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Gene: Dusp26 (dual specificity phosphatase 26) Rattus norvegicus

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Symbol:

Dusp26

Name:

dual specificity phosphatase 26

RGD ID:

1310090

Description:

Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; p53 binding activity; and phosphoprotein phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of transcription by RNA polymerase II; and positive regulation of cell adhesion. Predicted to be located in Golgi apparatus and nucleus. Predicted to be active in cytoplasm. Orthologous to human DUSP26 (dual specificity phosphatase 26); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dual specificity phosphatase 26 (putative); dual specificity protein phosphatase 26; LOC306527; MGC109288; RGD1310090; similar to 2310043K02Rik protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DUSP26 (dual specificity phosphatase 26)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dusp26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dusp26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DUSP26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DUSP26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dusp26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DUSP26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DUSP26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dusp26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dusp26 (dual specificity phosphatase 26)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PSAPL1 (prosaposin like 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Dusp26 (dual specificity phosphatase 26)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DUSP26 (dual specificity phosphatase 26)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F26A3.4	Alliance	DIOPT (Ensembl Compara\|OMA)
Saccharomyces cerevisiae (baker's yeast):	SDP1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7378	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7378	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dusp26	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dusp26	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	67,744,830 - 67,752,673 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	67,744,842 - 67,752,101 (-)	Ensembl				GRCr8
mRatBN7.2	16	61,041,784 - 61,049,319 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	61,041,792 - 61,049,051 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	66,357,195 - 66,364,502 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	69,771,709 - 69,779,012 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	64,998,081 - 65,005,413 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	64,798,782 - 64,806,459 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	64,798,778 - 64,806,050 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	64,455,731 - 64,463,284 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	64,952,300 - 64,959,604 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	59,046,361 - 59,053,665 (-)	NCBI		Celera
RGSC_v3.1	16	64,952,379 - 64,959,679 (-)	NCBI
Cytogenetic Map	16	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

lung adenocarcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlorohydrocarbon (EXP)

choline (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

genistein (ISO)

GW 4064 (ISO)

hydrogen peroxide (ISO)

L-methionine (ISO)

methylmercury chloride (EXP)

mono(2-ethylhexyl) phthalate (ISO)

ozone (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorooctanoic acid (EXP)

pioglitazone (ISO)

progesterone (ISO)

propanal (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

Soman (EXP)

sunitinib (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of ERK1 and ERK2 cascade (IEA,ISO)

negative regulation of MAPK cascade (IBA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of cell adhesion (IEA,ISO)

protein dephosphorylation (ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

Golgi apparatus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

hydrolase activity (IEA)

MAP kinase phosphatase activity (IBA)

p53 binding (IEA,ISO)

phosphoprotein phosphatase activity (IEA,ISO)

protein binding (ISO)

protein serine/threonine phosphatase activity (IEA)

protein tyrosine phosphatase activity (IEA)

protein tyrosine/serine/threonine phosphatase activity (IBA,IEA,ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	A seven-gene prognostic model related to immune checkpoint PD-1 revealing overall survival in patients with lung adenocarcinoma.	Niu W and Jiang L, Math Biosci Eng. 2021 Jul 13;18(5):6136-6154. doi: 10.3934/mbe.2021307.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15796912	PMID:16581800	PMID:18614015	PMID:19043453	PMID:19056867	PMID:20562916	PMID:38705402

Genomics

Comparative Map Data

Dusp26
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	67,744,830 - 67,752,673 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	67,744,842 - 67,752,101 (-)	Ensembl				GRCr8
mRatBN7.2	16	61,041,784 - 61,049,319 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	61,041,792 - 61,049,051 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	66,357,195 - 66,364,502 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	69,771,709 - 69,779,012 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	64,998,081 - 65,005,413 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	64,798,782 - 64,806,459 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	64,798,778 - 64,806,050 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	64,455,731 - 64,463,284 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	64,952,300 - 64,959,604 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	59,046,361 - 59,053,665 (-)	NCBI		Celera
RGSC_v3.1	16	64,952,379 - 64,959,679 (-)	NCBI
Cytogenetic Map	16	q12.3	NCBI

DUSP26
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	33,591,330 - 33,600,023 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	33,591,330 - 33,600,176 (-)	Ensembl			hg38	GRCh38
GRCh37	8	33,448,848 - 33,457,541 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	33,568,393 - 33,576,981 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	8	32,398,523 - 32,407,113 (-)	NCBI		Celera
Cytogenetic Map	8	p12	NCBI
HuRef	8	31,980,747 - 31,988,923 (-)	NCBI		HuRef
CHM1_1	8	33,650,334 - 33,658,924 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	33,862,584 - 33,871,277 (-)	NCBI		T2T-CHM13v2.0

Dusp26
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	31,579,555 - 31,587,074 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	31,579,499 - 31,587,075 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	31,089,527 - 31,097,046 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	31,089,471 - 31,097,047 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	32,200,134 - 32,207,519 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	32,555,597 - 32,562,982 (+)	NCBI		MGSCv36	mm8
Celera	8	32,614,701 - 32,622,121 (+)	NCBI		Celera
Cytogenetic Map	8	A3	NCBI
cM Map	8	17.93	NCBI

Dusp26
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	9,712,954 - 9,718,959 (-)	Ensembl
ChiLan1.0	NW_004955463	9,712,943 - 9,718,959 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUSP26
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	52,166,122 - 52,174,877 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	27,881,863 - 27,890,613 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	32,906,182 - 32,915,015 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	30,091,084 - 30,100,699 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	30,091,092 - 30,100,699 (-)	Ensembl			panPan2	panpan1.1

DUSP26
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	31,115,317 - 31,122,767 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	31,115,475 - 31,132,033 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	31,638,685 - 31,647,937 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	33,140,928 - 33,146,814 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	33,141,000 - 33,147,846 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	31,237,257 - 31,246,487 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	31,816,290 - 31,822,141 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	31,854,968 - 31,864,230 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dusp26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	54,103,079 - 54,109,849 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936766	363,029 - 370,281 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936766	363,172 - 370,234 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUSP26
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	15	59,480,305 - 59,486,816 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DUSP26
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	31,667,984 - 31,679,040 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	31,666,691 - 31,679,058 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666052	10,369,786 - 10,378,220 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dusp26
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	10,368,975 - 10,375,215 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624780	10,368,988 - 10,376,731 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dusp26
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	55,816,125 - 55,823,582 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dusp26
36 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	92
Count of miRNA genes:	75
Interacting mature miRNAs:	90
Transcripts:	ENSRNOT00000015725
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	44455123	89455123	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	36928782	81928782	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	41992064	86992064	Rat
2302057	Pia29	Pristane induced arthritis QTL 29	3.6	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	16	28468701	73468701	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	49099196	91442908	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	62414464	75736480	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	32361043	77361043	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	31058039	76058039	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	59428714	91442908	Rat
1298529	Arunc1	Aerobic running capacity QTL 1	4		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	34398294	79398294	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	31885271	76885271	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	44455123	89455123	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	59428714	91442908	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	59428714	91442908	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17730818	72536785	Rat

Markers in Region

UniSTS:235863

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	61,041,806 - 61,042,065 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	64,798,805 - 64,799,063	NCBI	Rnor6.0
Rnor_5.0	16	64,455,754 - 64,456,012	UniSTS	Rnor5.0
RGSC_v3.4	16	64,952,320 - 64,952,578	UniSTS	RGSC3.4
Celera	16	59,046,381 - 59,046,639	UniSTS
Cytogenetic Map	16	q12.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	64	152	83	82	51	32	51	6	253	129	10	124	49	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015725 ⟹ ENSRNOP00000015725

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	67,744,842 - 67,752,101 (-)	Ensembl
mRatBN7.2 Ensembl	16	61,041,792 - 61,049,051 (-)	Ensembl
Rnor_6.0 Ensembl	16	64,798,778 - 64,806,050 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092758

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	64,799,459 - 64,804,127 (-)	Ensembl

RefSeq Acc Id:

NM_001012352 ⟹ NP_001012352

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	67,744,837 - 67,752,101 (-)	NCBI
mRatBN7.2	16	61,041,787 - 61,049,051 (-)	NCBI
Rnor_6.0	16	64,798,785 - 64,806,050 (-)	NCBI
Rnor_5.0	16	64,455,731 - 64,463,284 (-)	NCBI
RGSC_v3.4	16	64,952,300 - 64,959,604 (-)	RGD
Celera	16	59,046,361 - 59,053,665 (-)	RGD

Sequence:

show sequence

CGGGGCTGTAAACAGGGGCGGGCTGTGTCGCTGCGGTGTGGCGGCTCCCACCGCTGCGTGACAC
GGTGTCCCTGGATGTCACCAGCGCGCACACCGAAAGGAACCTGCTTCGATGTACGTGTCATGGC
TTAAAAATAGCTGGGATCCACCTGCGCGCCGGGGCGGCGGCGCAGCGGCGGGGGCCGTGAAGGA
GCCATGGGCACCGGACTGCGGGAGCCCGCAGGCCAACTCGGGATCTGAGACCCTTGCGACCAGG
AGCAACAGCCACCTGGTGACAAAGCCCATCACTGCTGAAACCACTCCGCGTTGGCCGCAGATCC
CGCCACCTTGAAGATGTGCCCCGGTAACTGGCTGTGGGCTTCCATGACTTTTATGGCCCGCTTC
TCCCGAAGCAGCTCAAGGTCCCCTGTTCGTACCCGAGGGAGCCTGGAGGAGATGCCCAGTGTTC
ACCATCCCTTCCTCAATGTCTTTGAGTTGGAAAGGCTCCTCTACACGGGCAAGACAGCCTGCAA
CCATGCTGACGAGGTCTGGCCAGGCCTCTACCTCGGAGACCAGGACATGGCCAACAACCGCCGT
GAGCTTCGTCGCCTGGGCATCACCCACGTCCTCAACGCCTCCCACAGCAGGTGGCGAGGCACCC
CCGAGGCCTACGAGGGACTGGGCATCCGCTACCTGGGTGTTGAAGCCCACGACTCGCCAGCCTT
TGACATGAGCGTCCACTTTCAAACCGCTGCGGACTTTATCCATCGGGCACTGAGCCAGCCAGGA
GGGAAGATCCTGGTGCACTGTGCGGTGGGAGTGAGCAGATCTGCCACCCTGGTGCTGGCCTACC
TCATGCTGTACCACCACTTCACCCTCGTGGAGGCCATCAAGAAAGTCAAGGACCACCGAGGCAT
CATCCCCAACAGGGGCTTCTTGAGACAGCTCCTAGCCCTGGACCGTAGGCTGCGTCAGGGTCTA
GAAGCATGAGCTGAAGGGGATCAGGCCAGGTCCCTGAGTGGTTTCCTGACTCCCAGCTGGGAAG
AGAAAACCTGGGAGGCAGGTAGTAGAAAGGCCATACCACCCATCCTCCCCCAGTGGCAGGAGAG
TGAAGAGTCCCAAGACCGCTGTGGCTCTTTGTGGATGGGGATGGAGGGCCAGGTTGGGCAATGT
GGTCGGTGGGGGCTGCTGACCAGGAAGCAGTGGGGCTCTAAGTAGAGGATGGCTCGATGATTAG
GATATCCCCGCGTTCCAGCAGGGTACGCCCAAATGACTCAGAATCTCTTCCCCTCATTGTGTTC
AAGTGTCCCCCTCTCTCGCTTTTCCAAACAAAACGACCACTGCCCTGAAGTACCTGAGCAGTGG
GGATGTCAGGGACCCAGCAACACGGATGTGAAGGAAGATTGTACAGGTTGCAGAAAACAACACA
GTCAGTTGGTGATGGTGTGGTGTGAAAGTTACCAATCCAGAGGGAGAAACCTACCCCCCTGTGC
AACTGCAGGAAGAGGAGGTGTGTGACAGGACACCCTACCGGAGCTGCTTGGGGTCTAATGACTT
GGAGTCTTTAGGTGGTCATATTCTCACTGAAAACCATGCGTCTGGAGTAAAAATAAAGAAGTGA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006253232 ⟹ XP_006253294

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	67,744,830 - 67,752,673 (-)	NCBI
mRatBN7.2	16	61,041,784 - 61,049,319 (-)	NCBI
Rnor_6.0	16	64,798,782 - 64,806,459 (-)	NCBI
Rnor_5.0	16	64,455,731 - 64,463,284 (-)	NCBI

Sequence:

show sequence

GTTGGAAGAGTCATAACACGAACTTCAGGGTCTCACTACCATCCTCTGAAGCTCAGCCCTTTCA
ATACCTAGCTGGTGACTTGGGCTTAGCCTGTCTATATTTTAATATCATCCCTTCGTAAAATGCA
GATGAAGACGCCTGTCTTACACATCTCTGATGAAAATGAAACTCTCTAAGCCAGGTGAAGTGCC
TAGCATGTGCAACAGCCACCTGGTGACAAAGCCCATCACTGCTGAAACCACTCCGCGTTGGCCG
CAGATCCCGCCACCTTGAAGATGTGCCCCGGTAACTGGCTGTGGGCTTCCATGACTTTTATGGC
CCGCTTCTCCCGAAGCAGCTCAAGGTCCCCTGTTCGTACCCGAGGGAGCCTGGAGGAGATGCCC
AGTGTTCACCATCCCTTCCTCAATGTCTTTGAGTTGGAAAGGCTCCTCTACACGGGCAAGACAG
CCTGCAACCATGCTGACGAGGTCTGGCCAGGCCTCTACCTCGGAGACCAGGACATGGCCAACAA
CCGCCGTGAGCTTCGTCGCCTGGGCATCACCCACGTCCTCAACGCCTCCCACAGCAGGTGGCGA
GGCACCCCCGAGGCCTACGAGGGACTGGGCATCCGCTACCTGGGTGTTGAAGCCCACGACTCGC
CAGCCTTTGACATGAGCGTCCACTTTCAAACCGCTGCGGACTTTATCCATCGGGCACTGAGCCA
GCCAGGAGGGAAGATCCTGGTGCACTGTGCGGTGGGAGTGAGCAGATCTGCCACCCTGGTGCTG
GCCTACCTCATGCTGTACCACCACTTCACCCTCGTGGAGGCCATCAAGAAAGTCAAGGACCACC
GAGGCATCATCCCCAACAGGGGCTTCTTGAGACAGCTCCTAGCCCTGGACCGTAGGCTGCGTCA
GGGTCTAGAAGCATGAGCTGAAGGGGATCAGGCCAGGTCCCTGAGTGGTTTCCTGACTCCCAGC
TGGGAAGAGAAAACCTGGGAGGCAGGTAGTAGAAAGGCCATACCACCCATCCTCCCCCAGTGGC
AGGAGAGTGAAGAGTCCCAAGACCGCTGTGGCTCTTTGTGGATGGGGATGGAGGGCCAGGTTGG
GCAATGTGGTCGGTGGGGGCTGCTGACCAGGAAGCAGTGGGGCTCTAAGTAGAGGATGGCTCGA
TGATTAGGATATCCCCGCGTTCCAGCAGGGTACGCCCAAATGACTCAGAATCTCTTCCCCTCAT
TGTGTTCAAGTGTCCCCCTCTCTCGCTTTTCCAAACAAAACGACCACTGCCCTGAAGTACCTGA
GCAGTGGGGATGTCAGGGACCCAGCAACACGGATGTGAAGGAAGATTGTACAGGTTGCAGAAAA
CAACACAGTCAGTTGGTGATGGTGTGGTGTGAAAGTTACCAATCCAGAGGGAGAAACCTACCCC
CCTGTGCAACTGCAGGAAGAGGAGGTGTGTGACAGGACACCCTACCGGAGCTGCTTGGGGTCTA
ATGACTTGGAGTCTTTAGGTGGTCATATTCTCACTGAAAACCATGCGTCTGGAGTAAAAATAAA
GAAGTGAAAAAGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012352	(Get FASTA)	NCBI Sequence Viewer
	XP_006253294	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89954	(Get FASTA)	NCBI Sequence Viewer
	EDM09110	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015725
	ENSRNOP00000015725.4
GenBank Protein	Q5FVI9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012352 ⟸ NM_001012352

- UniProtKB:

Q5FVI9 (UniProtKB/Swiss-Prot), A6IVW2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MCPGNWLWASMTFMARFSRSSSRSPVRTRGSLEEMPSVHHPFLNVFELERLLYTGKTACNHADE
VWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSV
HFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHFTLVEAIKKVKDHRGIIPNR
GFLRQLLALDRRLRQGLEA

hide sequence

RefSeq Acc Id:	XP_006253294 ⟸ XM_006253232
- Peptide Label:	isoform X1
- UniProtKB:	Q5FVI9 (UniProtKB/Swiss-Prot), A6IVW2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MCPGNWLWASMTFMARFSRSSSRSPVRTRGSLEEMPSVHHPFLNVFELERLLYTGKTACNHADE VWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSV HFQTAADFIHRALSQPGGKILVHCAVGVSRSATLVLAYLMLYHHFTLVEAIKKVKDHRGIIPNR GFLRQLLALDRRLRQGLEA hide sequence

Ensembl Acc Id:

ENSRNOP00000015725 ⟸ ENSRNOT00000015725

Protein Domains

Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5FVI9-F1-model_v2	AlphaFold	Q5FVI9	1-211	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310090	AgrOrtholog
BioCyc Gene	G2FUF-11084	BioCyc
Ensembl Genes	ENSRNOG00000011518	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000015725	ENTREZGENE
	ENSRNOT00000015725.8	UniProtKB/Swiss-Prot
Gene3D-CATH	3.90.190.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7312637	IMAGE-MGC_LOAD
InterPro	Atypical_DUSP_famA	UniProtKB/Swiss-Prot
	Dual-sp_phosphatase_cat-dom	UniProtKB/Swiss-Prot
	Prot-tyrosine_phosphatase-like	UniProtKB/Swiss-Prot
	Tyr_Pase_AS	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_dom	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_DUAL_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:306527	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109288	IMAGE-MGC_LOAD
NCBI Gene	306527	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE 26	UniProtKB/Swiss-Prot
	PTHR45682	UniProtKB/Swiss-Prot
Pfam	DSPc	UniProtKB/Swiss-Prot
PhenoGen	Dusp26	PhenoGen
PRINTS	ADSPHPHTASE	UniProtKB/Swiss-Prot
	ADSPHPHTASEA	UniProtKB/Swiss-Prot
PROSITE	TYR_PHOSPHATASE_1	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_2	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_DUAL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000011518	RatGTEx
SMART	DSPc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52799	UniProtKB/Swiss-Prot
UniProt	A6IVW2	ENTREZGENE, UniProtKB/TrEMBL
	DUS26_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-12-15	Dusp26	dual specificity phosphatase 26	Dusp26	dual specificity phosphatase 26 (putative)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-27	Dusp26	dual specificity phosphatase 26 (putative)	RGD1310090	similar to 2310043K02Rik protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1310090	similar to 2310043K02Rik protein	RGD1310090_predicted	similar to 2310043K02Rik protein (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1310090_predicted	similar to 2310043K02Rik protein (predicted)	LOC306527_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC306527_predicted	similar to 2310043K02Rik protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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