Dmpk (DM1 protein kinase) - Rat Genome Database

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Pathways
Gene: Dmpk (DM1 protein kinase) Rattus norvegicus
Analyze
Symbol: Dmpk
Name: DM1 protein kinase
RGD ID: 1309825
Description: Predicted to enable ATP binding activity; myosin phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including muscle cell apoptotic process; regulation of skeletal muscle contraction by calcium ion signaling; and regulation of synapse structural plasticity. Predicted to act upstream of or within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction and regulation of sodium ion transport. Predicted to be located in several cellular components, including bounding membrane of organelle; cytosol; and nuclear membrane. Human ortholog(s) of this gene implicated in myotonic dystrophy type 1. Orthologous to human DMPK (DM1 protein kinase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dm15; dystrophia myotonica kinase, B15; dystrophia myotonica-protein kinase; LOC308405; myotonin-protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,858,294 - 87,868,624 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl187,858,316 - 87,868,910 (+)EnsemblGRCr8
mRatBN7.2178,730,255 - 78,740,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,730,275 - 78,740,593 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,119,202 - 84,129,502 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,676,889 - 92,687,183 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,874,300 - 85,884,600 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,988,096 - 79,999,358 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,989,019 - 79,999,364 (+)Ensemblrn6Rnor6.0
Rnor_5.0181,257,000 - 81,267,133 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,449,324 - 78,450,578 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,194,993 - 73,206,254 (+)NCBICelera
RGSC_v3.1178,518,239 - 78,529,227 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
aflatoxin B1  (EXP)
alpha-Zearalanol  (EXP)
amosite asbestos  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
inulin  (ISO)
L-methionine  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
quercetin  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP)

References

References - curated
# Reference Title Reference Citation
1. A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. Boucher CA, etal., Hum Mol Genet. 1995 Oct;4(10):1919-25.
2. Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK). Forner F, etal., Biochim Biophys Acta. 2010 Jun;1804(6):1334-41. Epub 2010 Feb 25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9294109   PMID:10913253   PMID:11287000   PMID:11526199   PMID:12612014   PMID:15598648   PMID:15684391   PMID:17719582   PMID:18729234   PMID:21949239   PMID:29648621  


Genomics

Comparative Map Data
Dmpk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,858,294 - 87,868,624 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl187,858,316 - 87,868,910 (+)EnsemblGRCr8
mRatBN7.2178,730,255 - 78,740,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,730,275 - 78,740,593 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,119,202 - 84,129,502 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,676,889 - 92,687,183 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,874,300 - 85,884,600 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,988,096 - 79,999,358 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,989,019 - 79,999,364 (+)Ensemblrn6Rnor6.0
Rnor_5.0181,257,000 - 81,267,133 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,449,324 - 78,450,578 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,194,993 - 73,206,254 (+)NCBICelera
RGSC_v3.1178,518,239 - 78,529,227 (+)NCBI
Cytogenetic Map1q21NCBI
DMPK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,769,717 - 45,782,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,769,709 - 45,782,552 (-)Ensemblhg38GRCh38
GRCh371946,272,975 - 46,285,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,964,815 - 50,977,655 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341950,964,815 - 50,977,576NCBI
Celera1943,079,095 - 43,090,866 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,701,722 - 42,714,534 (-)NCBIHuRef
CHM1_11946,276,489 - 46,288,326 (-)NCBICHM1_1
T2T-CHM13v2.01948,597,252 - 48,609,980 (-)NCBIT2T-CHM13v2.0
Dmpk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,817,571 - 18,827,746 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,817,774 - 18,827,746 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,083,646 - 19,093,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,083,849 - 19,093,821 (+)Ensemblmm10GRCm38
MGSCv37719,669,198 - 19,679,170 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,242,517 - 18,251,624 (+)NCBIMGSCv36mm8
Celera716,495,229 - 16,505,182 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.46NCBI
Dmpk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574226,292 - 237,526 (-)Ensembl
ChiLan1.0NW_004955574225,615 - 237,526 (-)NCBIChiLan1.0ChiLan1.0
DMPK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,935,294 - 51,948,741 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,806,747 - 53,819,563 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,779,173 - 42,791,981 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,316,099 - 51,329,421 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,316,099 - 51,329,355 (-)EnsemblpanPan2panpan1.1
DMPK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,824,103 - 109,834,986 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,824,597 - 109,834,976 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1109,309,270 - 109,320,016 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01110,357,335 - 110,368,093 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,357,272 - 110,368,093 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,032,956 - 110,043,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,667,626 - 109,678,376 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,536,417 - 110,547,165 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dmpk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,777,894 - 17,788,794 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367062,124,238 - 2,134,976 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367062,125,237 - 2,135,974 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMPK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,100,259 - 52,110,478 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1652,100,259 - 52,110,822 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DMPK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,219,625 - 39,232,203 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,220,355 - 39,232,015 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607318,852,196 - 18,865,776 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dmpk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,419,689 - 7,429,084 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248327,419,529 - 7,429,744 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dmpk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12171,530,458 - 171,540,754 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dmpk
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:503
Count of miRNA genes:181
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000020428, ENSRNOT00000038152, ENSRNOT00000041817, ENSRNOT00000067933
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
Dm15  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0181,265,083 - 81,266,858NCBIRnor5.0
RGSC_v3.4178,449,067 - 78,450,841UniSTSRGSC3.4
Celera173,204,205 - 73,205,979UniSTS
Cytogenetic Map1q21UniSTS
RH130797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,740,351 - 78,740,551 (+)MAPPERmRatBN7.2
Rnor_6.0179,999,125 - 79,999,324NCBIRnor6.0
Rnor_5.0181,266,900 - 81,267,099UniSTSRnor5.0
RGSC_v3.4178,450,883 - 78,451,082UniSTSRGSC3.4
Celera173,206,021 - 73,206,220UniSTS
RH 3.4 Map1789.7UniSTS
Cytogenetic Map1q21UniSTS
RH139376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,736,150 - 78,736,220 (+)MAPPERmRatBN7.2
Rnor_6.0179,994,924 - 79,994,993NCBIRnor6.0
Rnor_5.0181,262,699 - 81,262,768UniSTSRnor5.0
RGSC_v3.4178,446,682 - 78,446,751UniSTSRGSC3.4
Celera173,201,820 - 73,201,889UniSTS
RH 3.4 Map1789.0UniSTS
Cytogenetic Map1q21UniSTS
Dmpk  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8187,860,791 - 87,861,359 (+)Marker Load Pipeline
mRatBN7.2178,732,752 - 78,733,320 (+)MAPPERmRatBN7.2
Rnor_6.0179,991,526 - 79,992,093NCBIRnor6.0
Rnor_5.0181,259,498 - 81,260,065UniSTSRnor5.0
RGSC_v3.4178,442,586 - 78,443,153UniSTSRGSC3.4
Celera173,198,423 - 73,198,989UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 83 59 6 347 183 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001372064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020428   ⟹   ENSRNOP00000020428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,858,344 - 87,868,620 (+)Ensembl
mRatBN7.2 Ensembl178,730,284 - 78,740,581 (+)Ensembl
Rnor_6.0 Ensembl179,989,019 - 79,999,364 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071916   ⟹   ENSRNOP00000067795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,858,329 - 87,868,620 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105612   ⟹   ENSRNOP00000095056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,858,323 - 87,868,624 (+)Ensembl
mRatBN7.2 Ensembl178,730,275 - 78,740,593 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150391   ⟹   ENSRNOP00000109310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,858,316 - 87,868,910 (+)Ensembl
RefSeq Acc Id: NM_001372064   ⟹   NP_001358993
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,323 - 87,868,624 (+)NCBI
mRatBN7.2178,730,284 - 78,740,585 (+)NCBI
RefSeq Acc Id: NM_001415847   ⟹   NP_001402776
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,323 - 87,868,624 (+)NCBI
mRatBN7.2178,730,284 - 78,740,585 (+)NCBI
RefSeq Acc Id: NM_001415848   ⟹   NP_001402777
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,323 - 87,868,624 (+)NCBI
mRatBN7.2178,730,284 - 78,740,585 (+)NCBI
RefSeq Acc Id: NM_001415849   ⟹   NP_001402778
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,323 - 87,868,624 (+)NCBI
mRatBN7.2178,730,284 - 78,740,585 (+)NCBI
RefSeq Acc Id: XM_008759049   ⟹   XP_008757271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,867,311 (+)NCBI
mRatBN7.2178,730,255 - 78,739,272 (+)NCBI
Rnor_6.0179,988,096 - 79,998,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589995   ⟹   XP_017445484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,740,585 (+)NCBI
Rnor_6.0179,988,096 - 79,999,358 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111232   ⟹   XP_038967160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,740,585 (+)NCBI
RefSeq Acc Id: XM_039111235   ⟹   XP_038967163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,740,585 (+)NCBI
RefSeq Acc Id: XM_039111254   ⟹   XP_038967182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,740,585 (+)NCBI
RefSeq Acc Id: XM_039111256   ⟹   XP_038967184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,739,861 (+)NCBI
RefSeq Acc Id: XM_039111258   ⟹   XP_038967186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,867,247 (+)NCBI
mRatBN7.2178,730,255 - 78,739,208 (+)NCBI
RefSeq Acc Id: XM_063261308   ⟹   XP_063117378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261309   ⟹   XP_063117379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261312   ⟹   XP_063117382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261313   ⟹   XP_063117383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261319   ⟹   XP_063117389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,867,311 (+)NCBI
RefSeq Acc Id: XM_063261320   ⟹   XP_063117390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261324   ⟹   XP_063117394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261329   ⟹   XP_063117399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261330   ⟹   XP_063117400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,867,900 (+)NCBI
RefSeq Acc Id: XM_063261332   ⟹   XP_063117402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,860,725 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261333   ⟹   XP_063117403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,426 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261336   ⟹   XP_063117406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,426 - 87,868,624 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001358993 (Get FASTA)   NCBI Sequence Viewer  
  NP_001402776 (Get FASTA)   NCBI Sequence Viewer  
  NP_001402777 (Get FASTA)   NCBI Sequence Viewer  
  NP_001402778 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757271 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445484 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967160 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967163 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967182 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967184 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967186 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117378 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117379 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117382 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117383 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117389 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117390 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117394 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117399 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117400 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117402 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117403 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117406 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM08238 (Get FASTA)   NCBI Sequence Viewer  
  EDM08239 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020428
  ENSRNOP00000020428.9
  ENSRNOP00000067795
  ENSRNOP00000095056
  ENSRNOP00000095056.2
  ENSRNOP00000109310
  ENSRNOP00000109310.1
RefSeq Acc Id: XP_008757271   ⟸   XM_008759049
- Peptide Label: isoform X12
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445484   ⟸   XM_017589995
- Peptide Label: isoform X8
- UniProtKB: D3ZYV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020428   ⟸   ENSRNOT00000020428
RefSeq Acc Id: XP_038967182   ⟸   XM_039111254
- Peptide Label: isoform X10
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967160   ⟸   XM_039111232
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967163   ⟸   XM_039111235
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967184   ⟸   XM_039111256
- Peptide Label: isoform X13
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967186   ⟸   XM_039111258
- Peptide Label: isoform X14
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001358993   ⟸   NM_001372064
- Peptide Label: isoform 2
- UniProtKB: D3ZYV4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095056   ⟸   ENSRNOT00000105612
RefSeq Acc Id: NP_001402776   ⟸   NM_001415847
- Peptide Label: isoform 1
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402777   ⟸   NM_001415848
- Peptide Label: isoform 3
- UniProtKB: D3ZYV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402778   ⟸   NM_001415849
- Peptide Label: isoform 4
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117379   ⟸   XM_063261309
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117378   ⟸   XM_063261308
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117383   ⟸   XM_063261313
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117382   ⟸   XM_063261312
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117394   ⟸   XM_063261324
- Peptide Label: isoform X11
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117399   ⟸   XM_063261329
- Peptide Label: isoform X15
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117390   ⟸   XM_063261320
- Peptide Label: isoform X9
- UniProtKB: D3ZYV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117400   ⟸   XM_063261330
- Peptide Label: isoform X16
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117389   ⟸   XM_063261319
- Peptide Label: isoform X7
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117406   ⟸   XM_063261336
- Peptide Label: isoform X19
- UniProtKB: D3ZYV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117403   ⟸   XM_063261333
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063117402   ⟸   XM_063261332
- Peptide Label: isoform X17
Ensembl Acc Id: ENSRNOP00000067795   ⟸   ENSRNOT00000071916
Ensembl Acc Id: ENSRNOP00000109310   ⟸   ENSRNOT00000150391
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYV4-F1-model_v2 AlphaFold D3ZYV4 1-626 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689758
Promoter ID:EPDNEW_R283
Type:multiple initiation site
Name:Dmpk_1
Description:DM1 protein kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,989,057 - 79,989,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309825 AgrOrtholog
BioCyc Gene G2FUF-60533 BioCyc
Ensembl Genes ENSRNOG00000015085 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020428 ENTREZGENE
  ENSRNOT00000020428.10 UniProtKB/TrEMBL
  ENSRNOT00000071916 ENTREZGENE
  ENSRNOT00000105612 ENTREZGENE
  ENSRNOT00000105612.2 UniProtKB/TrEMBL
  ENSRNOT00000150391 ENTREZGENE
  ENSRNOT00000150391.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.340 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Myotonic_dystrophy_kinase_coil UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Rho-assoc_Ser/Thr_Kinase UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 308405 ENTREZGENE
PANTHER LOW QUALITY PROTEIN: MYOTONIN-PROTEIN KINASE UniProtKB/TrEMBL
  MYOTONIC DYSTROPHY S/T KINASE-RELATED UniProtKB/TrEMBL
Pfam DMPK_coil UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Dmpk PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015085 RatGTEx
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6ANX6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M2M3_RAT UniProtKB/TrEMBL
  A6J8J5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYV4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-12 Dmpk  DM1 protein kinase  Dmpk  dystrophia myotonica-protein kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dmpk  dystrophia myotonica-protein kinase   Dmpk_predicted  dystrophia myotonica-protein kinase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Dmpk_predicted  dystrophia myotonica-protein kinase (predicted)  Dm15_predicted  dystrophia myotonica kinase, B15 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Dm15_predicted  dystrophia myotonica kinase, B15 (predicted)      Symbol and Name status set to approved 70820 APPROVED