FARSA (phenylalanyl-tRNA synthetase subunit alpha) - Rat Genome Database

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Gene: FARSA (phenylalanyl-tRNA synthetase subunit alpha) Sus scrofa
Analyze
Symbol: FARSA
Name: phenylalanyl-tRNA synthetase subunit alpha
RGD ID: 14104111
Description: ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); ligase activity (inferred); INVOLVED IN phenylalanyl-tRNA aminoacylation (inferred); protein heterotetramerization (inferred); tRNA aminoacylation (inferred); PARTICIPATES IN phenylketonuria pathway; tyrosinemia type II pathway; tyrosinemia type III pathway; ASSOCIATED WITH alpha-mannosidosis (ortholog); Charcot-Marie-Tooth disease dominant intermediate B (ortholog); episodic ataxia type 2 (ortholog); FOUND IN phenylalanine-tRNA ligase complex (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phenylalanine--tRNA ligase alpha subunit; phenylalanyl-tRNA synthetase alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,105,429 - 66,118,191 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,105,393 - 66,114,867 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,271,545 - 66,280,456 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA)
phenylalanine-tRNA ligase complex  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FARSA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,105,429 - 66,118,191 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,105,393 - 66,114,867 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,271,545 - 66,280,456 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FARSA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,922,479 - 12,933,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,922,479 - 12,934,037 (-)EnsemblGRCh38hg38GRCh38
GRCh371913,033,293 - 13,044,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,894,284 - 12,905,558 (-)NCBINCBI36Build 36hg18NCBI36
Build 341912,894,292 - 12,905,522NCBI
Celera1912,923,020 - 12,934,291 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,605,186 - 12,616,461 (-)NCBIHuRef
CHM1_11913,033,781 - 13,045,058 (-)NCBICHM1_1
T2T-CHM13v2.01913,046,966 - 13,058,199 (-)NCBIT2T-CHM13v2.0
Farsa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,583,597 - 85,595,886 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,583,618 - 85,595,886 (+)EnsemblGRCm39 Ensembl
GRCm38884,856,969 - 84,869,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,856,989 - 84,869,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,380,885 - 87,393,156 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,747,129 - 87,757,131 (+)NCBIMGSCv36mm8
Celera889,156,659 - 89,168,787 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.23NCBI
Farsa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,196,255 - 40,205,830 (-)NCBIGRCr8
mRatBN7.21923,291,409 - 23,300,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,268,869 - 23,300,980 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,114,305 - 30,123,855 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,768,669 - 30,778,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,991,355 - 33,000,904 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,969,255 - 25,978,777 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,969,255 - 25,978,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,944,878 - 36,954,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,947,663 - 24,957,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,952,488 - 24,962,012 (-)NCBI
Celera1922,848,305 - 22,857,809 (-)NCBICelera
Cytogenetic Map19q11NCBI
Farsa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,968,980 - 31,981,424 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,972,888 - 31,981,424 (-)NCBIChiLan1.0ChiLan1.0
FARSA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,851,642 - 17,863,414 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,852,290 - 16,864,068 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,484,607 - 12,496,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,227,193 - 13,238,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,227,193 - 13,238,244 (-)Ensemblpanpan1.1panPan2
FARSA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,258,827 - 49,267,279 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,258,845 - 49,267,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,131,070 - 49,139,532 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,775,682 - 49,784,201 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,775,704 - 49,819,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,986,876 - 48,995,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,413,365 - 49,421,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,655,888 - 49,664,348 (+)NCBIUU_Cfam_GSD_1.0
Farsa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,364,421 - 208,372,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,981,723 - 1,990,322 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,982,343 - 1,990,277 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FARSA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,602,352 - 11,613,851 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,600,516 - 11,613,345 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,173,868 - 8,185,230 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Farsa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901492,817 - 505,911 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901492,673 - 505,815 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FARSA
145 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 10 4 3 5 2 21 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015019   ⟹   ENSSSCP00000014614
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl266,105,438 - 66,118,191 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000046506   ⟹   ENSSSCP00000059011
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl266,105,429 - 66,114,310 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000066869   ⟹   ENSSSCP00000060573
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl266,105,438 - 66,118,191 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082207   ⟹   ENSSSCP00000074536
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl266,105,430 - 66,114,860 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000087819   ⟹   ENSSSCP00000072722
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl266,105,429 - 66,113,083 (+)Ensembl
RefSeq Acc Id: XM_003123337   ⟹   XP_003123385
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1266,105,393 - 66,114,867 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083714   ⟹   XP_020939373
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1266,105,405 - 66,114,867 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003123385   ⟸   XM_003123337
- Peptide Label: isoform X2
- UniProtKB: F1SD97 (UniProtKB/TrEMBL),   A0A4X1TE37 (UniProtKB/TrEMBL),   A0A8D1I4M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939373   ⟸   XM_021083714
- Peptide Label: isoform X1
- UniProtKB: A0A8D1Y1I5 (UniProtKB/TrEMBL),   A0A8D1L2F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000014614   ⟸   ENSSSCT00000015019
RefSeq Acc Id: ENSSSCP00000060573   ⟸   ENSSSCT00000066869
RefSeq Acc Id: ENSSSCP00000059011   ⟸   ENSSSCT00000046506
RefSeq Acc Id: ENSSSCP00000072722   ⟸   ENSSSCT00000087819
RefSeq Acc Id: ENSSSCP00000074536   ⟸   ENSSSCT00000082207
Protein Domains
Aminoacyl-transfer RNA synthetases class-II family


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013745 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015043187 UniProtKB/TrEMBL
  ENSSSCG00025061699 UniProtKB/TrEMBL
  ENSSSCG00030008648 UniProtKB/TrEMBL
  ENSSSCG00035045212 UniProtKB/TrEMBL
  ENSSSCG00040013655 UniProtKB/TrEMBL
  ENSSSCG00045024629 UniProtKB/TrEMBL
  ENSSSCG00050059455 UniProtKB/TrEMBL
  ENSSSCG00055022598 UniProtKB/TrEMBL
  ENSSSCG00060012888 UniProtKB/TrEMBL
  ENSSSCG00065021277 UniProtKB/TrEMBL
  ENSSSCG00070008151 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015019 ENTREZGENE
  ENSSSCT00000015019.4 UniProtKB/TrEMBL
  ENSSSCT00000046506.3 UniProtKB/TrEMBL
  ENSSSCT00000066869.1 UniProtKB/TrEMBL
  ENSSSCT00000082207.2 UniProtKB/TrEMBL
  ENSSSCT00000087819.1 UniProtKB/TrEMBL
  ENSSSCT00015059681.1 UniProtKB/TrEMBL
  ENSSSCT00015060247.1 UniProtKB/TrEMBL
  ENSSSCT00015060336.1 UniProtKB/TrEMBL
  ENSSSCT00025084967.1 UniProtKB/TrEMBL
  ENSSSCT00025085162.1 UniProtKB/TrEMBL
  ENSSSCT00025085386.1 UniProtKB/TrEMBL
  ENSSSCT00030011800.1 UniProtKB/TrEMBL
  ENSSSCT00030011811.1 UniProtKB/TrEMBL
  ENSSSCT00030011817.1 UniProtKB/TrEMBL
  ENSSSCT00035060265.1 UniProtKB/TrEMBL
  ENSSSCT00035060312.1 UniProtKB/TrEMBL
  ENSSSCT00035060318.1 UniProtKB/TrEMBL
  ENSSSCT00040018197.1 UniProtKB/TrEMBL
  ENSSSCT00040018215.1 UniProtKB/TrEMBL
  ENSSSCT00040018237.1 UniProtKB/TrEMBL
  ENSSSCT00045042334.1 UniProtKB/TrEMBL
  ENSSSCT00045042463.1 UniProtKB/TrEMBL
  ENSSSCT00050080989.1 UniProtKB/TrEMBL
  ENSSSCT00050080991.1 UniProtKB/TrEMBL
  ENSSSCT00055044913.1 UniProtKB/TrEMBL
  ENSSSCT00055045283.1 UniProtKB/TrEMBL
  ENSSSCT00055045419.1 UniProtKB/TrEMBL
  ENSSSCT00060016970.1 UniProtKB/TrEMBL
  ENSSSCT00060016995.1 UniProtKB/TrEMBL
  ENSSSCT00060017001.1 UniProtKB/TrEMBL
  ENSSSCT00065028410.1 UniProtKB/TrEMBL
  ENSSSCT00065028416.1 UniProtKB/TrEMBL
  ENSSSCT00065028439.1 UniProtKB/TrEMBL
  ENSSSCT00070016368.1 UniProtKB/TrEMBL
  ENSSSCT00070016369.1 UniProtKB/TrEMBL
  ENSSSCT00070016374.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2320 UniProtKB/TrEMBL
  1.10.10.2330 UniProtKB/TrEMBL
  3.30.1370.240 UniProtKB/TrEMBL
InterPro aa-tRNA-synth_II UniProtKB/TrEMBL
  aa-tRNA-synth_II/BPL/LPL UniProtKB/TrEMBL
  Phe-tRNA-synth_IIc_asu UniProtKB/TrEMBL
  Phenylalanyl-tRNA_Synthase UniProtKB/TrEMBL
  PheRS_DBD1 UniProtKB/TrEMBL
  PheRS_DBD2 UniProtKB/TrEMBL
  PheRS_DBD3 UniProtKB/TrEMBL
KEGG Report ssc:100524304 UniProtKB/TrEMBL
NCBI Gene FARSA ENTREZGENE
PANTHER PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT UniProtKB/TrEMBL
  PHENYLALANYL-TRNA SYNTHETASE UniProtKB/TrEMBL
Pfam PheRS_DBD1 UniProtKB/TrEMBL
  PheRS_DBD2 UniProtKB/TrEMBL
  PheRS_DBD3 UniProtKB/TrEMBL
  tRNA-synt_2d UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_II UniProtKB/TrEMBL
Superfamily-SCOP SSF55681 UniProtKB/TrEMBL
UniProt A0A287BRE0_PIG UniProtKB/TrEMBL
  A0A4X1TBJ8_PIG UniProtKB/TrEMBL
  A0A4X1TE37 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TFJ6_PIG UniProtKB/TrEMBL
  A0A5G2QQL7_PIG UniProtKB/TrEMBL
  A0A5G2RKP2_PIG UniProtKB/TrEMBL
  A0A5G2RNP2_PIG UniProtKB/TrEMBL
  A0A8D1I4M4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1L2F0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1Y1I5 ENTREZGENE, UniProtKB/TrEMBL
  F1SD97 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88014 ENTREZGENE