Akr1e2 (aldo-keto reductase family 1, member E2)

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Gene: Akr1e2 (aldo-keto reductase family 1, member E2) Rattus norvegicus

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Symbol:

Akr1e2

Name:

aldo-keto reductase family 1, member E2

RGD ID:

1309599

Description:

Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Orthologous to human AKR1E2 (aldo-keto reductase family 1 member E2); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

1,5-anhydro-D-fructose reductase; AF reductase; Akr1cl2; Akr1e1; aldo-keto reductase family 1 member C-like protein 2; aldo-keto reductase family 1 member E2; aldo-keto reductase family 1, member C-like 2; aldo-keto reductase family 1, member E1; LOC307091; MGC105536

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AKR1E2 (aldo-keto reductase family 1 member E2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Akr1e1 (aldo-keto reductase family 1, member E1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Akr1e2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AKR1E2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AKR1E2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Akr1e2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AKR1E2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AKR1E2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AKR1E2 (aldo-keto reductase family 1 member E2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Akr1e1 (aldo-keto reductase family 1, member E1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6084	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GCY1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GRE3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder)
Caenorhabditis elegans (roundworm):	Y39G8B.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YPR1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C07D8.6	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	akr1b1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	70,645,835 - 70,660,366 (+)	NCBI		GRCr8
mRatBN7.2	17	65,735,909 - 65,750,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	65,735,943 - 65,750,441 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	69,231,629 - 69,246,118 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,060,477 - 73,074,961 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	67,103,460 - 67,117,949 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	69,365,437 - 69,379,944 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	69,365,453 - 69,379,947 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	71,079,217 - 71,093,701 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,011,336 - 77,025,824 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	77,022,168 - 77,036,651 (+)	NCBI
Celera	17	65,268,655 - 65,283,123 (+)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypoparathyroidism-deafness-renal disease syndrome (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,6-dinitrotoluene (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

alpha-Zearalanol (EXP)

amitrole (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chlordecone (ISO)

clofibrate (ISO)

cocaine (EXP)

dorsomorphin (ISO)

epoxiconazole (ISO)

fipronil (EXP)

glafenine (EXP)

malathion (ISO)

methimazole (EXP)

methotrexate (ISO)

N-nitrosodiethylamine (EXP)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

quercetin (EXP)

rotenone (EXP)

SB 431542 (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytosol (IBA)

Molecular Function

1,5-anhydro-D-fructose reductase activity (IEA)

aldose reductase (NADPH) activity (IBA)

oxidoreductase activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15118078	PMID:23376485

Genomics

Comparative Map Data

Akr1e2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	70,645,835 - 70,660,366 (+)	NCBI		GRCr8
mRatBN7.2	17	65,735,909 - 65,750,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	65,735,943 - 65,750,441 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	69,231,629 - 69,246,118 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,060,477 - 73,074,961 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	67,103,460 - 67,117,949 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	69,365,437 - 69,379,944 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	69,365,453 - 69,379,947 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	71,079,217 - 71,093,701 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,011,336 - 77,025,824 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	77,022,168 - 77,036,651 (+)	NCBI
Celera	17	65,268,655 - 65,283,123 (+)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

AKR1E2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	4,824,973 - 4,873,237 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	4,786,629 - 4,848,062 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	4,868,369 - 4,890,254 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	4,858,402 - 4,880,254 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	4,858,425 - 4,880,249	NCBI
Celera	10	4,811,323 - 4,833,177 (+)	NCBI		Celera
Cytogenetic Map	10	p15.1	NCBI
HuRef	10	4,802,403 - 4,824,264 (+)	NCBI		HuRef
CHM1_1	10	4,868,717 - 4,890,574 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	4,825,330 - 4,873,573 (+)	NCBI		T2T-CHM13v2.0

Akr1e1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	4,641,122 - 4,659,163 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	4,640,749 - 4,659,173 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	4,591,123 - 4,609,164 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	4,590,750 - 4,609,174 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	4,591,736 - 4,608,410 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	4,591,777 - 4,608,381 (-)	NCBI		MGSCv36	mm8
Celera	13	4,571,016 - 4,587,416 (-)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI
cM Map	13	2.57	NCBI

Akr1e2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	715,157 - 731,303 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	714,843 - 731,285 (-)	NCBI	ChiLan1.0	ChiLan1.0

AKR1E2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	17,376,873 - 17,506,881 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	17,379,890 - 17,404,469 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	10	4,850,001 - 4,872,215 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	4,850,001 - 4,872,210 (+)	Ensembl	panpan1.1		panPan2

AKR1E2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	30,694,119 - 30,706,693 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	30,694,249 - 30,706,637 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	27,723,671 - 27,736,248 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	31,074,880 - 31,087,459 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	31,074,883 - 31,087,898 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	28,164,234 - 28,176,774 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	29,001,557 - 29,014,106 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	29,725,464 - 29,738,044 (-)	NCBI		UU_Cfam_GSD_1.0

Akr1e2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	33,305,613 - 33,325,444 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	9,474,458 - 9,490,676 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	9,472,920 - 9,490,624 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AKR1E2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	65,680,332 - 65,702,190 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	65,680,314 - 65,704,701 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	72,108,978 - 72,133,547 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AKR1E2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	5,012,793 - 5,033,946 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	5,013,032 - 5,033,947 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	10,188,747 - 10,209,140 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Akr1e2
20 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	31
Count of miRNA genes:	29
Interacting mature miRNAs:	30
Transcripts:	ENSRNOT00000023133
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	7e-07	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	57246723	70156904	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	65703580	81153923	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	53498828	82479847	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	62619516	86533673	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	57246723	70852846	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24184890	79524188	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	42073160	69599340	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63640009	73951021	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	59005649	77910000	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			23930421	79524188	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	57246843	82046127	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat

Markers in Region

RH127938

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	65,750,099 - 65,750,288 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	69,379,603 - 69,379,791	NCBI	Rnor6.0
Rnor_5.0	17	71,093,360 - 71,093,548	UniSTS	Rnor5.0
RGSC_v3.4	17	77,025,483 - 77,025,671	UniSTS	RGSC3.4
Celera	17	65,282,782 - 65,282,970	UniSTS
RH 3.4 Map	17	637.9	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

BE121379

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	65,736,321 - 65,736,472 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	69,365,826 - 69,365,976	NCBI	Rnor6.0
Rnor_5.0	17	71,079,583 - 71,079,733	UniSTS	Rnor5.0
RGSC_v3.4	17	77,011,702 - 77,011,852	UniSTS	RGSC3.4
Celera	17	65,269,022 - 65,269,172	UniSTS
RH 3.4 Map	17	637.4	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212583	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023133 ⟹ ENSRNOP00000023133

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	65,735,943 - 65,750,435 (+)	Ensembl
Rnor_6.0 Ensembl	17	69,365,453 - 69,379,947 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109731 ⟹ ENSRNOP00000083564

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	65,736,023 - 65,750,441 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113194 ⟹ ENSRNOP00000087312

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	65,737,747 - 65,750,441 (+)	Ensembl

RefSeq Acc Id:

NM_001008342 ⟹ NP_001008343

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	70,645,882 - 70,660,366 (+)	NCBI
mRatBN7.2	17	65,735,956 - 65,750,441 (+)	NCBI
Rnor_6.0	17	69,365,460 - 69,379,944 (+)	NCBI
Rnor_5.0	17	71,079,217 - 71,093,701 (+)	NCBI
RGSC_v3.4	17	77,011,336 - 77,025,824 (+)	RGD
Celera	17	65,268,655 - 65,283,123 (+)	RGD

Sequence:

show sequence

CGCCCGGGGCTGCTCGCCGTCACCTCCAGTGCAGGTTGGGGGCTGATCCTCTGAGCGAAGGGGA
GCCATGCATCAAATCCCCACAGTGGGCCTGGGCACCTGGAAGGCCTCTCCAGGAGAAGTGACCG
ATGCGGTTAAGGTGGCTATCAACCTGGGCTACCGGCACTTCGACTGTGCTTACTTATACCACAA
TGAGAGTGAGGTTGGGATGGGAATCAAGGAGAAAATCAAGGAGGGTGTGGTGAAGAGAGACGAG
CTGTTCATCGTCAGTAAGCTGTGGTGCACGTACCACAAGCAGTCTTTGGTGAAAACGGCATGCA
TCAATACCCTGGAGGCCTTAAACCTGGATTACCTGGACCTCTACCTCATACACTGGCCCATGGG
CTTCAAGCCTGGGGACAAAGATATCCCTTTGGATCGCAGTGGCAAGGTCATACCCAGTCACACC
AGCTTTCTGGACACTTGGGAGGCCATGGAGGACCTGGTGATTGAGGGTCTGGTGAAGAACATTG
GGGTGTCCAACTTCAACCATGAACAGCTTGACAGACTTTTGAATAAGCCTGGTTTGAGAATCAA
GCCAATAACTAACCAGATTGAATGCCACCCATATCTTAATCAAAAGAGCCTAATTGATTTTTGC
CATGGAAGAAATGTGTCTGTGACCGCTTACCGTCCCCTCGGTGGCTCAAGAGATGGGGTTCACT
TGATGGATGATATCGTTATTCGGAAGATTGCAAAGAAGCATGGGAAGTCTCCTGCTCAGATTTT
GATCCGATTTCAGATCCAAAGGAACTTGATAGTGATTCCCAAATCTGTCAACCCAAGTCGGATT
AGAGAGAATATTCAGGTATTTGATTTTGAATTAACTGAAAAAGATATGGAGGAACTTCTCAGCC
TCGACAAGAACCTCCGCTTGGCCACCTTCCCCTCAACTGAAAATCATAAGGACTATCCTTTCCA
CATAGAGTACTAAAGACAGCCTCACTCTCCGTCATTTCTGCCCAGTGGAAACAGATCTCCAGGG
TCAGCAGCACTGATCCACCTCTGCAGAGGCTGTGTGGTCCCTGCGTGGCCACAGCAACAGACGC
AGCCACAGCCAAGAATGACAACAGAGTCGGAACAAGGAAAACTCTGCCTAGAACAGAACCAGTT
CGGAGAAAAATAAAGATCTAGGGATGAGAAAGGGAGGTACCACAAGGCGTGTGGCTGCTTCCAA
GTTGTTATGGAAAGCCAAGCGCCAAGAATAATGTAATTTATGTCAGTTAGCCCTAGTCCTTGTG
GCTTCTATTCTAGGAAGCGAGATGCTGATTGCTCATGAATTAAAGTTACCTTCACATTTTAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008771865 ⟹ XP_008770087

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	70,645,835 - 70,660,366 (+)	NCBI
mRatBN7.2	17	65,735,909 - 65,750,441 (+)	NCBI
Rnor_6.0	17	69,365,437 - 69,379,944 (+)	NCBI

Sequence:

show sequence

GCCAATCACGGCATTACCCTGAGCGCCCGGGGCTGCTCGCCGTCACCTCCAGTGCAGGTTGGGG
GCTGATCCTCTGAGCGAAGGGGAGCCATGCATCAAATCCCCACAGTGGGCCTGGGCACCTGGAA
GGCCTCTCCAGGAGAAGTGACCGATGCGGTTAAGGTGGCTATCAACCTGGGCTACCGGCACTTC
GACTGTGCTTACTTATACCACAATGAGAGTGAGGTTGGGATGGGAATCAAGGAGAAAATCAAGG
AGGGTGTGGTGAAGAGAGACGAGCTGTTCATCGTCAGTAAGCCTGGGGACAAAGATATCCCTTT
GGATCGCAGTGGCAAGGTCATACCCAGTCACACCAGCTTTCTGGACACTTGGGAGGCCATGGAG
GACCTGGTGATTGAGGGTCTGGTGAAGAACATTGGGGTGTCCAACTTCAACCATGAACAGCTTG
ACAGACTTTTGAATAAGCCTGGTTTGAGAATCAAGCCAATAACTAACCAGATTGAATGCCACCC
ATATCTTAATCAAAAGAGCCTAATTGATTTTTGCCATGGAAGAAATGTGTCTGTGACCGCTTAC
CGTCCCCTCGGTGGCTCAAGAGATGGGGTTCACTTGATGGATGATATCGTTATTCGGAAGATTG
CAAAGAAGCATGGGAAGTCTCCTGCTCAGATTTTGATCCGATTTCAGATCCAAAGGAACTTGAT
AGTGATTCCCAAATCTGTCAACCCAAGTCGGATTAGAGAGAATATTCAGGTATTTGATTTTGAA
TTAACTGAAAAAGATATGGAGGAACTTCTCAGCCTCGACAAGAACCTCCGCTTGGCCACCTTCC
CCTCAACTGAAAATCATAAGGACTATCCTTTCCACATAGAGTACTAAAGACAGCCTCACTCTCC
GTCATTTCTGCCCAGTGGAAACAGATCTCCAGGGTCAGCAGCACTGATCCACCTCTGCAGAGGC
TGTGTGGTCCCTGCGTGGCCACAGCAACAGACGCAGCCACAGCCAAGAATGACAACAGAGTCGG
AACAAGGAAAACTCTGCCTAGAACAGAACCAGTTCGGAGAAAAATAAAGATCTAGGGATGAGAA
AGGGAGGTACCACAAGGCGTGTGGCTGCTTCCAAGTTGTTATGGAAAGCCAAGCGCCAAGAATA
ATGTAATTTATGTCAGTTAGCCCTAGTCCTTGTGGCTTCTATTCTAGGAAGCGAGATGCTGATT
GCTCATGAATTAAAGTTACCTTCACATTTTAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008343	(Get FASTA)	NCBI Sequence Viewer
	XP_008770087	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86397	(Get FASTA)	NCBI Sequence Viewer
	EDL78561	(Get FASTA)	NCBI Sequence Viewer
	EDL78562	(Get FASTA)	NCBI Sequence Viewer
	EDL78563	(Get FASTA)	NCBI Sequence Viewer
	EDL78564	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023133.5
	ENSRNOP00000083564.1
	ENSRNOP00000087312.1
	ENSRNOP00055024928
	ENSRNOP00060023300
	ENSRNOP00065003475
GenBank Protein	Q5U1Y4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008343 ⟸ NM_001008342

- UniProtKB:

Q5U1Y4 (UniProtKB/Swiss-Prot), A0A8I6GF05 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHQIPTVGLGTWKASPGEVTDAVKVAINLGYRHFDCAYLYHNESEVGMGIKEKIKEGVVKRDEL
FIVSKLWCTYHKQSLVKTACINTLEALNLDYLDLYLIHWPMGFKPGDKDIPLDRSGKVIPSHTS
FLDTWEAMEDLVIEGLVKNIGVSNFNHEQLDRLLNKPGLRIKPITNQIECHPYLNQKSLIDFCH
GRNVSVTAYRPLGGSRDGVHLMDDIVIRKIAKKHGKSPAQILIRFQIQRNLIVIPKSVNPSRIR
ENIQVFDFELTEKDMEELLSLDKNLRLATFPSTENHKDYPFHIEY

hide sequence

RefSeq Acc Id:	XP_008770087 ⟸ XM_008771865
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GF05 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHQIPTVGLGTWKASPGEVTDAVKVAINLGYRHFDCAYLYHNESEVGMGIKEKIKEGVVKRDEL FIVSKPGDKDIPLDRSGKVIPSHTSFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLDRLLNKPGL RIKPITNQIECHPYLNQKSLIDFCHGRNVSVTAYRPLGGSRDGVHLMDDIVIRKIAKKHGKSPA QILIRFQIQRNLIVIPKSVNPSRIRENIQVFDFELTEKDMEELLSLDKNLRLATFPSTENHKDY PFHIEY hide sequence

Ensembl Acc Id:

ENSRNOP00000023133 ⟸ ENSRNOT00000023133

Ensembl Acc Id:

ENSRNOP00000083564 ⟸ ENSRNOT00000109731

Ensembl Acc Id:

ENSRNOP00000087312 ⟸ ENSRNOT00000113194

Protein Domains

NADP-dependent oxidoreductase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U1Y4-F1-model_v2	AlphaFold	Q5U1Y4	1-301	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700541

Promoter ID:

EPDNEW_R11064

Type:

initiation region

Name:

Akr1e2_1

Description:

aldo-keto reductase family 1, member E2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	69,365,478 - 69,365,538	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309599	AgrOrtholog
BioCyc Gene	G2FUF-8843	BioCyc
Ensembl Genes	ENSRNOG00000017165	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055018208	UniProtKB/Swiss-Prot
	ENSRNOG00060016684	UniProtKB/Swiss-Prot
	ENSRNOG00065003462	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023133.8	UniProtKB/Swiss-Prot
	ENSRNOT00000109731.1	UniProtKB/TrEMBL
	ENSRNOT00000113194.1	UniProtKB/TrEMBL
	ENSRNOT00055030943	UniProtKB/Swiss-Prot
	ENSRNOT00060028940	UniProtKB/Swiss-Prot
	ENSRNOT00065004925	UniProtKB/Swiss-Prot
Gene3D-CATH	3.20.20.100	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7302893	IMAGE-MGC_LOAD
InterPro	AKR	UniProtKB/TrEMBL
	Aldo/ket_reductase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldo/keto_reductase	UniProtKB/Swiss-Prot
	NADP_OxRdtase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADP_OxRdtase_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:307091	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105536	IMAGE-MGC_LOAD
NCBI Gene	307091	ENTREZGENE
PANTHER	1,5-ANHYDRO-D-FRUCTOSE REDUCTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDO/KETO REDUCTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aldo_ket_red	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Akr1e2	PhenoGen
PIRSF	AKR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	ALDKETRDTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ALDOKETO_REDUCTASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017165	RatGTEx
	ENSRNOG00055018208	RatGTEx
	ENSRNOG00060016684	RatGTEx
	ENSRNOG00065003462	RatGTEx
Superfamily-SCOP	SSF51430	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZXF6_RAT	UniProtKB/TrEMBL
	A0A8I6GF05	ENTREZGENE, UniProtKB/TrEMBL
	AKCL2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-02	Akr1e2	aldo-keto reductase family 1, member E2	Akr1cl2	aldo-keto reductase family 1, member C-like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Akr1cl2	aldo-keto reductase family 1, member C-like 2	Akr1e1	aldo-keto reductase family 1, member E1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Akr1e1	aldo-keto reductase family 1, member E1	Akr1e1_predicted	aldo-keto reductase family 1, member E1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Akr1e1_predicted	aldo-keto reductase family 1, member E1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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