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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Klhl18 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of KLHL18 mRNA | CTD | PMID:22079256 | Klhl18 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | AW545966 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of KLHL18 mRNA | CTD | PMID:22206623 | Klhl18 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | AW545966 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of KLHL18 mRNA | CTD | PMID:22206623 | Klhl18 | Rat | 17beta-estradiol | affects expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Estradiol affects the expression of KLHL18 mRNA | CTD | PMID:22574217 | Klhl18 | Rat | 17beta-estradiol | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Estradiol results in increased expression of KLHL18 mRNA | CTD | PMID:31614463 | Klhl18 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | AW545966 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLHL18 mRNA | CTD | PMID:21570461 | Klhl18 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLHL18 mRNA | CTD | PMID:33387578 | Klhl18 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of KLHL18 mRNA | CTD | PMID:30851411 | Klhl18 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of KLHL18 mRNA | CTD | PMID:28628672 | Klhl18 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of KLHL18 mRNA | CTD | PMID:28628672 | Klhl18 | Rat | aflatoxin B1 | increases methylation | ISO | KLHL18 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of KLHL18 gene | CTD | PMID:27153756 | Klhl18 | Rat | aristolochic acid A | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KLHL18 mRNA | CTD | PMID:33212167 | Klhl18 | Rat | belinostat | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | belinostat results in increased expression of KLHL18 mRNA | CTD | PMID:27188386 | Klhl18 | Rat | benzo[a]pyrene | increases expression | ISO | AW545966 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of KLHL18 mRNA | CTD | PMID:22228805 | Klhl18 | Rat | bisphenol A | decreases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of KLHL18 mRNA | CTD | PMID:20678512 | Klhl18 | Rat | bisphenol A | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of KLHL18 gene | CTD | PMID:31601247 | Klhl18 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KLHL18 mRNA | CTD | PMID:25181051 | Klhl18 | Rat | bisphenol A | increases expression | ISO | AW545966 (Mus musculus) | 6480464 | bisphenol A results in increased expression of KLHL18 mRNA | CTD | PMID:17706920 | Klhl18 | Rat | bisphenol A | multiple interactions | ISO | AW545966 (Mus musculus) | 6480464 | LHB protein affects the reaction [bisphenol A results in increased expression of KLHL18 mRNA] | CTD | PMID:17706920 | Klhl18 | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of KLHL18 mRNA | CTD | PMID:19167457 | Klhl18 | Rat | chlorpyrifos | increases expression | ISO | AW545966 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of KLHL18 mRNA | CTD | PMID:37019170 | Klhl18 | Rat | chrysene | increases expression | ISO | AW545966 (Mus musculus) | 6480464 | chrysene results in increased expression of KLHL18 mRNA | CTD | PMID:26377693 | Klhl18 | Rat | CU-O LINKAGE | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | cupric oxide results in increased expression of KLHL18 mRNA | CTD | PMID:22077320 | Klhl18 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of KLHL18 mRNA | CTD | PMID:27523638 | Klhl18 | Rat | cyclosporin A | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of KLHL18 mRNA | CTD | PMID:25562108 | Klhl18 | Rat | cylindrospermopsin | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | cylindrospermopsin results in increased expression of KLHL18 mRNA | CTD | PMID:24921660 | Klhl18 | Rat | dexamethasone | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of KLHL18 mRNA | CTD | PMID:28628672 | Klhl18 | Rat | Dibutyl phosphate | affects expression | ISO | KLHL18 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of KLHL18 mRNA | CTD | PMID:37042841 | Klhl18 | Rat | dorsomorphin | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLHL18 mRNA | CTD | PMID:27188386 | Klhl18 | Rat | doxorubicin | decreases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of KLHL18 mRNA | CTD | PMID:29803840 | Klhl18 | Rat | entinostat | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | entinostat results in increased expression of KLHL18 mRNA | CTD | PMID:26272509 | Klhl18 | Rat | entinostat | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLHL18 mRNA | CTD | PMID:27188386 | Klhl18 | Rat | folic acid | decreases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of KLHL18 mRNA | CTD | PMID:21867686 | Klhl18 | Rat | folic acid | multiple interactions | ISO | AW545966 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of KLHL18 mRNA | CTD | PMID:22206623 | Klhl18 | Rat | fulvestrant | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of KLHL18 gene | CTD | PMID:31601247 | Klhl18 | Rat | genistein | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Genistein results in increased expression of KLHL18 mRNA | CTD | PMID:26865667 | Klhl18 | Rat | indometacin | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of KLHL18 mRNA | CTD | PMID:28628672 | Klhl18 | Rat | ozone | multiple interactions | ISO | AW545966 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of KLHL18 mRNA | CTD | PMID:34911549 | Klhl18 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of KLHL18 mRNA | CTD | PMID:33387578 | Klhl18 | Rat | potassium chromate | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of KLHL18 mRNA | CTD | PMID:22079256 | Klhl18 | Rat | potassium chromate | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of KLHL18 mRNA | CTD | PMID:22079256 | Klhl18 | Rat | rac-lactic acid | decreases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of KLHL18 mRNA | CTD | PMID:30851411 | Klhl18 | Rat | resveratrol | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of KLHL18 mRNA | CTD | PMID:23557933 | Klhl18 | Rat | SB 431542 | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLHL18 mRNA | CTD | PMID:27188386 | Klhl18 | Rat | sodium arsenite | affects expression | ISO | KLHL18 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of KLHL18 mRNA | CTD | PMID:34032870 | Klhl18 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of KLHL18 mRNA | CTD | PMID:31150632 | Klhl18 | Rat | triptonide | decreases expression | ISO | AW545966 (Mus musculus) | 6480464 | triptonide results in decreased expression of KLHL18 mRNA | CTD | PMID:33045310 | Klhl18 | Rat | valproic acid | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KLHL18 mRNA | CTD | PMID:23179753 | Klhl18 | Rat | valproic acid | affects expression | ISO | KLHL18 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KLHL18 mRNA | CTD | PMID:25979313 | Klhl18 | Rat | vorinostat | increases expression | ISO | KLHL18 (Homo sapiens) | 6480464 | vorinostat results in increased expression of KLHL18 mRNA | CTD | PMID:27188386 | Klhl18 | Rat | zinc atom | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of KLHL18 mRNA | CTD | PMID:18593933 | Klhl18 | Rat | zinc(0) | multiple interactions | ISO | KLHL18 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of KLHL18 mRNA | CTD | PMID:18593933 | |