Ssh2 (slingshot protein phosphatase 2) - Rat Genome Database

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Gene: Ssh2 (slingshot protein phosphatase 2) Rattus norvegicus
Analyze
Symbol: Ssh2
Name: slingshot protein phosphatase 2
RGD ID: 1309389
Description: Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human SSH2 (slingshot protein phosphatase 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC303342; protein phosphatase Slingshot homolog 2; slingshot homolog 2; slingshot homolog 2 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81062,555,388 - 62,807,457 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1062,555,460 - 62,807,453 (+)EnsemblGRCr8
mRatBN7.21062,057,400 - 62,309,328 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,057,044 - 62,306,563 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1066,848,057 - 66,956,415 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01066,353,548 - 66,461,899 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01061,826,271 - 61,935,143 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,702,286 - 62,954,907 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,705,051 - 62,814,520 (-)Ensemblrn6Rnor6.0
Rnor_5.01062,399,739 - 62,652,214 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41066,659,774 - 66,721,700 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1061,203,749 - 61,310,006 (+)NCBICelera
RGSC_v3.11066,674,931 - 66,739,136 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytoskeleton  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase. Horita Y, etal., J Biol Chem. 2008 Mar 7;283(10):6013-21. doi: 10.1074/jbc.M706538200. Epub 2008 Jan 1.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11832213   PMID:22664934  


Genomics

Comparative Map Data
Ssh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81062,555,388 - 62,807,457 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1062,555,460 - 62,807,453 (+)EnsemblGRCr8
mRatBN7.21062,057,400 - 62,309,328 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,057,044 - 62,306,563 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1066,848,057 - 66,956,415 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01066,353,548 - 66,461,899 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01061,826,271 - 61,935,143 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,702,286 - 62,954,907 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,705,051 - 62,814,520 (-)Ensemblrn6Rnor6.0
Rnor_5.01062,399,739 - 62,652,214 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41066,659,774 - 66,721,700 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1061,203,749 - 61,310,006 (+)NCBICelera
RGSC_v3.11066,674,931 - 66,739,136 (-)NCBI
Cytogenetic Map10q24NCBI
SSH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381729,625,938 - 29,930,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1729,625,938 - 29,930,276 (-)Ensemblhg38GRCh38
GRCh371727,952,956 - 28,257,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,977,091 - 25,281,144 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341724,977,090 - 25,281,144NCBI
Celera1724,813,835 - 25,116,991 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1724,162,366 - 24,466,605 (-)NCBIHuRef
CHM1_11728,015,437 - 28,319,488 (-)NCBICHM1_1
T2T-CHM13v2.01730,568,840 - 30,873,583 (-)NCBIT2T-CHM13v2.0
Ssh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,107,020 - 77,351,046 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1177,107,113 - 77,351,046 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381177,216,157 - 77,460,220 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,216,287 - 77,460,220 (+)Ensemblmm10GRCm38
MGSCv371177,029,927 - 77,269,050 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361177,032,620 - 77,271,743 (+)NCBIMGSCv36mm8
Celera1184,715,068 - 84,954,113 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.36NCBI
Ssh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554813,380,213 - 3,633,074 (+)Ensembl
ChiLan1.0NW_0049554813,380,212 - 3,633,074 (+)NCBIChiLan1.0ChiLan1.0
SSH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21934,526,793 - 34,830,388 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11736,409,239 - 36,712,585 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01726,845,369 - 27,148,615 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11727,363,861 - 27,665,630 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1727,363,861 - 27,665,630 (+)EnsemblpanPan2panpan1.1
SSH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1943,726,726 - 43,907,199 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl943,731,635 - 43,907,220 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha942,879,709 - 43,118,190 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0944,542,580 - 44,781,109 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl944,545,759 - 44,781,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1943,327,152 - 43,565,592 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0943,617,598 - 43,856,553 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0943,697,972 - 43,936,580 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ssh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560242,857,854 - 43,112,560 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365385,735,797 - 5,990,546 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365385,735,806 - 5,990,480 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SSH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1245,823,002 - 46,015,446 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11245,818,103 - 46,085,720 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21248,414,412 - 48,468,229 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SSH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11623,369,123 - 23,667,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1623,370,701 - 23,503,161 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660756,403,386 - 6,703,410 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ssh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247862,126,039 - 2,438,598 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247862,121,036 - 2,438,846 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ssh2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1995,890,349 - 96,131,800 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ssh2
1244 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:175
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000019410
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106174653268282731Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106184363367241334Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Rat211  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81062,643,554 - 62,643,700 (+)Marker Load Pipeline
mRatBN7.21062,145,410 - 62,145,556 (-)MAPPERmRatBN7.2
Rnor_6.01062,866,705 - 62,866,850NCBIRnor6.0
Rnor_5.01062,564,197 - 62,564,342UniSTSRnor5.0
RGSC_v3.41066,961,941 - 66,962,087RGDRGSC3.4
RGSC_v3.41066,961,942 - 66,962,087UniSTSRGSC3.4
Celera1061,151,533 - 61,151,678UniSTS
RGSC_v3.11066,975,564 - 66,975,710RGD
SHRSP x BN Map1046.5699RGD
SHRSP x BN Map1046.5699UniSTS
FHH x ACI Map1051.71RGD
Cytogenetic Map10q26UniSTS
AU048526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,696,131 - 156,697,074 (+)MAPPERmRatBN7.2
mRatBN7.21062,202,385 - 62,202,577 (-)MAPPERmRatBN7.2
Rnor_6.01167,413,466 - 167,414,408NCBIRnor6.0
Rnor_6.01062,809,569 - 62,809,760NCBIRnor6.0
Rnor_5.01062,507,061 - 62,507,252UniSTSRnor5.0
Rnor_5.01173,602,074 - 173,603,016UniSTSRnor5.0
Cytogenetic Map10q26UniSTS
Cytogenetic Map1q32UniSTS
BF399703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21062,275,830 - 62,276,036 (-)MAPPERmRatBN7.2
Rnor_6.01062,735,982 - 62,736,187NCBIRnor6.0
Rnor_5.01062,433,435 - 62,433,640UniSTSRnor5.0
RGSC_v3.41066,690,298 - 66,690,503UniSTSRGSC3.4
Celera1061,279,493 - 61,279,698UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019410   ⟹   ENSRNOP00000019410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1062,695,727 - 62,807,453 (+)Ensembl
mRatBN7.2 Ensembl1062,197,626 - 62,306,563 (+)Ensembl
Rnor_6.0 Ensembl1062,705,051 - 62,814,520 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100327   ⟹   ENSRNOP00000094168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1062,695,727 - 62,807,453 (+)Ensembl
mRatBN7.2 Ensembl1062,197,626 - 62,306,563 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100799   ⟹   ENSRNOP00000091756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1062,555,645 - 62,807,453 (+)Ensembl
mRatBN7.2 Ensembl1062,057,044 - 62,306,563 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158620   ⟹   ENSRNOP00000101336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1062,555,460 - 62,807,453 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158707   ⟹   ENSRNOP00000102001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1062,555,609 - 62,807,453 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000172940   ⟹   ENSRNOP00000106220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1062,555,460 - 62,807,453 (+)Ensembl
RefSeq Acc Id: NM_001107024   ⟹   NP_001100494
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,695,770 - 62,804,692 (+)NCBI
mRatBN7.21062,197,626 - 62,306,563 (+)NCBI
Rnor_6.01062,705,051 - 62,814,520 (-)NCBI
Rnor_5.01062,399,739 - 62,652,214 (-)NCBI
RGSC_v3.41066,659,774 - 66,721,700 (-)RGD
Celera1061,203,749 - 61,310,006 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246905   ⟹   XP_006246967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,555,388 - 62,807,457 (+)NCBI
mRatBN7.21062,057,400 - 62,309,328 (+)NCBI
Rnor_6.01062,702,286 - 62,954,907 (-)NCBI
Rnor_5.01062,399,739 - 62,652,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086021   ⟹   XP_038941949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,555,404 - 62,807,457 (+)NCBI
mRatBN7.21062,057,400 - 62,309,328 (+)NCBI
RefSeq Acc Id: XM_039086022   ⟹   XP_038941950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81062,584,268 - 62,807,457 (+)NCBI
mRatBN7.21062,086,141 - 62,309,328 (+)NCBI
RefSeq Acc Id: NP_001100494   ⟸   NM_001107024
- UniProtKB: F1M4Q5 (UniProtKB/TrEMBL),   A6HGX4 (UniProtKB/TrEMBL),   A0A8I6APG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246967   ⟸   XM_006246905
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ATT8 (UniProtKB/TrEMBL),   A0A8I6APG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019410   ⟸   ENSRNOT00000019410
RefSeq Acc Id: XP_038941949   ⟸   XM_039086021
- Peptide Label: isoform X1
- UniProtKB: A0A8I6APG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941950   ⟸   XM_039086022
- Peptide Label: isoform X3
- UniProtKB: A0A8I6APG2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091756   ⟸   ENSRNOT00000100799
Ensembl Acc Id: ENSRNOP00000094168   ⟸   ENSRNOT00000100327
Ensembl Acc Id: ENSRNOP00000101336   ⟸   ENSRNOT00000158620
Ensembl Acc Id: ENSRNOP00000106220   ⟸   ENSRNOT00000172940
Ensembl Acc Id: ENSRNOP00000102001   ⟸   ENSRNOT00000158707
Protein Domains
DEK-C   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4Q5-F1-model_v2 AlphaFold F1M4Q5 1-1430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697429
Promoter ID:EPDNEW_R7954
Type:multiple initiation site
Name:Ssh2_1
Description:slingshot protein phosphatase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01062,814,519 - 62,814,579EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309389 AgrOrtholog
BioCyc Gene G2FUF-24130 BioCyc
Ensembl Genes ENSRNOG00000014285 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019410 ENTREZGENE
  ENSRNOT00000019410.8 UniProtKB/TrEMBL
  ENSRNOT00000100327.2 UniProtKB/TrEMBL
  ENSRNOT00000100799 ENTREZGENE
  ENSRNOT00000100799.2 UniProtKB/TrEMBL
  ENSRNOT00000158620 ENTREZGENE
  ENSRNOT00000158620.1 UniProtKB/TrEMBL
  ENSRNOT00000158707.1 UniProtKB/TrEMBL
  ENSRNOT00000172940 ENTREZGENE
  ENSRNOT00000172940.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro DEK_C UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  Dual-sp_phosphatase_subgr_cat UniProtKB/TrEMBL
  Phosphatase_SSH-like UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  SSH-N UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
KEGG Report rno:303342 UniProtKB/TrEMBL
NCBI Gene 303342 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 2 UniProtKB/TrEMBL
  PTHR45864 UniProtKB/TrEMBL
Pfam DEK_C UniProtKB/TrEMBL
  DSPc UniProtKB/TrEMBL
  PH_SSH1-like_1st UniProtKB/TrEMBL
PhenoGen Ssh2 PhenoGen
PROSITE DEK_C UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014285 RatGTEx
SMART DSPc UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A8I6APG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATT8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L091_RAT UniProtKB/TrEMBL
  A0ABK0LAG9_RAT UniProtKB/TrEMBL
  A0ABK0LZ34_RAT UniProtKB/TrEMBL
  A6HGX4 ENTREZGENE, UniProtKB/TrEMBL
  F1M4Q5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-20 Ssh2  slingshot protein phosphatase 2  Ssh2  slingshot homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ssh2  slingshot homolog 2 (Drosophila)   Ssh2_predicted  slingshot homolog 2 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ssh2_predicted  slingshot homolog 2 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED