Aopep (aminopeptidase O) - Rat Genome Database

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Pathways
Gene: Aopep (aminopeptidase O) Rattus norvegicus
Analyze
Symbol: Aopep
Name: aminopeptidase O
RGD ID: 1309592
Description: Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in dystonia 31. Orthologous to human AOPEP (aminopeptidase O (putative)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AP-O; Apo; LOC290963; Npepo; RGD1309592; similar to hypothetical protein FLJ14675
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8171,817,001 - 2,133,008 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl171,817,001 - 2,133,104 (-)EnsemblGRCr8
mRatBN7.2171,811,281 - 2,127,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,811,980 - 2,127,331 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx171,829,980 - 2,145,965 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0173,372,578 - 3,688,561 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0171,827,430 - 2,143,418 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.017507,389 - 825,062 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17507,377 - 821,582 (+)Ensemblrn6Rnor6.0
Rnor_5.017550,168 - 550,965 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.017568,777 - 814,393 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,353,426 - 7,624,936 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera17446,696 - 707,342 (+)NCBICelera
RGSC_v3.1177,353,425 - 7,624,936 (-)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
manganese(II) chloride  (EXP)
methapyrilene  (EXP,ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
permethrin  (EXP)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component
nucleolus  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase. Diaz-Perales A, etal., J Biol Chem. 2005 Apr 8;280(14):14310-7. Epub 2005 Feb 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17803194  


Genomics

Comparative Map Data
Aopep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8171,817,001 - 2,133,008 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl171,817,001 - 2,133,104 (-)EnsemblGRCr8
mRatBN7.2171,811,281 - 2,127,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,811,980 - 2,127,331 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx171,829,980 - 2,145,965 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0173,372,578 - 3,688,561 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0171,827,430 - 2,143,418 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.017507,389 - 825,062 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17507,377 - 821,582 (+)Ensemblrn6Rnor6.0
Rnor_5.017550,168 - 550,965 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.017568,777 - 814,393 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4177,353,426 - 7,624,936 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera17446,696 - 707,342 (+)NCBICelera
RGSC_v3.1177,353,425 - 7,624,936 (-)NCBI
Cytogenetic Map17p14NCBI
AOPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38994,726,699 - 95,150,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl994,726,604 - 95,151,793 (+)Ensemblhg38GRCh38
GRCh37997,488,981 - 97,849,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,528,815 - 96,889,262 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34994,568,548 - 94,928,995NCBI
Celera967,929,905 - 68,290,531 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef967,097,489 - 67,459,053 (+)NCBIHuRef
CHM1_1997,635,390 - 97,995,978 (+)NCBICHM1_1
T2T-CHM13v2.09106,896,013 - 107,317,676 (+)NCBIT2T-CHM13v2.0
Aopep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391363,112,707 - 63,473,910 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1363,112,707 - 63,473,910 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381362,964,893 - 63,326,096 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1362,964,893 - 63,326,096 (+)Ensemblmm10GRCm38
MGSCv371363,116,294 - 63,400,964 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361362,974,516 - 63,309,939 (+)NCBIMGSCv36mm8
Celera1364,682,940 - 64,953,836 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1332.8NCBI
Aopep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542221,680,488 - 21,920,775 (+)Ensembl
ChiLan1.0NW_00495542221,680,488 - 22,020,935 (+)NCBIChiLan1.0ChiLan1.0
AOPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21144,299,187 - 44,728,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1944,301,567 - 44,730,736 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0965,825,138 - 66,188,001 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1993,953,844 - 94,315,510 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl993,986,951 - 94,311,201 (+)EnsemblpanPan2panpan1.1
AOPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1171,770,687 - 72,009,374 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl171,677,068 - 72,009,395 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha172,438,651 - 72,771,366 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0171,981,049 - 72,313,890 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl171,981,051 - 72,313,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1171,792,454 - 72,124,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0171,556,523 - 71,890,575 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0172,262,807 - 72,595,715 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aopep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049444,466,607 - 4,745,317 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366263,667,123 - 3,970,433 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366263,704,474 - 3,973,913 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AOPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,078,113 - 27,472,310 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11027,078,115 - 27,472,347 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,342,998 - 31,670,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AOPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112108,007,895 - 108,360,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12108,171,743 - 108,360,041 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603896,390,611 - 96,723,601 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aopep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475316,188,323 - 16,588,989 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aopep
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11476,233,649 - 76,540,744 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aopep
472 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:87
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000023638
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat

Markers in Region
D17Got1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,957,814 - 1,958,035 (-)MAPPERmRatBN7.2
Rnor_6.017677,347 - 677,567NCBIRnor6.0
Rnor_5.017671,509 - 671,729UniSTSRnor5.0
RGSC_v3.4177,505,126 - 7,505,347RGDRGSC3.4
RGSC_v3.4177,505,127 - 7,505,347UniSTSRGSC3.4
Celera17565,615 - 565,835UniSTS
RGSC_v3.1177,505,127 - 7,505,347RGD
RH 3.4 Map170.0RGD
RH 3.4 Map170.0UniSTS
Cytogenetic Map17p14UniSTS
RH133549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,831,529 - 1,831,709 (-)MAPPERmRatBN7.2
Rnor_6.017805,275 - 805,454NCBIRnor6.0
Rnor_5.017798,088 - 798,267UniSTSRnor5.0
RGSC_v3.4177,369,552 - 7,369,731UniSTSRGSC3.4
Celera17691,037 - 691,216UniSTS
RH 3.4 Map1721.3UniSTS
Cytogenetic Map17p14UniSTS
BF399621  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2172,011,959 - 2,012,089 (-)MAPPERmRatBN7.2
Rnor_6.017623,260 - 623,389NCBIRnor6.0
Rnor_5.017617,422 - 617,551UniSTSRnor5.0
RGSC_v3.4177,559,715 - 7,559,844UniSTSRGSC3.4
Celera17511,519 - 511,648UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 355 191 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ810421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023638   ⟹   ENSRNOP00000023638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl171,817,001 - 2,133,104 (-)Ensembl
mRatBN7.2 Ensembl171,811,980 - 2,127,331 (-)Ensembl
Rnor_6.0 Ensembl17507,377 - 821,582 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129167   ⟹   ENSRNOP00000102309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl171,817,001 - 2,132,979 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153177   ⟹   ENSRNOP00000101943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl171,817,001 - 2,132,979 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160757   ⟹   ENSRNOP00000107620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl171,817,001 - 2,132,979 (-)Ensembl
RefSeq Acc Id: NM_001012346   ⟹   NP_001012346
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,001 - 2,132,979 (-)NCBI
mRatBN7.2171,811,281 - 2,127,286 (-)NCBI
Rnor_6.017558,184 - 821,580 (+)NCBI
Rnor_5.017550,168 - 550,965 (+)NCBI
Rnor_5.017568,777 - 814,393 (+)NCBI
RGSC_v3.4177,353,426 - 7,624,936 (-)RGD
Celera17446,696 - 707,342 (+)RGD
Sequence:
RefSeq Acc Id: XM_008771429   ⟹   XP_008769651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,002 (-)NCBI
mRatBN7.2171,811,922 - 2,127,306 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771431   ⟹   XP_008769653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,007 (-)NCBI
mRatBN7.2171,811,922 - 2,127,315 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771432   ⟹   XP_008769654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,006 (-)NCBI
mRatBN7.2171,811,922 - 2,127,316 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600471   ⟹   XP_017455960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
mRatBN7.2171,811,922 - 2,127,314 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600473   ⟹   XP_017455962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,083,259 (-)NCBI
mRatBN7.2171,811,922 - 2,077,548 (-)NCBI
Rnor_6.017556,489 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063276125   ⟹   XP_063132195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276126   ⟹   XP_063132196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276127   ⟹   XP_063132197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,132,803 (-)NCBI
RefSeq Acc Id: XM_063276129   ⟹   XP_063132199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276130   ⟹   XP_063132200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276131   ⟹   XP_063132201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,889,130 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276132   ⟹   XP_063132202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,963,589 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276133   ⟹   XP_063132203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,035,545 (-)NCBI
RefSeq Acc Id: XR_010058813
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,821,246 - 2,133,008 (-)NCBI
RefSeq Acc Id: XR_010058814
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,947,406 - 2,133,008 (-)NCBI
RefSeq Acc Id: XR_010058815
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,923,488 - 2,133,008 (-)NCBI
RefSeq Acc Id: XR_010058816
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,966,904 - 2,133,008 (-)NCBI
RefSeq Acc Id: NP_001012346   ⟸   NM_001012346
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008769651   ⟸   XM_008771429
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QC72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769653   ⟸   XM_008771431
- Peptide Label: isoform X2
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769654   ⟸   XM_008771432
- Peptide Label: isoform X2
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455960   ⟸   XM_017600471
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QC72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455962   ⟸   XM_017600473
- Peptide Label: isoform X2
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023638   ⟸   ENSRNOT00000023638
RefSeq Acc Id: XP_063132199   ⟸   XM_063276129
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132200   ⟸   XM_063276130
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132195   ⟸   XM_063276125
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QC72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132196   ⟸   XM_063276126
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QC72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132197   ⟸   XM_063276127
- Peptide Label: isoform X2
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132203   ⟸   XM_063276133
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063132201   ⟸   XM_063276131
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132202   ⟸   XM_063276132
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000101943   ⟸   ENSRNOT00000153177
Ensembl Acc Id: ENSRNOP00000102309   ⟸   ENSRNOT00000129167
Ensembl Acc Id: ENSRNOP00000107620   ⟸   ENSRNOT00000160757
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P69527-F1-model_v2 AlphaFold P69527 1-822 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700258
Promoter ID:EPDNEW_R10781
Type:multiple initiation site
Name:Npepo_1
Description:aminopeptidase O
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.017507,410 - 507,470EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309592 AgrOrtholog
BioCyc Gene G2FUF-10526 BioCyc
Ensembl Genes ENSRNOG00000017505 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023638 ENTREZGENE
  ENSRNOT00000160757 ENTREZGENE
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot
  1.25.40.320 UniProtKB/Swiss-Prot
  2.60.40.1730 UniProtKB/Swiss-Prot
  3.30.2010.30 UniProtKB/Swiss-Prot
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  AOPep UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  M1_LTA-4_hydro/amino_C_sf UniProtKB/Swiss-Prot
  Peptidase_M1_C UniProtKB/Swiss-Prot
  Peptidase_M1_dom UniProtKB/Swiss-Prot
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot
KEGG Report rno:290963 UniProtKB/Swiss-Prot
NCBI Gene 290963 ENTREZGENE
PANTHER AMINOPEPTIDASE O UniProtKB/Swiss-Prot
  PTHR46627 UniProtKB/Swiss-Prot
Pfam Leuk-A4-hydro_C UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
PhenoGen Aopep PhenoGen
RatGTEx ENSRNOG00000017505 RatGTEx
SMART Leuk-A4-hydro_C UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot
  SSF63737 UniProtKB/Swiss-Prot
UniProt A0A8L2QC72 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L117_RAT UniProtKB/TrEMBL
  A0ABK0LGC2_RAT UniProtKB/TrEMBL
  AMPO_RAT UniProtKB/Swiss-Prot
  F1LRV1 ENTREZGENE
  P69527 ENTREZGENE
UniProt Secondary F1LRV1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Aopep  aminopeptidase O  Npepo  aminopeptidase O  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-11 Npepo  aminopeptidase O  RGD1309592  similar to hypothetical protein FLJ14675  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309592  similar to hypothetical protein FLJ14675  RGD1309592_predicted  similar to hypothetical protein FLJ14675 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309592_predicted  similar to hypothetical protein FLJ14675 (predicted)  LOC290963_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290963_predicted  similar to hypothetical protein FLJ14675 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL