Kif18b (kinesin family member 18B) - Rat Genome Database

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Gene: Kif18b (kinesin family member 18B) Rattus norvegicus
Analyze
Symbol: Kif18b
Name: kinesin family member 18B
RGD ID: 1310360
Description: Predicted to enable ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in several processes, including microtubule depolymerization; mitotic sister chromatid segregation; and regulation of cell division. Predicted to be located in astral microtubule and microtubule plus-end. Predicted to be part of kinesin complex. Predicted to be active in mitotic spindle astral microtubule; mitotic spindle midzone; and nucleus. Orthologous to human KIF18B (kinesin family member 18B); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kinesin-like protein KIF18B; kinesin-like protein KIF18B-like; LOC303575; MGC116269; RGD1310360; similar to 3000004C01Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,370,520 - 88,392,388 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1088,370,524 - 88,389,691 (-)EnsemblGRCr8
mRatBN7.21087,870,424 - 87,889,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,870,428 - 87,889,850 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1092,906,842 - 92,925,928 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,372,926 - 92,392,015 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,766,272 - 87,785,366 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,008,294 - 91,027,760 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,008,269 - 91,027,738 (-)Ensemblrn6Rnor6.0
Rnor_5.01090,780,841 - 90,800,298 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41092,077,414 - 92,096,586 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1086,573,019 - 86,592,126 (-)NCBICelera
RGSC_v3.11092,090,453 - 92,111,229 (-)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
heptachlor  (EXP)
leflunomide  (ISO)
lidocaine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
mirex  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
astral microtubule  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
kinesin complex  (IBA)
microtubule  (IEA)
microtubule end  (IEA,ISO)
microtubule plus-end  (IEA,ISO)
mitotic spindle astral microtubule  (IBA)
mitotic spindle midzone  (IBA)
nuclear body  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
spindle  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:20600703   PMID:21820309  


Genomics

Comparative Map Data
Kif18b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,370,520 - 88,392,388 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1088,370,524 - 88,389,691 (-)EnsemblGRCr8
mRatBN7.21087,870,424 - 87,889,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,870,428 - 87,889,850 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1092,906,842 - 92,925,928 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,372,926 - 92,392,015 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,766,272 - 87,785,366 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,008,294 - 91,027,760 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,008,269 - 91,027,738 (-)Ensemblrn6Rnor6.0
Rnor_5.01090,780,841 - 90,800,298 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41092,077,414 - 92,096,586 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1086,573,019 - 86,592,126 (-)NCBICelera
RGSC_v3.11092,090,453 - 92,111,229 (-)NCBI
Cytogenetic Map10q32.1NCBI
KIF18B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,924,711 - 44,947,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,924,707 - 44,947,776 (-)Ensemblhg38GRCh38
GRCh371743,002,079 - 43,025,141 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361740,358,974 - 40,380,608 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1739,713,954 - 39,735,621 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,767,158 - 38,790,158 (-)NCBIHuRef
CHM1_11743,238,220 - 43,261,223 (-)NCBICHM1_1
T2T-CHM13v2.01745,778,623 - 45,801,668 (-)NCBIT2T-CHM13v2.0
Kif18b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,796,344 - 102,815,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,796,355 - 102,815,950 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811102,905,518 - 102,925,134 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,905,529 - 102,925,124 (-)Ensemblmm10GRCm38
MGSCv3711102,766,832 - 102,786,438 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611102,721,619 - 102,741,182 (-)NCBIMGSCv36mm8
Celera11114,616,983 - 114,636,710 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.48NCBI
Kif18b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,706,661 - 17,722,433 (-)Ensembl
ChiLan1.0NW_00495545117,707,150 - 17,722,376 (-)NCBIChiLan1.0ChiLan1.0
KIF18B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21919,880,933 - 19,908,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11721,849,534 - 21,876,740 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,374,072 - 12,398,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11712,547,824 - 12,569,899 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1712,558,976 - 12,569,899 (+)EnsemblpanPan2panpan1.1
KIF18B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,541,632 - 18,562,341 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,551,373 - 18,562,355 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha917,927,050 - 17,947,781 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0919,215,036 - 19,235,776 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,214,992 - 19,235,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,092,943 - 18,113,406 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,271,698 - 18,292,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,428,507 - 18,449,250 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kif18b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,890,179 - 17,910,167 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,285,661 - 1,295,458 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,285,137 - 1,304,179 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF18B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,426,835 - 18,448,208 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11218,426,828 - 18,448,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21218,671,527 - 18,692,733 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KIF18B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11661,455,785 - 61,478,232 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,456,467 - 61,478,002 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607732,204,743 - 32,229,005 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif18b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795377,001 - 391,934 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624795376,659 - 394,750 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Kif18b
149 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:323
Count of miRNA genes:184
Interacting mature miRNAs:207
Transcripts:ENSRNOT00000032339
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 66 160 91 90 59 92 59 6 351 191 11 139 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032339   ⟹   ENSRNOP00000034491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1088,370,524 - 88,389,691 (-)Ensembl
mRatBN7.2 Ensembl1087,870,428 - 87,889,597 (-)Ensembl
Rnor_6.0 Ensembl1091,008,294 - 91,027,465 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084128   ⟹   ENSRNOP00000070718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,870,428 - 87,889,850 (-)Ensembl
Rnor_6.0 Ensembl1091,008,269 - 91,027,731 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1091,011,843 - 91,012,494 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093704   ⟹   ENSRNOP00000076180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1091,019,133 - 91,027,738 (-)Ensembl
RefSeq Acc Id: NM_001039019   ⟹   NP_001034108
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,370,520 - 88,389,691 (-)NCBI
mRatBN7.21087,870,424 - 87,889,597 (-)NCBI
Rnor_6.01091,008,294 - 91,027,465 (-)NCBI
Rnor_5.01090,780,841 - 90,800,298 (-)NCBI
RGSC_v3.41092,077,414 - 92,096,586 (-)RGD
Celera1086,573,019 - 86,592,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247505   ⟹   XP_006247567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,370,520 - 88,392,388 (-)NCBI
mRatBN7.21087,870,424 - 87,889,895 (-)NCBI
Rnor_6.01091,008,294 - 91,027,758 (-)NCBI
Rnor_5.01090,780,841 - 90,800,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768283   ⟹   XP_008766505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,370,520 - 88,389,986 (-)NCBI
mRatBN7.21087,870,424 - 87,889,895 (-)NCBI
Rnor_6.01091,008,294 - 91,027,760 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001034108   ⟸   NM_001039019
- UniProtKB: Q4KLL9 (UniProtKB/Swiss-Prot),   A0A8L2R323 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247567   ⟸   XM_006247505
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008766505   ⟸   XM_008768283
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000076180   ⟸   ENSRNOT00000093704
Ensembl Acc Id: ENSRNOP00000034491   ⟸   ENSRNOT00000032339
Ensembl Acc Id: ENSRNOP00000070718   ⟸   ENSRNOT00000084128
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLL9-F1-model_v2 AlphaFold Q4KLL9 1-826 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697807
Promoter ID:EPDNEW_R8324
Type:initiation region
Name:Kif18b_1
Description:kinesin family member 18B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01091,027,749 - 91,027,809EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310360 AgrOrtholog
BioCyc Gene G2FUF-23064 BioCyc
Ensembl Genes ENSRNOG00000021713 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032339 ENTREZGENE
  ENSRNOT00000032339.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7455959 IMAGE-MGC_LOAD
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot
  Kinesin_motor_CS UniProtKB/Swiss-Prot
  Kinesin_motor_dom UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:303575 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116269 IMAGE-MGC_LOAD
NCBI Gene 303575 ENTREZGENE
PANTHER CENTROMERE PROTEIN E UniProtKB/Swiss-Prot
  KINESIN-LIKE PROTEIN UniProtKB/Swiss-Prot
Pfam Kinesin UniProtKB/Swiss-Prot
PhenoGen Kif18b PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot
PROSITE KINESIN_MOTOR_1 UniProtKB/Swiss-Prot
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021713 RatGTEx
SMART KISc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8L2R323 ENTREZGENE
  KI18B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-02 Kif18b  kinesin family member 18B  RGD1310360  similar to 3000004C01Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310360  similar to 3000004C01Rik protein  RGD1310360_predicted  similar to 3000004C01Rik protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310360_predicted  similar to 3000004C01Rik protein (predicted)  LOC303575_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303575_predicted  similar to 3000004C01Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL