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Gene: Crb1 (crumbs cell polarity complex component 1) Rattus norvegicus

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Symbol:

Crb1

Name:

crumbs cell polarity complex component 1

RGD ID:

1309947

Description:

Predicted to enable calcium ion binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to act upstream of with a positive effect on gene expression. Predicted to act upstream of with a negative effect on intracellular protein localization. Predicted to act upstream of or within several processes, including camera-type eye development; detection of light stimulus involved in visual perception; and neurogenesis. Located in microvillus and photoreceptor inner segment. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

crumbs 1, cell polarity complex component; crumbs family member 1, photoreceptor morphogenesis associated; crumbs homolog 1; crumbs homolog 1 (Drosophila); LOC304825

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CRB1 (crumbs cell polarity complex component 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Crb1 (crumbs family member 1, photoreceptor morphogenesis associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Crb1 (crumbs cell polarity complex component 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CRB1 (crumbs cell polarity complex component 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CRB1 (crumbs cell polarity complex component 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Crb1 (crumbs cell polarity complex component 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CRB1 (crumbs cell polarity complex component 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CRB1 (crumbs cell polarity complex component 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Crb1 (crumbs cell polarity complex component 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Crb1 (crumbs cell polarity complex component 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PXMP2 (peroxisomal membrane protein 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CRB1 (crumbs cell polarity complex component 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Crb1 (crumbs family member 1, photoreceptor morphogenesis associated)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	crb1 (crumbs cell polarity complex component 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	crb	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	crb	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	crb-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector)
Caenorhabditis elegans (roundworm):	crb-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	crb1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	crb1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Crb1^m1

Genetic Models:

BN-Crb1^m1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	53,352,932 - 53,540,019 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	53,352,932 - 53,540,019 (-)	Ensembl				GRCr8
mRatBN7.2	13	50,801,484 - 50,989,261 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	50,800,959 - 50,989,261 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	53,408,027 - 53,587,968 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	54,695,960 - 54,875,896 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	51,963,725 - 52,151,483 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	56,270,519 - 56,462,893 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	56,270,781 - 56,462,834 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	61,292,273 - 61,369,526 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	13	61,413,282 - 61,480,872 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	52,558,317 - 52,725,099 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	51,073,846 - 51,253,703 (-)	NCBI		Celera
RGSC_v3.1	13	52,572,656 - 52,715,591 (-)	NCBI
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bestrophinopathy (ISO)

cone dystrophy (ISO)

cone-rod dystrophy (ISO)

Eye Abnormalities (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Idiopathic Juxtafoveal Retinal Telangiectasia (IAGP)

intellectual disability (ISO)

late-onset retinal degeneration (ISO)

Leber congenital amaurosis (ISO)

Leber congenital amaurosis 1 (ISO)

Leber congenital amaurosis 2 (ISO)

Leber congenital amaurosis 8 (ISO,ISS)

macular degeneration (ISO)

optic atrophy (ISO)

pigmented paravenous chorioretinal atrophy (ISO)

retinal detachment (ISO)

Retinal Dysplasia (ISO)

retinal telangiectasia (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa 1 (ISO)

retinitis pigmentosa 12 (ISO,ISS)

retinitis pigmentosa 13 (ISO)

retinitis pigmentosa-deafness syndrome (ISO)

schizophrenia (ISO)

Stargardt disease (ISO)

Usher syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

cannabidiol (EXP)

carbon nanotube (ISO)

cobalt dichloride (ISO)

dorsomorphin (ISO)

ethylparaben (ISO)

isoprenaline (ISO)

lipopolysaccharide (ISO)

lycopene (ISO)

methapyrilene (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propanal (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

triptonide (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

blood vessel remodeling (ISO)

cellular response to light stimulus (ISO)

detection of light stimulus involved in visual perception (ISO)

establishment of bipolar cell polarity involved in cell morphogenesis (ISO)

establishment or maintenance of cell polarity (IEA)

establishment or maintenance of epithelial cell apical/basal polarity (IBA)

eye photoreceptor cell development (ISO)

glial cell differentiation (ISO)

heterophilic cell-cell adhesion (IBA)

membrane organization (ISO)

photoreceptor cell maintenance (ISO)

photoreceptor cell outer segment organization (ISO)

plasma membrane organization (ISO)

post-embryonic retina morphogenesis in camera-type eye (ISO)

retina development in camera-type eye (ISO)

retina layer formation (ISO)

retina morphogenesis in camera-type eye (IEA,ISO)

sensory organ morphogenesis (IEA)

visual perception (ISO)

Cellular Component

adherens junction (IEA,ISO)

apical junction complex (IEA,ISO)

apical part of cell (IEA,ISO)

apical plasma membrane (IEA)

cell-cell junction (IEA,ISO)

extracellular region (IEA)

glial cell projection (IEA,ISO)

membrane (IEA)

microvillus (IDA,IEA,ISO)

photoreceptor inner segment (IDA,IEA)

photoreceptor outer segment (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

protein-containing complex (IBA,IEA,ISO)

subapical complex (IEA,ISO)

Molecular Function

calcium ion binding (IEA)

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal Muller cell morphology (IAGP)

abnormal retina pigmentation (IAGP)

disorganized retina outer nuclear layer (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12).	den Hollander AI, etal., Nat Genet. 1999 Oct;23(2):217-21.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Phenotypic variability in patients with retinal dystrophies due to mutations in CRB1.	Henderson RH, etal., Br J Ophthalmol. 2011 Jun;95(6):811-7. doi: 10.1136/bjo.2010.186882. Epub 2010 Oct 17.
5.	Childhood cone-rod dystrophy with macular cystic degeneration from recessive CRB1 mutation.	Khan AO, etal., Ophthalmic Genet. 2014 Sep;35(3):130-7. doi: 10.3109/13816810.2013.804097. Epub 2013 Jun 14.
6.	Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.	Low BE, etal., Invest Ophthalmol Vis Sci. 2014 Jan 20;55(1):387-95. doi: 10.1167/iovs.13-13278.
7.	Pigmented paravenous chorioretinal atrophy is associated with a mutation within the crumbs homolog 1 (CRB1) gene.	McKay GJ, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):322-8.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.	Pellissier LP, etal., PLoS Genet. 2013 Dec;9(12):e1003976. doi: 10.1371/journal.pgen.1003976. Epub 2013 Dec 5.
11.	Evaluating Potential Therapies in a Mouse Model of Focal Retinal Degeneration with Age-related Macular Degeneration (AMD)-Like Lesions.	Popp N, etal., J Clin Exp Ophthalmol. 2013 Oct 1;4(5):1000296.
12.	GOA pipeline	RGD automated data pipeline
13.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Comprehensive gene review and curation	RGD comprehensive gene curation
16.	A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1.	van de Pavert SA, etal., J Neurosci. 2007 Jan 17;27(3):564-73.
17.	Novel mutations of CRB1 in Chinese families presenting with retinal dystrophies.	Yang L, etal., Mol Vis. 2014 Mar 26;20:359-67. eCollection 2014.
18.	A new CRB1 rat mutation links Müller glial cells to retinal telangiectasia.	Zhao M, etal., J Neurosci. 2015 Apr 15;35(15):6093-106. doi: 10.1523/JNEUROSCI.3412-14.2015.

Additional References at PubMed

PMID:12915475	PMID:15316081	PMID:15914641	PMID:16885194	PMID:21052544	PMID:22447858	PMID:25147295	PMID:25636444	PMID:33808129

Genomics

Comparative Map Data

Crb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	53,352,932 - 53,540,019 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	53,352,932 - 53,540,019 (-)	Ensembl				GRCr8
mRatBN7.2	13	50,801,484 - 50,989,261 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	50,800,959 - 50,989,261 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	53,408,027 - 53,587,968 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	54,695,960 - 54,875,896 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	51,963,725 - 52,151,483 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	56,270,519 - 56,462,893 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	56,270,781 - 56,462,834 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	61,292,273 - 61,369,526 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	13	61,413,282 - 61,480,872 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	52,558,317 - 52,725,099 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	51,073,846 - 51,253,703 (-)	NCBI		Celera
RGSC_v3.1	13	52,572,656 - 52,715,591 (-)	NCBI
Cytogenetic Map	13	q13	NCBI

CRB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	197,201,504 - 197,478,455 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	197,268,204 - 197,478,455 (+)	Ensembl			hg38	GRCh38
GRCh37	1	197,170,634 - 197,447,585 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	195,504,031 - 195,714,208 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	193,969,064 - 194,179,241	NCBI
Celera	1	170,362,823 - 170,573,037 (+)	NCBI		Celera
Cytogenetic Map	1	q31.3	NCBI
HuRef	1	168,328,124 - 168,606,472 (+)	NCBI		HuRef
CHM1_1	1	198,593,055 - 198,870,040 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	196,463,303 - 196,740,260 (+)	NCBI		T2T-CHM13v2.0

Crb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	139,101,288 - 139,307,262 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	139,124,794 - 139,304,838 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	139,176,649 - 139,379,316 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	139,197,056 - 139,377,100 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	141,094,831 - 141,273,653 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	141,014,754 - 141,193,452 (-)	NCBI		MGSCv36	mm8
Celera	1	141,833,551 - 142,013,612 (-)	NCBI		Celera
Cytogenetic Map	1	E4- F	NCBI
cM Map	1	60.87	NCBI

Crb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	33,817,605 - 34,005,943 (+)	Ensembl
ChiLan1.0	NW_004955406	33,817,754 - 34,005,937 (+)	NCBI	ChiLan1.0	ChiLan1.0

CRB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	51,895,729 - 52,177,256 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	51,867,477 - 52,146,450 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	172,794,523 - 173,076,045 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	177,174,431 - 177,389,289 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	177,174,431 - 177,422,867 (+)	Ensembl			panPan2	panpan1.1

CRB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	5,277,394 - 5,490,542 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	5,277,394 - 5,490,470 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	4,896,806 - 5,113,389 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	4,967,450 - 5,180,345 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	4,967,446 - 5,180,191 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	4,909,374 - 5,120,084 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	5,009,956 - 5,223,118 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	5,042,374 - 5,255,595 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Crb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	77,112,995 - 77,325,150 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	6,366,489 - 6,559,766 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936567	6,347,661 - 6,559,731 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	20,137,451 - 20,332,414 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	20,137,246 - 20,332,539 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	24,720,738 - 24,900,728 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	31,710,712 - 32,143,121 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	31,906,803 - 32,088,995 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	32,840,856 - 33,051,363 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624798	2,861,520 - 2,999,697 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624798	2,861,481 - 2,999,387 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Crb1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	19,564,407 - 19,737,873 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Crb1
2343 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	214
Count of miRNA genes:	163
Interacting mature miRNAs:	182
Transcripts:	ENSRNOT00000032122
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

D13Got230

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	50,880,586 - 50,880,742 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	56,349,844 - 56,349,999	NCBI	Rnor6.0
Rnor_5.0	13	61,371,158 - 61,371,313	UniSTS	Rnor5.0
RGSC_v3.4	13	52,637,499 - 52,637,654	UniSTS	RGSC3.4
Celera	13	51,152,836 - 51,152,983	UniSTS
Cytogenetic Map	13	q13	UniSTS

AB072758

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	50,935,075 - 50,935,204 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	56,408,146 - 56,408,274	NCBI	Rnor6.0
Rnor_5.0	13	61,426,184 - 61,426,312	UniSTS	Rnor5.0
Celera	13	51,201,544 - 51,201,672	UniSTS
Cytogenetic Map	13	q13	UniSTS

RH133772

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	50,836,641 - 50,836,840 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	56,305,855 - 56,306,053	NCBI	Rnor6.0
Rnor_5.0	13	61,327,347 - 61,327,545	UniSTS	Rnor5.0
RGSC_v3.4	13	52,593,564 - 52,593,762	UniSTS	RGSC3.4
Celera	13	51,108,919 - 51,109,117	UniSTS
Cytogenetic Map	13	q13	UniSTS

Genetic Models

This gene Crb1 is modified in the following models/strains:

BN-Crb1^m1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	11	32	141	46	42	17	58	17	6	238	120	8	116	80	87	25	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000032122 ⟹ ENSRNOP00000037018

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	53,352,932 - 53,540,019 (-)	Ensembl
mRatBN7.2 Ensembl	13	50,801,484 - 50,989,261 (-)	Ensembl
Rnor_6.0 Ensembl	13	56,270,781 - 56,462,834 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097209 ⟹ ENSRNOP00000078309

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	53,387,764 - 53,540,019 (-)	Ensembl
mRatBN7.2 Ensembl	13	50,800,959 - 50,989,261 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110674 ⟹ ENSRNOP00000096962

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	53,406,817 - 53,540,019 (-)	Ensembl
mRatBN7.2 Ensembl	13	50,855,374 - 50,989,261 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114575 ⟹ ENSRNOP00000086071

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	53,389,797 - 53,540,019 (-)	Ensembl
mRatBN7.2 Ensembl	13	50,838,338 - 50,989,261 (-)	Ensembl

RefSeq Acc Id:

NM_001107182 ⟹ NP_001100652

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	53,352,932 - 53,540,019 (-)	NCBI
mRatBN7.2	13	50,801,484 - 50,989,261 (-)	NCBI
Rnor_6.0	13	56,270,781 - 56,462,834 (-)	NCBI
Rnor_5.0	13	61,292,273 - 61,369,526 (-)	NCBI
Rnor_5.0	13	61,413,282 - 61,480,872 (-)	NCBI
RGSC_v3.4	13	52,558,317 - 52,725,099 (-)	RGD
Celera	13	51,073,846 - 51,253,703 (-)	RGD

Sequence:

show sequence

CATGGAGGGTGGGACAGAGATGGCATCCCGGCTCTCTGAAGCACCTGCTCCTCTCTGAGCCACA
CACAGTCAGGAGCCATCCAGGGATAGCTTCATCAACATTTCAGAGAGTGTTGAACATGAACATG
AAGCTCAAGAAAACTGCCTACCTTCTCGCCCTCTACCTCAGTTCCTCACTGCTCATCTGCGTAA
AGAATTCATTTTGCAACAAAAACAATACCAGGTGTCTCTCAAACTCTTGCCAAAACAATTCTAC
GTGCAAGCGTTTCCCACAAGACAGCAGTTGTTGCTTAGACACAGCCAATGATTTGGACACAGAC
TGTGAAGATCTGAAAGACCCCTGCTTGTCCAGTCCCTGCCAAGGAACCGCCACTTGTGTGAATA
TCCCAGGGGAAAGGAGCTTCCTGTGCCAATGTCCTCCCGGGTACAGTGGGCTAACCTGTGACAC
TGCCACCAATTCCTGTGGAGGGAATTTGTGCCAACATGGAGGCACCTGCCATAAAGACCCTGAG
CATCCTGTCTGTATCTGCCCTCCTGGGTATGCTGGAAGGTTCTGTGAGACAGATCACAATGAGT
GTGATTCTAGCCCTTGCCACAATGGGGCTGTGTGCCAAGACAGAATCAACGGCTACTCCTGCTT
CTGTGTGCCTGGATACCAAGGCAGGCATTGTGACTTGGAAGTGGATGAATGTGTTTCTGATCCC
TGCATGAATGAGGCTGTGTGCCTCAACGAGATAGGAAGGTACACTTGTGTCTGTCCTCAAGAGT
ACTCTGGCGTGAACTGCGAGTTGGAGATTGATGAATGCGGATCCCAGCCATGTCTACATGGTGC
CACGTGTCGGGACGCCCTTGGGGGCTACTTCTGCGACTGTGCACCTGGATTCCTTGGAGACCAC
TGTGAACTCAACTTTAATGAATGTGAAAGTCAGCCGTGTCTCCATGGAGGTCTATGCGTAGATG
GAAGAAACAGTTACCACTGTGACTGCACGGGTAGTGGATTCAGAGGGATCCACTGTGAGTCCTT
GATTCCTCTTTGTTGGTCAAAGCCTTGTCACAATGATGCGACATGTGAAGACACTGTTGACAGC
TATATTTGTCACTGCTGGCCTGGATACACAGGTGCTCTGTGTGAGACGGACATAAATGAATGCA
GTAGCAACCCCTGCCAATTTGGGGGGGAATGTGCCGAGCTGTCCTCACAGGATCTATATGGAAA
CACCGCTGGCCTGCCTTCCTCCTTCAGCTACCTTGGAGCCTCGGGCTATGTTTGTATCTGTCTG
CCTGGATTCACAGGGAGGCACTGTGAAGAAGACATTGATGAATGTTTACCAAACCCCTGCCTAA
ATGGTGGTACTTGTCAGAACTTGCCTGGGAATTATACCTGTCACTGCCCCTTTGATGATACTTC
TAGGACATTTTATGGAGGAGAAGACTGCTCTGAAATTCTCCTGGGTTGCACTCATCACCAGTGT
CTGAACAATGGAAAATGTATCCCTCACTTCCAAAACGGCCAGCACGAATTCACCTGCCAGTGTC
CTTCTGGCTACGCCGGTCCACTGTGTGAAACTGTCACCACACTTTCTTTTGAGAGCAATGGCTT
CCTGTGGGTCACCAGTGGCTCCCATACAAGCATGGGGTCAGAATGTAACATATCCTTGAAGTTT
CAGACTGTTCAGCCAAATGCACTTCTCCTTGTACGAGGCAACAAGGATATGTCTGTGAAGCTGG
AGTTGCTGGACGGCTGTGTTCACTTATCAATCGAAGTCTGGAATCAGTCAAAGGTGCTCTTGTA
TATTTCCCATAACACCAGTGATGGAGAATGGCATTTGGTGGAAGTAACATTCGCAGAAACTATA
ACCCTTGCCCTGAATGGCAGCTCCTGCAAGGAGAAATGCACCACTAAGTCTTCTGTTTCCATTG
AGAATCATCAATCAATATGTGCTTTGCAGAACTCTTTTTTGGGTGGCTTACCAATGGGGACAGC
TAGCGACAGCATGTCTGTTCTTAACATCTATAATGTGCCGTCCACACCTTCCTTTGTAGGTTGT
CTCCAAGATATTAGATTTGATTTGAATCACATTACTCTGGAGAGCATTTCATCTGGCTTGTCAT
CAAATGTCAAAGCAGGCTGCCTGAGAAAGGACTGGTGTGAAAGTCAACCCTGTCAAAACAGAGG
ACGCTGCATCAACTTGTGGCAGGGTTATCGGTGTGAATGTGACAGGCCCTATGCAGGCTCCAAC
TGCCTGAAAGAGTATGTAGCGGGAAGATTTGGCCAGGATGACTCCACCGGATATGCTGCCTTTA
AAGTTAATGATAATTTTGGACAGAACTTCAATCTCTCCATGTTTGTCCGAACACGTCAACCCCT
GGGCTTCCTTCTGACGTTAGGAAACAGTACTTACCAGTATGTCTGTGTCTGGCTAGAGCATGGC
AGTCTAGCACTGAAGACTCCGGGCTCTCCCAAGTTAGTAGCAAATTTTTTTCTCAGTGATGGAA
ATGCCCACTTAATATCTTTGAGAATCAAACCAAATGAAATTGAACTGTATCAGTCTTCACAAAA
CCTAGGCTTCATGTCTGTTCCTGCATGGACAATTCAAAGAGGAGATGTCATCTTCATTGGTGGT
CTACCTGACAGAGAGAAGACTGAAGCTTATGGTGGCTTCCTCAAAGGCTGTATTCAAGATGTAA
GATTAAACAGCCAGAATCTGGAATTCTTTCCCAATTCAACAAACAGTGCACAGCATGATCCAGT
TCTTGTCAATGTGACTCAAGGCTGCCCTGGAGACAACGTCTGTAAGTCCAACCCCTGCCATAAT
GGAGGTGTCTGCCACTCCCTGTGGGATGACTTCTCCTGCTCCTGCCCTACAAACACTTCGGGGA
GAGCCTGCGACGAAGTTCAGTGGTGTCAGCTCAGCCCATGTCCTCCCATTGCAGAATGCCAGCT
GGTCCCTCAAGGGTTTGAATGTATCGCCAATGCTGCTTTCAGCGGATTAAGCAGCGAAATATTG
TTCAGAAGCAATGGGAATATTACCAGAGAACTCACCAACATCACATTTGGTTTCAGAACACAGG
ATACAAATGCGGTGATACTGCATGCAGAAAAAGAACCAGAGTTTCTCAATATTAGCATTCAAGA
CTCCAGACTACTCTTTCAACTGCGAAGTGGCAACAGCTTTTATACGCTGCATCTGACGGGTTCC
CAATTGGTGAATGACGGCGCATGGCACCGAGTGACTTTTTCCATGATAGACCCACGGGCCCAGA
CCTCCCTGTGGCAGATGGAGGTGGACGACCAGACACCCTTTGTGATAAGTGCAGTTGCTACTGG
AAACCTGAACTTTCTGAAGGACAATACTGACATCTATGTGGGTGACCAAGCTGTTGACAATCAG
AAAGGCCTGCAGGGCTGTCTGAGCACAGTACAGATAGGAGGGCTATATCTCTCTTACTTTGAAA
GTCTTCATGGTTTCACTAGTAAGCCCCAAGAAGAGCAGTTTCTCAAAGTTTCTACAAATGTGGC
ACTTACTGGCTGTTTGCCACTCAGTGCCTGCCACTCTAGCCCCTGTCTGCATGGAGGAATTTGC
GAAGACAGCTACAGCTCTTATCGGTGTGCCTGTCTCCCGGGATGGTCGGGGGCACACTGCGAAA
TCAACGTTGATGAGTGCTCCTCCAGCCCCTGTGTCCATGGCAACTGCTCGGACGGGGTTGCAGC
CTACCACTGCAGGTGTGAGCCTGGCTATACTGGTGGGAACTGTGAAGCGGAGGTAGACACTTGC
AAGAGTCATCAGTGTGCCAATGGGGCCACCTGCGTCAGTGGCGCTCAGGGCTACTCTTGCCTCT
GTCTTGGAAATTTTACCGGCAGATTTTGCAGACACAGCAGATTACCCTCAACAGTCTGTGGGAA
CGAGAAGACAAACTTCACTTGCTACAACGGAGGCAGCTGCTCCGTGTTCCAGGAGGACTGGAAA
TGTGTGTGCCGGCCAGGTTTCACTGGAGAGTGGTGTGAAGAGAACATCAATGAATGTGCCTCTG
ACCCCTGCATCAACGGAGGCCTGTGCAGGGACTTGGTCAACAGATTCCAGTGCATCTGTGATGT
GGCCTTTGCGGGCGAGCGCTGTGAGCTGGATTTGGCTGATGACAGGCTCGTGGGCATTATCACC
GCCGTGGGCTCCGGAACGTTGGTCCTGTTATTCATCCTCTTGCTTGCTGCAATTGTTTCTCTTA
TCGCTTCCAACAAGAGGGCGACTCAAGGAACCTACAGCCCCAGTGGTCAGGAGAAGGCCGGCCC
TCGAGTGGAAATGTGGAGCAGGATGCCGCCCCCAGCACTGGAAAGGCTCATCTAGGAAGCCCCC
TGCTCCTCTCAGAACAGAGCAGAGCATGTTGAGTACCCTGGTCATGCCGGACCGAAGGTGGTTT
TACATCAGTAGAGATACTTACTGGAACTGTCGGAAGGGTTTCCATAGATACCTCATAGACCTTC
CTGAGGGTTCGCCTTACATGACTGTTTAGTTATGTCATCCATTCACAGAAGAGTGTCCCTGTGT
CATGTCTGTCAGCCTCAGAATTAGCAAACCATCTTCCAGACAGAGAACACAGTATTTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100652	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM09625	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000037018
	ENSRNOP00000037018.5
	ENSRNOP00000078309.2
	ENSRNOP00000086071.1
	ENSRNOP00000096962.1

RefSeq Acc Id:	NP_001100652 ⟸ NM_001107182
- Peptide Label:	precursor
- UniProtKB:	D3ZZL8 (UniProtKB/TrEMBL), A6ICM2 (UniProtKB/TrEMBL), A0A8I5ZKN7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNMKLKKTAYLLALYLSSSLLICVKNSFCNKNNTRCLSNSCQNNSTCKRFPQDSSCCLDTANDL DTDCEDLKDPCLSSPCQGTATCVNIPGERSFLCQCPPGYSGLTCDTATNSCGGNLCQHGGTCHK DPEHPVCICPPGYAGRFCETDHNECDSSPCHNGAVCQDRINGYSCFCVPGYQGRHCDLEVDECV SDPCMNEAVCLNEIGRYTCVCPQEYSGVNCELEIDECGSQPCLHGATCRDALGGYFCDCAPGFL GDHCELNFNECESQPCLHGGLCVDGRNSYHCDCTGSGFRGIHCESLIPLCWSKPCHNDATCEDT VDSYICHCWPGYTGALCETDINECSSNPCQFGGECAELSSQDLYGNTAGLPSSFSYLGASGYVC ICLPGFTGRHCEEDIDECLPNPCLNGGTCQNLPGNYTCHCPFDDTSRTFYGGEDCSEILLGCTH HQCLNNGKCIPHFQNGQHEFTCQCPSGYAGPLCETVTTLSFESNGFLWVTSGSHTSMGSECNIS LKFQTVQPNALLLVRGNKDMSVKLELLDGCVHLSIEVWNQSKVLLYISHNTSDGEWHLVEVTFA ETITLALNGSSCKEKCTTKSSVSIENHQSICALQNSFLGGLPMGTASDSMSVLNIYNVPSTPSF VGCLQDIRFDLNHITLESISSGLSSNVKAGCLRKDWCESQPCQNRGRCINLWQGYRCECDRPYA GSNCLKEYVAGRFGQDDSTGYAAFKVNDNFGQNFNLSMFVRTRQPLGFLLTLGNSTYQYVCVWL EHGSLALKTPGSPKLVANFFLSDGNAHLISLRIKPNEIELYQSSQNLGFMSVPAWTIQRGDVIF IGGLPDREKTEAYGGFLKGCIQDVRLNSQNLEFFPNSTNSAQHDPVLVNVTQGCPGDNVCKSNP CHNGGVCHSLWDDFSCSCPTNTSGRACDEVQWCQLSPCPPIAECQLVPQGFECIANAAFSGLSS EILFRSNGNITRELTNITFGFRTQDTNAVILHAEKEPEFLNISIQDSRLLFQLRSGNSFYTLHL TGSQLVNDGAWHRVTFSMIDPRAQTSLWQMEVDDQTPFVISAVATGNLNFLKDNTDIYVGDQAV DNQKGLQGCLSTVQIGGLYLSYFESLHGFTSKPQEEQFLKVSTNVALTGCLPLSACHSSPCLHG GICEDSYSSYRCACLPGWSGAHCEINVDECSSSPCVHGNCSDGVAAYHCRCEPGYTGGNCEAEV DTCKSHQCANGATCVSGAQGYSCLCLGNFTGRFCRHSRLPSTVCGNEKTNFTCYNGGSCSVFQE DWKCVCRPGFTGEWCEENINECASDPCINGGLCRDLVNRFQCICDVAFAGERCELDLADDRLVG IITAVGSGTLVLLFILLLAAIVSLIASNKRATQGTYSPSGQEKAGPRVEMWSRMPPPALERLI hide sequence

Ensembl Acc Id:

ENSRNOP00000037018 ⟸ ENSRNOT00000032122

Ensembl Acc Id:

ENSRNOP00000078309 ⟸ ENSRNOT00000097209

Ensembl Acc Id:

ENSRNOP00000096962 ⟸ ENSRNOT00000110674

Ensembl Acc Id:

ENSRNOP00000086071 ⟸ ENSRNOT00000114575

Protein Domains

EGF-like Laminin G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZZL8-F1-model_v2	AlphaFold	D3ZZL8	1-1407	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309947	AgrOrtholog
BioCyc Gene	G2FUF-18077	BioCyc
Ensembl Genes	ENSRNOG00000010903	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000032122	ENTREZGENE
	ENSRNOT00000032122.7	UniProtKB/TrEMBL
	ENSRNOT00000097209.2	UniProtKB/TrEMBL
	ENSRNOT00000110674.2	UniProtKB/TrEMBL
	ENSRNOT00000114575.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	ConA-like_subgrp	UniProtKB/TrEMBL
	EG-like_dom	UniProtKB/TrEMBL
	EGF-like_Ca-bd	UniProtKB/TrEMBL
	EGF-like_CS	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Growth_fac_rcpt_N_dom	UniProtKB/TrEMBL
	Laminin_G	UniProtKB/TrEMBL
KEGG Report	rno:304825	UniProtKB/TrEMBL
NCBI Gene	304825	ENTREZGENE
PANTHER	CRUMBS 1, CELL POLARITY COMPLEX COMPONENT	UniProtKB/TrEMBL
	CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2	UniProtKB/TrEMBL
	UNINFLATABLE, ISOFORM C	UniProtKB/TrEMBL
Pfam	EGF	UniProtKB/TrEMBL
	hEGF	UniProtKB/TrEMBL
	Laminin_G_2	UniProtKB/TrEMBL
PhenoGen	Crb1	PhenoGen
PRINTS	EGFBLOOD	UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LAM_G_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010903	RatGTEx
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LamG	UniProtKB/TrEMBL
Superfamily-SCOP	ConA_like_lec_gl	UniProtKB/TrEMBL
	EGF/Laminin	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	A0A8I5ZKN7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A4M0_RAT	UniProtKB/TrEMBL
	A0A8I6AQJ2_RAT	UniProtKB/TrEMBL
	A6ICM2	ENTREZGENE, UniProtKB/TrEMBL
	D3ZZL8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Crb1	crumbs 1, cell polarity complex component	Crb1	crumbs family member 1, photoreceptor morphogenesis associated	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-02-13	Crb1	crumbs family member 1, photoreceptor morphogenesis associated	Crb1	crumbs homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Crb1	crumbs homolog 1 (Drosophila)	Crb1_predicted	crumbs homolog 1 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Crb1_predicted	crumbs homolog 1 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype