Fars2 (phenylalanyl-tRNA synthetase 2, mitochondrial) - Rat Genome Database

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Pathways
Gene: Fars2 (phenylalanyl-tRNA synthetase 2, mitochondrial) Rattus norvegicus
Analyze
Symbol: Fars2
Name: phenylalanyl-tRNA synthetase 2, mitochondrial
RGD ID: 1309416
Description: Predicted to enable phenylalanine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and tRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fars1; LOC306879; phenylalanine--tRNA ligase; phenylalanine--tRNA ligase, mitochondrial; phenylalanine-tRNA synthetase 1 (mitochondrial); phenylalanine-tRNA synthetase 2 (mitochondrial); phenylalanyl-tRNA synthetase, mitochondrial; pheRS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81728,524,737 - 28,951,818 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1728,524,738 - 28,951,591 (-)EnsemblGRCr8
mRatBN7.21728,319,215 - 28,746,217 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1728,319,280 - 28,746,337 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1728,172,413 - 28,606,316 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01729,775,948 - 30,209,861 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01728,156,059 - 28,582,258 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01729,006,981 - 29,438,906 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1729,006,988 - 29,438,668 (-)Ensemblrn6Rnor6.0
Rnor_5.01730,910,287 - 31,335,424 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41734,595,255 - 35,048,596 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1727,926,270 - 28,350,728 (-)NCBICelera
RGSC_v3.11734,598,096 - 35,051,437 (-)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
mitochondrial matrix  (IEA)
mitochondrion  (IBA,IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. A Newly Identified Missense Mutation in FARS2 Causes Autosomal-Recessive Spastic Paraplegia. Yang Y, etal., Hum Mutat. 2016 Feb;37(2):165-9. doi: 10.1002/humu.22930. Epub 2015 Dec 10.
Additional References at PubMed
PMID:10329163   PMID:15489334   PMID:18614015   PMID:38362779  


Genomics

Comparative Map Data
Fars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81728,524,737 - 28,951,818 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1728,524,738 - 28,951,591 (-)EnsemblGRCr8
mRatBN7.21728,319,215 - 28,746,217 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1728,319,280 - 28,746,337 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1728,172,413 - 28,606,316 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01729,775,948 - 30,209,861 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01728,156,059 - 28,582,258 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01729,006,981 - 29,438,906 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1729,006,988 - 29,438,668 (-)Ensemblrn6Rnor6.0
Rnor_5.01730,910,287 - 31,335,424 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41734,595,255 - 35,048,596 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1727,926,270 - 28,350,728 (-)NCBICelera
RGSC_v3.11734,598,096 - 35,051,437 (-)NCBI
Cytogenetic Map17p12NCBI
FARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3865,249,934 - 5,771,583 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl65,261,044 - 5,829,192 (+)Ensemblhg38GRCh38
GRCh3765,261,240 - 5,771,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3665,206,583 - 5,716,815 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3465,206,725 - 5,716,815NCBI
Celera66,488,372 - 6,998,947 (+)NCBICelera
Cytogenetic Map6p25.1NCBI
HuRef65,135,999 - 5,646,422 (+)NCBIHuRef
CHM1_165,264,226 - 5,774,754 (+)NCBICHM1_1
T2T-CHM13v2.065,119,147 - 5,640,982 (+)NCBIT2T-CHM13v2.0
Fars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391336,301,373 - 36,721,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1336,301,395 - 36,910,254 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381336,117,428 - 36,537,595 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1336,117,412 - 36,726,280 (+)Ensemblmm10GRCm38
MGSCv371336,209,280 - 36,629,462 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361336,124,876 - 36,545,059 (+)NCBIMGSCv36mm8
Celera1337,233,059 - 37,656,949 (+)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.44NCBI
Fars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554657,877,824 - 8,241,742 (-)Ensembl
ChiLan1.0NW_0049554657,878,115 - 8,345,749 (-)NCBIChiLan1.0ChiLan1.0
FARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2519,889,702 - 20,402,181 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1615,894,194 - 16,406,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v065,096,453 - 5,608,362 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.165,279,111 - 5,790,110 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl65,387,291 - 5,792,749 (+)EnsemblpanPan2panpan1.1
FARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1355,389,694 - 5,887,911 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl355,460,664 - 5,948,574 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha355,394,516 - 5,893,227 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0355,458,863 - 5,962,520 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl355,458,887 - 6,023,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1355,324,623 - 5,823,834 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0355,350,375 - 5,849,465 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0356,683,189 - 7,182,810 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494618,434,776 - 18,936,050 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365346,703,749 - 7,087,658 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365346,703,760 - 7,205,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl73,262,396 - 3,557,407 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.173,193,433 - 3,557,413 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11766,356,479 - 66,921,276 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1766,543,452 - 66,898,446 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660445,208,363 - 5,718,281 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475619,550,103 - 19,928,538 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475619,550,198 - 20,016,561 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fars2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11455,222,038 - 55,594,407 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fars2
2964 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:97
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000021660
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
D17Got38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21728,634,837 - 28,634,931 (+)MAPPERmRatBN7.2
Rnor_6.01729,327,419 - 29,327,512NCBIRnor6.0
Rnor_5.01731,224,244 - 31,224,337UniSTSRnor5.0
RGSC_v3.41734,936,490 - 34,936,584RGDRGSC3.4
RGSC_v3.41734,936,491 - 34,936,584UniSTSRGSC3.4
Celera1728,239,714 - 28,239,807UniSTS
RGSC_v3.11734,939,332 - 34,939,425RGD
RH 3.4 Map17327.6RGD
RH 3.4 Map17327.6UniSTS
RH 2.0 Map17253.3RGD
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001440250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000021660   ⟹   ENSRNOP00000021660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1728,524,738 - 28,951,551 (-)Ensembl
mRatBN7.2 Ensembl1728,319,281 - 28,746,096 (-)Ensembl
Rnor_6.0 Ensembl1729,006,988 - 29,438,668 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080031   ⟹   ENSRNOP00000069318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1728,524,738 - 28,951,591 (-)Ensembl
mRatBN7.2 Ensembl1728,319,280 - 28,746,160 (-)Ensembl
Rnor_6.0 Ensembl1729,025,996 - 29,360,822 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096528   ⟹   ENSRNOP00000095619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1728,524,738 - 28,800,752 (-)Ensembl
mRatBN7.2 Ensembl1728,319,280 - 28,595,119 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108459   ⟹   ENSRNOP00000092101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1728,319,289 - 28,746,337 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113971   ⟹   ENSRNOP00000079964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1728,543,594 - 28,951,591 (-)Ensembl
mRatBN7.2 Ensembl1728,329,644 - 28,746,160 (-)Ensembl
RefSeq Acc Id: NM_001013139   ⟹   NP_001013157
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,737 - 28,951,551 (-)NCBI
mRatBN7.21728,319,280 - 28,746,096 (-)NCBI
Rnor_6.01729,006,983 - 29,438,668 (-)NCBI
Rnor_5.01730,910,287 - 31,335,424 (-)NCBI
RGSC_v3.41734,595,255 - 35,048,596 (-)RGD
Celera1727,926,270 - 28,350,728 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253823   ⟹   XP_006253885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,818 (-)NCBI
mRatBN7.21728,319,435 - 28,746,217 (-)NCBI
Rnor_6.01729,007,192 - 29,438,789 (-)NCBI
Rnor_5.01730,910,287 - 31,335,424 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253825   ⟹   XP_006253887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,737 - 28,951,688 (-)NCBI
mRatBN7.21728,319,280 - 28,746,211 (-)NCBI
Rnor_6.01729,006,981 - 29,438,789 (-)NCBI
Rnor_5.01730,910,287 - 31,335,424 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253826   ⟹   XP_006253888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,659,202 - 28,951,818 (-)NCBI
mRatBN7.21728,471,430 - 28,746,216 (-)NCBI
Rnor_6.01729,159,736 - 29,438,789 (-)NCBI
Rnor_5.01730,910,287 - 31,335,424 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095689   ⟹   XP_038951617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,558,487 - 28,951,818 (-)NCBI
mRatBN7.21728,359,133 - 28,746,216 (-)NCBI
RefSeq Acc Id: XM_063276391   ⟹   XP_063132461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,663 (-)NCBI
RefSeq Acc Id: XM_063276393   ⟹   XP_063132463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,799 (-)NCBI
RefSeq Acc Id: XM_063276394   ⟹   XP_063132464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,799 (-)NCBI
RefSeq Acc Id: XM_063276395   ⟹   XP_063132465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,663 (-)NCBI
RefSeq Acc Id: XM_063276396   ⟹   XP_063132466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,817 (-)NCBI
RefSeq Acc Id: XM_063276397   ⟹   XP_063132467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,664 (-)NCBI
RefSeq Acc Id: XM_063276398   ⟹   XP_063132468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,664 (-)NCBI
RefSeq Acc Id: XM_063276399   ⟹   XP_063132469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,818 (-)NCBI
RefSeq Acc Id: XM_063276400   ⟹   XP_063132470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,951,659 (-)NCBI
RefSeq Acc Id: XM_063276401   ⟹   XP_063132471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,737 - 28,951,653 (-)NCBI
RefSeq Acc Id: XM_063276403   ⟹   XP_063132473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,737 - 28,951,799 (-)NCBI
RefSeq Acc Id: XM_063276404   ⟹   XP_063132474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,737 - 28,951,817 (-)NCBI
RefSeq Acc Id: XM_063276405   ⟹   XP_063132475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,737 - 28,951,799 (-)NCBI
RefSeq Acc Id: XM_063276406   ⟹   XP_063132476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,737 - 28,951,654 (-)NCBI
RefSeq Acc Id: XM_063276407   ⟹   XP_063132477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,737 - 28,951,654 (-)NCBI
RefSeq Acc Id: XM_063276408   ⟹   XP_063132478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,524,891 - 28,862,870 (-)NCBI
RefSeq Acc Id: XR_010058866
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,558,487 - 28,951,818 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001013157 (Get FASTA)   NCBI Sequence Viewer  
  NP_001427175 (Get FASTA)   NCBI Sequence Viewer  
  NP_001427176 (Get FASTA)   NCBI Sequence Viewer  
  NP_001427177 (Get FASTA)   NCBI Sequence Viewer  
  NP_001427178 (Get FASTA)   NCBI Sequence Viewer  
  NP_001427179 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253885 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253887 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253888 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951617 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132461 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132463 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132464 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132465 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132466 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132467 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132468 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132469 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132470 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132471 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132473 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132474 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132475 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132476 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132477 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132478 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78956 (Get FASTA)   NCBI Sequence Viewer  
  EDL98284 (Get FASTA)   NCBI Sequence Viewer  
  EDL98285 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021660
  ENSRNOP00000021660.5
  ENSRNOP00000069318
  ENSRNOP00000079964
GenBank Protein Q6AYQ3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013157   ⟸   NM_001013139
- UniProtKB: Q6AYQ3 (UniProtKB/Swiss-Prot),   A0A8I6AGZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253887   ⟸   XM_006253825
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006253885   ⟸   XM_006253823
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253888   ⟸   XM_006253826
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069318   ⟸   ENSRNOT00000080031
Ensembl Acc Id: ENSRNOP00000021660   ⟸   ENSRNOT00000021660
RefSeq Acc Id: XP_038951617   ⟸   XM_039095689
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079964   ⟸   ENSRNOT00000113971
Ensembl Acc Id: ENSRNOP00000095619   ⟸   ENSRNOT00000096528
Ensembl Acc Id: ENSRNOP00000092101   ⟸   ENSRNOT00000108459
RefSeq Acc Id: XP_063132474   ⟸   XM_063276404
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGZ1 (UniProtKB/TrEMBL),   A6J7D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132473   ⟸   XM_063276403
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132475   ⟸   XM_063276405
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132477   ⟸   XM_063276407
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGZ1 (UniProtKB/TrEMBL),   A6J7D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132476   ⟸   XM_063276406
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGZ1 (UniProtKB/TrEMBL),   A6J7D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132471   ⟸   XM_063276401
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132469   ⟸   XM_063276399
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132466   ⟸   XM_063276396
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132464   ⟸   XM_063276394
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132463   ⟸   XM_063276393
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132468   ⟸   XM_063276398
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132467   ⟸   XM_063276397
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132461   ⟸   XM_063276391
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132465   ⟸   XM_063276395
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132470   ⟸   XM_063276400
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZNT2 (UniProtKB/TrEMBL),   A0A0G2JV20 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132478   ⟸   XM_063276408
- Peptide Label: isoform X6
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYQ3-F1-model_v2 AlphaFold Q6AYQ3 1-472 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700400
Promoter ID:EPDNEW_R10923
Type:initiation region
Name:Fars2_1
Description:phenylalanyl-tRNA synthetase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01729,438,714 - 29,438,774EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309416 AgrOrtholog
BioCyc Gene G2FUF-9635 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000016135 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021660 ENTREZGENE
  ENSRNOT00000021660.8 UniProtKB/Swiss-Prot
  ENSRNOT00000080031 ENTREZGENE
  ENSRNOT00000113971 ENTREZGENE
Gene3D-CATH 3.30.70.380 UniProtKB/Swiss-Prot
  Bira Bifunctional Protein, Domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110464 IMAGE-MGC_LOAD
InterPro aa-tRNA-synth_II UniProtKB/Swiss-Prot
  aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot
  Fdx_antiC-bd UniProtKB/Swiss-Prot
  Fdx_antiC-bd_sf UniProtKB/Swiss-Prot
  Phe-tRNA-synth_IIc_mito UniProtKB/Swiss-Prot
  Phenylalanyl-tRNA_Synthase UniProtKB/Swiss-Prot
KEGG Report rno:306879 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93815 IMAGE-MGC_LOAD
NCBI Gene 306879 ENTREZGENE
PANTHER PHENYLALANYL-TRNA SYNTHETASE UniProtKB/Swiss-Prot
  PTHR11538:SF41 UniProtKB/Swiss-Prot
Pfam FDX-ACB UniProtKB/Swiss-Prot
  tRNA-synt_2d UniProtKB/Swiss-Prot
PhenoGen Fars2 PhenoGen
PROSITE AA_TRNA_LIGASE_II UniProtKB/Swiss-Prot
  FDX_ACB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016135 RatGTEx
SMART FDX-ACB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54991 UniProtKB/Swiss-Prot
  SSF55681 UniProtKB/Swiss-Prot
UniProt A0A0G2JV20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNT2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGZ1 ENTREZGENE
  A0A8I6ANQ6_RAT UniProtKB/TrEMBL
  A6J7D4 ENTREZGENE, UniProtKB/TrEMBL
  A6J7D5_RAT UniProtKB/TrEMBL
  Q6AYQ3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Fars2  phenylalanyl-tRNA synthetase 2, mitochondrial  Fars2  phenylalanine-tRNA synthetase 2 (mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Fars2  phenylalanine-tRNA synthetase 2 (mitochondrial)  Fars1  phenylalanine-tRNA synthetase 1 (mitochondrial)  Symbol and Name updated 1299863 APPROVED
2005-12-06 Fars1  phenylalanine-tRNA synthetase 1 (mitochondrial)  Fars1_predicted  phenylalanine-tRNA synthetase 1 (mitochondrial) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fars1_predicted  phenylalanine-tRNA synthetase 1 (mitochondrial) (predicted)      Symbol and Name status set to approved 70820 APPROVED