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Gene: Slc29a4 (solute carrier family 29 member 4) Rattus norvegicus

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Symbol:

Slc29a4

Name:

solute carrier family 29 member 4

RGD ID:

1310545

Description:

Enables monoamine transmembrane transporter activity. Involved in monoamine transport. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC29A4 (solute carrier family 29 member 4); PARTICIPATES IN metformin pharmacokinetics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

equilibrative nucleoside transporter 4; LOC288499; solute carrier family 29 (equilibrative nucleoside transporter), member 4; solute carrier family 29 (nucleoside transporters), member 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	16,967,047 - 16,998,276 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	16,967,047 - 16,988,338 (-)	Ensembl				GRCr8
mRatBN7.2	12	11,853,540 - 11,884,660 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	11,853,540 - 11,874,834 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	12,656,630 - 12,677,805 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	13,279,899 - 13,301,070 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	12,311,024 - 12,332,201 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	13,914,114 - 13,924,511 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	13,914,114 - 13,924,531 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	15,942,167 - 15,976,640 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	12,241,259 - 12,251,656 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	13,639,832 - 13,659,864 (-)	NCBI		Celera
RGSC_v3.1	12	12,272,150 - 12,284,079 (-)	NCBI
Cytogenetic Map	12	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-adrenaline (ISO)

(R)-noradrenaline (ISO)

1,1'-diethyl-2,2'-cyanine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butanal (ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

chlorpyrifos (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diazinon (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP,ISO)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dimethylarsinic acid (ISO)

dopamine (ISO)

doxorubicin (ISO)

FR900359 (ISO)

furan (EXP)

histamine (ISO)

metformin (ISO)

methimazole (EXP)

methylarsonic acid (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

nickel sulfate (ISO)

niclosamide (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

rifampicin (ISO)

rotenone (EXP)

serotonin (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

T-2 toxin (EXP)

titanium dioxide (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenosine transport (IEA,ISO)

cellular detoxification (IEA,ISO)

dopamine transport (IEA,ISO)

dopamine uptake (IEA,ISO)

epinephrine transport (IEA,ISO)

epinephrine uptake (IEA,ISO)

export across plasma membrane (IEA,ISO)

histamine transport (IEA,ISO)

histamine uptake (IEA,ISO)

monoamine transport (IDA,IEA,ISO)

monoatomic cation transmembrane transport (IEA,ISO)

neurotransmitter transport (IEA,ISO)

norepinephrine transport (IEA,ISO)

norepinephrine uptake (IEA,ISO)

nucleoside transmembrane transport (IEA)

nucleoside transport (IEA)

organic cation transport (IEA,ISO)

serotonin transport (IEA,ISO)

serotonin uptake (IEA,ISO)

transmembrane transport (IEA,ISO)

xenobiotic transport (IEA,ISO)

Cellular Component

apical plasma membrane (IDA,IEA,ISO)

basolateral plasma membrane (IDA,IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IDA,IEA,ISO)

presynapse (IEA)

Molecular Function

efflux transmembrane transporter activity (IEA,ISO)

monoamine transmembrane transporter activity (IBA,IDA,IEA,ISO)

monoatomic cation transmembrane transporter activity (IEA,ISO)

neurotransmitter transmembrane transporter activity (IEA,ISO)

nucleoside transmembrane transporter activity (IEA)

toxin transmembrane transporter activity (IEA,ISO)

transmembrane transporter activity (IEA,ISO)

xenobiotic transmembrane transporter activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

metformin pharmacokinetics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Metformin pathways: pharmacokinetics and pharmacodynamics.	Gong L, etal., Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.
3.	Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers.	Okura T, etal., J Pharm Sci. 2011 Sep;100(9):3924-38. doi: 10.1002/jps.22594. Epub 2011 May 2.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood-brain barrier and its implications to the transport of neurotoxins.	Wu KC, etal., J Neurochem. 2015 Dec;135(6):1178-88. doi: 10.1111/jnc.13363. Epub 2015 Oct 14.

Additional References at PubMed

PMID:20858707	PMID:27501284

Genomics

Comparative Map Data

Slc29a4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	16,967,047 - 16,998,276 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	16,967,047 - 16,988,338 (-)	Ensembl				GRCr8
mRatBN7.2	12	11,853,540 - 11,884,660 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	11,853,540 - 11,874,834 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	12,656,630 - 12,677,805 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	13,279,899 - 13,301,070 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	12,311,024 - 12,332,201 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	13,914,114 - 13,924,511 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	13,914,114 - 13,924,531 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	15,942,167 - 15,976,640 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	12,241,259 - 12,251,656 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	13,639,832 - 13,659,864 (-)	NCBI		Celera
RGSC_v3.1	12	12,272,150 - 12,284,079 (-)	NCBI
Cytogenetic Map	12	p11	NCBI

SLC29A4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	5,282,943 - 5,306,912 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	5,274,369 - 5,307,194 (+)	Ensembl			hg38	GRCh38
GRCh37	7	5,322,574 - 5,346,543 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	5,289,087 - 5,310,230 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	5,095,815 - 5,116,931	NCBI
Celera	7	5,287,760 - 5,304,022 (+)	NCBI		Celera
Cytogenetic Map	7	p22.1	NCBI
HuRef	7	5,237,590 - 5,258,085 (+)	NCBI		HuRef
CHM1_1	7	5,322,266 - 5,343,242 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	5,400,703 - 5,424,610 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	5,368,916 - 5,390,059 (+)	NCBI

Slc29a4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	142,678,226 - 142,708,245 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	142,678,267 - 142,708,245 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	142,692,478 - 142,722,490 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	142,692,512 - 142,722,490 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	143,178,055 - 143,198,443 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	142,954,391 - 142,977,880 (+)	NCBI		MGSCv36	mm8
Celera	5	139,765,811 - 139,776,351 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	81.56	NCBI

Slc29a4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	10,155,899 - 10,181,974 (+)	Ensembl
ChiLan1.0	NW_004955460	10,155,916 - 10,181,974 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC29A4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	10,247,668 - 10,268,779 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	58,572,394 - 58,593,482 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	5,538,436 - 5,559,506 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	5,559,540 - 5,576,771 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	5,560,565 - 5,575,637 (+)	Ensembl			panPan2	panpan1.1

SLC29A4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	12,607,708 - 12,634,572 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	12,608,713 - 12,622,478 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	14,078,449 - 14,105,244 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	12,743,923 - 12,770,753 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	12,743,935 - 12,760,238 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	12,554,855 - 12,581,654 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	12,488,064 - 12,514,839 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	12,764,693 - 12,791,487 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc29a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	140,863,645 - 140,887,329 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936765	855,667 - 864,900 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936765	854,712 - 868,001 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC29A4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	3,853,307 - 3,878,236 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	3,854,466 - 3,879,117 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	4,537,619 - 4,541,229 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC29A4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	16,429,879 - 16,450,580 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	16,429,413 - 16,450,324 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666090	5,524,669 - 5,546,232 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc29a4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	28,254,635 - 28,267,133 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	28,254,635 - 28,280,304 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc29a4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	10,421,977 - 10,452,855 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc29a4
140 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	105
Count of miRNA genes:	88
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000001477
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

UniSTS:547070

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	11,853,563 - 11,854,398 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	13,914,138 - 13,914,972	NCBI	Rnor6.0
Rnor_5.0	12	15,942,191 - 15,943,025	UniSTS	Rnor5.0
Celera	12	13,639,856 - 13,640,690	UniSTS
Cytogenetic Map	12	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	10	54	150	84	83	52	69	52	6	293	149	4	135	70	92	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001477 ⟹ ENSRNOP00000001477

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	16,967,047 - 16,988,338 (-)	Ensembl
mRatBN7.2 Ensembl	12	11,853,540 - 11,874,834 (-)	Ensembl
Rnor_6.0 Ensembl	12	13,914,114 - 13,924,531 (-)	Ensembl

RefSeq Acc Id:

NM_001105911 ⟹ NP_001099381

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,967,047 - 16,988,338 (-)	NCBI
mRatBN7.2	12	11,853,540 - 11,874,834 (-)	NCBI
Rnor_6.0	12	13,914,114 - 13,924,511 (-)	NCBI
Rnor_5.0	12	15,942,167 - 15,976,640 (-)	NCBI
RGSC_v3.4	12	12,241,259 - 12,251,656 (-)	RGD
Celera	12	13,639,832 - 13,659,864 (-)	RGD

Sequence:

show sequence

CGGGCGGGGCGTGAGCCGGGCTAGCTCGCCGCAGCTGCTGCGCCCCTCGCACGCGCTCGCGGAC
CCGGGCCCGCGGACCGGGACACCAAGGAGGACGCCCGCCGCGCCCGGCCCAAGCCTCGAAGAAC
GGGGCACAGCGCAAAGGGTCCGGGCGCGGGCGGCGGGCAGCCACCGAGGATCCCAGCCTGGGGC
CGGCCGAGTGTGAACTGCCATGGGCTCCATTGGAAGCCAGCGCCTCAAGGAGCCCTGTGTGGCA
GCCACATCTGGCCAGAGTGTGGTGACAAGCTTTGACAACTTTCAGCTGGAGACGACAATCGAGG
GGGCTCAGGATCCAGGCATCAGAGTCAGGGGCGTCCCCCCTTTCACAGACTCTGCGGTAGACGA
GCCTGTGCCGGACGACCGCTACCATGCCATCTACTTTGCCATGCTGCTGGCTGGCGTGGGCTTC
CTACTGCCCTACAACAGTTTTATCACCGATGTGGACTATCTTCACCACAAGTACCCAGGAACCT
CCATCGTGTTTGACATGAGCCTCACCTATATCTTGGTGGCACTGGCAGCCGTGCTCCTCAACAA
CGTTGTGGTGGAGAGGTTGAACCTGCACACTAGGATCACCACAGGTTACCTCCTGGCCTTGGGT
CCCTTGCTCTTTATCAGCATCTTTGATGTGTGGCTTCAGCTCTTCTCTCACGACCAGGCTTACG
CCATCAACCTGGCCGCCGTGGGCACTGTGGCCTTTGGCTGCACAGTGCAGCAATCTAGCTTCTA
CGGCTACACAGGATTACTGCCCAAGAGGTACACGCAGGGGGTGATGACTGGAGAGAGCACGGCA
GGGGTGATGATCTCTCTGAGCCGAATCCTCACTAAGCTGCTGCTCCCGGATGAGCGGGCCAGCA
CCATCATCTTCTTCCTGGTCTCTGCTGGCTTGGAGCTCCTGTGCTTCCTGCTGCACTTGCTGGT
GCGACGCAGCCGTTTTGTGCTCTACTACACCACTCGGCCTCGTGACAGCCGCCCTGTCCGGGCA
GGCTACCGAGTGCACCATGATGTCGCGTCAGGAGACATCCACTTTCACCAAACTCCAGCCCTGT
CCAGCAGCAGGTCCCCAAAGGACAGCCCAGCCCATGAGGTGACCCACAGCAACAGCGGCGTCTA
CATGCGTTTTGATGTGCCCCGGCCACGAGTCAAACGGAGCTGGCCCACCTTCAGAGCCCTGCTG
CTGCACCGATACGTCGTGGCGCGGGTCATCTGGGCCGACATGCTATCCATTGCGGTAACTTACT
TCATTACGCTCTGCCTGTTTCCTGGCCTGGAGTCCGAGATCCGCCACTGCGTGCTGGGCGAGTG
GCTGCCCATCCTGGTCATGGCCGTGTTCAACCTGTCAGACTTTGTGGGCAAGATCCTGGCAGCC
CTACCCGTGGACTGGAGGGGTACCCATCTGCTTGCCTGCTCTTGCCTTCGTGTGGTCTTCATCC
CCCTCTTCATCCTGTGTGTGTACCCCACTGGTATGCCTGCCCTCCGTCACCCTGCCTGGCCCTG
TGTCTTCTCACTGCTAATGGGCATCAGCAATGGCTACTTTGGCAGCGTGCCCATGATCCTGGCA
GCTGGAAAAGTGAGCCCCAAGCAGCGGGAGCTGGCAGGGAACACCATGACTGTGTCCTATATGT
CGGGGTTGACCCTGGGCTCTGCTGTGGCCTATTGCACCTACAGCCTCACCCGTGACGCCCACAG
CAGCTGCTTTCAAACAGCCACCGCCAACGACTCCATCCTTGTTGGCCCCTGAGCCAGGCCCACC
CGATCCTGCCACCTGCCCAGGAAGGGCTGCTCGGGCCAGATACCCCAAGGCCTGAGGACCCTCC
CACCCCTGCCTCAGTGCCTGCGGGGTCCTGGCCGCCTCCTAAGCCACTAACGCCACCTTGCTAC
CTTGTTCCAGTCGCACACTGCAGTTGGAGCATCACCACCCAGGGCACCACCTCCTCGTGTCTGG
GTTGGGTCGGACACCTGCCCTTCACCCTCTATGTCCAGAGGCTCCACGTTTGTCACCATGGTGG
GGTTATTCAGCCACTCGGAATGGCTGACCACAATCTGAGTTGACTTCCTTCACTGTGACCCCAC
TGTGCGGTCCCATGACGGTCTTCAATGTAGTTTTCATTTACTGGACGGGGGGGGGGGCACCTCC
TCATGAGTATGAGAGATCTTGGAGGCAAGTCCCCAACCCCGTTCTGTCCCCTTCTTGTTCTTAC
ACACTTCTTCACAACCCTCCCCGAGCTCCCACATACATAAAGGATTAAGACTCATTCCTACGTC
TACACAGGCCTCCTGTAGTCATAGCAACAGAGCTGACCTGGGTGCACCCACCTTAGGTGGAGGA
CCCCCAAGCCCTCAGAGCACAGGCTAAGGGCCACACCCAACAGATGTCCCATTTCCTCCCCGGC
TCCATTCAATTTATCCATAATGCAGGGACAGCTGAGATCCACTGTGACCTACGTCGCCCCACTC
CCATCCACTGAGAGTCAAGCAGTGACACATCACACCTGAACCCCTGGCAAGTAGCGGGCAAGGT
GAGGAGTGGAGTCCTGGGAGCCAGGACTGGCTGTAGGACCTCCTGCCAGAGAGAGCTTTGGCTG
AACCACGACACTTGCCTCTCCACACATCTGGCCCCAGCTGTGACCACCTTGTACCAATCCCTGC
TGTGTCCTGTCTACCTGTGTGTTCTCTGACTACCGCACTGGCCATTAAAGATGGCAGAGACTGC
C

hide sequence

RefSeq Acc Id:

XM_039089185 ⟹ XP_038945113

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,967,047 - 16,988,362 (-)	NCBI
mRatBN7.2	12	11,853,540 - 11,874,834 (-)	NCBI

RefSeq Acc Id:

XM_039089186 ⟹ XP_038945114

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,967,047 - 16,998,276 (-)	NCBI
mRatBN7.2	12	11,853,999 - 11,884,660 (-)	NCBI

RefSeq Acc Id:

XM_039089187 ⟹ XP_038945115

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,967,047 - 16,976,498 (-)	NCBI
mRatBN7.2	12	11,853,999 - 11,862,993 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099381	(Get FASTA)	NCBI Sequence Viewer
	XP_038945113	(Get FASTA)	NCBI Sequence Viewer
	XP_038945114	(Get FASTA)	NCBI Sequence Viewer
	XP_038945115	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL89703	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001477
	ENSRNOP00000001477.6

RefSeq Acc Id:

NP_001099381 ⟸ NM_001105911

- UniProtKB:

A6K1P5 (UniProtKB/TrEMBL), F1M2Y4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSIGSQRLKEPCVAATSGQSVVTSFDNFQLETTIEGAQDPGIRVRGVPPFTDSAVDEPVPDDR
YHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSIVFDMSLTYILVALAAVLLNNVVVERL
NLHTRITTGYLLALGPLLFISIFDVWLQLFSHDQAYAINLAAVGTVAFGCTVQQSSFYGYTGLL
PKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTIIFFLVSAGLELLCFLLHLLVRRSRFV
LYYTTRPRDSRPVRAGYRVHHDVASGDIHFHQTPALSSSRSPKDSPAHEVTHSNSGVYMRFDVP
RPRVKRSWPTFRALLLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCVLGEWLPILVM
AVFNLSDFVGKILAALPVDWRGTHLLACSCLRVVFIPLFILCVYPTGMPALRHPAWPCVFSLLM
GISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHSSCFQTA
TANDSILVGP

hide sequence

Ensembl Acc Id:

ENSRNOP00000001477 ⟸ ENSRNOT00000001477

RefSeq Acc Id:	XP_038945113 ⟸ XM_039089185
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038945114 ⟸ XM_039089186
- Peptide Label:	isoform X1
- UniProtKB:	A6K1P5 (UniProtKB/TrEMBL), F1M2Y4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945115 ⟸ XM_039089187
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M2Y4-F1-model_v2	AlphaFold	F1M2Y4	1-475	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310545	AgrOrtholog
BioCyc Gene	G2FUF-19973	BioCyc
Ensembl Genes	ENSRNOG00000001115	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001477	ENTREZGENE
	ENSRNOT00000001477.7	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/TrEMBL
InterPro	DER/eqnu_transpt	UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/TrEMBL
KEGG Report	rno:288499	UniProtKB/TrEMBL
NCBI Gene	288499	ENTREZGENE
PANTHER	DER/eqnu_transpt	UniProtKB/TrEMBL
	EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4	UniProtKB/TrEMBL
Pfam	Nucleoside_tran	UniProtKB/TrEMBL
PhenoGen	Slc29a4	PhenoGen
PIRSF	ENT	UniProtKB/TrEMBL
PRINTS	DERENTRNSPRT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001115	RatGTEx
Superfamily-SCOP	MFS_gen_substrate_transporter	UniProtKB/TrEMBL
UniProt	A6K1P5	ENTREZGENE, UniProtKB/TrEMBL
	F1M2Y4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc29a4	solute carrier family 29 member 4	Slc29a4	solute carrier family 29 (equilibrative nucleoside transporter), member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc29a4	solute carrier family 29 (equilibrative nucleoside transporter), member 4	Slc29a4	solute carrier family 29 (nucleoside transporters), member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Slc29a4	solute carrier family 29 (nucleoside transporters), member 4	Slc29a4_predicted	solute carrier family 29 (nucleoside transporters), member 4 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Slc29a4_predicted	solute carrier family 29 (nucleoside transporters), member 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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