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Gene: Farsa (phenylalanyl-tRNA synthetase subunit alpha) Rattus norvegicus

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Symbol:

Farsa

Name:

phenylalanyl-tRNA synthetase subunit alpha

RGD ID:

1310314

Description:

Predicted to enable magnesium ion binding activity and phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Located in cytoplasm. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha); PARTICIPATES IN phenylketonuria pathway; tyrosinemia type II pathway; tyrosinemia type III pathway; INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; fipronil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Farsla; LOC288917; phenylalanine--tRNA ligase alpha chain; phenylalanine--tRNA ligase alpha subunit; phenylalanine-tRNA synthetase-like, alpha subunit; phenylalanyl-tRNA synthetase alpha chain; phenylalanyl-tRNA synthetase alpha subunit; phenylalanyl-tRNA synthetase, alpha subunit; pheRS

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FARSA (phenylalanyl-tRNA synthetase subunit alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Farsa (phenylalanyl-tRNA synthetase, alpha subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Farsa (phenylalanyl-tRNA synthetase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FARSA (phenylalanyl-tRNA synthetase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FARSA (phenylalanyl-tRNA synthetase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Farsa (phenylalanyl-tRNA synthetase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FARSA (phenylalanyl-tRNA synthetase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FARSA (phenylalanyl-tRNA synthetase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Farsa (phenylalanyl-tRNA synthetase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Farsa (phenylalanyl-tRNA synthetase subunit alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FARSA (phenylalanyl-tRNA synthetase subunit alpha)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Farsa (phenylalanyl-tRNA synthetase, alpha subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	farsa (phenylalanyl-tRNA synthetase subunit alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FRS2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alpha-PheRS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fars-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	farsa	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	farsa	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	XB1017155 [provisional]	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	40,196,255 - 40,205,830 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	40,173,716 - 40,205,823 (-)	Ensembl				GRCr8
mRatBN7.2	19	23,291,409 - 23,300,985 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	23,268,869 - 23,300,980 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	30,114,305 - 30,123,855 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	30,768,669 - 30,778,219 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	32,991,355 - 33,000,904 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	25,969,255 - 25,978,777 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	25,969,255 - 25,978,776 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	36,944,878 - 36,954,400 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	24,947,663 - 24,957,186 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	22,848,305 - 22,857,809 (-)	NCBI		Celera
RGSC_v3.1	19	24,952,488 - 24,962,012 (-)	NCBI
Cytogenetic Map	19	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Rajab Interstitial Lung Disease with Brain Calcifications 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4,6-tribromophenol (ISO)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bortezomib (ISO)

caffeine (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

DDE (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

furfural (ISO)

gentamycin (EXP)

indometacin (ISO)

ivermectin (ISO)

lead diacetate (EXP)

nickel atom (ISO)

nitrates (ISO)

ozone (ISO)

PCB138 (ISO)

rotenone (EXP,ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sunitinib (ISO)

thiram (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

phenylalanyl-tRNA aminoacylation (IBA,IEA,ISO,ISS)

protein heterotetramerization (ISO,ISS)

synaptonemal complex assembly (IEA)

translation (IEA)

tRNA aminoacylation (IEA)

Cellular Component

central element (IEA)

cytoplasm (IBA,IDA,IEA)

phenylalanine-tRNA ligase complex (IBA,ISO,ISS)

Molecular Function

aminoacyl-tRNA ligase activity (IEA)

ATP binding (IEA)

ligase activity (IEA)

magnesium ion binding (ISS)

metal ion binding (IEA)

nucleotide binding (IEA)

phenylalanine-tRNA ligase activity (IBA,IEA,ISO,ISS)

protein binding (ISO)

tRNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

aminoacyl-tRNA biosynthetic pathway (IEA)

phenylketonuria pathway (ISO)

tyrosinemia type II pathway (ISO)

tyrosinemia type III pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Association of an aminoacyl-tRNA synthetase complex and of phenylalanyl-tRNA synthetase with the cytoskeletal framework fraction from mammalian cells.	Mirande M, etal., Exp Cell Res. 1985 Jan;156(1):91-102.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:19946888	PMID:20223217	PMID:22681889	PMID:30053369

Genomics

Comparative Map Data

Farsa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	40,196,255 - 40,205,830 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	40,173,716 - 40,205,823 (-)	Ensembl				GRCr8
mRatBN7.2	19	23,291,409 - 23,300,985 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	23,268,869 - 23,300,980 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	30,114,305 - 30,123,855 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	30,768,669 - 30,778,219 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	32,991,355 - 33,000,904 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	25,969,255 - 25,978,777 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	25,969,255 - 25,978,776 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	36,944,878 - 36,954,400 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	24,947,663 - 24,957,186 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	22,848,305 - 22,857,809 (-)	NCBI		Celera
RGSC_v3.1	19	24,952,488 - 24,962,012 (-)	NCBI
Cytogenetic Map	19	q11	NCBI

FARSA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	12,922,479 - 12,933,711 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	12,922,276 - 12,934,037 (-)	Ensembl			hg38	GRCh38
GRCh37	19	13,033,293 - 13,044,525 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	12,894,284 - 12,905,558 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	12,894,292 - 12,905,522	NCBI
Celera	19	12,923,020 - 12,934,291 (-)	NCBI		Celera
Cytogenetic Map	19	p13.13	NCBI
HuRef	19	12,605,186 - 12,616,461 (-)	NCBI		HuRef
CHM1_1	19	13,033,781 - 13,045,058 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	13,046,966 - 13,058,199 (-)	NCBI		T2T-CHM13v2.0

Farsa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	85,583,597 - 85,595,886 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	85,583,618 - 85,595,886 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	84,856,969 - 84,869,257 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	84,856,989 - 84,869,257 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	87,380,885 - 87,393,156 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	87,747,129 - 87,757,131 (+)	NCBI		MGSCv36	mm8
Celera	8	89,156,659 - 89,168,787 (+)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.23	NCBI

Farsa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	31,968,980 - 31,981,424 (-)	Ensembl
ChiLan1.0	NW_004955415	31,972,888 - 31,981,424 (-)	NCBI	ChiLan1.0	ChiLan1.0

FARSA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	17,851,642 - 17,863,414 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	16,852,290 - 16,864,068 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	12,484,607 - 12,496,160 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	13,227,193 - 13,238,085 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	13,227,193 - 13,238,244 (-)	Ensembl			panPan2	panpan1.1

FARSA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	49,258,827 - 49,267,279 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	49,258,845 - 49,267,198 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	49,131,070 - 49,139,532 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	49,775,682 - 49,784,201 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	49,775,704 - 49,819,242 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	48,986,876 - 48,995,337 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	49,413,365 - 49,421,812 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	49,655,888 - 49,664,348 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Farsa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	208,364,421 - 208,372,363 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	1,981,723 - 1,990,322 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	1,982,343 - 1,990,277 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FARSA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	66,105,429 - 66,118,191 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	66,105,393 - 66,114,867 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	66,271,545 - 66,280,456 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FARSA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	11,602,352 - 11,613,851 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	11,600,516 - 11,613,345 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	8,173,868 - 8,185,230 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Farsa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624901	492,817 - 505,911 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624901	492,673 - 505,815 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Farsa
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	15,425,203 - 15,436,650 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Farsa
54 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	44
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000004370
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	5748064	50748064	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	31287532	51431640	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	30099383	47207961	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005496619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC094515	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004370 ⟹ ENSRNOP00000004370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	23,291,409 - 23,300,980 (-)	Ensembl
Rnor_6.0 Ensembl	19	25,969,255 - 25,978,776 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000004404 ⟹ ENSRNOP00000004404

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	23,268,869 - 23,287,064 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098538 ⟹ ENSRNOP00000083198

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	23,268,869 - 23,286,806 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102461 ⟹ ENSRNOP00000080009

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	23,291,409 - 23,300,980 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110603 ⟹ ENSRNOP00000076655

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	23,271,993 - 23,300,979 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111986 ⟹ ENSRNOP00000080885

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	23,291,416 - 23,300,979 (-)	Ensembl

RefSeq Acc Id:

NM_001024237 ⟹ NP_001019408

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	40,196,255 - 40,205,823 (-)	NCBI
mRatBN7.2	19	23,291,409 - 23,300,979 (-)	NCBI
Rnor_6.0	19	25,969,255 - 25,978,777 (+)	NCBI
Rnor_5.0	19	36,944,878 - 36,954,400 (+)	NCBI
RGSC_v3.4	19	24,947,663 - 24,957,186 (-)	RGD
Celera	19	22,848,305 - 22,857,809 (-)	RGD

Sequence:

show sequence

GGGATAGCCATGGCGGATAATCCCGTCTTGGAGCAGTTGCTGCGGAGGCTGGAGGTAGCTGATG
GCGGCCTGGACAGCGCGGAGTTGGCTACGCAGCTGGGCGTGGAGCACCAGGCAGTGGTGGGCGC
TGTGAAGAGCCTCCAGGCTCTGGGTGAAGTCATTGAAGCCGAGCTTCGTTCTACCAAGTGCTGG
GAGCTGACTACTGAGGGTGAGGAGATTGCCCGGGAGGGCAGCCATGAGGCCCGTGTGTTTAGAA
GCATCCCTCTCGAGGGCCTGGTGCAAAGTGAGCTCATGCAACTGCCCAGCGGCAAGGTGGGCTT
CAGCAAGGCCATGTCCAACAAGTGGATCCGAGTGGACAAGAGTGCAGCCGATGGGCCCCGGGTG
TTCCGCGTGGTGGACAGTATAGAGGATGAAGTACAGAGGCGGCTGCAGCAGGTCCAGGCAGGCC
AGGCTGAGAAGCTGGCTGAAAAGGAAAGGAATGAGCTCCGGAAGAGGAAGCTGCTGACCGAAGT
GATCCTGAAAACCTACTGGGTGAGCAAGGGCAAGGGCTTCAGCACAAGTGTGTCTAAGCAGGAG
GCCGAGCTGAGCCCAGAGATGATCTCCAGTGGCTCCTGGAGGGACCGACCCTTCAAACCCTACA
ACTTCTCTGCCCGTGGTGTGCTCCCAGACAGTGGCCACCTGCACCCCTTACTCAAGGTCCGCTC
CCAGTTCCGACAAATCTTCTTGGAGATGGGGTTCACAGAGATGCCTACGGACAATTTCATCGAG
AGCTCCTTCTGGAACTTTGATGCACTCTTCCAGCCTCAGCAGCACCCAGCGCGTGACCAACATG
ATACTTTCTTCCTGCGAGATCCAGCCGAGGCCCTGCAGCTCCCAATGGACTATGTCCAGCGGGT
GAAACGGACCCACTCCCAGGGTGGCTACGGCTCACAAGGCTACAAGTATACCTGGAAGCTGGAA
GAGGCCCGGAAAAACCTGCTTCGCACACATACCACAGCAGCCAGCGCCCGAGCCCTCTACCGTT
TAGCCCAGAAGAAGCCATTTACACCAGCCAAGTACTTCTCTATTGATCGTGTGTTTCGGAATGA
GACGCTGGACGCCACACACCTGGCCGAGTTCCACCAGATTGAGGGTGTGATAGCTGACCATGGT
CTCACCCTGGGCCACCTCATGGGTGTACTGAGGGAGTTCTTCACCAAGCTGGGAATCACACAGC
TGCGCTTCAAGCCGGCCTACAACCCCTACACAGAGCCCAGCATGGAAGTGTTCAGCTACCACCA
AGGTCTAAAGAAGTGGGTTGAAGTTGGCAACTCTGGAGTCTTCCGCCCTGAGATGCTCCTGCCT
ATGGGGCTCCCTGAGAATGTGTCTGTCATTGCTTGGGGTCTCTCTCTGGAGCGCCCAACAATGA
TCAAATATGGTATCAATAACATCCGAGAGCTGGTGGGCCACAAGGTGAACCTGCAGATGGTATA
CGACAGCCCCGTGTGCCGACTGGACATTGAGCCCAGGTCCTCAAAGACACAGGAGGCTGCATGA
TAACAGGCTGCCCCAGCGATCCCTGTCTAGTCCCTGTGCATCCCGCAGCAGTGACCTAGTATTT
ATGAGGCCTCCGTGAGGCCAGCTGTCTTCCTCTGCCTCACACACCCCAAGGGTAGGGTTCCAAC
TATGGGAGCAGGTTCCTTGTGGTGGCTTTTAGTGGTCTGTGTAGTTTGCTTGTGAGGATGGGTT
TGGGCCCTACAGGTTAGCTGTTTAATAAAGTGGGCACGTTCCCTTGGGTGGTGCCTTTTGTTAG
GAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

RefSeq Acc Id:

XR_005496619

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	40,197,355 - 40,205,830 (-)	NCBI
mRatBN7.2	19	23,291,409 - 23,300,985 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001019408	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH94515	(Get FASTA)	NCBI Sequence Viewer
	EDL92194	(Get FASTA)	NCBI Sequence Viewer
	EDL92195	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004370
	ENSRNOP00000004370.4
GenBank Protein	Q505J8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001019408 ⟸ NM_001024237

- UniProtKB:

Q505J8 (UniProtKB/Swiss-Prot), A6IY66 (UniProtKB/TrEMBL), A0A8I5ZPK4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADNPVLEQLLRRLEVADGGLDSAELATQLGVEHQAVVGAVKSLQALGEVIEAELRSTKCWELT
TEGEEIAREGSHEARVFRSIPLEGLVQSELMQLPSGKVGFSKAMSNKWIRVDKSAADGPRVFRV
VDSIEDEVQRRLQQVQAGQAEKLAEKERNELRKRKLLTEVILKTYWVSKGKGFSTSVSKQEAEL
SPEMISSGSWRDRPFKPYNFSARGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSF
WNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYTWKLEEAR
KNLLRTHTTAASARALYRLAQKKPFTPAKYFSIDRVFRNETLDATHLAEFHQIEGVIADHGLTL
GHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGL
PENVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPVCRLDIEPRSSKTQEAA

hide sequence

Ensembl Acc Id:

ENSRNOP00000004370 ⟸ ENSRNOT00000004370

Ensembl Acc Id:

ENSRNOP00000080009 ⟸ ENSRNOT00000102461

Ensembl Acc Id:

ENSRNOP00000080885 ⟸ ENSRNOT00000111986

Ensembl Acc Id:

ENSRNOP00000083198 ⟸ ENSRNOT00000098538

Ensembl Acc Id:

ENSRNOP00000076655 ⟸ ENSRNOT00000110603

Ensembl Acc Id:

ENSRNOP00000004404 ⟸ ENSRNOT00000004404

Protein Domains

Aminoacyl-transfer RNA synthetases class-II family

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q505J8-F1-model_v2	AlphaFold	Q505J8	1-508	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701026

Promoter ID:

EPDNEW_R11550

Type:

multiple initiation site

Name:

Farsa_1

Description:

phenylalanyl-tRNA synthetase, alpha subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	25,969,219 - 25,969,279	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310314	AgrOrtholog
BioCyc Gene	G2FUF-6124	BioCyc
BioCyc Pathway	TRNA-CHARGING-PWY [tRNA charging]	BioCyc
BioCyc Pathway Image	TRNA-CHARGING-PWY	BioCyc
Ensembl Genes	ENSRNOG00000003149	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000004370	ENTREZGENE
	ENSRNOT00000004370.8	UniProtKB/Swiss-Prot
	ENSRNOT00000120784	ENTREZGENE
Gene3D-CATH	1.10.10.2320	UniProtKB/Swiss-Prot
	1.10.10.2330	UniProtKB/Swiss-Prot
	3.30.1370.240	UniProtKB/Swiss-Prot
	Bira Bifunctional Protein, Domain 2	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7314191	IMAGE-MGC_LOAD
InterPro	aa-tRNA-synth_II	UniProtKB/Swiss-Prot
	aa-tRNA-synth_II/BPL/LPL	UniProtKB/Swiss-Prot
	Phe-tRNA-synth_IIc_asu	UniProtKB/Swiss-Prot
	Phenylalanyl-tRNA_Synthase	UniProtKB/Swiss-Prot
	PheRS_DBD1	UniProtKB/Swiss-Prot
	PheRS_DBD2	UniProtKB/Swiss-Prot
	PheRS_DBD3	UniProtKB/Swiss-Prot
	WH_DNA-bd_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:288917	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105738	IMAGE-MGC_LOAD
NCBI Gene	288917	ENTREZGENE
PANTHER	PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT	UniProtKB/Swiss-Prot
	PHENYLALANYL-TRNA SYNTHETASE	UniProtKB/Swiss-Prot
Pfam	PheRS_DBD1	UniProtKB/Swiss-Prot
	PheRS_DBD2	UniProtKB/Swiss-Prot
	PheRS_DBD3	UniProtKB/Swiss-Prot
	tRNA-synt_2d	UniProtKB/Swiss-Prot
PhenoGen	Farsa	PhenoGen
PROSITE	AA_TRNA_LIGASE_II	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003149	RatGTEx
Superfamily-SCOP	SSF46785	UniProtKB/Swiss-Prot
	SSF55681	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZPK4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZRA4_RAT	UniProtKB/TrEMBL
	A0ABK0L757_RAT	UniProtKB/TrEMBL
	A0ABK0L7J9_RAT	UniProtKB/TrEMBL
	A0ABK0M192_RAT	UniProtKB/TrEMBL
	A6IY66	ENTREZGENE, UniProtKB/TrEMBL
	Q505J8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-07	Farsa	phenylalanyl-tRNA synthetase subunit alpha	Farsa	phenylalanyl-tRNA synthetase, alpha subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Farsa	phenylalanyl-tRNA synthetase, alpha subunit	Farsla	phenylalanine-tRNA synthetase-like, alpha subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Farsla	phenylalanine-tRNA synthetase-like, alpha subunit	Farsla_predicted	phenylalanine-tRNA synthetase-like, alpha subunit (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Farsla_predicted	phenylalanine-tRNA synthetase-like, alpha subunit (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways