Nectin2 (nectin cell adhesion molecule 2) - Rat Genome Database

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Gene: Nectin2 (nectin cell adhesion molecule 2) Rattus norvegicus
Analyze
Symbol: Nectin2
Name: nectin cell adhesion molecule 2
RGD ID: 1309505
Description: Predicted to enable cell adhesion molecule binding activity; protein homodimerization activity; and receptor ligand activity. Predicted to be involved in several processes, including coreceptor-mediated virion attachment to host cell; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of immune response. Predicted to act upstream of or within several processes, including negative regulation of natural killer cell mediated cytotoxicity; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in several cellular components, including cell surface; cell-cell contact zone; and zonula adherens. Predicted to be active in apical junction complex and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC308417; MGC94554; nectin-2; poliovirus receptor related 2; poliovirus receptor-related 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; Pvrl2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,500,086 - 88,535,474 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,500,087 - 88,535,305 (-)EnsemblGRCr8
mRatBN7.2179,372,123 - 79,407,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,372,119 - 79,407,360 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,767,039 - 84,801,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,318,394 - 93,353,445 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,522,146 - 86,557,049 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,631,449 - 80,666,617 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,631,450 - 80,666,585 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,896,927 - 81,932,099 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,021,831 - 79,059,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,831,315 - 73,865,827 (-)NCBICelera
RGSC_v3.1179,099,942 - 79,137,797 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
etoposide  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
glafenine  (EXP)
hexaconazole  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical junction complex  (IBA,IEA,ISO)
cell surface  (IEA,ISO)
cell-cell contact zone  (IEA,ISO)
cell-cell junction  (IEA,ISO)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
zonula adherens  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A comprehensive genetic association study of Alzheimer disease in African Americans. Logue MW, etal., Arch Neurol. 2011 Dec;68(12):1569-79.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis. Ramagopalan SV, etal., J Neuroimmunol. 2007 May;186(1-2):156-60. Epub 2007 Mar 21.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. Schmidt S, etal., Genes Immun. 2006 Jul;7(5):384-92. Epub 2006 Jun 1.
Additional References at PubMed
PMID:9845526   PMID:10225955   PMID:10733589   PMID:11602758   PMID:12477932   PMID:12826663   PMID:12913096   PMID:12915581   PMID:15039383   PMID:15660130   PMID:15728677   PMID:16304049  
PMID:16831868   PMID:17133358   PMID:21423176   PMID:21982860   PMID:22512338   PMID:22902367   PMID:22927415   PMID:23376485   PMID:23533145   PMID:23533177   PMID:23758976   PMID:26755705  
PMID:28515320  


Genomics

Comparative Map Data
Nectin2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,500,086 - 88,535,474 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,500,087 - 88,535,305 (-)EnsemblGRCr8
mRatBN7.2179,372,123 - 79,407,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,372,119 - 79,407,360 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,767,039 - 84,801,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,318,394 - 93,353,445 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,522,146 - 86,557,049 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,631,449 - 80,666,617 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,631,450 - 80,666,585 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,896,927 - 81,932,099 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,021,831 - 79,059,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,831,315 - 73,865,827 (-)NCBICelera
RGSC_v3.1179,099,942 - 79,137,797 (-)NCBI
Cytogenetic Map1q21NCBI
NECTIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,846,297 - 44,889,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,846,175 - 44,889,228 (+)Ensemblhg38GRCh38
GRCh371945,349,554 - 45,392,480 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,041,233 - 50,084,325 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341950,041,473 - 50,074,034NCBI
Celera1942,153,754 - 42,196,828 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,779,725 - 41,822,792 (+)NCBIHuRef
CHM1_11945,352,150 - 45,395,259 (+)NCBICHM1_1
T2T-CHM13v2.01947,671,015 - 47,713,944 (+)NCBIT2T-CHM13v2.0
Nectin2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,450,569 - 19,483,498 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,450,569 - 19,484,408 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,716,644 - 19,749,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,716,644 - 19,750,483 (-)Ensemblmm10GRCm38
MGSCv37720,301,993 - 20,334,922 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,875,183 - 18,907,991 (-)NCBIMGSCv36mm8
Celera717,122,731 - 17,155,753 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Nectin2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,960,032 - 1,980,965 (+)Ensembl
ChiLan1.0NW_0049555551,959,702 - 1,985,679 (+)NCBIChiLan1.0ChiLan1.0
NECTIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,005,664 - 51,048,736 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,877,594 - 52,920,640 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,794,037 - 41,837,047 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,399,367 - 50,443,024 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,399,668 - 50,443,024 (+)EnsemblpanPan2panpan1.1
NECTIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,543,140 - 110,569,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,543,247 - 110,569,143 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1110,024,087 - 110,050,106 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01111,072,925 - 111,094,462 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,072,991 - 111,131,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,747,557 - 110,773,459 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,383,024 - 110,409,042 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,251,830 - 111,278,287 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nectin2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,123,454 - 17,151,649 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,470,738 - 1,498,993 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,470,910 - 1,498,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NECTIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1651,317,386 - 51,358,665 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,217,254 - 47,335,651 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NECTIN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,320,791 - 38,361,419 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,320,933 - 38,361,742 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607317,889,617 - 17,931,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nectin2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,713,443 - 1,740,627 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249071,713,786 - 1,739,158 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nectin2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12170,868,183 - 170,902,894 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nectin2
183 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:493
Count of miRNA genes:241
Interacting mature miRNAs:281
Transcripts:ENSRNOT00000025388
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
D1Got83  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8188,531,298 - 88,531,498 (+)Marker Load Pipeline
Rnor_6.0180,662,610 - 80,662,778NCBIRnor6.0
Rnor_5.0181,928,000 - 81,928,136UniSTSRnor5.0
RGSC_v3.4179,055,618 - 79,055,879UniSTSRGSC3.4
RGSC_v3.4179,055,617 - 79,055,879RGDRGSC3.4
RGSC_v3.1179,133,728 - 79,133,990RGD
RH 3.4 Map1820.6UniSTS
RH 3.4 Map1820.6RGD
Cytogenetic Map1q21UniSTS
RH130455  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,407,263 - 79,407,476 (+)MAPPERmRatBN7.2
Rnor_6.0180,666,499 - 80,666,711NCBIRnor6.0
Rnor_5.0181,931,857 - 81,932,069UniSTSRnor5.0
RGSC_v3.4179,059,600 - 79,059,812UniSTSRGSC3.4
Celera173,865,741 - 73,865,953UniSTS
RH 3.4 Map1787.2UniSTS
Cytogenetic Map1q21UniSTS
BE102426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,377,211 - 79,377,390 (+)MAPPERmRatBN7.2
Rnor_6.0180,636,474 - 80,636,652NCBIRnor6.0
Rnor_5.0181,901,864 - 81,902,042UniSTSRnor5.0
RGSC_v3.4179,027,797 - 79,027,975UniSTSRGSC3.4
Celera173,836,398 - 73,836,576UniSTS
RH 3.4 Map1786.7UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 39 59 6 303 139 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025388   ⟹   ENSRNOP00000025388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,500,087 - 88,535,305 (-)Ensembl
mRatBN7.2 Ensembl179,372,119 - 79,407,360 (-)Ensembl
Rnor_6.0 Ensembl180,631,450 - 80,666,585 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082125   ⟹   ENSRNOP00000075285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,380,394 - 79,407,360 (-)Ensembl
Rnor_6.0 Ensembl180,639,785 - 80,666,566 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117594   ⟹   ENSRNOP00000085213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,500,087 - 88,535,305 (-)Ensembl
mRatBN7.2 Ensembl179,372,119 - 79,396,873 (-)Ensembl
RefSeq Acc Id: NM_001012064   ⟹   NP_001012064
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,500,086 - 88,535,305 (-)NCBI
mRatBN7.2179,372,123 - 79,407,350 (-)NCBI
Rnor_6.0180,631,449 - 80,666,585 (-)NCBI
Rnor_5.0181,896,927 - 81,932,099 (-)NCBI
RGSC_v3.4179,021,831 - 79,059,686 (-)RGD
Celera173,831,315 - 73,865,827 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228421   ⟹   XP_006228483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,508,355 - 88,535,474 (-)NCBI
mRatBN7.2179,380,394 - 79,407,379 (-)NCBI
Rnor_6.0180,639,654 - 80,666,617 (-)NCBI
Rnor_5.0181,896,927 - 81,932,099 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012064 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228483 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH90075 (Get FASTA)   NCBI Sequence Viewer  
  EDM08139 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025388
  ENSRNOP00000025388.5
  ENSRNOP00000085213.2
RefSeq Acc Id: NP_001012064   ⟸   NM_001012064
- Peptide Label: precursor
- UniProtKB: Q5FVC5 (UniProtKB/TrEMBL),   A0A8I6A2S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228483   ⟸   XM_006228421
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KA71 (UniProtKB/TrEMBL),   A6J8U5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075285   ⟸   ENSRNOT00000082125
Ensembl Acc Id: ENSRNOP00000025388   ⟸   ENSRNOT00000025388
Ensembl Acc Id: ENSRNOP00000085213   ⟸   ENSRNOT00000117594
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVC5-F1-model_v2 AlphaFold Q5FVC5 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689789
Promoter ID:EPDNEW_R306
Type:initiation region
Name:Nectin2_1
Description:nectin cell adhesion molecule 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,666,547 - 80,666,607EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309505 AgrOrtholog
BioCyc Gene G2FUF-60486 BioCyc
Ensembl Genes ENSRNOG00000018730 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025388 ENTREZGENE
  ENSRNOT00000025388.8 UniProtKB/TrEMBL
  ENSRNOT00000117594.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189358 IMAGE-MGC_LOAD
InterPro CD80_C2-set UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Nectin/PVR UniProtKB/TrEMBL
KEGG Report rno:308417 UniProtKB/TrEMBL
MGC_CLONE MGC:94554 IMAGE-MGC_LOAD
NCBI Gene 308417 ENTREZGENE
PANTHER NECTIN-2 UniProtKB/TrEMBL
  PTHR47387:SF1 UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Nectin2 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018730 RatGTEx
SMART IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2KA71 ENTREZGENE
  A0A8I6A2S9 ENTREZGENE, UniProtKB/TrEMBL
  A6J8U5 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVC5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Nectin2  nectin cell adhesion molecule 2  Pvrl2  poliovirus receptor-related 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Pvrl2  poliovirus receptor-related 2  Pvrl2  poliovirus receptor-related 2 (herpesvirus entry mediator B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Pvrl2  poliovirus receptor-related 2 (herpesvirus entry mediator B)  Pvrl2_predicted  poliovirus receptor-related 2 (herpesvirus entry mediator B) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pvrl2_predicted  poliovirus receptor-related 2 (herpesvirus entry mediator B) (predicted)      Symbol and Name status set to approved 70820 APPROVED