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Gene: Serpinb8 (serpin family B member 8) Rattus norvegicus

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Symbol:

Serpinb8

Name:

serpin family B member 8

RGD ID:

1309833

Description:

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in peeling skin syndrome 5. Orthologous to human SERPINB8 (serpin family B member 8); INTERACTS WITH (+)-schisandrin B; 3-chloropropane-1,2-diol; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC288937; serine (or cysteine) peptdiase inhibitor, clade B, member 8; serine (or cysteine) peptidase inhibitor, clade B, member 8; serine (or cysteine) proteinase inhibitor, clade B, member 8; serpin B8; serpin peptidase inhibitor, clade B (ovalbumin), member 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SERPINB8 (serpin family B member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Serpinb8 (serine (or cysteine) peptidase inhibitor, clade B, member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Serpinb8 (serpin family B member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SERPINB8 (serpin family B member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SERPINB8 (serpin family B member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Serpinb8 (serpin family B member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SERPINB8 (serpin family B member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SERPINB8 (serpin family B member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SERPINB9 (serpin family B member 9)	HGNC	OrthoDB
Homo sapiens (human):	SERPINB6 (serpin family B member 6)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	SERPINB8 (serpin family B member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Serpinb8 (serine (or cysteine) peptidase inhibitor, clade B, member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	serpinb1l1 (serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	serpinb1l1 (serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 1)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	serpinb1l4 (serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	zgc:173729	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	zgc:173729	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	serpinb1l3 (serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	serpinb14 (serpin peptidase inhibitor, clade B (ovalbumin), member 14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	serpinb14 (serpin peptidase inhibitor, clade B (ovalbumin), member 14)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	srp-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn28Da	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Spn28Dc	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn55B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn55B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn77Ba	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn77Bc	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Spn77Bb	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	serpinb6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	serpinb6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	24,141,557 - 24,164,894 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	24,129,855 - 24,166,076 (+)	Ensembl				GRCr8
mRatBN7.2	13	23,626,936 - 23,650,277 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	23,626,945 - 23,650,835 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	24,003,700 - 24,026,951 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	25,288,158 - 25,311,407 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,973,889 - 23,997,138 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	13	23,878,168 - 23,901,632 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	13	23,877,576 - 23,901,040 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	13	23,891,475 - 23,914,939 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	13	23,797,997 - 23,821,461 (+)	NCBI		F344_StmMcwi
Rnor_6.0	13	27,876,662 - 27,914,038 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	27,889,345 - 27,914,006 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	33,035,661 - 33,058,982 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	13,718,139 - 13,741,460 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	23,473,106 - 23,496,452 (+)	NCBI		Celera
RGSC_v3.1	13	13,689,411 - 13,714,475 (+)	NCBI
Cytogenetic Map	13	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

peeling skin syndrome (ISO)

peeling skin syndrome 5 (ISO)

psoriasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-demecolcine (ISO)

1-nitropyrene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

4-nitrophenol (ISO)

9-cis-retinoic acid (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dimethylarsinic acid (EXP)

dinophysistoxin 1 (ISO)

dioxygen (ISO)

diquat (ISO)

doxorubicin (ISO)

drometrizole (ISO)

endosulfan (EXP,ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

gentamycin (EXP)

iron atom (ISO)

iron(0) (ISO)

isotretinoin (ISO)

ivermectin (ISO)

Licochalcone B (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N-Nitrosopyrrolidine (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rifampicin (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

succimer (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trametinib (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

epithelial cell-cell adhesion (ISO)

negative regulation of endopeptidase activity (ISO)

Cellular Component

cytosol (ISO)

extracellular space (IEA)

Molecular Function

peptidase inhibitor activity (IEA)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:8530382	PMID:23533145	PMID:27476651

Genomics

Comparative Map Data

Serpinb8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	24,141,557 - 24,164,894 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	24,129,855 - 24,166,076 (+)	Ensembl				GRCr8
mRatBN7.2	13	23,626,936 - 23,650,277 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	23,626,945 - 23,650,835 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	24,003,700 - 24,026,951 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	25,288,158 - 25,311,407 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,973,889 - 23,997,138 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	13	23,878,168 - 23,901,632 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	13	23,877,576 - 23,901,040 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	13	23,891,475 - 23,914,939 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	13	23,797,997 - 23,821,461 (+)	NCBI		F344_StmMcwi
Rnor_6.0	13	27,876,662 - 27,914,038 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	27,889,345 - 27,914,006 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	33,035,661 - 33,058,982 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	13,718,139 - 13,741,460 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	23,473,106 - 23,496,452 (+)	NCBI		Celera
RGSC_v3.1	13	13,689,411 - 13,714,475 (+)	NCBI
Cytogenetic Map	13	p11	NCBI

SERPINB8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	63,970,081 - 64,019,779 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	63,970,029 - 64,019,779 (+)	Ensembl			hg38	GRCh38
GRCh37	18	61,637,315 - 61,687,013 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	59,788,243 - 59,807,588 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	59,788,242 - 59,807,587	NCBI
Celera	18	58,357,699 - 58,377,053 (+)	NCBI		Celera
Cytogenetic Map	18	q22.1	NCBI
HuRef	18	58,338,377 - 58,357,732 (+)	NCBI		HuRef
CHM1_1	18	61,633,434 - 61,652,779 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	64,175,116 - 64,224,810 (+)	NCBI		T2T-CHM13v2.0

Serpinb8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	107,517,668 - 107,536,708 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	107,517,736 - 107,538,214 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	107,589,926 - 107,608,978 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	107,590,006 - 107,610,484 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	109,486,583 - 109,505,555 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	109,417,618 - 109,436,456 (+)	NCBI		MGSCv36	mm8
Celera	1	110,430,564 - 110,449,516 (+)	NCBI		Celera
Cytogenetic Map	1	E2.1	NCBI
cM Map	1	50.34	NCBI

Serpinb8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	47,763,322 - 47,781,523 (+)	Ensembl
ChiLan1.0	NW_004955402	47,761,900 - 47,781,281 (+)	NCBI	ChiLan1.0	ChiLan1.0

SERPINB8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	81,454,672 - 81,494,845 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	67,167,662 - 67,484,657 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	57,313,562 - 57,373,502 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	60,634,212 - 60,684,096 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	60,634,206 - 60,669,118 (+)	Ensembl			panPan2	panpan1.1

SERPINB8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	13,213,506 - 13,223,489 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	13,200,602 - 13,222,943 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	14,174,267 - 14,187,709 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	13,068,163 - 13,082,065 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	13,068,049 - 13,082,039 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	13,107,196 - 13,120,647 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	13,036,467 - 13,049,898 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	13,285,466 - 13,298,939 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Serpinb8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	26,507,259 - 26,520,035 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	1,742,764 - 1,759,141 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936497	1,746,236 - 1,759,122 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINB8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	157,820,657 - 157,836,904 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	157,820,641 - 157,836,922 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	175,308,376 - 175,324,323 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINB8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	15,766,510 - 15,787,350 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	15,765,671 - 15,787,370 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666060	9,905,719 - 9,926,364 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Serpinb8
252 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	389
Count of miRNA genes:	231
Interacting mature miRNAs:	263
Transcripts:	ENSRNOT00000003274
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317027	Aia22	Adjuvant induced arthritis QTL 22	2.29		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	13	1	34785618	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2317034	Aia9	Adjuvant induced arthritis QTL 9	4.62		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12285517	34884386	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	6002008	37088115	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
2317044	Aia23	Adjuvant induced arthritis QTL 23	2.3		joint integrity trait (VT:0010548)	ankle joint diameter (CMO:0002148)	13	12285517	34884386	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
738036	Lnnr4	Liver neoplastic nodule remodeling QTL 4	3.64		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	1	34785618	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	50	90	73	72	41	80	41	6	304	162	11	64	77	85	31	5	5

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC134265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003274 ⟹ ENSRNOP00000003274

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	23,626,945 - 23,649,739 (+)	Ensembl
Rnor_6.0 Ensembl	13	27,889,395 - 27,912,716 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079134 ⟹ ENSRNOP00000074210

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	24,129,855 - 24,166,076 (+)	Ensembl
mRatBN7.2 Ensembl	13	23,626,945 - 23,650,835 (+)	Ensembl
Rnor_6.0 Ensembl	13	27,889,345 - 27,914,006 (+)	Ensembl

RefSeq Acc Id:

NM_001105948 ⟹ NP_001099418

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	24,141,557 - 24,164,894 (+)	NCBI
mRatBN7.2	13	23,626,936 - 23,650,277 (+)	NCBI
Dahl_SR_JrHsd	13	23,878,168 - 23,901,632 (+)	NCBI
Lyon_Normotensive	13	23,877,576 - 23,901,040 (+)	NCBI
Lyon_Hypertensive	13	23,891,475 - 23,914,939 (+)	NCBI
F344_StmMcwi	13	23,797,997 - 23,821,461 (+)	NCBI
Rnor_6.0	13	27,889,395 - 27,912,716 (+)	NCBI
Rnor_5.0	13	33,035,661 - 33,058,982 (+)	NCBI
RGSC_v3.4	13	13,718,139 - 13,741,460 (+)	RGD
Celera	13	23,473,106 - 23,496,452 (+)	RGD

Sequence:

show sequence

GTTCTGAGTCATTCAACAGGCGCCTTGCCCAGGATCAAGGCGGACTTTAAGTGTTCACAAAGCA
AGATTAGCAGCAGAAGCAGCCACAGCAGCAGGTATCTTCAAAGTGAAGCTCTAAGGAAGCTCTA
AGACCTCTCAGACTCTCGGAGCCTGGGATCTATATTGGCTCTTTAGAGTCAGGACAGAAGCTAA
GCAGGACAAAGGCTGGGATCTCACCAGAGCTGCAGGAAGAGCCCAGGAGCTAGCAAAAGACTCC
AGTGACAGAGAGCCTAGACCCTGCAAATGGATGACCTCTGTGAAGCCAATGGCTCTTTTGCCAT
CAGCCTATTAAAAATATTGGGTGAAGAAGACAAGTCACGGAACCTGTTCTTCTGCCCCATGAGT
GTCTCCTCAGCCCTGGCTATGGTTTACCTCGGAGCCAAAGGAAACACTGCTACCCAGATGTCCC
AGGTACTTGGTTTGAGTGGAGACGGAGATGTTCATCAAGGTTTCCAGACACTTCTCGCCGAAGT
TAACAAAAGTGGCACTCAGTACTTGTTAAAAAGTGCCTGTCGACTCTTTGGAGAGGAATCATGT
GATTTCCTTTCGACCTTCAAGGAATCCTGCCAGAAGTTCTACCAGGCTGGGATAGAAGAGATGT
CCTTTGTTAAAGACACTGAAGGGTGCAGGAAACGCATCAATGATTGGGTGTTGGAAAAAACTGA
AGGTAAAATTTCCGAAGTTCTGAGTCCTGGAACAGTTTGCCCACTGACTAAGCTGGTTCTTGTG
AATGCCATGTATTTCAAAGGGAAGTGGAAGGCTCAGTTTGACAGGAAGTACACGAGGGGCATGC
CCTTTAAAACTAATCAGGAGGAGAAGAAGACAGTCCAGATGATGTTCAAGCATGCTAAATTTAA
GATGGCACATGTGGATGAGGTGAACGCGCAGGTTCTGGCTCTGCCCTATGCTGAGGACGAGCTG
AGCATGGTCGTCCTCCTTCCTGATGAGAGCTCTGATCTCACTGTGGTGGAGAAAGCACTTACAT
ATGAGAAGCTTAGAGCTTGGACAAATCCAGAAACCCTGACAGAAAGTAAAGTGCAAGTCTTTTT
CCCCAGACTAAAGCTGGAGGAAAGTTATGACCTGGAAACTGTTCTTCAGAGTTTGGGAATGACA
GATGCCTTTGAGGAAACAAAGGCTGACTTCTCTGGGATGACAAGTAAGAAGAATGTGCCTGTGT
CCAAGGTTGCCCACAAGTGCTTTGTGGAGGTTAATGAGGAAGGCACCGAAGCAGCTGCGACCAC
TGCAGTGATCAGGAATACCCGGAGCTGCAGAATAGAGCCAAGGTTCTGTGCTGACCGCCCATTC
CTTTTCTTCATCTGGCACCAGAAAACCAGCAGCATCTTGTTCTGTGGCAGGTTCTCTTCTCCAT
AATGTCCTTATGGGGTTGAGGATGTGGTTCAGTTGGCGGAGTGTTTGCAGAACAAGCACAAGGC
CCTAGGCTCAGCCCTAAGCACCCTATGAAGCTAGGCATGATTGTGCCTACCTGCCATCCTAGCA
TTTGGGAGGTGCAGGATGAGTGAGTCACACATTCAAGGTCATCCTAAATGACACAGGACTCTGT
CTCAAACACCACCACCACCACCACCACCACCACCACCACCACCACCGCCAACAACAACAACAAC
AATAACAATAAAAAACAAGAAAGTAGATGTGTGATTGATTGACACATCATTCTCTGCTGAATTC
TGGAATTAAAATTCCATGTTGTCAGATTTGCCAAGGTGATTTCAATGTAAAAATAAAAAGAATA
TACTTAGTAGTTGGTGACTATCCTTCCTGACTGTCCCAATACTGTGTATGGCAGTTTGGAGTGG
ACGAGAAGGCCATACTTGGTTTGGAGTGTCTGAGGTGATTCTCAGTATCTCCAGCCTTACTCCC
AACCCAGATTCTAAAGTGCTGCTCCACCCTGTTAACATCTCTAAACTGTCCCCACCACTGAAAG
ACTTACCCGGGAATGCCAGTGACCATTCACAAAGCCAAGGGTAAGAGCTACAGAATAACTGCTG
TAACTGCCCATGACTCCTACGTAGCTGAGAGAGTGTCTCCTTCCGTCAGTGTCACTCAATGCTC
TCTTATGACTCAGGGTTCAGGCAACTCTTTCCACAAGTTTTCAGTGAATGTTTAAGAACTCAGT
GAGAGCCTTCAGGATGGAGCTGAGACATGACGCTCCAAAGTGTTTCCTCCCCCAAACCCCTGAC
TGCTTTCTAAAGCTCCAAGTGTTTTCCTTATTTCCCCTGACTCTAATGAAAATGTCACACAGGA
TGATTCTTACAAACCATCTCTCTAATTAACTACGTGCTCAGACATGATTCAAATGTACCCTTAA
TGCCCTAAATGCATATGCATGCTAGCATCAGTACATAGACTCAGTGGGTTGTACTTATACATGT
GTGTGTGTTTGTGCGTGTGTGTGTGTGTGTTTGTGCGTGTGTGTGTGTGTGTGTATGTGCATGT
GTAACAAAGAAGTCATGAATATGAGAGGGAGTGAGGGGGGCACAGGAGGAGTCAGGTGAGAAGT
GAGGAGTGGGCAAAAATAGACTATTTATATATGAAATTCTAAAATAAAATTAAAGATTAAATAA
AAAAGACAACTATATTTTCTGACTGAATAAAATTTTTATTATTGGCAGAAAGTGGGAAATTATA
GGAACACATACAAAGAAATTTAAGCTTTCTGCAAGTCCCCTCCTCAGAAATCACTATTTTGAAT
ATGCATTATATCCATTATATGGATGCAAATATAAATTCATAATGTTTTAGCACAGGATAATGAT
CATTTTTTGTAGCTTATTTTCACTGTAAGTCTTGCTCAAGACAATTATCATTCAGTGTCAACAT
CTTGCTGTGCATTGAATTGTGGGATGAGGGAGCGTTTTCTGTAAGCAAACCTATTTAGACAATT
TGGAAAATTAAACATGTATTACAGACTACTGTGTTGAATATCTTCAATGGTTGATTACACTCTT
AATTTCTCAATAAATATTGCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099418	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL91759	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074210
	ENSRNOP00000074210.1

RefSeq Acc Id:

NP_001099418 ⟸ NM_001105948

- UniProtKB:

D3ZHB5 (UniProtKB/TrEMBL), A6JSW1 (UniProtKB/TrEMBL), A0A0G2K7H6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDDLCEANGSFAISLLKILGEEDKSRNLFFCPMSVSSALAMVYLGAKGNTATQMSQVLGLSGDG
DVHQGFQTLLAEVNKSGTQYLLKSACRLFGEESCDFLSTFKESCQKFYQAGIEEMSFVKDTEGC
RKRINDWVLEKTEGKISEVLSPGTVCPLTKLVLVNAMYFKGKWKAQFDRKYTRGMPFKTNQEEK
KTVQMMFKHAKFKMAHVDEVNAQVLALPYAEDELSMVVLLPDESSDLTVVEKALTYEKLRAWTN
PETLTESKVQVFFPRLKLEESYDLETVLQSLGMTDAFEETKADFSGMTSKKNVPVSKVAHKCFV
EVNEEGTEAAATTAVIRNTRSCRIEPRFCADRPFLFFIWHQKTSSILFCGRFSSP

hide sequence

Ensembl Acc Id:

ENSRNOP00000074210 ⟸ ENSRNOT00000079134

Ensembl Acc Id:

ENSRNOP00000003274 ⟸ ENSRNOT00000003274

Protein Domains

SERPIN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZHB5-F1-model_v2	AlphaFold	D3ZHB5	1-375	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698757

Promoter ID:

EPDNEW_R9281

Type:

multiple initiation site

Name:

Serpinb8_1

Description:

serpin family B member 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	27,889,470 - 27,889,530	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309833	AgrOrtholog
BioCyc Gene	G2FUF-18577	BioCyc
Ensembl Genes	ENSRNOG00000002396	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000079134	ENTREZGENE
	ENSRNOT00000079134.3	UniProtKB/TrEMBL
Gene3D-CATH	2.30.39.10	UniProtKB/TrEMBL
	3.30.497.10	UniProtKB/TrEMBL
	Serpins superfamily	UniProtKB/TrEMBL
InterPro	Protease_inhib_I4_serpin	UniProtKB/TrEMBL
	Protease_inhib_I4_serpin_CS	UniProtKB/TrEMBL
	Sepin_dom	UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/TrEMBL
KEGG Report	rno:288937	UniProtKB/TrEMBL
NCBI Gene	288937	ENTREZGENE
PANTHER	Prot_inh_serpin	UniProtKB/TrEMBL
	SERPIN B8	UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/TrEMBL
PhenoGen	Serpinb8	PhenoGen
PROSITE	SERPIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002396	RatGTEx
SMART	SERPIN	UniProtKB/TrEMBL
Superfamily-SCOP	Prot_inh_serpin	UniProtKB/TrEMBL
UniProt	A0A0G2K7H6	ENTREZGENE, UniProtKB/TrEMBL
	A6JSW1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZHB5	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Serpinb8	serpin family B member 8	Serpinb8	serpin peptidase inhibitor, clade B (ovalbumin), member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-04-30	Serpinb8	serpin peptidase inhibitor, clade B (ovalbumin), member 8	Serpinb8	serine (or cysteine) peptdiase inhibitor, clade B, member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Serpinb8	serine (or cysteine) peptdiase inhibitor, clade B, member 8	Serpinb8_predicted	serine (or cysteine) peptdiase inhibitor, clade B, member 8 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Serpinb8_predicted	serine (or cysteine) peptdiase inhibitor, clade B, member 8 (predicted)		serine (or cysteine) proteinase inhibitor, clade B, member 8 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Serpinb8_predicted	serine (or cysteine) proteinase inhibitor, clade B, member 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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