHER PTHR10980 UniProtKB/TrEMBL
  RHO GDP-DISSOCIATION INHIBITOR 3 UniProtKB/TrEMBL
Pfam Rho_GDI UniProtKB/TrEMBL
PhenoGen Arhgdig PhenoGen
PRINTS RHOGDI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000068707 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
UniProt A0A8I5ZRJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6HD94 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Arhgdig  Rho GDP dissociation inhibitor gamma  Arhgdig  Rho GDP dissociation inhibitor (GDI) gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arhgdig  Rho GDP dissociation inhibitor (GDI) gamma   Arhgdig_predicted  Rho GDP dissociation inhibitor (GDI) gamma (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgdig_predicted  Rho GDP dissociation inhibitor (GDI) gamma (predicted)      Symbol and Name status set to approved 70820 APPROVED