Diaph1 (diaphanous-related formin 1) - Rat Genome Database

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Gene: Diaph1 (diaphanous-related formin 1) Rattus norvegicus
Analyze
Symbol: Diaph1
Name: diaphanous-related formin 1
RGD ID: 1310707
Description: Predicted to enable several functions, including profilin binding activity; small GTPase binding activity; and transmembrane transporter binding activity. Involved in positive regulation of cell migration. Predicted to be located in several cellular components, including brush border; ruffle membrane; and spindle. Predicted to be active in actin filament. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 1 and sensorineural hearing loss. Orthologous to human DIAPH1 (diaphanous related formin 1); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Diap1; diaphanous homolog 1; diaphanous homolog 1 (Drosophila); DRF1; LOC307483; mDIA1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81829,920,889 - 30,020,280 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1829,920,889 - 30,020,280 (-)EnsemblGRCr8
mRatBN7.21829,669,659 - 29,769,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1829,669,659 - 29,769,172 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1829,773,984 - 29,873,376 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01830,535,964 - 30,635,353 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01829,871,305 - 29,970,698 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01830,972,907 - 31,071,371 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1830,972,907 - 31,071,371 (-)Ensemblrn6Rnor6.0
Rnor_5.01830,663,859 - 30,762,658 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41830,757,191 - 30,855,548 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1829,313,748 - 29,412,995 (-)NCBICelera
RGSC_v3.11830,784,366 - 30,882,101 (-)NCBI
Cytogenetic Map18p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
finasteride  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
kanamycin A  (ISO)
latrunculin A  (ISO)
methimazole  (EXP)
methoxychlor  (EXP,ISO)
nickel atom  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous. Lynch ED, etal., Science. 1997 Nov 14;278(5341):1315-8.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Yamana N, etal., Mol Cell Biol. 2006 Sep;26(18):6844-58.
Additional References at PubMed
PMID:9214622   PMID:10559899   PMID:12906795   PMID:14992721   PMID:15123714   PMID:16472745   PMID:17170370   PMID:18362183   PMID:18572016   PMID:18651670   PMID:20071339   PMID:20937854  
PMID:21834987   PMID:22114352   PMID:22658674   PMID:23558171   PMID:24781755   PMID:26912466   PMID:28877993   PMID:30358011  


Genomics

Comparative Map Data
Diaph1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81829,920,889 - 30,020,280 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1829,920,889 - 30,020,280 (-)EnsemblGRCr8
mRatBN7.21829,669,659 - 29,769,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1829,669,659 - 29,769,172 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1829,773,984 - 29,873,376 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01830,535,964 - 30,635,353 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01829,871,305 - 29,970,698 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01830,972,907 - 31,071,371 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1830,972,907 - 31,071,371 (-)Ensemblrn6Rnor6.0
Rnor_5.01830,663,859 - 30,762,658 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41830,757,191 - 30,855,548 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1829,313,748 - 29,412,995 (-)NCBICelera
RGSC_v3.11830,784,366 - 30,882,101 (-)NCBI
Cytogenetic Map18p11NCBI
DIAPH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385141,515,021 - 141,619,000 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5141,515,016 - 141,619,055 (-)Ensemblhg38GRCh38
GRCh375140,894,588 - 140,998,567 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,874,772 - 140,978,747 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345140,874,772 - 140,978,691NCBI
Celera5136,971,324 - 137,075,350 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5136,039,428 - 136,143,262 (-)NCBIHuRef
CHM1_15140,327,865 - 140,431,904 (-)NCBICHM1_1
T2T-CHM13v2.05142,041,005 - 142,145,005 (-)NCBIT2T-CHM13v2.0
Diaph1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391837,976,654 - 38,068,573 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1837,976,654 - 38,068,529 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381837,843,601 - 37,935,622 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1837,843,601 - 37,935,476 (-)Ensemblmm10GRCm38
MGSCv371838,004,478 - 38,095,065 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361837,970,798 - 38,061,385 (-)NCBIMGSCv36mm8
Celera1839,188,303 - 39,278,736 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1819.71NCBI
Diaph1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541512,156,152 - 12,272,961 (+)Ensembl
ChiLan1.0NW_00495541512,156,152 - 12,272,961 (+)NCBIChiLan1.0ChiLan1.0
DIAPH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24136,764,381 - 136,867,993 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15134,960,673 - 135,007,628 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05136,876,396 - 136,980,097 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15142,990,248 - 143,092,558 (-)NCBIPanPan1.1PanPan1.1panPan2
DIAPH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1236,483,781 - 36,581,390 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl236,485,571 - 36,581,320 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha233,535,791 - 33,633,355 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0236,937,687 - 37,035,539 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl236,937,690 - 37,035,611 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1234,012,555 - 34,110,155 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,824,079 - 34,921,683 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0235,631,288 - 35,728,900 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Diaph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213150,974,209 - 151,071,265 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650412,548,452 - 12,643,399 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650412,548,452 - 12,645,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIAPH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2143,158,585 - 143,271,147 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12143,158,691 - 143,271,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22149,363,162 - 149,473,567 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIAPH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12344,139,495 - 44,244,505 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2344,139,360 - 44,244,490 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603433,608,326 - 33,713,597 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Diaph1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624774739,206 - 845,272 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624774738,717 - 845,187 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Diaph1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1156,988,249 - 7,083,665 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Diaph1
497 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:103
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000060432, ENSRNOT00000060433
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
RH130783  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,770,659 - 29,770,857 (+)MAPPERmRatBN7.2
Rnor_6.01831,072,987 - 31,073,184NCBIRnor6.0
Rnor_5.01830,764,274 - 30,764,471UniSTSRnor5.0
RGSC_v3.41830,857,139 - 30,857,336UniSTSRGSC3.4
Celera1829,414,611 - 29,414,808UniSTS
RH 3.4 Map18444.2UniSTS
Cytogenetic Map18p11UniSTS
RH127883  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,669,684 - 29,669,893 (+)MAPPERmRatBN7.2
Rnor_6.01830,972,933 - 30,973,141NCBIRnor6.0
Rnor_5.01830,663,885 - 30,664,093UniSTSRnor5.0
RGSC_v3.41830,756,025 - 30,756,233UniSTSRGSC3.4
Celera1829,313,774 - 29,313,982UniSTS
Cytogenetic Map18p11UniSTS
BE119953  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2247,231,083 - 47,231,306 (+)MAPPERmRatBN7.2
mRatBN7.21829,730,201 - 29,730,413 (+)MAPPERmRatBN7.2
Rnor_6.01831,032,769 - 31,032,980NCBIRnor6.0
Rnor_6.0247,876,688 - 47,876,910NCBIRnor6.0
Rnor_5.01830,724,159 - 30,724,370UniSTSRnor5.0
Rnor_5.0266,264,138 - 66,264,360UniSTSRnor5.0
RGSC_v3.4246,345,568 - 46,345,790UniSTSRGSC3.4
RGSC_v3.41830,816,539 - 30,816,750UniSTSRGSC3.4
Celera1829,374,164 - 29,374,375UniSTS
Celera242,965,202 - 42,965,424UniSTS
RH 3.4 Map18428.3UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map2q14UniSTS
RH124673  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,669,710 - 29,670,024 (+)MAPPERmRatBN7.2
Rnor_6.01830,972,959 - 30,973,272NCBIRnor6.0
Rnor_5.01830,663,911 - 30,664,224UniSTSRnor5.0
RGSC_v3.41830,756,051 - 30,756,364UniSTSRGSC3.4
Celera1829,313,800 - 29,314,113UniSTS
Cytogenetic Map18p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000060432   ⟹   ENSRNOP00000057176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1829,920,889 - 30,020,280 (-)Ensembl
mRatBN7.2 Ensembl1829,669,659 - 29,769,044 (-)Ensembl
Rnor_6.0 Ensembl1830,972,907 - 31,071,371 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102970   ⟹   ENSRNOP00000088426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1829,920,889 - 30,020,280 (-)Ensembl
mRatBN7.2 Ensembl1829,669,659 - 29,769,172 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147673   ⟹   ENSRNOP00000108105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1829,920,889 - 30,020,280 (-)Ensembl
RefSeq Acc Id: NM_001107393   ⟹   NP_001100863
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81829,920,889 - 30,020,280 (-)NCBI
mRatBN7.21829,669,659 - 29,769,070 (-)NCBI
Rnor_6.01830,972,907 - 31,071,371 (-)NCBI
Rnor_5.01830,663,859 - 30,762,658 (-)NCBI
RGSC_v3.41830,757,191 - 30,855,548 (-)RGD
Celera1829,313,748 - 29,412,995 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001395102   ⟹   NP_001382031
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81829,920,889 - 30,020,280 (-)NCBI
mRatBN7.21829,669,659 - 29,769,070 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100863 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382031 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76410 (Get FASTA)   NCBI Sequence Viewer  
  EDL76411 (Get FASTA)   NCBI Sequence Viewer  
  EDL76412 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057176
  ENSRNOP00000088426
GenBank Protein F1M775 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001100863   ⟸   NM_001107393
- Peptide Label: isoform 1
- UniProtKB: F1M775 (UniProtKB/Swiss-Prot),   A0A8L2QTN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057176   ⟸   ENSRNOT00000060432
Ensembl Acc Id: ENSRNOP00000088426   ⟸   ENSRNOT00000102970
RefSeq Acc Id: NP_001382031   ⟸   NM_001395102
- Peptide Label: isoform 2
- UniProtKB: F1M775 (UniProtKB/Swiss-Prot),   A0A8I6A828 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108105   ⟸   ENSRNOT00000147673
Protein Domains
DAD   FH1   FH2   GBD/FH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700736
Promoter ID:EPDNEW_R11260
Type:initiation region
Name:Diaph1_1
Description:diaphanous-related formin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01831,071,369 - 31,071,429EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310707 AgrOrtholog
BioCyc Gene G2FUF-7792 BioCyc
Ensembl Genes ENSRNOG00000019688 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000060432 ENTREZGENE
  ENSRNOT00000102970 ENTREZGENE
Gene3D-CATH 1.10.20.40 UniProtKB/Swiss-Prot
  1.20.1170.10 UniProtKB/Swiss-Prot
  1.20.58.2220 UniProtKB/Swiss-Prot
  1.20.58.630 UniProtKB/Swiss-Prot
  1.25.10.10 UniProtKB/Swiss-Prot
  6.10.30.30 UniProtKB/Swiss-Prot
  Formin, FH3 diaphanous domain UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  DAD_dom UniProtKB/Swiss-Prot
  DIA_GBD_sf UniProtKB/Swiss-Prot
  Drf_DAD UniProtKB/Swiss-Prot
  FH2_Formin UniProtKB/Swiss-Prot
  FH2_Formin_sf UniProtKB/Swiss-Prot
  FH3_dom UniProtKB/Swiss-Prot
  Formin_Homology_Diaphanous_sf UniProtKB/Swiss-Prot
  GBD/FH3_dom UniProtKB/Swiss-Prot
  GTPase-bd UniProtKB/Swiss-Prot
NCBI Gene 307483 ENTREZGENE
PANTHER PROTEIN DIAPHANOUS UniProtKB/Swiss-Prot
  PTHR45691:SF4 UniProtKB/Swiss-Prot
Pfam Drf_DAD UniProtKB/Swiss-Prot
  Drf_FH1 UniProtKB/Swiss-Prot
  Drf_FH3 UniProtKB/Swiss-Prot
  Drf_GBD UniProtKB/Swiss-Prot
  FH2 UniProtKB/Swiss-Prot
PhenoGen Diaph1 PhenoGen
PROSITE DAD UniProtKB/Swiss-Prot
  FH2 UniProtKB/Swiss-Prot
  GBD_FH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019688 RatGTEx
SMART Drf_FH3 UniProtKB/Swiss-Prot
  Drf_GBD UniProtKB/Swiss-Prot
  FH2 UniProtKB/Swiss-Prot
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot
UniProt A0A8I6A828 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QTN9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LBQ2_RAT UniProtKB/TrEMBL
  DIAP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Diaph1  diaphanous-related formin 1  Diaph1  diaphanous homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Diaph1  diaphanous homolog 1 (Drosophila)  Diap1  diaphanous homolog 1 (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Diap1  diaphanous homolog 1 (Drosophila)   Diap1_predicted  diaphanous homolog 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Diap1_predicted  diaphanous homolog 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED