Zfp358 (zinc finger protein 358) - Rat Genome Database

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Gene: Zfp358 (zinc finger protein 358) Rattus norvegicus
Analyze
Symbol: Zfp358
Name: zinc finger protein 358
RGD ID: 1310416
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZNF358 (zinc finger protein 358); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC360754
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,350,266 - 6,354,359 (+)NCBIGRCr8
mRatBN7.2121,552,367 - 1,556,460 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,552,366 - 1,556,460 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,216,693 - 2,220,785 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0122,840,263 - 2,844,355 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,612,277 - 1,616,370 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,046,472 - 2,050,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,046,472 - 2,050,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,209,518 - 4,213,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,658,623 - 2,662,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,658,625 - 2,662,716 (-)NCBI
Celera123,408,729 - 3,412,822 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp358
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,350,266 - 6,354,359 (+)NCBIGRCr8
mRatBN7.2121,552,367 - 1,556,460 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,552,366 - 1,556,460 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,216,693 - 2,220,785 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0122,840,263 - 2,844,355 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,612,277 - 1,616,370 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,046,472 - 2,050,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,046,472 - 2,050,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,209,518 - 4,213,613 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,658,623 - 2,662,716 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,658,625 - 2,662,716 (-)NCBI
Celera123,408,729 - 3,412,822 (+)NCBICelera
Cytogenetic Map12p12NCBI
ZNF358
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,513,880 - 7,521,025 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,515,292 - 7,521,025 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,580,989 - 7,585,911 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,487,004 - 7,491,911 (+)NCBINCBI36Build 36hg18NCBI36
Build 34197,487,074 - 7,491,911NCBI
Celera197,453,515 - 7,458,434 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,255,266 - 7,257,086 (+)NCBIHuRef
CHM1_1197,584,011 - 7,585,831 (+)NCBICHM1_1
T2T-CHM13v2.0197,514,603 - 7,521,761 (+)NCBIT2T-CHM13v2.0
Zfp358
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,543,138 - 3,547,208 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,543,138 - 3,547,208 (+)EnsemblGRCm39 Ensembl
GRCm3883,493,138 - 3,497,208 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,493,138 - 3,497,208 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,493,138 - 3,497,208 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,493,171 - 3,497,208 (+)NCBIMGSCv36mm8
Celera83,719,112 - 3,723,182 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Znf358
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555631,714,393 - 1,716,499 (-)NCBIChiLan1.0ChiLan1.0
ZNF358
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,186,904 - 12,192,614 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,305,440 - 11,310,704 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,806,690 - 6,811,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,664,219 - 7,670,123 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,668,319 - 7,670,046 (+)Ensemblpanpan1.1panPan2
SAXO5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,297,373 - 52,304,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,101,541 - 52,108,348 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,826,937 - 52,833,752 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,810,257 - 52,845,852 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,030,490 - 52,037,288 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,474,070 - 52,480,878 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,705,000 - 52,711,807 (+)NCBIUU_Cfam_GSD_1.0
Znf358
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,236,010 - 213,245,945 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,597,045 - 4,598,700 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,592,060 - 4,598,775 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF358
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,615,551 - 71,619,865 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,615,475 - 71,619,683 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,153,917 - 72,158,957 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF358
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,011,795 - 7,017,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,015,733 - 7,017,439 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081851,029 - 856,800 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf358
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828629,530 - 632,986 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828629,686 - 632,799 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp358
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:88
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000001289
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat

Markers in Region
RH133337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25136,692,262 - 136,692,445 (+)MAPPERmRatBN7.2
mRatBN7.2121,556,254 - 1,556,437 (+)MAPPERmRatBN7.2
Rnor_6.0122,050,360 - 2,050,542NCBIRnor6.0
Rnor_6.05142,423,772 - 142,423,954NCBIRnor6.0
Rnor_5.05146,197,399 - 146,197,581UniSTSRnor5.0
Rnor_5.0124,213,406 - 4,213,588UniSTSRnor5.0
RGSC_v3.4122,658,646 - 2,658,828UniSTSRGSC3.4
Celera123,412,617 - 3,412,799UniSTS
Celera5135,217,076 - 135,217,258UniSTS
Cytogenetic Map12p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001289   ⟹   ENSRNOP00000001289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,552,366 - 1,556,460 (+)Ensembl
Rnor_6.0 Ensembl122,046,472 - 2,050,565 (+)Ensembl
RefSeq Acc Id: NM_001108328   ⟹   NP_001101798
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,350,266 - 6,354,359 (+)NCBI
mRatBN7.2121,552,367 - 1,556,460 (+)NCBI
Rnor_6.0122,046,472 - 2,050,565 (+)NCBI
Rnor_5.0124,209,518 - 4,213,613 (+)NCBI
RGSC_v3.4122,658,623 - 2,662,716 (-)RGD
Celera123,408,729 - 3,412,822 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101798 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL74930 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001289.4
RefSeq Acc Id: NP_001101798   ⟸   NM_001108328
- UniProtKB: D3ZRG3 (UniProtKB/TrEMBL),   A6KQ05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001289   ⟸   ENSRNOT00000001289
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRG3-F1-model_v2 AlphaFold D3ZRG3 1-652 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698367
Promoter ID:EPDNEW_R8892
Type:initiation region
Name:Zfp358_1
Description:zinc finger protein 358
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,046,559 - 2,046,619EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310416 AgrOrtholog
BioCyc Gene G2FUF-20399 BioCyc
Ensembl Genes ENSRNOG00000000974 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001289.6 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:360754 UniProtKB/TrEMBL
NCBI Gene 360754 ENTREZGENE
PANTHER GENE 12845-RELATED UniProtKB/TrEMBL
  TRANSCRIPTIONAL REPRESSOR PROTEIN YY UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp358 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000974 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A6KQ05 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRG3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Zfp358  zinc finger protein 358   Zfp358_predicted  zinc finger protein 358 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Zfp358_predicted  zinc finger protein 358 (predicted)      Symbol and Name status set to approved 70820 APPROVED