Vangl2 (VANGL planar cell polarity protein 2) - Rat Genome Database

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Gene: Vangl2 (VANGL planar cell polarity protein 2) Rattus norvegicus
Analyze
Symbol: Vangl2
Name: VANGL planar cell polarity protein 2
RGD ID: 1309442
Description: Predicted to be involved in several processes, including axon guidance; cell migration involved in kidney development; and morphogenesis of an epithelium. Predicted to act upstream of or within several processes, including heart morphogenesis; inner ear development; and morphogenesis of an epithelium. Predicted to be located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC289229; loop tail associated protein; Ltap; van Gogh-like protein 2; vang-like 2 (van gogh, Drosophila); vang-like protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,995,124 - 87,021,770 (-)NCBIGRCr8
mRatBN7.21384,462,731 - 84,489,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,465,527 - 84,489,378 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,968,878 - 86,992,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,369,149 - 88,393,001 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,553,752 - 85,577,558 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,379,203 - 90,405,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,380,632 - 90,405,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,902,313 - 94,928,719 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,964,426 - 87,988,364 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,152,106 - 88,178,412 (-)NCBI
Celera1384,077,622 - 84,101,482 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
apical protein localization  (ISO)
biological_process  (ND)
cell migration involved in kidney development  (ISO)
cochlea development  (ISO)
cochlea morphogenesis  (ISO)
convergent extension involved in axis elongation  (ISO)
convergent extension involved in neural plate elongation  (ISO)
convergent extension involved in organogenesis  (ISO)
digestive tract morphogenesis  (ISO)
dopaminergic neuron axon guidance  (ISO)
establishment of body hair planar orientation  (ISO)
establishment of planar polarity  (IBA,ISO)
establishment of planar polarity involved in neural tube closure  (ISO)
establishment or maintenance of epithelial cell apical/basal polarity  (ISO)
glomerulus development  (ISO)
hair follicle development  (ISO)
heart looping  (ISO)
heparan sulfate proteoglycan biosynthetic process  (ISO)
inner ear receptor cell development  (ISO)
inner ear receptor cell stereocilium organization  (ISO)
kidney morphogenesis  (ISO)
lateral sprouting involved in lung morphogenesis  (ISO)
membranous septum morphogenesis  (ISO)
muscular septum morphogenesis  (ISO)
neural tube closure  (ISO)
non-canonical Wnt signaling pathway  (ISO)
non-motile cilium assembly  (ISO)
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis  (ISO)
planar cell polarity pathway involved in axis elongation  (ISO)
planar cell polarity pathway involved in heart morphogenesis  (ISO)
planar cell polarity pathway involved in neural tube closure  (ISO)
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis  (ISO)
post-anal tail morphogenesis  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of establishment of planar polarity  (ISO)
regulation of synapse pruning  (ISO)
regulation of Wnt signaling pathway  (ISO)
Rho protein signal transduction  (ISO)
serotonergic neuron axon guidance  (ISO)
somatic stem cell division  (ISO)
somatic stem cell population maintenance  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (IBA,ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Planar cell polarity signaling in vertebrates. Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32.
3. Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23. Katoh M Int J Oncol. 2002 Jun;20(6):1197-203.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2. Nagaoka T, etal., Sci Rep. 2015 Aug 10;5:12916. doi: 10.1038/srep12916.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11440971   PMID:11709546   PMID:12499390   PMID:12724779   PMID:14512015   PMID:15057822   PMID:15195140   PMID:15229603   PMID:15637299   PMID:16116426   PMID:16170314   PMID:16495441  
PMID:16571627   PMID:16687519   PMID:16962386   PMID:17229766   PMID:17376975   PMID:17433286   PMID:18066062   PMID:18257070   PMID:18606138   PMID:18849982   PMID:19008950   PMID:19300477  
PMID:19497282   PMID:19701191   PMID:19966784   PMID:20215345   PMID:20223754   PMID:20473291   PMID:20534871   PMID:20643356   PMID:20704721   PMID:20843830   PMID:20940229   PMID:21106844  
PMID:21246654   PMID:21718540   PMID:21761479   PMID:22871113   PMID:23760952   PMID:24302887   PMID:25387771   PMID:25605782   PMID:26683906   PMID:26990065   PMID:29454802   PMID:29497043  


Genomics

Comparative Map Data
Vangl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,995,124 - 87,021,770 (-)NCBIGRCr8
mRatBN7.21384,462,731 - 84,489,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,465,527 - 84,489,378 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,968,878 - 86,992,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,369,149 - 88,393,001 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,553,752 - 85,577,558 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,379,203 - 90,405,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,380,632 - 90,405,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,902,313 - 94,928,719 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,964,426 - 87,988,364 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,152,106 - 88,178,412 (-)NCBI
Celera1384,077,622 - 84,101,482 (-)NCBICelera
Cytogenetic Map13q24NCBI
VANGL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,400,564 - 160,428,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,400,564 - 160,428,670 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,370,354 - 160,398,460 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,636,988 - 158,665,088 (+)NCBINCBI36Build 36hg18NCBI36
Build 341157,198,538 - 157,211,533NCBI
Celera1133,439,094 - 133,467,201 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,726,520 - 131,754,628 (+)NCBIHuRef
CHM1_11161,765,749 - 161,793,853 (+)NCBICHM1_1
T2T-CHM13v2.01159,537,640 - 159,565,747 (+)NCBIT2T-CHM13v2.0
Vangl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,828,527 - 171,856,532 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,828,527 - 171,856,011 (-)EnsemblGRCm39 Ensembl
GRCm381172,000,960 - 172,027,318 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,000,960 - 172,028,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,934,502 - 173,957,399 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,841,046 - 173,863,943 (-)NCBIMGSCv36mm8
Celera1174,856,349 - 174,879,265 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
Vangl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,161,843 - 12,189,547 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,162,084 - 12,189,322 (+)NCBIChiLan1.0ChiLan1.0
VANGL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,423,065 - 89,451,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,163,031 - 89,190,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,754,897 - 135,783,031 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11139,676,595 - 139,704,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,683,745 - 139,704,281 (+)Ensemblpanpan1.1panPan2
VANGL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,822,873 - 21,824,537 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,892,456 - 21,915,854 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,934,985 - 21,958,434 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,928,893 - 21,958,752 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,823,051 - 21,846,540 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,235,964 - 22,259,526 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,645,964 - 22,669,547 (-)NCBIUU_Cfam_GSD_1.0
Vangl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,512,192 - 6,526,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740228,317 - 242,601 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936740228,377 - 242,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VANGL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,051,277 - 90,080,635 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,051,994 - 90,080,701 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,945,552 - 97,971,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VANGL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,521,066 - 3,549,301 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,521,060 - 3,548,718 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660382,578,515 - 2,606,736 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vangl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794841,247 - 867,708 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794841,302 - 867,717 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vangl2
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:56
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000006849
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH138077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21384,464,329 - 84,464,464 (+)MAPPERmRatBN7.2
Rnor_6.01390,380,801 - 90,380,935NCBIRnor6.0
Rnor_5.01394,903,911 - 94,904,045UniSTSRnor5.0
RGSC_v3.41387,963,229 - 87,963,363UniSTSRGSC3.4
Celera1384,076,429 - 84,076,563UniSTS
RH 3.4 Map13550.7UniSTS
Cytogenetic Map13q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 4 4 4 55 18 25
Low 3 33 20 8 19 8 2 2 19 16 15 11 2
Below cutoff 4 30 26 26 6 9 1 1 6

Sequence


RefSeq Acc Id: ENSRNOT00000006849   ⟹   ENSRNOP00000006849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1384,465,527 - 84,489,378 (-)Ensembl
Rnor_6.0 Ensembl1390,381,998 - 90,405,591 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091710   ⟹   ENSRNOP00000072619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1390,380,632 - 90,405,358 (-)Ensembl
RefSeq Acc Id: NM_001105969   ⟹   NP_001099439
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,997,920 - 87,021,770 (-)NCBI
mRatBN7.21384,465,527 - 84,489,378 (-)NCBI
Rnor_6.01390,381,998 - 90,405,591 (-)NCBI
Rnor_5.01394,902,313 - 94,928,719 (-)NCBI
RGSC_v3.41387,964,426 - 87,988,364 (-)RGD
Celera1384,077,622 - 84,101,482 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250276   ⟹   XP_006250338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,995,124 - 87,021,621 (-)NCBI
mRatBN7.21384,462,731 - 84,489,404 (-)NCBI
Rnor_6.01390,379,203 - 90,405,627 (-)NCBI
Rnor_5.01394,902,313 - 94,928,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250277   ⟹   XP_006250339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,995,124 - 87,021,622 (-)NCBI
mRatBN7.21384,462,731 - 84,489,404 (-)NCBI
Rnor_6.01390,379,203 - 90,405,627 (-)NCBI
Rnor_5.01394,902,313 - 94,928,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598712   ⟹   XP_017454201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,995,124 - 87,021,404 (-)NCBI
mRatBN7.21384,462,731 - 84,489,037 (-)NCBI
Rnor_6.01390,379,203 - 90,405,045 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598713   ⟹   XP_017454202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,995,124 - 87,021,616 (-)NCBI
mRatBN7.21384,462,731 - 84,489,404 (-)NCBI
Rnor_6.01390,379,203 - 90,405,627 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090512   ⟹   XP_038946440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,995,124 - 87,021,284 (-)NCBI
mRatBN7.21384,462,731 - 84,489,037 (-)NCBI
RefSeq Acc Id: XM_039090513   ⟹   XP_038946441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,995,124 - 87,011,279 (-)NCBI
mRatBN7.21384,462,731 - 84,478,875 (-)NCBI
RefSeq Acc Id: XM_039090514   ⟹   XP_038946442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,995,124 - 87,021,284 (-)NCBI
mRatBN7.21384,462,731 - 84,489,037 (-)NCBI
RefSeq Acc Id: NP_001099439   ⟸   NM_001105969
- UniProtKB: P84889 (UniProtKB/Swiss-Prot),   A6JG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250339   ⟸   XM_006250277
- Peptide Label: isoform X1
- UniProtKB: P84889 (UniProtKB/Swiss-Prot),   A6JG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250338   ⟸   XM_006250276
- Peptide Label: isoform X1
- UniProtKB: P84889 (UniProtKB/Swiss-Prot),   A6JG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454202   ⟸   XM_017598713
- Peptide Label: isoform X1
- UniProtKB: P84889 (UniProtKB/Swiss-Prot),   A6JG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454201   ⟸   XM_017598712
- Peptide Label: isoform X1
- UniProtKB: P84889 (UniProtKB/Swiss-Prot),   A6JG15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006849   ⟸   ENSRNOT00000006849
RefSeq Acc Id: ENSRNOP00000072619   ⟸   ENSRNOT00000091710
RefSeq Acc Id: XP_038946442   ⟸   XM_039090514
- Peptide Label: isoform X1
- UniProtKB: P84889 (UniProtKB/Swiss-Prot),   A6JG15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946440   ⟸   XM_039090512
- Peptide Label: isoform X1
- UniProtKB: P84889 (UniProtKB/Swiss-Prot),   A6JG15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946441   ⟸   XM_039090513
- Peptide Label: isoform X1
- UniProtKB: P84889 (UniProtKB/Swiss-Prot),   A6JG15 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84889-F1-model_v2 AlphaFold P84889 1-521 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309442 AgrOrtholog
BioCyc Gene G2FUF-17335 BioCyc
Ensembl Genes ENSRNOG00000004889 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006849 ENTREZGENE
  ENSRNOT00000006849.6 UniProtKB/Swiss-Prot
InterPro VANGL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 289229 ENTREZGENE
PANTHER PTHR20886 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VANG-LIKE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Strabismus UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vangl2 PhenoGen
PIRSF Strabismus UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004889 RatGTEx
UniProt A6JG15 ENTREZGENE, UniProtKB/TrEMBL
  P84889 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-20 Vangl2  VANGL planar cell polarity protein 2  Vangl2  vang-like 2 (van gogh, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Vangl2  vang-like 2 (van gogh, Drosophila)   Vangl2_predicted  vang-like 2 (van gogh, Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Vangl2_predicted  vang-like 2 (van gogh, Drosophila) (predicted)  Ltap_predicted  loop tail associated protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Ltap_predicted  loop tail associated protein (predicted)      Symbol and Name status set to approved 70820 APPROVED