Rnase10 (ribonuclease A family member 10) - Rat Genome Database

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Gene: Rnase10 (ribonuclease A family member 10) Rattus norvegicus
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Symbol: Rnase10
Name: ribonuclease A family member 10
RGD ID: 1310415
Description: Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including defense response to Gram-positive bacterium; positive regulation of flagellated sperm motility; and regulation of fertilization. Predicted to act upstream of or within epithelial cell morphogenesis; seminiferous tubule development; and single fertilization. Predicted to be located in extracellular region. Orthologous to human RNASE10 (ribonuclease A family member 10 (inactive)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; azoxystrobin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inactive ribonuclease-like protein 10; LOC305840; protein Train A; Rah1; RGD1310415; ribonuclease 10; ribonuclease A h1; ribonuclease, RNase A family, 10 (non-active); ribonuclease-like protein 10; similar to Ribonuclease pancreatic precursor (RNase 1) (RNase A) (RL1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,700,219 - 26,702,681 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,688,102 - 26,706,105 (+)EnsemblGRCr8
mRatBN7.21524,226,687 - 24,229,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,226,691 - 24,228,561 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1526,997,864 - 27,000,326 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,956,742 - 27,959,203 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,206,416 - 26,208,878 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,930,581 - 27,933,873 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,933,211 - 27,933,849 (+)Ensemblrn6Rnor6.0
Rnor_5.01531,764,636 - 31,766,642 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41526,987,636 - 26,988,274 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,548,103 - 24,548,741 (+)NCBICelera
RGSC_v3.11527,003,335 - 27,003,973 (+)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Cho S, etal., Genomics. 2005 Feb;85(2):208-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14561640   PMID:21084446   PMID:22750516   PMID:24337645  


Genomics

Comparative Map Data
Rnase10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,700,219 - 26,702,681 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,688,102 - 26,706,105 (+)EnsemblGRCr8
mRatBN7.21524,226,687 - 24,229,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,226,691 - 24,228,561 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1526,997,864 - 27,000,326 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,956,742 - 27,959,203 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,206,416 - 26,208,878 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,930,581 - 27,933,873 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,933,211 - 27,933,849 (+)Ensemblrn6Rnor6.0
Rnor_5.01531,764,636 - 31,766,642 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41526,987,636 - 26,988,274 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,548,103 - 24,548,741 (+)NCBICelera
RGSC_v3.11527,003,335 - 27,003,973 (+)NCBI
Cytogenetic Map15p14NCBI
RNASE10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,504,233 - 20,513,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,505,537 - 20,513,884 (+)Ensemblhg38GRCh38
GRCh371420,972,392 - 20,982,043 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,048,471 - 20,049,121 (+)NCBIBuild 36Build 36hg18NCBI36
Celera14839,505 - 840,155 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,099,688 - 1,100,338 (+)NCBIHuRef
CHM1_11420,980,647 - 20,981,297 (+)NCBICHM1_1
T2T-CHM13v2.01414,701,150 - 14,711,005 (+)NCBIT2T-CHM13v2.0
Rnase10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,245,208 - 51,248,218 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,245,208 - 51,248,215 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381451,007,751 - 51,010,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,007,751 - 51,010,758 (+)Ensemblmm10GRCm38
MGSCv371451,627,426 - 51,630,433 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361449,929,880 - 49,932,709 (+)NCBIMGSCv36mm8
Celera1447,284,967 - 47,287,974 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.34NCBI
Rnase10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,328,294 - 1,331,558 (+)Ensembl
ChiLan1.0NW_0049555501,326,203 - 1,331,558 (+)NCBIChiLan1.0ChiLan1.0
RNASE10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,013,740 - 22,022,925 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,230,225 - 21,239,412 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,378,780 - 1,385,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,430,824 - 19,434,448 (+)NCBIPanPan1.1PanPan1.1panPan2
RNASE10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,845,687 - 17,908,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,840,091 - 17,844,406 (+)EnsemblcanFam3CanFam3.1
CanFam3.1 Ensembl1517,840,091 - 17,844,406 (+)NCBIcanFam3CanFam3.1
Dog10K_Boxer_Tasha1518,318,664 - 18,391,228 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01518,092,868 - 18,165,341 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,099,762 - 18,100,406 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,775,551 - 17,847,530 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,830,201 - 17,903,195 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,959,467 - 18,031,615 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rnase10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,752,759 - 77,753,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936877732,012 - 734,868 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936877732,012 - 734,592 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASE10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,391,475 - 78,394,035 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1778,390,612 - 78,414,401 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,418,433 - 83,440,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RNASE10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,029,470 - 21,034,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,033,443 - 21,034,078 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605925,395,604 - 25,400,909 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnase10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,655,122 - 4,655,772 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248254,653,995 - 4,664,793 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rnase10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11272,306,742 - 72,308,648 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rnase10
151 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:80
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000013619
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 4 30 123 87 86 56 38 56 6 212 94 10 97 51 64 30 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000013619   ⟹   ENSRNOP00000013619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,697,339 - 26,702,189 (+)Ensembl
mRatBN7.2 Ensembl1524,226,691 - 24,228,561 (+)Ensembl
Rnor_6.0 Ensembl1527,933,211 - 27,933,849 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131731   ⟹   ENSRNOP00000105579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,700,190 - 26,706,105 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134727   ⟹   ENSRNOP00000106472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,688,102 - 26,702,189 (+)Ensembl
RefSeq Acc Id: NM_001012467   ⟹   NP_001012485
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,700,219 - 26,702,681 (+)NCBI
mRatBN7.21524,226,687 - 24,229,149 (+)NCBI
Rnor_6.01527,933,211 - 27,933,849 (+)NCBI
Rnor_5.01531,764,636 - 31,766,642 (+)NCBI
RGSC_v3.41526,987,636 - 26,988,274 (+)RGD
Celera1524,548,103 - 24,548,741 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012485 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV87199 (Get FASTA)   NCBI Sequence Viewer  
  CDG32040 (Get FASTA)   NCBI Sequence Viewer  
  EDL88432 (Get FASTA)   NCBI Sequence Viewer  
  EDL88433 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013619
GenBank Protein Q5GAM0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012485   ⟸   NM_001012467
- Peptide Label: precursor
- UniProtKB: Q5GAM0 (UniProtKB/Swiss-Prot),   W0UTF9 (UniProtKB/TrEMBL),   A0A8L2Q6C1 (UniProtKB/TrEMBL),   A6KEC7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013619   ⟸   ENSRNOT00000013619
Ensembl Acc Id: ENSRNOP00000105579   ⟸   ENSRNOT00000131731
Ensembl Acc Id: ENSRNOP00000106472   ⟸   ENSRNOT00000134727
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GAM0-F1-model_v2 AlphaFold Q5GAM0 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310415 AgrOrtholog
BioCyc Gene G2FUF-14045 BioCyc
Ensembl Genes ENSRNOG00000010261 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013619 ENTREZGENE
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot
InterPro RNaseA UniProtKB/Swiss-Prot
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot
  RNaseA_domain UniProtKB/Swiss-Prot
KEGG Report rno:305840 UniProtKB/Swiss-Prot
NCBI Gene 305840 ENTREZGENE
PANTHER INACTIVE RIBONUCLEASE-LIKE PROTEIN 10 UniProtKB/Swiss-Prot
  PTHR11437 UniProtKB/Swiss-Prot
Pfam RnaseA UniProtKB/Swiss-Prot
PhenoGen Rnase10 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010261 RatGTEx
SMART RNAse_Pc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot
UniProt A0A8L2Q6C1 ENTREZGENE, UniProtKB/TrEMBL
  A6KEC7 ENTREZGENE, UniProtKB/TrEMBL
  Q5GAM0 ENTREZGENE, UniProtKB/Swiss-Prot
  W0UTF9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Rnase10  ribonuclease A family member 10  Rnase10  ribonuclease, RNase A family, 10 (non-active)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rnase10  ribonuclease, RNase A family, 10 (non-active)   Rnase10_predicted  ribonuclease, RNase A family, 10 (non-active) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Rnase10_predicted  ribonuclease, RNase A family, 10 (non-active) (predicted)  RGD1310415_predicted  similar to Ribonuclease pancreatic precursor (RNase 1) (RNase A) (RL1) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310415_predicted  similar to Ribonuclease pancreatic precursor (RNase 1) (RNase A) (RL1) (predicted)  LOC305840_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305840_predicted  similar to Ribonuclease pancreatic precursor (RNase 1) (RNase A) (RL1) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL