Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tut4 | Rat | (S)-nicotine | increases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Nicotine results in increased expression of TUT4 mRNA | CTD | PMID:16949557 | Tut4 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of TUT4 mRNA | CTD | PMID:22206623 | Tut4 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of ZCCHC11 mRNA | CTD | PMID:32145629 | Tut4 | Rat | 17beta-estradiol | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Estradiol results in decreased expression of TUT4 mRNA | CTD | PMID:39298647 | Tut4 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TUT4 mRNA | CTD | PMID:21394737 | Tut4 | Rat | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | 2,3',4,4',5-pentachlorobiphenyl results in increased expression of TUT4 mRNA | CTD | PMID:31388691 | Tut4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TUT4 mRNA | CTD | PMID:21215274 | Tut4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TUT4 mRNA | CTD | PMID:28922406 | Tut4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TUT4 mRNA | CTD | PMID:22298810|PMID:34747641 | Tut4 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TUT4 mRNA | CTD | PMID:20188158 | Tut4 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of TUT4 mRNA | CTD | PMID:39298647 | Tut4 | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | TUT4 (Homo sapiens) | 6480464 | bisphenol S results in increased methylation of TUT4 gene | CTD | PMID:31601247 | Tut4 | Rat | 4-nonylphenol | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:28611354 | Tut4 | Rat | 4-tert-Octylphenol | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:28611354 | Tut4 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of TUT4 mRNA | CTD | PMID:31881176 | Tut4 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of TUT4 mRNA | CTD | PMID:28959563 | Tut4 | Rat | acrylamide | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Acrylamide results in decreased expression of TUT4 mRNA | CTD | PMID:30807115 | Tut4 | Rat | aflatoxin B1 | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of TUT4 mRNA | CTD | PMID:19770486 | Tut4 | Rat | antirheumatic drug | increases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of TUT4 mRNA | CTD | PMID:24449571 | Tut4 | Rat | aristolochic acid A | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of TUT4 mRNA | CTD | PMID:33212167 | Tut4 | Rat | arsane | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Tut4 | Rat | arsenic atom | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Tut4 | Rat | atrazine | increases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Atrazine results in increased expression of TUT4 mRNA | CTD | PMID:22378314 | Tut4 | Rat | benzo[a]pyrene | affects methylation | ISO | TUT4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TUT4 intron | CTD | PMID:30157460 | Tut4 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TUT4 mRNA | CTD | PMID:19150397 | Tut4 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:28611354 | Tut4 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of ZCCHC11 mRNA | CTD | PMID:33754040 | Tut4 | Rat | bisphenol A | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of TUT4 mRNA | CTD | PMID:20678512 | Tut4 | Rat | bisphenol A | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:35598803 | Tut4 | Rat | bisphenol A | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TUT4 gene | CTD | PMID:31601247 | Tut4 | Rat | bisphenol A | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of TUT4 mRNA | CTD | PMID:33221593 | Tut4 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ZCCHC11 mRNA | CTD | PMID:32145629 | Tut4 | Rat | bisphenol A | increases expression | ISO | TUT4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:29275510|PMID:33670352 | Tut4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:25181051|PMID:30816183|PMID:32528016 | Tut4 | Rat | Butylbenzyl phthalate | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:28611354 | Tut4 | Rat | carbon nanotube | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of TUT4 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681|PMID:25620056 | Tut4 | Rat | CGP 52608 | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TUT4 gene] | CTD | PMID:28238834 | Tut4 | Rat | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of TUT4 mRNA | CTD | PMID:23125180 | Tut4 | Rat | choline | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Tut4 | Rat | cocaine | decreases expression | EXP | | 6480464 | Cocaine results in decreased expression of TUT4 mRNA | CTD | PMID:17898221 | Tut4 | Rat | copper(II) sulfate | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of TUT4 mRNA | CTD | PMID:19549813 | Tut4 | Rat | cyclosporin A | increases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of TUT4 mRNA | CTD | PMID:20106945 | Tut4 | Rat | Dibutyl phosphate | affects expression | ISO | TUT4 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of TUT4 mRNA | CTD | PMID:37042841 | Tut4 | Rat | dibutyl phthalate | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:28611354 | Tut4 | Rat | diuron | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Diuron results in decreased expression of TUT4 mRNA | CTD | PMID:35967413 | Tut4 | Rat | dorsomorphin | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Tut4 | Rat | doxorubicin | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of TUT4 mRNA | CTD | PMID:29803840 | Tut4 | Rat | enzyme inhibitor | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... | CTD | PMID:23301498 | Tut4 | Rat | ethanol | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Ethanol results in decreased expression of TUT4 mRNA | CTD | PMID:29018328 | Tut4 | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of TUT4 mRNA | CTD | PMID:24136188 | Tut4 | Rat | folic acid | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Tut4 | Rat | folic acid | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of TUT4 mRNA | CTD | PMID:25629700 | Tut4 | Rat | FR900359 | affects phosphorylation | ISO | TUT4 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of TUT4 protein | CTD | PMID:37730182 | Tut4 | Rat | fulvestrant | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TUT4 gene | CTD | PMID:31601247 | Tut4 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of TUT4 mRNA | CTD | PMID:22061828 | Tut4 | Rat | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of TUT4 mRNA | CTD | PMID:24136188 | Tut4 | Rat | L-methionine | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Tut4 | Rat | manganese atom | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Tut4 | Rat | manganese(0) | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Tut4 | Rat | manganese(II) chloride | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Tut4 | Rat | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of TUT4 mRNA | CTD | PMID:30467583 | Tut4 | Rat | nicotine | increases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Nicotine results in increased expression of TUT4 mRNA | CTD | PMID:16949557 | Tut4 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | Tut4 | Rat | p-tert-Amylphenol | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with more ... | CTD | PMID:28611354 | Tut4 | Rat | phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of TUT4 mRNA | CTD | PMID:20345932 | Tut4 | Rat | pirinixic acid | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Tut4 | Rat | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of TUT4 mRNA | CTD | PMID:25905778 | Tut4 | Rat | rotenone | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of TUT4 protein | CTD | PMID:39603559 | Tut4 | Rat | SB 431542 | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Tut4 | Rat | sodium arsenate | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of TUT4 mRNA | CTD | PMID:30953684 | Tut4 | Rat | sodium arsenate | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of TUT4 mRNA | CTD | PMID:39847705 | Tut4 | Rat | sodium arsenite | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Tut4 | Rat | sunitinib | increases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of TUT4 mRNA | CTD | PMID:31533062 | Tut4 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TUT4 mRNA | CTD | PMID:31150632 | Tut4 | Rat | tetrachloromethane | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of TUT4 mRNA | CTD | PMID:31919559 | Tut4 | Rat | titanium dioxide | increases methylation | ISO | Tut4 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of ZCCHC11 gene | CTD | PMID:35295148 | Tut4 | Rat | titanium dioxide | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of TUT4 mRNA | CTD | PMID:29264374 | Tut4 | Rat | titanium dioxide | decreases methylation | ISO | Tut4 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of ZCCHC11 gene; titanium dioxide results in decreased methylation more ... | CTD | PMID:35295148 | Tut4 | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | Tut4 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | Tut4 | Rat | trichostatin A | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of TUT4 mRNA | CTD | PMID:26272509 | Tut4 | Rat | trichostatin A | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Tut4 | Rat | triphenyl phosphate | affects expression | ISO | TUT4 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of TUT4 mRNA | CTD | PMID:37042841 | Tut4 | Rat | triptonide | affects expression | ISO | Tut4 (Mus musculus) | 6480464 | triptonide affects the expression of TUT4 mRNA | CTD | PMID:33045310 | Tut4 | Rat | tungsten | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Tungsten results in decreased expression of TUT4 mRNA | CTD | PMID:30912803 | Tut4 | Rat | valproic acid | decreases expression | ISO | TUT4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of TUT4 mRNA | CTD | PMID:23179753|PMID:24383497|PMID:26272509 | Tut4 | Rat | valproic acid | multiple interactions | ISO | TUT4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Tut4 | Rat | valproic acid | affects expression | ISO | Tut4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of TUT4 mRNA | CTD | PMID:17963808 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















