Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Arfgef3 | Rat | (+)-catechin | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ARFGEF3 mRNA | CTD | PMID:24763279 | Arfgef3 | Rat | 1,1-dichloroethene | decreases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of ARFGEF3 mRNA | CTD | PMID:26682919 | Arfgef3 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of ARFGEF3 mRNA | CTD | PMID:22206623 | Arfgef3 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of ARFGEF3 mRNA | CTD | PMID:29097150 | Arfgef3 | Rat | 17beta-estradiol | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of ARFGEF3 mRNA | CTD | PMID:30165855 | Arfgef3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ARFGEF3 mRNA | CTD | PMID:22298810 | Arfgef3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ARFGEF3 mRNA | CTD | PMID:33387578 | Arfgef3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ARFGEF3 mRNA | CTD | PMID:19465110 | Arfgef3 | Rat | 2-palmitoylglycerol | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of ARFGEF3 mRNA | CTD | PMID:37199045 | Arfgef3 | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | ARFGEF3 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of ARFGEF3 gene | CTD | PMID:31601247 | Arfgef3 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of ARFGEF3 mRNA | CTD | PMID:24780913 | Arfgef3 | Rat | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of ARFGEF3 mRNA | CTD | PMID:28959563 | Arfgef3 | Rat | aflatoxin B1 | decreases methylation | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ARFGEF3 intron | CTD | PMID:30157460 | Arfgef3 | Rat | all-trans-retinoic acid | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of ARFGEF3 mRNA | CTD | PMID:21934132 | Arfgef3 | Rat | aristolochic acid A | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of ARFGEF3 mRNA | CTD | PMID:33212167 | Arfgef3 | Rat | arsane | affects methylation | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ARFGEF3 gene | CTD | PMID:25304211 | Arfgef3 | Rat | arsenic atom | affects methylation | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ARFGEF3 gene | CTD | PMID:25304211 | Arfgef3 | Rat | benzo[a]pyrene | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of ARFGEF3 mRNA | CTD | PMID:21632981 | Arfgef3 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Arfgef3 (Mus musculus) | 6480464 | [Streptozocin co-treated with Diethylhexyl Phthalate] results in decreased expression of ARFGEF3 mRNA | CTD | PMID:31606821 | Arfgef3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ARFGEF3 mRNA | CTD | PMID:25181051|PMID:30816183 | Arfgef3 | Rat | bisphenol A | increases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ARFGEF3 mRNA | CTD | PMID:35598803 | Arfgef3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ARFGEF3 mRNA | CTD | PMID:29097150 | Arfgef3 | Rat | cadmium dichloride | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of ARFGEF3 mRNA | CTD | PMID:38568856 | Arfgef3 | Rat | caffeine | affects phosphorylation | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of ARFGEF3 protein | CTD | PMID:35688186 | Arfgef3 | Rat | calcitriol | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of ARFGEF3 mRNA | CTD | PMID:26485663 | Arfgef3 | Rat | carbon nanotube | increases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of ARFGEF3 mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25554681 | Arfgef3 | Rat | cefaloridine | decreases expression | EXP | | 6480464 | Cephaloridine results in decreased expression of ARFGEF3 mRNA | CTD | PMID:18500788 | Arfgef3 | Rat | chlorpyrifos | decreases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of ARFGEF3 mRNA | CTD | PMID:37019170 | Arfgef3 | Rat | cisplatin | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of ARFGEF3 mRNA | CTD | PMID:27392435 | Arfgef3 | Rat | coumestrol | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ARFGEF3 mRNA; [Coumestrol co-treated with resveratrol] more ... | CTD | PMID:19167446 | Arfgef3 | Rat | coumestrol | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of ARFGEF3 mRNA | CTD | PMID:19167446 | Arfgef3 | Rat | cyclosporin A | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of ARFGEF3 mRNA | CTD | PMID:20106945|PMID:21632981|PMID:25562108|PMID:27989131 | Arfgef3 | Rat | DDE | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of ARFGEF3 mRNA | CTD | PMID:38568856 | Arfgef3 | Rat | dorsomorphin | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Arfgef3 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of ARFGEF3 mRNA | CTD | PMID:29391264 | Arfgef3 | Rat | Enterolactone | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ARFGEF3 mRNA | CTD | PMID:19167446 | Arfgef3 | Rat | folic acid | decreases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of ARFGEF3 mRNA | CTD | PMID:25629700 | Arfgef3 | Rat | genistein | decreases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | Genistein results in decreased expression of ARFGEF3 mRNA | CTD | PMID:32186404 | Arfgef3 | Rat | mercury dichloride | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Mercuric Chloride results in decreased expression of ARFGEF3 mRNA | CTD | PMID:27188386 | Arfgef3 | Rat | nickel atom | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Nickel results in decreased expression of ARFGEF3 mRNA | CTD | PMID:24768652|PMID:25583101 | Arfgef3 | Rat | panobinostat | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | panobinostat results in decreased expression of ARFGEF3 mRNA | CTD | PMID:26272509 | Arfgef3 | Rat | panobinostat | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Arfgef3 | Rat | phenylmercury acetate | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of ARFGEF3 mRNA | CTD | PMID:26272509 | Arfgef3 | Rat | phenylmercury acetate | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Arfgef3 | Rat | poly(I:C) | multiple interactions | EXP | | 6480464 | [Poly I-C co-treated with HU 211] results in decreased expression of ARFGEF3 mRNA | CTD | PMID:26923065 | Arfgef3 | Rat | potassium chromate | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of ARFGEF3 mRNA | CTD | PMID:22714537 | Arfgef3 | Rat | potassium dichromate | increases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of ARFGEF3 mRNA | CTD | PMID:23608068 | Arfgef3 | Rat | quercetin | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Quercetin results in increased expression of ARFGEF3 mRNA | CTD | PMID:21632981 | Arfgef3 | Rat | resveratrol | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in decreased expression of ARFGEF3 mRNA | CTD | PMID:19167446 | Arfgef3 | Rat | SB 431542 | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... | CTD | PMID:27188386 | Arfgef3 | Rat | silicon dioxide | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of ARFGEF3 mRNA | CTD | PMID:25895662 | Arfgef3 | Rat | sodium arsenite | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of ARFGEF3 mRNA | CTD | PMID:38568856 | Arfgef3 | Rat | sotorasib | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ARFGEF3 mRNA | CTD | PMID:36139627 | Arfgef3 | Rat | streptozocin | increases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | Streptozocin results in increased expression of ARFGEF3 mRNA | CTD | PMID:31606821 | Arfgef3 | Rat | streptozocin | multiple interactions | ISO | Arfgef3 (Mus musculus) | 6480464 | [Streptozocin co-treated with Diethylhexyl Phthalate] results in decreased expression of ARFGEF3 mRNA | CTD | PMID:31606821 | Arfgef3 | Rat | succimer | multiple interactions | ISO | Arfgef3 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ARFGEF3 mRNA | CTD | PMID:21641980 | Arfgef3 | Rat | sulforaphane | decreases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | sulforaphane results in decreased expression of ARFGEF3 mRNA | CTD | PMID:30529165 | Arfgef3 | Rat | sunitinib | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of ARFGEF3 mRNA | CTD | PMID:31533062 | Arfgef3 | Rat | testosterone | decreases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of ARFGEF3 mRNA | CTD | PMID:33848595 | Arfgef3 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of ARFGEF3 mRNA | CTD | PMID:30723492|PMID:31150632 | Arfgef3 | Rat | thimerosal | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of ARFGEF3 mRNA | CTD | PMID:27188386 | Arfgef3 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of ARFGEF3 mRNA | CTD | PMID:34492290 | Arfgef3 | Rat | thiram | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Thiram results in increased expression of ARFGEF3 mRNA | CTD | PMID:38568856 | Arfgef3 | Rat | titanium dioxide | increases expression | ISO | Arfgef3 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of ARFGEF3 mRNA | CTD | PMID:23557971 | Arfgef3 | Rat | trametinib | multiple interactions | ISO | ARFGEF3 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ARFGEF3 mRNA | CTD | PMID:36139627 | Arfgef3 | Rat | trichostatin A | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of ARFGEF3 mRNA | CTD | PMID:24935251 | Arfgef3 | Rat | valproic acid | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ARFGEF3 mRNA | CTD | PMID:24935251 | Arfgef3 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of ARFGEF3 mRNA | CTD | PMID:29427782 | Arfgef3 | Rat | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of ARFGEF3 mRNA | CTD | PMID:29427782 | Arfgef3 | Rat | valproic acid | increases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ARFGEF3 mRNA | CTD | PMID:28001369 | Arfgef3 | Rat | vorinostat | decreases expression | ISO | ARFGEF3 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of ARFGEF3 mRNA | CTD | PMID:27188386 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















