Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | R3hdm2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of R3HDM2 mRNA | CTD | PMID:22206623 | R3hdm2 | Rat | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of R3HDM2 mRNA | CTD | PMID:25380136 | R3hdm2 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of R3HDM2 mRNA | CTD | PMID:21394737 | R3hdm2 | Rat | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | 2,3',4,4',5-pentachlorobiphenyl results in increased expression of R3HDM2 mRNA | CTD | PMID:31388691 | R3hdm2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of R3HDM2 mRNA | CTD | PMID:21215274 | R3hdm2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of R3HDM2 mRNA | CTD | PMID:33387578 | R3hdm2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | R3hdm2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of R3HDM2 mRNA | CTD | PMID:21570461 | R3hdm2 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of R3HDM2 mRNA | CTD | PMID:20188158 | R3hdm2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | R3hdm2 | Rat | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of R3HDM2 mRNA | CTD | PMID:25380136 | R3hdm2 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of R3HDM2 mRNA | CTD | PMID:39298647 | R3hdm2 | Rat | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | decreases expression | EXP | | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of R3HDM2 mRNA | CTD | PMID:22484513 | R3hdm2 | Rat | 5-fluorouracil | affects expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Fluorouracil affects the expression of R3HDM2 mRNA | CTD | PMID:16584549 | R3hdm2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of R3HDM2 mRNA | CTD | PMID:30047161 | R3hdm2 | Rat | acrolein | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... | CTD | PMID:32699268 | R3hdm2 | Rat | aflatoxin B1 | affects expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of R3HDM2 protein | CTD | PMID:20106945 | R3hdm2 | Rat | aflatoxin B1 | decreases methylation | ISO | R3HDM2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of R3HDM2 exon | CTD | PMID:30157460 | R3hdm2 | Rat | alpha-pinene | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... | CTD | PMID:32699268 | R3hdm2 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of R3HDM2 mRNA | CTD | PMID:30047161 | R3hdm2 | Rat | aristolochic acid A | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of R3HDM2 mRNA | CTD | PMID:33212167 | R3hdm2 | Rat | arsane | affects methylation | ISO | R3HDM2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of R3HDM2 gene | CTD | PMID:25304211 | R3hdm2 | Rat | arsenic atom | affects methylation | ISO | R3HDM2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of R3HDM2 gene | CTD | PMID:25304211 | R3hdm2 | Rat | arsenous acid | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of R3HDM2 mRNA | CTD | PMID:27829220 | R3hdm2 | Rat | atrazine | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of R3HDM2 mRNA | CTD | PMID:22378314 | R3hdm2 | Rat | benzo[a]pyrene | increases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of R3HDM2 mRNA | CTD | PMID:22228805 | R3hdm2 | Rat | benzo[a]pyrene | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of R3HDM2 mRNA | CTD | PMID:21632981|PMID:22316170|PMID:32234424 | R3hdm2 | Rat | benzo[b]fluoranthene | decreases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in decreased expression of R3HDM2 mRNA | CTD | PMID:26377693 | R3hdm2 | Rat | benzo[e]pyrene | decreases methylation | ISO | R3HDM2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of R3HDM2 exon | CTD | PMID:30157460 | R3hdm2 | Rat | beta-lapachone | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of R3HDM2 mRNA | CTD | PMID:38218311 | R3hdm2 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of R3HDM2 mRNA | CTD | PMID:33754040 | R3hdm2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of R3HDM2 protein | CTD | PMID:32145629 | R3hdm2 | Rat | bisphenol A | decreases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of R3HDM2 mRNA | CTD | PMID:33221593 | R3hdm2 | Rat | bisphenol F | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of R3HDM2 gene; [INS protein co-treated more ... | CTD | PMID:28628672|PMID:31601247 | R3hdm2 | Rat | bisphenol F | decreases methylation | ISO | R3HDM2 (Homo sapiens) | 6480464 | bisphenol F results in decreased methylation of R3HDM2 gene | CTD | PMID:31601247 | R3hdm2 | Rat | Bufotalin | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | bufotalin results in decreased expression of R3HDM2 mRNA | CTD | PMID:39904859 | R3hdm2 | Rat | buspirone | decreases expression | EXP | | 6480464 | Buspirone results in decreased expression of R3HDM2 mRNA | CTD | PMID:24136188 | R3hdm2 | Rat | cadmium atom | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of R3HDM2 more ... | CTD | PMID:35301059 | R3hdm2 | Rat | cadmium atom | multiple interactions | ISO | R3hdm2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of R3HDM2 more ... | CTD | PMID:37236586 | R3hdm2 | Rat | cadmium dichloride | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of R3HDM2 more ... | CTD | PMID:35301059 | R3hdm2 | Rat | cadmium dichloride | multiple interactions | ISO | R3hdm2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of R3HDM2 more ... | CTD | PMID:37236586 | R3hdm2 | Rat | caffeine | affects phosphorylation | ISO | R3HDM2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of R3HDM2 protein | CTD | PMID:35688186 | R3hdm2 | Rat | carbon nanotube | decreases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of R3HDM2 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | R3hdm2 | Rat | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of R3HDM2 mRNA | CTD | PMID:20187946 | R3hdm2 | Rat | coumarin | decreases expression | EXP | | 6480464 | coumarin results in decreased expression of R3HDM2 mRNA | CTD | PMID:18480146 | R3hdm2 | Rat | coumestrol | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of R3HDM2 mRNA | CTD | PMID:19167446 | R3hdm2 | Rat | dexamethasone | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | R3hdm2 | Rat | diarsenic trioxide | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of R3HDM2 mRNA | CTD | PMID:27829220 | R3hdm2 | Rat | Dibutyl phosphate | affects expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of R3HDM2 mRNA | CTD | PMID:37042841 | R3hdm2 | Rat | dibutyl phthalate | affects expression | EXP | | 6480464 | Dibutyl Phthalate affects the expression of R3HDM2 mRNA | CTD | PMID:30934153 | R3hdm2 | Rat | dicrotophos | increases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of R3HDM2 mRNA | CTD | PMID:28302478 | R3hdm2 | Rat | dorsomorphin | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | R3hdm2 | Rat | doxorubicin | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of R3HDM2 mRNA | CTD | PMID:29803840 | R3hdm2 | Rat | enzyme inhibitor | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... | CTD | PMID:23301498 | R3hdm2 | Rat | ethanol | multiple interactions | ISO | R3hdm2 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of R3HDM2 mRNA | CTD | PMID:30319688 | R3hdm2 | Rat | FR900359 | affects phosphorylation | ISO | R3HDM2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of R3HDM2 protein | CTD | PMID:37730182 | R3hdm2 | Rat | fulvestrant | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of R3HDM2 gene | CTD | PMID:31601247 | R3hdm2 | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of R3HDM2 mRNA | CTD | PMID:26194646 | R3hdm2 | Rat | hydrogen peroxide | affects expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of R3HDM2 mRNA | CTD | PMID:20044591 | R3hdm2 | Rat | indometacin | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... | CTD | PMID:28628672 | R3hdm2 | Rat | lead(0) | affects expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Lead affects the expression of R3HDM2 mRNA | CTD | PMID:28903495 | R3hdm2 | Rat | lead(0) | affects splicing | ISO | R3HDM2 (Homo sapiens) | 6480464 | Lead affects the splicing of R3HDM2 mRNA | CTD | PMID:28903495 | R3hdm2 | Rat | leflunomide | decreases expression | EXP | | 6480464 | leflunomide results in decreased expression of R3HDM2 mRNA | CTD | PMID:24136188 | R3hdm2 | Rat | menadione | affects expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of R3HDM2 mRNA | CTD | PMID:20044591 | R3hdm2 | Rat | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of R3HDM2 mRNA | CTD | PMID:22484513 | R3hdm2 | Rat | methapyrilene | decreases methylation | ISO | R3HDM2 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of R3HDM2 exon | CTD | PMID:30157460 | R3hdm2 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of R3HDM2 mRNA | CTD | PMID:30047161 | R3hdm2 | Rat | N-methyl-4-phenylpyridinium | increases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of R3HDM2 mRNA | CTD | PMID:24810058 | R3hdm2 | Rat | N-nitrosodimethylamine | decreases expression | EXP | | 6480464 | Dimethylnitrosamine results in decreased expression of R3HDM2 mRNA | CTD | PMID:25380136 | R3hdm2 | Rat | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of R3HDM2 mRNA | CTD | PMID:24136188 | R3hdm2 | Rat | niclosamide | increases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Niclosamide results in increased expression of R3HDM2 mRNA | CTD | PMID:36318118 | R3hdm2 | Rat | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of R3HDM2 mRNA | CTD | PMID:24136188 | R3hdm2 | Rat | nitrates | multiple interactions | ISO | R3hdm2 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of R3HDM2 more ... | CTD | PMID:35964746 | R3hdm2 | Rat | okadaic acid | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of R3HDM2 mRNA | CTD | PMID:38832940 | R3hdm2 | Rat | ozone | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... | CTD | PMID:32699268 | R3hdm2 | Rat | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of R3HDM2 mRNA | CTD | PMID:30047161 | R3hdm2 | Rat | rotenone | increases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Rotenone results in increased expression of R3HDM2 mRNA | CTD | PMID:29955902 | R3hdm2 | Rat | SB 431542 | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | R3hdm2 | Rat | silicon dioxide | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of R3HDM2 mRNA | CTD | PMID:23806026 | R3hdm2 | Rat | sodium arsenite | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of R3HDM2 mRNA | CTD | PMID:38568856 | R3hdm2 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of R3HDM2 mRNA | CTD | PMID:30047161 | R3hdm2 | Rat | sunitinib | increases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of R3HDM2 mRNA | CTD | PMID:31533062 | R3hdm2 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of R3HDM2 mRNA | CTD | PMID:15336504 | R3hdm2 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of R3HDM2 mRNA | CTD | PMID:31150632 | R3hdm2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of R3HDM2 mRNA | CTD | PMID:34492290 | R3hdm2 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of R3HDM2 mRNA | CTD | PMID:33387578 | R3hdm2 | Rat | triphenyl phosphate | affects expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of R3HDM2 mRNA | CTD | PMID:37042841 | R3hdm2 | Rat | triptonide | decreases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | triptonide results in decreased expression of R3HDM2 mRNA | CTD | PMID:33045310 | R3hdm2 | Rat | triptonide | affects expression | ISO | R3hdm2 (Mus musculus) | 6480464 | triptonide affects the expression of R3HDM2 mRNA | CTD | PMID:33045310 | R3hdm2 | Rat | tungsten | decreases expression | ISO | R3hdm2 (Mus musculus) | 6480464 | Tungsten results in decreased expression of R3HDM2 mRNA | CTD | PMID:30912803 | R3hdm2 | Rat | valdecoxib | decreases expression | EXP | | 6480464 | valdecoxib results in decreased expression of R3HDM2 mRNA | CTD | PMID:24136188 | R3hdm2 | Rat | valproic acid | affects expression | ISO | R3hdm2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of R3HDM2 mRNA | CTD | PMID:17292431 | R3hdm2 | Rat | valproic acid | multiple interactions | ISO | R3HDM2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | R3hdm2 | Rat | valproic acid | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of R3HDM2 mRNA | CTD | PMID:23179753|PMID:26272509|PMID:29154799 | R3hdm2 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of R3HDM2 mRNA | CTD | PMID:20566332|PMID:23034163 | R3hdm2 | Rat | vorinostat | decreases expression | ISO | R3HDM2 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of R3HDM2 mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||






















