Usp49 (ubiquitin specific peptidase 49) - Rat Genome Database

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Pathways
Gene: Usp49 (ubiquitin specific peptidase 49) Rattus norvegicus
Analyze
Symbol: Usp49
Name: ubiquitin specific peptidase 49
RGD ID: 1310513
Description: Predicted to enable histone binding activity and peptidase activity. Predicted to be involved in mRNA splicing, via spliceosome and protein deubiquitination. Predicted to act upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human USP49 (ubiquitin specific peptidase 49); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316211; RGD1310513; similar to hypothetical protein MGC20741; ubiquitin carboxyl-terminal hydrolase 49; ubiquitin thioesterase 49
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,803,177 - 20,867,681 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,804,921 - 20,863,667 (-)EnsemblGRCr8
mRatBN7.2913,305,640 - 13,366,132 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,308,178 - 13,366,132 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,888,201 - 21,945,900 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,952,281 - 27,010,031 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,251,607 - 25,309,304 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,314,875 - 15,375,365 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,317,413 - 15,375,365 (-)Ensemblrn6Rnor6.0
Rnor_5.0914,239,085 - 14,299,667 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,774,333 - 8,832,285 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera911,060,638 - 11,117,551 (-)NCBICelera
RGSC_v3.198,778,351 - 8,786,793 (-)NCBI
Cytogenetic Map9q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14715245   PMID:15632090   PMID:23824326  


Genomics

Comparative Map Data
Usp49
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,803,177 - 20,867,681 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,804,921 - 20,863,667 (-)EnsemblGRCr8
mRatBN7.2913,305,640 - 13,366,132 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,308,178 - 13,366,132 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,888,201 - 21,945,900 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,952,281 - 27,010,031 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,251,607 - 25,309,304 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,314,875 - 15,375,365 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,317,413 - 15,375,365 (-)Ensemblrn6Rnor6.0
Rnor_5.0914,239,085 - 14,299,667 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,774,333 - 8,832,285 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera911,060,638 - 11,117,551 (-)NCBICelera
RGSC_v3.198,778,351 - 8,786,793 (-)NCBI
Cytogenetic Map9q12NCBI
USP49
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,789,896 - 41,895,375 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,789,896 - 41,895,375 (-)Ensemblhg38GRCh38
GRCh37641,757,634 - 41,863,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,873,361 - 41,971,077 (-)NCBIBuild 36Build 36hg18NCBI36
Celera643,318,714 - 43,416,439 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef641,484,106 - 41,581,878 (-)NCBIHuRef
CHM1_1641,768,743 - 41,866,405 (-)NCBICHM1_1
T2T-CHM13v2.0641,618,461 - 41,723,935 (-)NCBIT2T-CHM13v2.0
Usp49
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,941,615 - 47,997,664 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,941,615 - 47,997,663 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381747,630,690 - 47,686,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,630,690 - 47,686,738 (+)Ensemblmm10GRCm38
MGSCv371747,767,639 - 47,821,016 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361747,093,881 - 47,147,258 (+)NCBIMGSCv36mm8
Celera1751,067,647 - 51,120,972 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.72NCBI
Usp49
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,191,236 - 8,198,809 (-)Ensembl
ChiLan1.0NW_0049554378,187,118 - 8,237,910 (-)NCBIChiLan1.0ChiLan1.0
USP49
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2556,282,907 - 56,389,693 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,152,885 - 52,256,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,375,083 - 41,479,143 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,678,680 - 42,781,748 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,683,149 - 42,695,707 (-)EnsemblpanPan2panpan1.1
USP49
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11210,474,873 - 10,556,900 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1210,479,733 - 10,577,918 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1210,504,358 - 10,589,769 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01210,955,129 - 11,041,174 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,955,164 - 11,051,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,485,701 - 10,567,699 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,569,381 - 10,654,952 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,663,097 - 10,748,867 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Usp49
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,957,669 - 46,049,495 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,991,688 - 18,000,794 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,946,875 - 18,002,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP49
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,981,383 - 37,052,568 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1736,978,291 - 37,054,027 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,393,547 - 42,458,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP49
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,265,322 - 30,373,547 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,356,698 - 30,366,940 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604441,783,918 - 41,895,090 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp49
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,266,561 - 17,274,926 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475417,226,723 - 17,281,206 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Usp49
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1482,195,210 - 82,263,698 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Usp49
575 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:656
Count of miRNA genes:293
Interacting mature miRNAs:357
Transcripts:ENSRNOT00000018550
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 82 211 91 90 59 151 59 6 480 276 22 189 114 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000018550   ⟹   ENSRNOP00000018550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,805,715 - 20,863,667 (-)Ensembl
mRatBN7.2 Ensembl913,308,178 - 13,366,132 (-)Ensembl
Rnor_6.0 Ensembl915,317,413 - 15,375,365 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154159   ⟹   ENSRNOP00000105669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,804,921 - 20,863,667 (-)Ensembl
RefSeq Acc Id: NM_001136470   ⟹   NP_001129942
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,805,715 - 20,863,667 (-)NCBI
mRatBN7.2913,308,178 - 13,366,132 (-)NCBI
Rnor_6.0915,317,413 - 15,375,365 (-)NCBI
Rnor_5.0914,239,085 - 14,299,667 (-)NCBI
RGSC_v3.498,774,333 - 8,832,285 (-)RGD
Celera911,060,638 - 11,117,551 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244435   ⟹   XP_006244497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,803,177 - 20,826,448 (-)NCBI
mRatBN7.2913,305,640 - 13,323,918 (-)NCBI
Rnor_6.0915,314,875 - 15,333,131 (-)NCBI
Rnor_5.0914,239,085 - 14,299,667 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596410   ⟹   XP_017451899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,803,177 - 20,863,303 (-)NCBI
mRatBN7.2913,305,640 - 13,365,484 (-)NCBI
Rnor_6.0915,314,875 - 15,374,664 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596411   ⟹   XP_017451900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,803,177 - 20,862,630 (-)NCBI
mRatBN7.2913,305,640 - 13,365,041 (-)NCBI
Rnor_6.0915,314,875 - 15,374,185 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083485   ⟹   XP_038939413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,803,177 - 20,862,751 (-)NCBI
mRatBN7.2913,305,640 - 13,365,194 (-)NCBI
RefSeq Acc Id: XM_063267083   ⟹   XP_063123153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,803,177 - 20,867,681 (-)NCBI
RefSeq Acc Id: NP_001129942   ⟸   NM_001136470
- UniProtKB: D3ZJ49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244497   ⟸   XM_006244435
- Peptide Label: isoform X1
- UniProtKB: D3ZJ49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451899   ⟸   XM_017596410
- Peptide Label: isoform X1
- UniProtKB: D3ZJ49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451900   ⟸   XM_017596411
- Peptide Label: isoform X1
- UniProtKB: D3ZJ49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018550   ⟸   ENSRNOT00000018550
RefSeq Acc Id: XP_038939413   ⟸   XM_039083485
- Peptide Label: isoform X1
- UniProtKB: D3ZJ49 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123153   ⟸   XM_063267083
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000105669   ⟸   ENSRNOT00000154159
Protein Domains
UBP-type   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJ49-F1-model_v2 AlphaFold D3ZJ49 1-685 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310513 AgrOrtholog
BioCyc Gene G2FUF-28276 BioCyc
Ensembl Genes ENSRNOG00000013866 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018550 ENTREZGENE
  ENSRNOT00000018550.7 UniProtKB/TrEMBL
  ENSRNOT00000154159.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19ubi-hydrolase_C_CS UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  Ub_carboxyl-term_hydrolase UniProtKB/TrEMBL
  UCH/PAN2 UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_UBP UniProtKB/TrEMBL
KEGG Report rno:316211 UniProtKB/TrEMBL
NCBI Gene 316211 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 49 UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
  zf-UBP UniProtKB/TrEMBL
PhenoGen Usp49 PhenoGen
PROSITE UCH_2_1 UniProtKB/TrEMBL
  UCH_2_2 UniProtKB/TrEMBL
  UCH_2_3 UniProtKB/TrEMBL
  ZF_UBP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013866 RatGTEx
SMART ZnF_UBP UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54001 UniProtKB/TrEMBL
UniProt A0ABK0L6U3_RAT UniProtKB/TrEMBL
  D3ZJ49 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Usp49  ubiquitin specific peptidase 49   Usp49_predicted  ubiquitin specific peptidase 49 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Usp49_predicted  ubiquitin specific peptidase 49 (predicted)  RGD1310513_predicted  similar to hypothetical protein MGC20741 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310513_predicted  similar to hypothetical protein MGC20741 (predicted)  LOC316211_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC316211_predicted  similar to hypothetical protein MGC20741 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL