Symbol:
Usp49
Name:
ubiquitin specific peptidase 49
RGD ID:
1310513
Description:
Predicted to enable histone binding activity and peptidase activity. Predicted to be involved in mRNA splicing, via spliceosome and protein deubiquitination. Predicted to act upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human USP49 (ubiquitin specific peptidase 49); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
LOC316211; RGD1310513; similar to hypothetical protein MGC20741; ubiquitin carboxyl-terminal hydrolase 49; ubiquitin thioesterase 49
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 9 20,803,177 - 20,867,681 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 9 20,804,921 - 20,863,667 (-) Ensembl GRCr8 mRatBN7.2 9 13,305,640 - 13,366,132 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 9 13,308,178 - 13,366,132 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 9 21,888,201 - 21,945,900 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 9 26,952,281 - 27,010,031 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 9 25,251,607 - 25,309,304 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 9 15,314,875 - 15,375,365 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 15,317,413 - 15,375,365 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 9 14,239,085 - 14,299,667 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 9 8,774,333 - 8,832,285 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 9 11,060,638 - 11,117,551 (-) NCBI Celera RGSC_v3.1 9 8,778,351 - 8,786,793 (-) NCBI Cytogenetic Map 9 q12 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Usp49 Rat (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of USP49 mRNA] CTD PMID:31150632 Usp49 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat 1,2-dimethylhydrazine decreases expression ISO Usp49 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in decreased expression of USP49 mRNA CTD PMID:22206623 Usp49 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat 2-hydroxypropanoic acid increases expression ISO USP49 (Homo sapiens) 6480464 Lactic Acid results in increased expression of USP49 mRNA CTD PMID:30851411 Usp49 Rat 4,4'-sulfonyldiphenol decreases expression ISO Usp49 (Mus musculus) 6480464 bisphenol S results in decreased expression of USP49 mRNA CTD PMID:39298647 Usp49 Rat 4,4'-sulfonyldiphenol affects methylation ISO Usp49 (Mus musculus) 6480464 bisphenol S affects the methylation of USP49 gene CTD PMID:31683443 Usp49 Rat 4,4'-sulfonyldiphenol decreases methylation ISO Usp49 (Mus musculus) 6480464 bisphenol S results in decreased methylation of USP49 exon CTD PMID:33297965 Usp49 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of USP49 mRNA CTD PMID:24780913|PMID:25825206 Usp49 Rat all-trans-retinoic acid decreases expression ISO USP49 (Homo sapiens) 6480464 Tretinoin results in decreased expression of USP49 mRNA CTD PMID:21934132 Usp49 Rat aristolochic acid A increases expression ISO USP49 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of USP49 mRNA CTD PMID:33212167 Usp49 Rat beta-lapachone decreases expression ISO USP49 (Homo sapiens) 6480464 beta-lapachone results in decreased expression of USP49 mRNA CTD PMID:38218311 Usp49 Rat bis(2-ethylhexyl) phthalate increases expression ISO USP49 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of USP49 mRNA; Diethylhexyl Phthalate results in increased expression more ... CTD PMID:32143396 Usp49 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of USP49 mRNA CTD PMID:25181051 Usp49 Rat bisphenol A decreases expression ISO Usp49 (Mus musculus) 6480464 bisphenol A results in decreased expression of USP49 mRNA CTD PMID:33221593 Usp49 Rat bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of USP49 mRNA CTD PMID:32479839 Usp49 Rat cadmium atom multiple interactions ISO USP49 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of USP49 more ... CTD PMID:35301059 Usp49 Rat cadmium atom multiple interactions ISO Usp49 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of USP49 more ... CTD PMID:37236586 Usp49 Rat cadmium dichloride increases expression ISO USP49 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of USP49 mRNA CTD PMID:38568856 Usp49 Rat cadmium dichloride multiple interactions ISO Usp49 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of USP49 more ... CTD PMID:37236586 Usp49 Rat cadmium dichloride multiple interactions ISO USP49 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of USP49 more ... CTD PMID:35301059 Usp49 Rat chlorpyrifos decreases expression ISO Usp49 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of USP49 mRNA CTD PMID:37019170 Usp49 Rat copper atom multiple interactions ISO USP49 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of USP49 mRNA CTD PMID:20971185 Usp49 Rat copper(0) multiple interactions ISO USP49 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of USP49 mRNA CTD PMID:20971185 Usp49 Rat Dibutyl phosphate affects expression ISO USP49 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of USP49 mRNA CTD PMID:37042841 Usp49 Rat dorsomorphin multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Usp49 Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of USP49 mRNA CTD PMID:29391264 Usp49 Rat entinostat decreases expression ISO USP49 (Homo sapiens) 6480464 entinostat results in decreased expression of USP49 mRNA CTD PMID:26272509 Usp49 Rat ethyl methanesulfonate increases expression ISO USP49 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of USP49 mRNA CTD PMID:23649840 Usp49 Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of USP49 mRNA CTD PMID:30307764 Usp49 Rat formaldehyde increases expression ISO USP49 (Homo sapiens) 6480464 Formaldehyde results in increased expression of USP49 mRNA CTD PMID:23649840 Usp49 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of USP49 mRNA CTD PMID:33387578 Usp49 Rat hydralazine multiple interactions ISO USP49 (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of USP49 mRNA CTD PMID:17183730 Usp49 Rat hydrogen peroxide affects expression ISO USP49 (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of USP49 mRNA CTD PMID:21179406 Usp49 Rat methyl methanesulfonate increases expression ISO USP49 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of USP49 mRNA CTD PMID:23649840 Usp49 Rat methylmercury chloride decreases expression ISO USP49 (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of USP49 mRNA CTD PMID:28001369 Usp49 Rat N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of USP49 mRNA CTD PMID:28801915 Usp49 Rat okadaic acid decreases expression ISO USP49 (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of USP49 mRNA CTD PMID:38832940 Usp49 Rat ozone multiple interactions ISO Usp49 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... CTD PMID:34911549 Usp49 Rat panobinostat multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Usp49 Rat panobinostat decreases expression ISO USP49 (Homo sapiens) 6480464 panobinostat results in decreased expression of USP49 mRNA CTD PMID:26272509 Usp49 Rat paracetamol affects expression ISO Usp49 (Mus musculus) 6480464 Acetaminophen affects the expression of USP49 mRNA CTD PMID:17562736 Usp49 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of USP49 mRNA CTD PMID:33387578 Usp49 Rat PCB138 multiple interactions ISO Usp49 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Usp49 Rat pentanal decreases expression ISO USP49 (Homo sapiens) 6480464 pentanal results in decreased expression of USP49 mRNA CTD PMID:26079696 Usp49 Rat phenylmercury acetate decreases expression ISO USP49 (Homo sapiens) 6480464 Phenylmercuric Acetate results in decreased expression of USP49 mRNA CTD PMID:26272509 Usp49 Rat phenylmercury acetate multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Usp49 Rat pirinixic acid multiple interactions ISO USP49 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... CTD PMID:19710929 Usp49 Rat rac-lactic acid increases expression ISO USP49 (Homo sapiens) 6480464 Lactic Acid results in increased expression of USP49 mRNA CTD PMID:30851411 Usp49 Rat SB 431542 multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Usp49 Rat silicon dioxide increases expression ISO USP49 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of USP49 mRNA CTD PMID:23806026 Usp49 Rat Soman increases expression EXP 6480464 Soman results in increased expression of USP49 mRNA CTD PMID:19281266 Usp49 Rat sunitinib decreases expression ISO USP49 (Homo sapiens) 6480464 Sunitinib results in decreased expression of USP49 mRNA CTD PMID:31533062 Usp49 Rat temozolomide decreases expression ISO USP49 (Homo sapiens) 6480464 Temozolomide results in decreased expression of USP49 mRNA CTD PMID:31758290 Usp49 Rat tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of USP49 mRNA CTD PMID:31150632 Usp49 Rat tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of USP49 mRNA] CTD PMID:31150632 Usp49 Rat thimerosal decreases expression ISO USP49 (Homo sapiens) 6480464 Thimerosal results in decreased expression of USP49 mRNA CTD PMID:27188386 Usp49 Rat thiram increases expression ISO USP49 (Homo sapiens) 6480464 Thiram results in increased expression of USP49 mRNA CTD PMID:38568856 Usp49 Rat titanium dioxide increases methylation ISO Usp49 (Mus musculus) 6480464 titanium dioxide results in increased methylation of USP49 gene CTD PMID:35295148 Usp49 Rat titanium dioxide decreases methylation ISO Usp49 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of USP49 promoter CTD PMID:35295148 Usp49 Rat torcetrapib increases expression ISO USP49 (Homo sapiens) 6480464 torcetrapib results in increased expression of USP49 mRNA CTD PMID:23228038 Usp49 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of USP49 mRNA CTD PMID:33387578 Usp49 Rat trichostatin A decreases expression ISO USP49 (Homo sapiens) 6480464 trichostatin A results in decreased expression of USP49 mRNA CTD PMID:24935251|PMID:26272509 Usp49 Rat trichostatin A affects expression ISO USP49 (Homo sapiens) 6480464 trichostatin A affects the expression of USP49 mRNA CTD PMID:28542535 Usp49 Rat trichostatin A multiple interactions ISO USP49 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Usp49 Rat triptonide increases expression ISO Usp49 (Mus musculus) 6480464 triptonide results in increased expression of USP49 mRNA CTD PMID:33045310 Usp49 Rat valproic acid multiple interactions ISO USP49 (Homo sapiens) 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of USP49 mRNA; [NOG protein co-treated more ... CTD PMID:17183730|PMID:27188386 Usp49 Rat valproic acid affects expression ISO Usp49 (Mus musculus) 6480464 Valproic Acid affects the expression of USP49 mRNA CTD PMID:17292431 Usp49 Rat valproic acid decreases expression ISO USP49 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of USP49 mRNA CTD PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509|PMID:28001369 Usp49 Rat vorinostat decreases expression ISO USP49 (Homo sapiens) 6480464 vorinostat results in decreased expression of USP49 mRNA CTD PMID:26272509|PMID:27188386