Ccna1 (cyclin A1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ccna1 (cyclin A1) Rattus norvegicus
Analyze
Symbol: Ccna1
Name: cyclin A1
RGD ID: 1310639
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be part of cyclin A1-CDK2 complex and cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1); PARTICIPATES IN G1/S transition pathway; acute myeloid leukemia pathway; cell cycle pathway, mitotic; INTERACTS WITH baicalein; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclin-A1; LOC295052
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,383,352 - 141,428,205 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2141,382,468 - 141,393,300 (-)EnsemblGRCr8
mRatBN7.22139,231,738 - 139,278,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2139,201,074 - 139,243,157 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2145,808,039 - 145,817,882 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,919,479 - 143,929,320 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,551,905 - 138,561,746 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02144,456,689 - 144,503,570 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2144,458,153 - 144,467,912 (-)Ensemblrn6Rnor6.0
Rnor_5.02163,874,794 - 163,886,211 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42144,275,211 - 144,285,196 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2133,716,972 - 133,726,933 (-)NCBICelera
RGSC_v3.12144,225,173 - 144,235,159 (-)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,4-benzoquinone  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
atropine  (ISO)
avobenzone  (ISO)
baicalein  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bufotalin  (ISO)
butanal  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinous acid  (ISO)
dinaciclib  (ISO)
dinophysistoxin 2  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
EHT 1864  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
flavanones  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
harmine  (ISO)
heptanal  (ISO)
hexanal  (ISO)
homocysteine  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
isosilybin A  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
melatonin  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nonanal  (ISO)
octanal  (ISO)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
silibinin  (ISO)
sodium arsenite  (EXP,ISO)
sunitinib  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
XL147  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. Diederichs S, etal., Int J Cancer. 2005 Aug 20;116(2):207-17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells. Katabami M, etal., J Biol Chem. 2005 Apr 29;280(17):16728-38. Epub 2005 Feb 28.
5. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
13. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. Wegiel B, etal., J Natl Cancer Inst. 2008 Jul 16;100(14):1022-36. Epub 2008 Jul 8.
14. Cyclin A1 expression in leukemia and normal hematopoietic cells. Yang R, etal., Blood. 1999 Mar 15;93(6):2067-74.
Additional References at PubMed
PMID:7739547   PMID:9344597   PMID:11340163   PMID:12477932   PMID:14985333   PMID:18278459   PMID:21764057   PMID:22180637  


Genomics

Comparative Map Data
Ccna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,383,352 - 141,428,205 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2141,382,468 - 141,393,300 (-)EnsemblGRCr8
mRatBN7.22139,231,738 - 139,278,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2139,201,074 - 139,243,157 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2145,808,039 - 145,817,882 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,919,479 - 143,929,320 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,551,905 - 138,561,746 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02144,456,689 - 144,503,570 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2144,458,153 - 144,467,912 (-)Ensemblrn6Rnor6.0
Rnor_5.02163,874,794 - 163,886,211 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42144,275,211 - 144,285,196 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2133,716,972 - 133,726,933 (-)NCBICelera
RGSC_v3.12144,225,173 - 144,235,159 (-)NCBI
Cytogenetic Map2q26NCBI
CCNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381336,431,517 - 36,442,870 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1336,431,520 - 36,442,870 (+)Ensemblhg38GRCh38
GRCh371337,006,092 - 37,017,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361335,904,633 - 35,915,008 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341335,904,632 - 35,915,008NCBI
Celera1318,073,175 - 18,084,229 (+)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1317,817,953 - 17,828,979 (+)NCBIHuRef
CHM1_11336,973,445 - 36,984,499 (+)NCBICHM1_1
T2T-CHM13v2.01335,651,206 - 35,662,375 (+)NCBIT2T-CHM13v2.0
Ccna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,952,890 - 54,965,055 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,952,890 - 54,962,922 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38355,045,469 - 55,057,634 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl355,045,469 - 55,055,501 (-)Ensemblmm10GRCm38
MGSCv37354,849,391 - 54,858,977 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36355,133,404 - 55,142,984 (-)NCBIMGSCv36mm8
Celera354,763,020 - 54,772,599 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map326.52NCBI
Ccna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554319,658,015 - 9,668,087 (-)Ensembl
ChiLan1.0NW_0049554319,658,301 - 9,668,659 (-)NCBIChiLan1.0ChiLan1.0
CCNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21435,959,752 - 35,976,246 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11327,065,796 - 27,082,221 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01317,649,064 - 17,660,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11336,080,331 - 36,092,078 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1336,080,331 - 36,092,078 (+)EnsemblpanPan2panpan1.1
CCNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,189,457 - 4,198,170 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,189,457 - 4,198,373 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha254,219,718 - 4,228,956 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0254,288,085 - 4,297,327 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl254,281,774 - 4,296,521 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1254,195,452 - 4,204,690 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0254,191,619 - 4,200,848 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,255,371 - 4,264,612 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945165,363,959 - 165,379,007 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647230,573,812 - 30,586,559 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647230,574,957 - 30,586,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1112,396,301 - 12,405,350 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11112,396,149 - 12,405,357 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21112,355,480 - 12,364,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1314,979,775 - 14,992,609 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl314,982,392 - 14,993,562 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605729,300,504 - 29,312,984 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624776939,823 - 950,833 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624776941,107 - 951,256 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ccna1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1399,337,155 - 99,383,198 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ccna1
290 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:23
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000040002
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
AA964510  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,233,313 - 139,234,987 (+)MAPPERmRatBN7.2
Rnor_6.02144,458,263 - 144,459,936NCBIRnor6.0
Rnor_5.02163,876,368 - 163,878,041UniSTSRnor5.0
RGSC_v3.42144,275,315 - 144,276,988UniSTSRGSC3.4
Celera2133,717,076 - 133,718,749UniSTS
RH 3.4 Map81278.9UniSTS
Cytogenetic Map2q26UniSTS
PMC86923P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22139,237,347 - 139,238,099 (+)MAPPERmRatBN7.2
Rnor_6.02144,462,297 - 144,463,048NCBIRnor6.0
Rnor_5.02163,880,402 - 163,881,153UniSTSRnor5.0
RGSC_v3.42144,279,349 - 144,280,100UniSTSRGSC3.4
Celera2133,721,110 - 133,721,861UniSTS
Cytogenetic Map2q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
17 12 67 172 59 58 29 25 29 6 259 125 11 151 80 91 29 23 23

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001011949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC079234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH771000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000040002   ⟹   ENSRNOP00000039931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,383,353 - 141,393,300 (-)Ensembl
mRatBN7.2 Ensembl2139,233,210 - 139,243,157 (-)Ensembl
Rnor_6.0 Ensembl2144,458,153 - 144,467,912 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095893   ⟹   ENSRNOP00000078779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,382,468 - 141,393,300 (-)Ensembl
mRatBN7.2 Ensembl2139,201,074 - 139,243,157 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128660   ⟹   ENSRNOP00000112221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2141,383,383 - 141,392,283 (-)Ensembl
RefSeq Acc Id: NM_001011949   ⟹   NP_001011949
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,353 - 141,393,300 (-)NCBI
mRatBN7.22139,233,210 - 139,243,157 (-)NCBI
Rnor_6.02144,458,159 - 144,468,106 (-)NCBI
Rnor_5.02163,874,794 - 163,886,211 (-)NCBI
RGSC_v3.42144,275,211 - 144,285,196 (-)RGD
Celera2133,716,972 - 133,726,933 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232359   ⟹   XP_006232421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,392,950 (-)NCBI
mRatBN7.22139,231,738 - 139,242,745 (-)NCBI
Rnor_6.02144,456,689 - 144,467,773 (-)NCBI
Rnor_5.02163,874,794 - 163,886,211 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232360   ⟹   XP_006232422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,392,962 (-)NCBI
mRatBN7.22139,231,738 - 139,242,745 (-)NCBI
Rnor_6.02144,456,689 - 144,467,773 (-)NCBI
Rnor_5.02163,874,794 - 163,886,211 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232361   ⟹   XP_006232423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,393,190 (-)NCBI
mRatBN7.22139,231,738 - 139,243,047 (-)NCBI
Rnor_6.02144,456,689 - 144,468,112 (-)NCBI
Rnor_5.02163,874,794 - 163,886,211 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760987   ⟹   XP_008759209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,394,275 (-)NCBI
mRatBN7.22139,231,738 - 139,244,373 (-)NCBI
Rnor_6.02144,456,689 - 144,469,223 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760988   ⟹   XP_008759210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,392,938 (-)NCBI
mRatBN7.22139,231,738 - 139,242,748 (-)NCBI
Rnor_6.02144,456,689 - 144,467,773 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590749   ⟹   XP_017446238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,428,178 (-)NCBI
mRatBN7.22139,231,738 - 139,278,034 (-)NCBI
Rnor_6.02144,456,689 - 144,503,570 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590750   ⟹   XP_017446239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,428,167 (-)NCBI
mRatBN7.22139,231,738 - 139,277,976 (-)NCBI
Rnor_6.02144,456,689 - 144,503,568 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102010   ⟹   XP_038957938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,392,899 (-)NCBI
mRatBN7.22139,231,738 - 139,242,746 (-)NCBI
RefSeq Acc Id: XM_039102011   ⟹   XP_038957939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,392,935 (-)NCBI
mRatBN7.22139,231,738 - 139,242,745 (-)NCBI
RefSeq Acc Id: XM_039102012   ⟹   XP_038957940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,392,927 (-)NCBI
mRatBN7.22139,231,738 - 139,242,745 (-)NCBI
RefSeq Acc Id: XM_039102014   ⟹   XP_038957942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,428,205 (-)NCBI
mRatBN7.22139,231,738 - 139,278,066 (-)NCBI
RefSeq Acc Id: XM_063281579   ⟹   XP_063137649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,393,190 (-)NCBI
RefSeq Acc Id: XM_063281580   ⟹   XP_063137650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,392,938 (-)NCBI
RefSeq Acc Id: XM_063281581   ⟹   XP_063137651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,392,938 (-)NCBI
RefSeq Acc Id: XM_063281582   ⟹   XP_063137652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,393,190 (-)NCBI
RefSeq Acc Id: XM_063281583   ⟹   XP_063137653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,393,190 (-)NCBI
RefSeq Acc Id: XM_063281584   ⟹   XP_063137654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,393,190 (-)NCBI
RefSeq Acc Id: XM_063281585   ⟹   XP_063137655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82141,383,352 - 141,428,192 (-)NCBI
RefSeq Acc Id: NP_001011949   ⟸   NM_001011949
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232423   ⟸   XM_006232361
- Peptide Label: isoform X1
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232422   ⟸   XM_006232360
- Peptide Label: isoform X1
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232421   ⟸   XM_006232359
- Peptide Label: isoform X1
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759209   ⟸   XM_008760987
- Peptide Label: isoform X1
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759210   ⟸   XM_008760988
- Peptide Label: isoform X1
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446238   ⟸   XM_017590749
- Peptide Label: isoform X1
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446239   ⟸   XM_017590750
- Peptide Label: isoform X1
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039931   ⟸   ENSRNOT00000040002
RefSeq Acc Id: XP_038957942   ⟸   XM_039102014
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038957938   ⟸   XM_039102010
- Peptide Label: isoform X1
- UniProtKB: Q6AY13 (UniProtKB/Swiss-Prot),   A6JVE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957940   ⟸   XM_039102012
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038957939   ⟸   XM_039102011
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZLN2 (UniProtKB/TrEMBL),   A6JVE2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078779   ⟸   ENSRNOT00000095893
RefSeq Acc Id: XP_063137655   ⟸   XM_063281585
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137653   ⟸   XM_063281583
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137654   ⟸   XM_063281584
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137652   ⟸   XM_063281582
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137649   ⟸   XM_063281579
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZLN2 (UniProtKB/TrEMBL),   A6JVE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137651   ⟸   XM_063281581
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137650   ⟸   XM_063281580
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZLN2 (UniProtKB/TrEMBL),   A6JVE2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112221   ⟸   ENSRNOT00000128660
Protein Domains
Cyclin C-terminal   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY13-F1-model_v2 AlphaFold Q6AY13 1-421 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310639 AgrOrtholog
BioCyc Gene G2FUF-53069 BioCyc
Ensembl Genes ENSRNOG00000014052 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040002 ENTREZGENE
  ENSRNOT00000040002.5 UniProtKB/Swiss-Prot
  ENSRNOT00000095893 ENTREZGENE
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132591 IMAGE-MGC_LOAD
InterPro Cyclin UniProtKB/Swiss-Prot
  Cyclin-A_N UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  Cyclin_C-dom UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
  Cyclins_cyclin-box UniProtKB/Swiss-Prot
KEGG Report rno:295052 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94315 IMAGE-MGC_LOAD
NCBI Gene 295052 ENTREZGENE
PANTHER PTHR10177 UniProtKB/Swiss-Prot
Pfam Cyclin_C UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
  Cyclin_N2 UniProtKB/Swiss-Prot
PharmGKB CCNA1 RGD
PhenoGen Ccna1 PhenoGen
PROSITE CYCLINS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014052 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot
  Cyclin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
UniProt A0A8I5ZLN2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M895_RAT UniProtKB/TrEMBL
  A6JVE2 ENTREZGENE, UniProtKB/TrEMBL
  A6JVE3 ENTREZGENE, UniProtKB/TrEMBL
  CCNA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Ccna1  cyclin A1  Ccna1_predicted  cyclin A1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ccna1_predicted  cyclin A1 (predicted)      Symbol and Name status set to approved 70820 APPROVED