Sh3bp2 (SH3-domain binding protein 2) - Rat Genome Database

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Gene: Sh3bp2 (SH3-domain binding protein 2) Rattus norvegicus
Analyze
Symbol: Sh3bp2
Name: SH3-domain binding protein 2
RGD ID: 1310588
Description: Predicted to enable SH3 domain binding activity and phosphotyrosine residue binding activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in cherubism. Orthologous to human SH3BP2 (SH3 domain binding protein 2); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305450; SH3 domain-binding protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,400,685 - 80,437,887 (-)NCBIGRCr8
mRatBN7.21476,176,097 - 76,213,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,176,101 - 76,213,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,628,679 - 80,665,764 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,869,326 - 81,906,411 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,314,567 - 78,351,655 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,435,445 - 81,473,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,435,449 - 81,472,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,122,929 - 82,160,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,818,728 - 81,855,875 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,822,156 - 81,855,721 (-)NCBI
Celera1475,100,620 - 75,137,766 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
azoxystrobin  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP,ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methoxychlor  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prothioconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
titanium dioxide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Ueki Y, etal., Nat Genet. 2001 Jun;28(2):125-6.
Additional References at PubMed
PMID:8438166   PMID:8889548   PMID:12477932   PMID:20624904   PMID:35481344  


Genomics

Comparative Map Data
Sh3bp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,400,685 - 80,437,887 (-)NCBIGRCr8
mRatBN7.21476,176,097 - 76,213,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,176,101 - 76,213,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,628,679 - 80,665,764 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,869,326 - 81,906,411 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,314,567 - 78,351,655 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,435,445 - 81,473,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,435,449 - 81,472,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,122,929 - 82,160,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,818,728 - 81,855,875 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,822,156 - 81,855,721 (-)NCBI
Celera1475,100,620 - 75,137,766 (-)NCBICelera
Cytogenetic Map14q21NCBI
SH3BP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,793,085 - 2,841,096 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,793,071 - 2,841,098 (+)EnsemblGRCh38hg38GRCh38
GRCh3742,794,812 - 2,842,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,790,339 - 2,810,712 (+)NCBINCBI36Build 36hg18NCBI36
Build 3442,857,545 - 2,877,920NCBI
Celera42,706,072 - 2,754,024 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,733,534 - 2,781,278 (+)NCBIHuRef
CHM1_142,792,693 - 2,840,796 (+)NCBICHM1_1
T2T-CHM13v2.042,791,852 - 2,839,552 (+)NCBIT2T-CHM13v2.0
Sh3bp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,683,128 - 34,720,983 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,683,182 - 34,720,985 (+)EnsemblGRCm39 Ensembl
GRCm38534,525,784 - 34,563,639 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,525,838 - 34,563,641 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,868,433 - 34,906,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,842,703 - 34,880,483 (+)NCBIMGSCv36mm8
Celera531,996,748 - 32,034,601 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.89NCBI
Sh3bp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,712,793 - 1,730,002 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,700,889 - 1,730,002 (+)NCBIChiLan1.0ChiLan1.0
SH3BP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,129,178 - 3,172,613 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,065,091 - 3,108,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,936,051 - 2,982,062 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,838,521 - 2,882,265 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,857,249 - 2,882,263 (+)Ensemblpanpan1.1panPan2
SH3BP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,454,945 - 61,488,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,358,162 - 61,474,830 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,038,628 - 64,072,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,930,906 - 61,964,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,930,906 - 61,964,886 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,422,146 - 61,456,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,627,161 - 61,661,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,986,786 - 62,020,764 (-)NCBIUU_Cfam_GSD_1.0
Sh3bp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,072,693 - 67,106,061 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,773,016 - 20,807,722 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,774,386 - 20,794,958 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3BP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,583,193 - 1,619,037 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,583,169 - 1,619,038 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,164,569 - 1,201,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH3BP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,919,717 - 45,961,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2745,920,171 - 45,942,425 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660512,275,298 - 2,323,644 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3bp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,941,813 - 24,957,004 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,942,542 - 24,968,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sh3bp2
155 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:440
Count of miRNA genes:240
Interacting mature miRNAs:277
Transcripts:ENSRNOT00000058111
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
D5Jcs82  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,188,162 - 76,188,305 (+)MAPPERmRatBN7.2
Rnor_6.01481,447,511 - 81,447,653NCBIRnor6.0
Rnor_5.01482,134,995 - 82,135,137UniSTSRnor5.0
RGSC_v3.41481,830,791 - 81,830,933UniSTSRGSC3.4
Celera1475,112,683 - 75,112,825UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 3 3 11 3 49 24 29 9
Low 1 43 54 38 8 38 8 11 25 11 10 2 8
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC098844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM384145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB762696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO557208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY320365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EX490894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000058111   ⟹   ENSRNOP00000054918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,176,101 - 76,213,251 (-)Ensembl
Rnor_6.0 Ensembl1481,435,449 - 81,472,952 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102949   ⟹   ENSRNOP00000090587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,176,103 - 76,188,899 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105950   ⟹   ENSRNOP00000079375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,176,101 - 76,188,179 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109599   ⟹   ENSRNOP00000082533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,176,101 - 76,188,179 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119239   ⟹   ENSRNOP00000093842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,176,101 - 76,196,102 (-)Ensembl
RefSeq Acc Id: NM_001100684   ⟹   NP_001094154
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,400,688 - 80,437,838 (-)NCBI
mRatBN7.21476,176,100 - 76,213,251 (-)NCBI
Rnor_6.01481,435,448 - 81,472,952 (-)NCBI
Rnor_5.01482,122,929 - 82,160,479 (-)NCBI
RGSC_v3.41481,818,728 - 81,855,875 (-)RGD
Celera1475,100,620 - 75,137,766 (-)RGD
Sequence:
RefSeq Acc Id: NM_001414976   ⟹   NP_001401905
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,400,685 - 80,437,887 (-)NCBI
mRatBN7.21476,176,097 - 76,213,300 (-)NCBI
RefSeq Acc Id: XM_006251247   ⟹   XP_006251309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,400,688 - 80,419,888 (-)NCBI
mRatBN7.21476,176,100 - 76,193,903 (-)NCBI
Rnor_6.01481,435,445 - 81,449,699 (-)NCBI
Rnor_5.01482,122,929 - 82,160,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251248   ⟹   XP_006251310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,400,688 - 80,425,860 (-)NCBI
mRatBN7.21476,176,100 - 76,198,338 (-)NCBI
Rnor_6.01481,435,445 - 81,455,680 (-)NCBI
Rnor_5.01482,122,929 - 82,160,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251252   ⟹   XP_006251314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,400,688 - 80,432,950 (-)NCBI
mRatBN7.21476,176,100 - 76,210,138 (-)NCBI
Rnor_6.01481,435,445 - 81,469,460 (-)NCBI
Rnor_5.01482,122,929 - 82,160,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251253   ⟹   XP_006251315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,400,688 - 80,430,400 (-)NCBI
mRatBN7.21476,176,100 - 76,205,821 (-)NCBI
Rnor_6.01481,435,445 - 81,465,531 (-)NCBI
Rnor_5.01482,122,929 - 82,160,479 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091976   ⟹   XP_038947904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,400,688 - 80,432,952 (-)NCBI
mRatBN7.21476,176,100 - 76,210,139 (-)NCBI
RefSeq Acc Id: XM_039091977   ⟹   XP_038947905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,400,688 - 80,429,810 (-)NCBI
mRatBN7.21476,176,100 - 76,205,821 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001094154   ⟸   NM_001100684
- Peptide Label: isoform 1
- UniProtKB: F1LS93 (UniProtKB/TrEMBL),   A0A8I5ZMQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251314   ⟸   XM_006251252
- Peptide Label: isoform X3
- UniProtKB: A6IK29 (UniProtKB/TrEMBL),   A0A8I5ZMQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251315   ⟸   XM_006251253
- Peptide Label: isoform X3
- UniProtKB: A6IK29 (UniProtKB/TrEMBL),   A0A8I5ZMQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251310   ⟸   XM_006251248
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AKD3 (UniProtKB/TrEMBL),   A0A8I5ZMQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251309   ⟸   XM_006251247
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9V6 (UniProtKB/TrEMBL),   A0A8I5ZMQ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054918   ⟸   ENSRNOT00000058111
RefSeq Acc Id: XP_038947904   ⟸   XM_039091976
- Peptide Label: isoform X3
- UniProtKB: A6IK29 (UniProtKB/TrEMBL),   A0A8I5ZMQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947905   ⟸   XM_039091977
- Peptide Label: isoform X3
- UniProtKB: A6IK29 (UniProtKB/TrEMBL),   A0A8I5ZMQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079375   ⟸   ENSRNOT00000105950
RefSeq Acc Id: ENSRNOP00000093842   ⟸   ENSRNOT00000119239
RefSeq Acc Id: ENSRNOP00000082533   ⟸   ENSRNOT00000109599
RefSeq Acc Id: ENSRNOP00000090587   ⟸   ENSRNOT00000102949
RefSeq Acc Id: NP_001401905   ⟸   NM_001414976
- Peptide Label: isoform 2
- UniProtKB: A6IK29 (UniProtKB/TrEMBL)
Protein Domains
PH   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LS93-F1-model_v2 AlphaFold F1LS93 1-591 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699400
Promoter ID:EPDNEW_R9924
Type:initiation region
Name:Sh3bp2_1
Description:SH3-domain binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01481,472,955 - 81,473,015EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310588 AgrOrtholog
BioCyc Gene G2FUF-15294 BioCyc
Ensembl Genes ENSRNOG00000013747 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058111 ENTREZGENE
  ENSRNOT00000058111.3 UniProtKB/TrEMBL
  ENSRNOT00000102949.1 UniProtKB/TrEMBL
  ENSRNOT00000105950 ENTREZGENE
  ENSRNOT00000105950.1 UniProtKB/TrEMBL
  ENSRNOT00000109599.1 UniProtKB/TrEMBL
  ENSRNOT00000119239.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7379327 IMAGE-MGC_LOAD
InterPro PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3BP2 UniProtKB/TrEMBL
  SH3BP2_SH2 UniProtKB/TrEMBL
KEGG Report rno:305450 UniProtKB/TrEMBL
MGC_CLONE MGC:112900 IMAGE-MGC_LOAD
NCBI Gene 305450 ENTREZGENE
PANTHER PTHR15126 UniProtKB/TrEMBL
  SH3 DOMAIN-BINDING PROTEIN 2 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Sh3bp2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013747 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8I5ZMQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZX84_RAT UniProtKB/TrEMBL
  A0A8I6A9V6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKD3 ENTREZGENE, UniProtKB/TrEMBL
  A6IK29 ENTREZGENE, UniProtKB/TrEMBL
  F1LS93 ENTREZGENE, UniProtKB/TrEMBL
  Q4G011_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Sh3bp2  SH3-domain binding protein 2  Sh3bp2_predicted  SH3-domain binding protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Sh3bp2_predicted  SH3-domain binding protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED