Fli1 (Fli-1 proto-oncogene, ETS transcription factor) - Rat Genome Database

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Gene: Fli1 (Fli-1 proto-oncogene, ETS transcription factor) Rattus norvegicus
Analyze
Symbol: Fli1
Name: Fli-1 proto-oncogene, ETS transcription factor
RGD ID: 1309837
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blood circulation; megakaryocyte development; and regulation of DNA-templated transcription. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Friend leukemia integration 1; Friend leukemia integration 1 transcription factor; Friend leukemia integration 1 transcription factor-like; Friend leukemia virus integration 1; LOC100910769; LOC315532
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8839,089,526 - 39,209,511 (-)NCBIGRCr8
mRatBN7.2830,831,422 - 30,950,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,832,753 - 30,950,433 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx834,903,577 - 35,021,956 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0833,197,989 - 33,316,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0831,060,872 - 31,179,270 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0833,541,932 - 33,661,111 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,543,258 - 33,661,049 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0833,586,162 - 33,704,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,187,952 - 32,309,782 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1832,196,722 - 32,318,548 (-)NCBI
Celera832,284,160 - 32,401,673 (-)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
anagrelide  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
romidepsin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sulindac  (EXP)
tetrachloromethane  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
nuclear body  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia. Raslova H, etal., J Clin Invest. 2004 Jul;114(1):77-84.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10981960   PMID:12527908   PMID:16757682   PMID:17606295   PMID:17962413   PMID:21867929   PMID:26316623   PMID:28255014  


Genomics

Comparative Map Data
Fli1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8839,089,526 - 39,209,511 (-)NCBIGRCr8
mRatBN7.2830,831,422 - 30,950,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,832,753 - 30,950,433 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx834,903,577 - 35,021,956 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0833,197,989 - 33,316,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0831,060,872 - 31,179,270 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0833,541,932 - 33,661,111 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,543,258 - 33,661,049 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0833,586,162 - 33,704,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4832,187,952 - 32,309,782 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1832,196,722 - 32,318,548 (-)NCBI
Celera832,284,160 - 32,401,673 (-)NCBICelera
Cytogenetic Map8q21NCBI
FLI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811128,685,351 - 128,813,267 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11128,686,535 - 128,813,267 (+)EnsemblGRCh38hg38GRCh38
GRCh3711128,556,430 - 128,683,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611128,069,199 - 128,187,521 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411128,069,198 - 128,187,520NCBI
Celera11125,728,561 - 125,849,286 (+)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11124,504,750 - 124,631,960 (+)NCBIHuRef
CHM1_111128,442,436 - 128,569,169 (+)NCBICHM1_1
T2T-CHM13v2.011128,719,763 - 128,845,984 (+)NCBIT2T-CHM13v2.0
Fli1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39932,333,500 - 32,454,292 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl932,333,500 - 32,454,157 (-)EnsemblGRCm39 Ensembl
GRCm38932,422,204 - 32,543,432 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl932,422,204 - 32,542,861 (-)EnsemblGRCm38mm10GRCm38
MGSCv37932,229,793 - 32,348,953 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36932,171,773 - 32,290,933 (-)NCBIMGSCv36mm8
Celera929,685,381 - 29,804,572 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map917.74NCBI
Fli1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541229,654,459 - 29,775,903 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541229,653,621 - 29,773,412 (+)NCBIChiLan1.0ChiLan1.0
FLI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29129,376,354 - 129,494,803 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111130,484,068 - 130,602,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011123,506,859 - 123,626,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111127,409,301 - 127,527,521 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11127,409,301 - 127,530,312 (+)Ensemblpanpan1.1panPan2
FLI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.155,841,533 - 5,968,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl55,843,023 - 5,966,822 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha55,899,065 - 6,025,150 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.055,799,196 - 5,922,120 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl55,799,200 - 5,920,609 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.155,858,425 - 5,981,002 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.055,836,777 - 5,962,717 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.055,870,453 - 5,993,208 (-)NCBIUU_Cfam_GSD_1.0
Fli1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947110,872,609 - 111,001,492 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365723,448,862 - 3,577,836 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365723,448,870 - 3,576,406 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl955,612,901 - 55,749,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1955,612,905 - 55,749,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2961,707,515 - 61,810,415 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11119,817,987 - 119,945,378 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1119,827,222 - 119,946,662 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660436,144,187 - 6,261,677 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fli1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248123,004,628 - 3,139,101 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248123,004,631 - 3,138,901 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fli1
587 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:135
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000068037
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)82815732330848259Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83084815440713225Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
D8Mit5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,848,154 - 30,848,259 (+)MAPPERmRatBN7.2
Rnor_6.0833,558,660 - 33,558,764NCBIRnor6.0
Rnor_5.0833,603,024 - 33,603,128UniSTSRnor5.0
RGSC_v3.4832,203,395 - 32,203,499UniSTSRGSC3.4
RGSC_v3.4832,203,394 - 32,203,499RGDRGSC3.4
RGSC_v3.1832,212,161 - 32,212,265RGD
Celera832,299,483 - 32,299,583UniSTS
RH 3.4 Map8248.5UniSTS
RH 3.4 Map8248.5RGD
RH 2.0 Map8167.4RGD
Cytogenetic Map8q21UniSTS
X59421  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,832,828 - 30,832,928 (+)MAPPERmRatBN7.2
Rnor_6.0833,543,334 - 33,543,433NCBIRnor6.0
Rnor_5.0833,587,564 - 33,587,663UniSTSRnor5.0
RGSC_v3.4832,188,069 - 32,188,168UniSTSRGSC3.4
Celera832,284,277 - 32,284,376UniSTS
Cytogenetic Map8q21UniSTS
RH138660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,892,174 - 30,892,407 (+)MAPPERmRatBN7.2
Rnor_6.0833,602,734 - 33,602,966NCBIRnor6.0
Rnor_5.0833,644,880 - 33,645,112UniSTSRnor5.0
RGSC_v3.4832,250,922 - 32,251,154UniSTSRGSC3.4
Celera832,343,459 - 32,343,691UniSTS
RH 3.4 Map8253.2UniSTS
Cytogenetic Map8q21UniSTS
Fli1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,832,911 - 30,833,057 (+)MAPPERmRatBN7.2
Rnor_6.0833,543,417 - 33,543,562NCBIRnor6.0
Rnor_5.0833,587,647 - 33,587,792UniSTSRnor5.0
RGSC_v3.4832,188,152 - 32,188,297UniSTSRGSC3.4
Celera832,284,360 - 32,284,505UniSTS
Cytogenetic Map8q21UniSTS
BF386415  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,930,560 - 30,930,712 (+)MAPPERmRatBN7.2
Rnor_6.0833,641,183 - 33,641,334NCBIRnor6.0
Rnor_5.0833,683,329 - 33,683,480UniSTSRnor5.0
RGSC_v3.4832,289,916 - 32,290,067UniSTSRGSC3.4
Celera832,381,833 - 32,381,984UniSTS
RH 3.4 Map8254.2UniSTS
Cytogenetic Map8q21UniSTS
BF405592  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,930,799 - 30,931,015 (+)MAPPERmRatBN7.2
Rnor_6.0833,641,422 - 33,641,637NCBIRnor6.0
Rnor_5.0833,683,568 - 33,683,783UniSTSRnor5.0
RGSC_v3.4832,290,155 - 32,290,370UniSTSRGSC3.4
Celera832,382,072 - 32,382,287UniSTS
RH 3.4 Map8253.5UniSTS
Cytogenetic Map8q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000068037   ⟹   ENSRNOP00000059605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,832,753 - 30,950,433 (-)Ensembl
Rnor_6.0 Ensembl833,543,258 - 33,661,049 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098203   ⟹   ENSRNOP00000085961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,832,753 - 30,950,433 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118943   ⟹   ENSRNOP00000097598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,832,950 - 30,887,253 (-)Ensembl
RefSeq Acc Id: NM_001017381   ⟹   NP_001017381
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,089,533 - 39,208,557 (-)NCBI
mRatBN7.2830,831,429 - 30,950,468 (-)NCBI
Rnor_6.0833,543,217 - 33,661,049 (-)NCBI
Rnor_5.0833,586,162 - 33,704,455 (-)NCBI
RGSC_v3.4832,187,952 - 32,309,782 (-)RGD
Celera832,284,160 - 32,401,673 (-)RGD
Sequence:
RefSeq Acc Id: XM_063265407   ⟹   XP_063121477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,089,526 - 39,209,414 (-)NCBI
RefSeq Acc Id: XM_063265408   ⟹   XP_063121478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,089,526 - 39,186,629 (-)NCBI
RefSeq Acc Id: XM_063265409   ⟹   XP_063121479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,089,526 - 39,209,511 (-)NCBI
RefSeq Acc Id: NP_001017381   ⟸   NM_001017381
- UniProtKB: Q4Z8P1 (UniProtKB/TrEMBL),   F7FFL9 (UniProtKB/TrEMBL),   A0A8I6ASZ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059605   ⟸   ENSRNOT00000068037
Ensembl Acc Id: ENSRNOP00000097598   ⟸   ENSRNOT00000118943
Ensembl Acc Id: ENSRNOP00000085961   ⟸   ENSRNOT00000098203
RefSeq Acc Id: XP_063121479   ⟸   XM_063265409
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121477   ⟸   XM_063265407
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121478   ⟸   XM_063265408
- Peptide Label: isoform X2
Protein Domains
ETS   PNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4Z8P1-F1-model_v2 AlphaFold Q4Z8P1 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695832
Promoter ID:EPDNEW_R6356
Type:multiple initiation site
Name:Fli1_1
Description:Fli-1 proto-oncogene, ETS transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0833,660,974 - 33,661,034EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309837 AgrOrtholog
BioCyc Gene G2FUF-31234 BioCyc
Ensembl Genes ENSRNOG00000008904 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068037.2 UniProtKB/TrEMBL
  ENSRNOT00000098203.1 UniProtKB/TrEMBL
  ENSRNOT00000118943.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.150.50 UniProtKB/TrEMBL
InterPro Ets UniProtKB/TrEMBL
  ETS_fam UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
  SAM_PNT-FLI-1 UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:315532 UniProtKB/TrEMBL
NCBI Gene 315532 ENTREZGENE
PANTHER PTHR11849 UniProtKB/TrEMBL
  PTHR11849:SF161 UniProtKB/TrEMBL
Pfam Ets UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
PhenoGen Fli1 PhenoGen
PRINTS ETSDOMAIN UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_1 UniProtKB/TrEMBL
  ETS_DOMAIN_2 UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/TrEMBL
  PNT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008904 RatGTEx
SMART ETS UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
Superfamily-SCOP SAM_homology UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A8I6A3J9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASZ2 ENTREZGENE, UniProtKB/TrEMBL
  F7FFL9 ENTREZGENE, UniProtKB/TrEMBL
  Q4Z8P1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Fli1  Fli-1 proto-oncogene, ETS transcription factor  LOC100910769  Friend leukemia integration 1 transcription factor-like  Data merged from RGD:6496556 737654 PROVISIONAL
2013-08-14 Fli1  Fli-1 proto-oncogene, ETS transcription factor  Fli1  Friend leukemia virus integration 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910769  Friend leukemia integration 1 transcription factor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-24 Fli1  Friend leukemia virus integration 1  Fli1  Friend leukemia integration 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Fli1  Friend leukemia integration 1  Fli1_predicted  Friend leukemia integration 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fli1_predicted  Friend leukemia integration 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED