Dgcr6 (DiGeorge syndrome critical region gene 6) - Rat Genome Database

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Pathways
Gene: Dgcr6 (DiGeorge syndrome critical region gene 6) Rattus norvegicus
Analyze
Symbol: Dgcr6
Name: DiGeorge syndrome critical region gene 6
RGD ID: 1309390
Description: Orthologous to human DGCR6 (DiGeorge syndrome critical region gene 6) and DGCR6L (DiGeorge syndrome critical region gene 6 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC303794
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,432,024 - 96,442,766 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1196,432,024 - 96,437,255 (-)EnsemblGRCr8
mRatBN7.21182,927,725 - 82,932,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,927,725 - 82,932,823 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,656,101 - 91,661,137 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,317,219 - 84,322,255 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,370,836 - 83,375,872 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,076,205 - 87,081,306 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,076,381 - 87,081,950 (-)Ensemblrn6Rnor6.0
Rnor_5.01190,168,058 - 90,173,154 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,922,649 - 84,927,694 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1181,703,405 - 81,708,450 (-)NCBICelera
RGSC_v3.11184,963,245 - 84,968,334 (-)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Dgcr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,432,024 - 96,442,766 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1196,432,024 - 96,437,255 (-)EnsemblGRCr8
mRatBN7.21182,927,725 - 82,932,823 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,927,725 - 82,932,823 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,656,101 - 91,661,137 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,317,219 - 84,322,255 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,370,836 - 83,375,872 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,076,205 - 87,081,306 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,076,381 - 87,081,950 (-)Ensemblrn6Rnor6.0
Rnor_5.01190,168,058 - 90,173,154 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,922,649 - 84,927,694 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1181,703,405 - 81,708,450 (-)NCBICelera
RGSC_v3.11184,963,245 - 84,968,334 (-)NCBI
Cytogenetic Map11q23NCBI
DGCR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,906,223 - 18,912,088 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,905,677 - 18,914,281 (+)Ensemblhg38GRCh38
GRCh372218,893,833 - 18,899,601 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,273,779 - 17,279,601 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342217,268,345 - 17,274,146NCBI
Celera222,745,929 - 2,751,791 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef222,515,964 - 2,521,863 (+)NCBIHuRef
CHM1_12218,893,495 - 18,899,360 (+)NCBICHM1_1
T2T-CHM13v2.02219,281,581 - 19,287,480 (+)NCBIT2T-CHM13v2.0
Dgcr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,870,736 - 17,889,497 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,870,724 - 17,889,496 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381618,052,860 - 18,071,633 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,052,860 - 18,071,632 (+)Ensemblmm10GRCm38
MGSCv371618,052,953 - 18,071,435 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361617,966,423 - 17,984,905 (+)NCBIMGSCv36mm8
Celera1618,625,430 - 18,643,927 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.19NCBI
DGCR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22328,531,539 - 28,538,834 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,080,221 - 31,086,535 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0221,647,018 - 1,653,326 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12217,348,556 - 17,350,597 (+)NCBIPanPan1.1PanPan1.1panPan2
DGCR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,418,938 - 5,424,585 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666100964,021 - 969,821 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:56
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000002574
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat

Markers in Region
Dgcr6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,927,925 - 82,929,587 (+)MAPPERmRatBN7.2
Rnor_6.01187,076,406 - 87,078,067NCBIRnor6.0
Rnor_5.01190,168,259 - 90,169,920UniSTSRnor5.0
RGSC_v3.41184,922,850 - 84,924,511UniSTSRGSC3.4
Celera1181,703,606 - 81,705,267UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002574   ⟹   ENSRNOP00000002574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1196,432,024 - 96,437,097 (-)Ensembl
mRatBN7.2 Ensembl1182,927,728 - 82,932,823 (-)Ensembl
Rnor_6.0 Ensembl1187,076,381 - 87,081,950 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102550   ⟹   ENSRNOP00000096660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1196,432,024 - 96,437,255 (-)Ensembl
mRatBN7.2 Ensembl1182,927,725 - 82,932,757 (-)Ensembl
RefSeq Acc Id: NM_001107080   ⟹   NP_001100550
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,432,024 - 96,437,069 (-)NCBI
mRatBN7.21182,927,725 - 82,932,770 (-)NCBI
Rnor_6.01187,076,205 - 87,081,250 (-)NCBI
Rnor_5.01190,168,058 - 90,173,154 (-)NCBI
RGSC_v3.41184,922,649 - 84,927,694 (-)RGD
Celera1181,703,405 - 81,708,450 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248609   ⟹   XP_006248671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,432,024 - 96,442,766 (-)NCBI
mRatBN7.21182,927,725 - 82,932,823 (-)NCBI
Rnor_6.01187,076,205 - 87,081,306 (-)NCBI
Rnor_5.01190,168,058 - 90,173,154 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270459   ⟹   XP_063126529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,432,024 - 96,437,129 (-)NCBI
RefSeq Acc Id: XM_063270460   ⟹   XP_063126530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,433,247 - 96,437,129 (-)NCBI
RefSeq Acc Id: XM_063270461   ⟹   XP_063126531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,433,936 - 96,437,122 (-)NCBI
RefSeq Acc Id: NP_001100550   ⟸   NM_001107080
- UniProtKB: B0BNH6 (UniProtKB/TrEMBL),   A6JSJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248671   ⟸   XM_006248609
- Peptide Label: isoform X1
- UniProtKB: F7FP83 (UniProtKB/TrEMBL),   A0A8I6AQQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002574   ⟸   ENSRNOT00000002574
Ensembl Acc Id: ENSRNOP00000096660   ⟸   ENSRNOT00000102550
RefSeq Acc Id: XP_063126529   ⟸   XM_063270459
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126530   ⟸   XM_063270460
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063126531   ⟸   XM_063270461
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNH6-F1-model_v2 AlphaFold B0BNH6 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698311
Promoter ID:EPDNEW_R8836
Type:multiple initiation site
Name:Dgcr6_1
Description:DiGeorge syndrome critical region gene 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,081,278 - 87,081,338EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309390 AgrOrtholog
BioCyc Gene G2FUF-20633 BioCyc
Ensembl Genes ENSRNOG00000001880 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002574 ENTREZGENE
  ENSRNOT00000002574.8 UniProtKB/TrEMBL
  ENSRNOT00000102550 ENTREZGENE
  ENSRNOT00000102550.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7378165 IMAGE-MGC_LOAD
InterPro DGCR6 UniProtKB/TrEMBL
KEGG Report rno:303794 UniProtKB/TrEMBL
MGC_CLONE MGC:188273 IMAGE-MGC_LOAD
NCBI Gene 303794 ENTREZGENE
PANTHER DGCR6 UniProtKB/TrEMBL
  PROTEIN DGCR6 UniProtKB/TrEMBL
Pfam DGCR6 UniProtKB/TrEMBL
PhenoGen Dgcr6 PhenoGen
RatGTEx ENSRNOG00000001880 RatGTEx
UniProt A0A8I6AQQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JSJ1 ENTREZGENE, UniProtKB/TrEMBL
  B0BNH6 ENTREZGENE, UniProtKB/TrEMBL
  F7FP83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dgcr6  DiGeorge syndrome critical region gene 6   Dgcr6_predicted  DiGeorge syndrome critical region gene 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dgcr6_predicted  DiGeorge syndrome critical region gene 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED