Pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) Rattus norvegicus
Analyze
Symbol: Pin1
Name: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
RGD ID: 1310299
Description: Predicted to enable several functions, including GTPase activating protein binding activity; beta-catenin binding activity; and protein phosphorylated amino acid binding activity. Involved in negative regulation of neuron apoptotic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of neuron apoptotic process. Predicted to be located in ciliary basal body; cytoplasm; and midbody. Predicted to be active in glutamatergic synapse; nucleus; and postsynaptic cytosol. Used to study asthma and secondary hyperparathyroidism. Orthologous to several human genes including PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC298696; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,465,538 - 27,477,016 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2819,189,408 - 19,200,785 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,189,373 - 19,200,785 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,209,724 - 23,221,104 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,507,563 - 21,518,943 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,419,155 - 19,430,528 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,669,236 - 21,680,615 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,669,236 - 21,680,615 (+)Ensemblrn6Rnor6.0
Rnor_5.0821,725,297 - 21,736,676 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4819,669,537 - 19,681,741 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera820,584,713 - 20,596,088 (+)NCBICelera
RGSC_v3.1819,668,944 - 19,681,740 (+)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,3-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
flutamide  (EXP)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ivermectin  (ISO)
juglone  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
syringic acid  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thiram  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hypoxia  (ISO)
microtubule polymerization  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of brown fat cell differentiation  (ISO)
negative regulation of cell motility  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of protein catabolic process  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron differentiation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of protein phosphorylation  (IMP,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein destabilization  (ISO)
protein peptidyl-prolyl isomerization  (ISO)
protein stabilization  (ISO)
protein targeting to mitochondrion  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cytokinesis  (ISO)
regulation of gene expression  (ISO)
regulation of macromolecule metabolic process  (IEA)
regulation of primary metabolic process  (IEA)
regulation of protein localization to nucleus  (ISO)
regulation of protein stability  (ISO)
regulation protein catabolic process at postsynapse  (ISO)
response to hypoxia  (ISO)
Rho protein signal transduction  (ISO)
synapse organization  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Pin1 inhibition activates cyclin D and produces neurodegenerative pathology. Atabay KD and Karabay A, J Neurochem. 2012 Feb;120(3):430-9. doi: 10.1111/j.1471-4159.2011.07259.x. Epub 2011 May 5.
2. Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery. Becker EB and Bonni A, Neuron. 2006 Mar 2;49(5):655-62.
3. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
4. Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. Buschdorf JP, etal., PLoS One. 2008 Jul 16;3(7):e2686. doi: 10.1371/journal.pone.0002686.
5. Pin1 deficiency causes endothelial dysfunction and hypertension. Chiasson VL, etal., Hypertension. 2011 Sep;58(3):431-8. doi: 10.1161/HYPERTENSIONAHA.111.172338. Epub 2011 Aug 1.
6. Pin1 modulates the type 1 immune response. Esnault S, etal., PLoS One. 2007 Feb 21;2(2):e226.
7. Mutant p53: one name, many proteins. Freed-Pastor WA and Prives C, Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112.
8. The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. Galas MC, etal., J Biol Chem. 2006 Jul 14;281(28):19296-304. Epub 2006 May 3.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Pin1 allows for differential Tau dephosphorylation in neuronal cells. Hamdane M, etal., Mol Cell Neurosci. 2006 May-Jun;32(1-2):155-60. doi: 10.1016/j.mcn.2006.03.006. Epub 2006 May 11.
12. Role of Pin1 in neointima formation: down-regulation of Nrf2-dependent heme oxygenase-1 expression by Pin1. Kim SE, etal., Free Radic Biol Med. 2010 Jun 15;48(12):1644-53. doi: 10.1016/j.freeradbiomed.2010.03.013. Epub 2010 Mar 20.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism. Nechama M, etal., J Clin Invest. 2009 Oct;119(10):3102-14. doi: 10.1172/JCI39522. Epub 2009 Sep 21.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Regulation of estrogen receptor alpha N-terminus conformation and function by peptidyl prolyl isomerase Pin1. Rajbhandari P, etal., Mol Cell Biol. 2012 Jan;32(2):445-57. doi: 10.1128/MCB.06073-11. Epub 2011 Nov 7.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins. Rudrabhatla P, etal., J Neurosci. 2009 Nov 25;29(47):14869-80. doi: 10.1523/JNEUROSCI.4469-09.2009.
21. Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. Shen ZJ, etal., J Clin Invest. 2008 Feb;118(2):479-90. doi: 10.1172/JCI32789.
22. Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Toko H, etal., Circ Res. 2013 Apr 26;112(9):1244-52. doi: 10.1161/CIRCRESAHA.113.301084. Epub 2013 Mar 13.
Additional References at PubMed
PMID:10037602   PMID:11533658   PMID:12477932   PMID:12810604   PMID:16554819   PMID:17548053   PMID:17626162   PMID:18635547   PMID:19122240   PMID:19638580   PMID:20179103   PMID:20956805  
PMID:22645310   PMID:23362255   PMID:23469846   PMID:24478626   PMID:24657892   PMID:24964035   PMID:25576397   PMID:26996940   PMID:28458925   PMID:29286102   PMID:34373763   PMID:35058248  
PMID:35227974   PMID:35416857   PMID:37567011   PMID:38795154  


Genomics

Comparative Map Data
Pin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,465,538 - 27,477,016 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2819,189,408 - 19,200,785 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,189,373 - 19,200,785 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,209,724 - 23,221,104 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,507,563 - 21,518,943 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,419,155 - 19,430,528 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0821,669,236 - 21,680,615 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,669,236 - 21,680,615 (+)Ensemblrn6Rnor6.0
Rnor_5.0821,725,297 - 21,736,676 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4819,669,537 - 19,681,741 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera820,584,713 - 20,596,088 (+)NCBICelera
RGSC_v3.1819,668,944 - 19,681,740 (+)NCBI
Cytogenetic Map8q13NCBI
PIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,835,318 - 9,849,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,835,257 - 9,849,690 (+)Ensemblhg38GRCh38
GRCh37199,945,994 - 9,960,365 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,806,999 - 9,821,358 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34199,806,998 - 9,821,358NCBI
Celera199,841,421 - 9,855,782 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,526,513 - 9,540,997 (+)NCBIHuRef
CHM1_1199,945,595 - 9,960,077 (+)NCBICHM1_1
T2T-CHM13v2.0199,961,482 - 9,975,854 (+)NCBIT2T-CHM13v2.0
Pin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,563,335 - 20,575,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,563,391 - 20,577,880 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38920,652,118 - 20,663,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,652,095 - 20,666,584 (+)Ensemblmm10GRCm38
MGSCv37920,456,574 - 20,471,028 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36920,402,532 - 20,416,986 (+)NCBIMGSCv36mm8
Celera917,922,575 - 17,937,026 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.6NCBI
Pin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,250,453 - 1,266,235 (+)Ensembl
ChiLan1.0NW_0049554951,250,557 - 1,261,617 (+)NCBIChiLan1.0ChiLan1.0
PIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22014,753,455 - 14,768,290 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11913,756,211 - 13,770,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,389,829 - 9,404,099 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,053,733 - 10,067,343 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,053,254 - 10,066,853 (+)EnsemblpanPan2panpan1.1
PIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12051,156,887 - 51,168,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2051,157,121 - 51,168,136 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2051,020,467 - 51,031,712 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02051,678,053 - 51,689,301 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,678,052 - 51,689,306 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,885,803 - 50,897,042 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,310,556 - 51,321,796 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,551,926 - 51,563,171 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118210,033,412 - 210,045,166 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659309,506 - 321,334 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936659309,530 - 321,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,715,880 - 68,729,870 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1268,715,898 - 68,729,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2268,943,628 - 68,957,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.168,920,860 - 8,935,943 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl68,920,785 - 8,936,033 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607411,165,736 - 11,180,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,121,329 - 2,131,645 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248282,121,262 - 2,131,645 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pin1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1816,919,829 - 16,931,022 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pin1
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:50
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000027818
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH134222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,187,419 - 19,187,607 (+)MAPPERmRatBN7.2
Rnor_6.0821,667,248 - 21,667,435NCBIRnor6.0
Rnor_5.0821,723,309 - 21,723,496UniSTSRnor5.0
RGSC_v3.4819,667,549 - 19,667,736UniSTSRGSC3.4
Celera820,582,725 - 20,582,912UniSTS
Cytogenetic Map8q13UniSTS
RH134127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21629,333,863 - 29,334,078 (+)MAPPERmRatBN7.2
mRatBN7.2819,200,556 - 19,200,775 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,387 - 21,680,605NCBIRnor6.0
Rnor_6.01632,656,297 - 32,656,511NCBIRnor6.0
Rnor_5.01632,490,170 - 32,490,384UniSTSRnor5.0
Rnor_5.0821,736,448 - 21,736,666UniSTSRnor5.0
RGSC_v3.41632,656,876 - 32,657,090UniSTSRGSC3.4
RGSC_v3.4819,681,513 - 19,681,731UniSTSRGSC3.4
Celera820,595,860 - 20,596,078UniSTS
Celera1629,327,779 - 29,327,993UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map8q13UniSTS
RH144258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,200,984 - 19,201,192 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,815 - 21,681,022NCBIRnor6.0
Rnor_5.0821,736,876 - 21,737,083UniSTSRnor5.0
RGSC_v3.4819,681,941 - 19,682,148UniSTSRGSC3.4
Celera820,596,288 - 20,596,495UniSTS
Cytogenetic Map8q13UniSTS
AA962972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,200,533 - 19,200,714 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,364 - 21,680,544NCBIRnor6.0
Rnor_5.0821,736,425 - 21,736,605UniSTSRnor5.0
RGSC_v3.4819,681,490 - 19,681,670UniSTSRGSC3.4
Celera820,595,837 - 20,596,017UniSTS
Cytogenetic Map8q13UniSTS
BI273895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,200,345 - 19,200,555 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,176 - 21,680,385NCBIRnor6.0
Rnor_5.0821,736,237 - 21,736,446UniSTSRnor5.0
RGSC_v3.4819,681,302 - 19,681,511UniSTSRGSC3.4
Celera820,595,649 - 20,595,858UniSTS
Cytogenetic Map8q13UniSTS
RH125187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,200,594 - 19,200,716 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,425 - 21,680,546NCBIRnor6.0
Rnor_5.0821,736,486 - 21,736,607UniSTSRnor5.0
RGSC_v3.4819,681,551 - 19,681,672UniSTSRGSC3.4
Celera820,595,898 - 20,596,019UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 82 214 91 90 59 153 59 6 475 277 21 193 108 123 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000027818   ⟹   ENSRNOP00000027819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,192,419 - 19,200,785 (+)Ensembl
Rnor_6.0 Ensembl821,669,236 - 21,680,615 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097790   ⟹   ENSRNOP00000090877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,189,819 - 19,200,785 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105043   ⟹   ENSRNOP00000094395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,192,288 - 19,200,784 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117909   ⟹   ENSRNOP00000090826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,189,373 - 19,193,895 (+)Ensembl
RefSeq Acc Id: NM_001106701   ⟹   NP_001100171
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,465,642 - 27,477,016 (+)NCBI
mRatBN7.2819,189,408 - 19,200,785 (+)NCBI
Rnor_6.0821,669,236 - 21,680,615 (+)NCBI
Rnor_5.0821,725,297 - 21,736,676 (+)NCBI
RGSC_v3.4819,669,537 - 19,681,741 (+)RGD
Celera820,584,713 - 20,596,088 (+)RGD
Sequence:
RefSeq Acc Id: XM_063265037   ⟹   XP_063121107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,465,538 - 27,477,016 (+)NCBI
RefSeq Acc Id: NP_001100171   ⟸   NM_001106701
- UniProtKB: B0BNL2 (UniProtKB/TrEMBL),   F7EW79 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027819   ⟸   ENSRNOT00000027818
Ensembl Acc Id: ENSRNOP00000094395   ⟸   ENSRNOT00000105043
Ensembl Acc Id: ENSRNOP00000090877   ⟸   ENSRNOT00000097790
Ensembl Acc Id: ENSRNOP00000090826   ⟸   ENSRNOT00000117909
RefSeq Acc Id: XP_063121107   ⟸   XM_063265037
- Peptide Label: isoform X1
Protein Domains
PpiC   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNL2-F1-model_v2 AlphaFold B0BNL2 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695761
Promoter ID:EPDNEW_R6286
Type:multiple initiation site
Name:Pin1_1
Description:peptidylprolyl cis/trans isomerase, NIMA-interacting 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0821,669,220 - 21,669,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310299 AgrOrtholog
BioCyc Gene G2FUF-31461 BioCyc
Ensembl Genes ENSRNOG00000020474 Ensembl
  ENSRNOG00000085482 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000135076 ENTREZGENE
  ENSRNOT00000135076.1 UniProtKB/TrEMBL
  ENSRNOT00000161557.1 UniProtKB/TrEMBL
  ENSRNOT00000170412.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  3.10.50.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623763 IMAGE-MGC_LOAD
InterPro PPIase_dom_sf UniProtKB/TrEMBL
  PPIase_Pin1 UniProtKB/TrEMBL
  PPIase_PpiC UniProtKB/TrEMBL
  PPIase_PpiC_CS UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
KEGG Report rno:298696 UniProtKB/TrEMBL
MGC_CLONE MGC:188496 IMAGE-MGC_LOAD
NCBI Gene 298696 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED UniProtKB/TrEMBL
Pfam PF00397 UniProtKB/TrEMBL
  Rotamase UniProtKB/TrEMBL
PhenoGen Pin1 PhenoGen
PROSITE PPIC_PPIASE_1 UniProtKB/TrEMBL
  PPIC_PPIASE_2 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020474 RatGTEx
  ENSRNOG00000085482 RatGTEx
SMART SM00456 UniProtKB/TrEMBL
Superfamily-SCOP FKBP-like UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
UniProt A0ABK0KWT6_RAT UniProtKB/TrEMBL
  A0ABK0LF11_RAT UniProtKB/TrEMBL
  A0ABK0LFD7_RAT UniProtKB/TrEMBL
  B0BNL2 ENTREZGENE, UniProtKB/TrEMBL
  F7EW79 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Pin1  peptidylprolyl cis/trans isomerase, NIMA-interacting 1  Pin1  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pin1  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1   Pin1_predicted  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pin1_predicted  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED