Symbol:
Bbx
Name:
BBX high mobility group box domain containing
RGD ID:
1309769
Description:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone development. Predicted to be active in nucleus. Orthologous to human BBX (BBX high mobility group box domain containing); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
BBX, HMG-box containing; bobby sox homolog; HMG box transcription factor BBX; HMG box transcription factor BBX-like; LOC100912484; LOC303970
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Allele / Splice:
BbxTn(sb-T2/Bart3)2.291Mcwi
Genetic Models:
F344-BbxTn(sb-T2/Bart3)2.291Mcwi
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 11 63,850,034 - 64,097,700 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 11 63,850,018 - 64,093,265 (+) Ensembl GRCr8 mRatBN7.2 11 50,381,249 - 50,628,934 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 11 50,381,247 - 50,623,251 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 11 59,249,540 - 59,392,174 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 11 51,911,234 - 52,053,882 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 11 51,035,362 - 51,177,756 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Dahl_SR_JrHsd 11 65,864,012 - 66,006,652 (+) NCBI Dahl_SR_JrHsd Lyon_Normotensive 11 64,047,272 - 64,189,914 (+) NCBI Lyon_Normotensive Lyon_Hypertensive 11 64,991,631 - 65,134,270 (+) NCBI Lyon_Hypertensive F344_StmMcwi 11 63,773,700 - 63,916,456 (+) NCBI F344_StmMcwi Rnor_6.0 11 52,983,286 - 53,228,557 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 53,081,025 - 53,228,716 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 11 56,153,038 - 56,397,255 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 11 51,655,446 - 51,799,132 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 11 50,128,289 - 50,267,567 (+) NCBI Celera RGSC_v3.1 11 51,765,817 - 51,857,084 (+) NCBI Cytogenetic Map 11 q21 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Bbx Rat (-)-epigallocatechin 3-gallate multiple interactions ISO BBX (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BBX mRNA CTD PMID:22079256 Bbx Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Bbx (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Bbx Rat 1,2-dichloroethane decreases expression ISO Bbx (Mus musculus) 6480464 ethylene dichloride results in decreased expression of BBX mRNA CTD PMID:28960355 Bbx Rat 1,2-dimethylhydrazine decreases expression ISO Bbx (Mus musculus) 6480464 1,2-Dimethylhydrazine results in decreased expression of BBX mRNA CTD PMID:22206623 Bbx Rat 17beta-estradiol increases expression ISO BBX (Homo sapiens) 6480464 Estradiol results in increased expression of BBX mRNA CTD PMID:21185374 Bbx Rat 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO BBX (Homo sapiens) 6480464 Dihydrotestosterone results in increased expression of BBX mRNA CTD PMID:29581250 Bbx Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Bbx (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Bbx Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Bbx (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Bbx Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Bbx (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of BBX mRNA CTD PMID:21570461 Bbx Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of BBX mRNA CTD PMID:33387578 Bbx Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Bbx (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Bbx Rat 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of BBX mRNA CTD PMID:21346803 Bbx Rat 2-methylcholine affects expression ISO BBX (Homo sapiens) 6480464 beta-methylcholine affects the expression of BBX mRNA CTD PMID:21179406 Bbx Rat 2-palmitoylglycerol increases expression ISO BBX (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of BBX mRNA CTD PMID:37199045 Bbx Rat 3-methylcholanthrene multiple interactions ISO BBX (Homo sapiens) 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to BBX promoter] CTD PMID:20348232 Bbx Rat 4,4'-diaminodiphenylmethane increases expression ISO Bbx (Mus musculus) 6480464 4,4'-diaminodiphenylmethane results in increased expression of BBX mRNA CTD PMID:18648102 Bbx Rat 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2,6-dinitrotoluene affects the expression of BBX mRNA CTD PMID:21346803 Bbx Rat 4-hydroxynon-2-enal increases expression ISO Bbx (Mus musculus) 6480464 4-hydroxy-2-nonenal results in increased expression of BBX mRNA CTD PMID:19191707 Bbx Rat 5-fluorouracil affects response to substance ISO BBX (Homo sapiens) 6480464 BBX protein affects the susceptibility to Fluorouracil CTD PMID:16217747 Bbx Rat acrolein multiple interactions ISO BBX (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268 Bbx Rat aflatoxin B1 decreases methylation ISO BBX (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of BBX intron CTD PMID:30157460 Bbx Rat alpha-pinene multiple interactions ISO BBX (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268 Bbx Rat aristolochic acid A decreases expression ISO BBX (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of BBX mRNA CTD PMID:33212167 Bbx Rat Aroclor 1254 decreases expression ISO Bbx (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of BBX mRNA CTD PMID:23650126 Bbx Rat benzo[a]pyrene decreases expression ISO BBX (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of BBX mRNA CTD PMID:20064835 Bbx Rat benzo[a]pyrene affects methylation ISO BBX (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of BBX 5' UTR; Benzo(a)pyrene affects the methylation of BBX intron CTD PMID:27901495|PMID:30157460 Bbx Rat benzo[a]pyrene decreases expression ISO Bbx (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of BBX mRNA CTD PMID:19770486 Bbx Rat benzo[a]pyrene diol epoxide I decreases expression ISO BBX (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BBX mRNA CTD PMID:20018196 Bbx Rat benzo[e]pyrene increases methylation ISO BBX (Homo sapiens) 6480464 benzo(e)pyrene results in increased methylation of BBX intron CTD PMID:30157460 Bbx Rat bis(2-ethylhexyl) phthalate multiple interactions ISO Bbx (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased methylation of and results in decreased expression of BBX mRNA CTD PMID:34120004 Bbx Rat bisphenol A increases expression ISO Bbx (Mus musculus) 6480464 bisphenol A results in increased expression of BBX mRNA CTD PMID:26063408 Bbx Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of BBX mRNA CTD PMID:30816183|PMID:34947998 Bbx Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of BBX protein CTD PMID:24552547 Bbx Rat Butylbenzyl phthalate increases methylation ISO Bbx (Mus musculus) 6480464 butylbenzyl phthalate results in increased methylation of BBX intron CTD PMID:28392331 Bbx Rat C60 fullerene affects expression EXP 6480464 fullerene C60 affects the expression of BBX mRNA CTD PMID:19167457 Bbx Rat cadmium atom multiple interactions ISO Bbx (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BBX more ... CTD PMID:37236586 Bbx Rat cadmium dichloride increases expression ISO Bbx (Mus musculus) 6480464 Cadmium Chloride results in increased expression of BBX mRNA CTD PMID:18974090 Bbx Rat cadmium dichloride multiple interactions ISO Bbx (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BBX more ... CTD PMID:37236586 Bbx Rat cadmium dichloride increases expression ISO BBX (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of BBX mRNA CTD PMID:26472689 Bbx Rat caffeine affects phosphorylation ISO BBX (Homo sapiens) 6480464 Caffeine affects the phosphorylation of BBX protein CTD PMID:35688186 Bbx Rat CGP 52608 multiple interactions ISO BBX (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to BBX gene] CTD PMID:28238834 Bbx Rat chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of BBX mRNA CTD PMID:23125180 Bbx Rat cisplatin increases phosphorylation ISO Bbx (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of BBX protein CTD PMID:22006019 Bbx Rat copper(II) sulfate increases expression ISO BBX (Homo sapiens) 6480464 Copper Sulfate results in increased expression of BBX mRNA CTD PMID:19549813 Bbx Rat coumarin affects phosphorylation ISO BBX (Homo sapiens) 6480464 coumarin affects the phosphorylation of BBX protein CTD PMID:35688186 Bbx Rat Dibutyl phosphate affects expression ISO BBX (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of BBX mRNA CTD PMID:37042841 Bbx Rat dibutyl phthalate decreases expression ISO Bbx (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of BBX mRNA CTD PMID:21266533 Bbx Rat dorsomorphin multiple interactions ISO BBX (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Bbx Rat doxorubicin decreases expression ISO BBX (Homo sapiens) 6480464 Doxorubicin results in decreased expression of BBX mRNA CTD PMID:29803840 Bbx Rat elemental selenium multiple interactions ISO BBX (Homo sapiens) 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNA CTD PMID:19244175 Bbx Rat elemental selenium decreases expression ISO BBX (Homo sapiens) 6480464 Selenium results in decreased expression of BBX mRNA CTD PMID:19244175 Bbx Rat enzyme inhibitor multiple interactions ISO BBX (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... CTD PMID:23301498 Bbx Rat folic acid decreases expression ISO Bbx (Mus musculus) 6480464 Folic Acid results in decreased expression of BBX mRNA CTD PMID:25629700 Bbx Rat FR900359 affects phosphorylation ISO BBX (Homo sapiens) 6480464 FR900359 affects the phosphorylation of BBX protein CTD PMID:37730182 Bbx Rat geraniol increases expression ISO BBX (Homo sapiens) 6480464 geraniol results in increased expression of BBX mRNA CTD PMID:27683099 Bbx Rat lead diacetate decreases methylation EXP 6480464 lead acetate results in decreased methylation of BBX gene CTD PMID:29571894 Bbx Rat lead(0) affects splicing ISO BBX (Homo sapiens) 6480464 Lead affects the splicing of BBX mRNA CTD PMID:28903495 Bbx Rat levonorgestrel multiple interactions ISO BBX (Homo sapiens) 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of BBX mRNA CTD PMID:19074003 Bbx Rat methapyrilene increases methylation ISO BBX (Homo sapiens) 6480464 Methapyrilene results in increased methylation of BBX intron CTD PMID:30157460 Bbx Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of BBX gene CTD PMID:35440735 Bbx Rat methylmercury chloride decreases expression ISO BBX (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of BBX mRNA CTD PMID:28001369 Bbx Rat mitoxantrone affects response to substance ISO BBX (Homo sapiens) 6480464 BBX protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 Bbx Rat N(4)-hydroxycytidine decreases expression ISO Bbx (Mus musculus) 6480464 N(4)-hydroxycytidine results in decreased expression of BBX mRNA CTD PMID:37748715 Bbx Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of BBX mRNA CTD PMID:25729387 Bbx Rat ozone multiple interactions ISO BBX (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... CTD PMID:32699268 Bbx Rat paracetamol decreases expression ISO BBX (Homo sapiens) 6480464 Acetaminophen results in decreased expression of BBX mRNA CTD PMID:21420995 Bbx Rat PCB138 multiple interactions ISO Bbx (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Bbx Rat pirinixic acid multiple interactions ISO Bbx (Mus musculus) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... CTD PMID:19710929 Bbx Rat potassium chromate decreases expression ISO BBX (Homo sapiens) 6480464 potassium chromate(VI) results in decreased expression of BBX mRNA CTD PMID:22079256 Bbx Rat potassium chromate multiple interactions ISO BBX (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BBX mRNA CTD PMID:22079256 Bbx Rat propiconazole decreases expression ISO Bbx (Mus musculus) 6480464 propiconazole results in decreased expression of BBX mRNA CTD PMID:21278054 Bbx Rat SB 431542 multiple interactions ISO BBX (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Bbx Rat selenium atom multiple interactions ISO BBX (Homo sapiens) 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNA CTD PMID:19244175 Bbx Rat selenium atom decreases expression ISO BBX (Homo sapiens) 6480464 Selenium results in decreased expression of BBX mRNA CTD PMID:19244175 Bbx Rat sodium arsenate increases expression ISO Bbx (Mus musculus) 6480464 sodium arsenate results in increased expression of BBX mRNA CTD PMID:21795629 Bbx Rat testosterone enanthate affects expression ISO BBX (Homo sapiens) 6480464 testosterone enanthate affects the expression of BBX mRNA CTD PMID:17440010 Bbx Rat testosterone undecanoate multiple interactions ISO BBX (Homo sapiens) 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of BBX mRNA CTD PMID:19074003 Bbx Rat tetrachloromethane increases expression ISO Bbx (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of BBX mRNA CTD PMID:31919559 Bbx Rat titanium dioxide decreases expression ISO Bbx (Mus musculus) 6480464 titanium dioxide results in decreased expression of BBX mRNA CTD PMID:35295148 Bbx Rat titanium dioxide decreases methylation ISO Bbx (Mus musculus) 6480464 titanium dioxide results in decreased methylation of BBX gene CTD PMID:35295148 Bbx Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of BBX mRNA CTD PMID:25729387 Bbx Rat trichostatin A increases expression ISO BBX (Homo sapiens) 6480464 trichostatin A results in increased expression of BBX mRNA CTD PMID:24935251|PMID:26272509 Bbx Rat trichostatin A multiple interactions ISO BBX (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Bbx Rat triphenyl phosphate affects expression ISO BBX (Homo sapiens) 6480464 triphenyl phosphate affects the expression of BBX mRNA CTD PMID:37042841 Bbx Rat urethane increases expression ISO BBX (Homo sapiens) 6480464 Urethane results in increased expression of BBX mRNA CTD PMID:28818685 Bbx Rat valproic acid decreases expression ISO BBX (Homo sapiens) 6480464 Valproic Acid results in decreased expression of BBX mRNA CTD PMID:23179753|PMID:28001369 Bbx Rat valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of BBX mRNA CTD PMID:29427782 Bbx Rat valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of BBX mRNA CTD PMID:29427782 Bbx Rat valproic acid affects expression ISO BBX (Homo sapiens) 6480464 Valproic Acid affects the expression of BBX mRNA CTD PMID:25979313 Bbx Rat valproic acid increases expression ISO BBX (Homo sapiens) 6480464 Valproic Acid results in increased expression of BBX mRNA CTD PMID:19101580|PMID:26272509 Bbx Rat vitamin E multiple interactions ISO BBX (Homo sapiens) 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of BBX mRNA CTD PMID:19244175 Bbx Rat vitamin E decreases expression ISO BBX (Homo sapiens) 6480464 Vitamin E results in decreased expression of BBX mRNA CTD PMID:19244175 Bbx Rat zoledronic acid decreases expression ISO BBX (Homo sapiens) 6480464 zoledronic acid results in decreased expression of BBX mRNA CTD PMID:20977926