Nsmce3 (NSE3 component of SMC5/6 complex) - Rat Genome Database

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Gene: Nsmce3 (NSE3 component of SMC5/6 complex) Rattus norvegicus
Analyze
Symbol: Nsmce3
Name: NSE3 component of SMC5/6 complex
RGD ID: 1309206
Description: Orthologous to human NSMCE3 (NSE3 homolog, SMC5-SMC6 complex component); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC309259; melanoma-associated antigen G1; Ndnl2; necdin-like 2; non-structural maintenance of chromosomes element 3 homolog; NSE3 homolog, SMC5-SMC6 complex component
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81127,812,572 - 127,813,899 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21118,401,302 - 118,402,629 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1126,380,491 - 126,381,812 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01133,563,093 - 133,564,414 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01126,395,442 - 126,396,769 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,663,987 - 125,665,314 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01126,770,609 - 126,771,936 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41119,276,434 - 119,278,432 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1110,652,748 - 110,654,075 (-)NCBICelera
RGSC_v3.11119,354,776 - 119,356,775 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14593116   PMID:18086888   PMID:20864041   PMID:27427983  


Genomics

Comparative Map Data
Nsmce3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81127,812,572 - 127,813,899 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21118,401,302 - 118,402,629 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1126,380,491 - 126,381,812 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01133,563,093 - 133,564,414 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01126,395,442 - 126,396,769 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,663,987 - 125,665,314 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01126,770,609 - 126,771,936 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41119,276,434 - 119,278,432 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1110,652,748 - 110,654,075 (-)NCBICelera
RGSC_v3.11119,354,776 - 119,356,775 (-)NCBI
Cytogenetic Map1q22NCBI
NSMCE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381529,264,989 - 29,269,822 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1529,264,989 - 29,269,822 (-)Ensemblhg38GRCh38
GRCh371529,557,193 - 29,562,026 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361527,347,650 - 27,349,309 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341527,347,650 - 27,349,309NCBI
Celera157,197,619 - 7,199,278 (-)NCBICelera
Cytogenetic Map15q13.1NCBI
HuRef157,218,489 - 7,220,156 (-)NCBIHuRef
CHM1_11529,527,055 - 29,528,722 (-)NCBICHM1_1
T2T-CHM13v2.01527,043,359 - 27,048,192 (-)NCBIT2T-CHM13v2.0
Nsmce3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39764,521,430 - 64,522,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl764,516,800 - 64,522,745 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38764,871,682 - 64,873,040 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl764,867,052 - 64,872,997 (-)Ensemblmm10GRCm38
MGSCv37772,016,536 - 72,017,926 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36764,750,600 - 64,751,990 (-)NCBIMGSCv36mm8
Celera762,288,671 - 62,290,065 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.77NCBI
NSMCE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.0338,959,399 - 38,961,052 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1338,499,740 - 38,501,393 (-)NCBIUMICH_Zoey_3.1
NSMCE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11144,469,617 - 144,474,026 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21160,545,499 - 160,547,107 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NSMCE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12652,187,217 - 52,189,718 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2652,187,898 - 52,188,812 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604888,626,768 - 88,628,977 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsmce3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247682,402,456 - 2,403,944 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nsmce3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12135,583,895 - 135,585,340 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nsmce3
23 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611131244255Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat

Markers in Region
PMC64493P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21118,401,356 - 118,401,859 (+)MAPPERmRatBN7.2
Rnor_6.01125,664,042 - 125,664,544NCBIRnor6.0
Rnor_5.01126,770,664 - 126,771,166UniSTSRnor5.0
RGSC_v3.41119,276,494 - 119,276,996UniSTSRGSC3.4
Celera1110,652,803 - 110,653,305UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 51 67 138 95 11 50 36 32 17 17

Sequence


RefSeq Acc Id: NM_001173527   ⟹   NP_001166998
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81127,812,572 - 127,813,899 (-)NCBI
mRatBN7.21118,401,302 - 118,402,629 (-)NCBI
Rnor_6.01125,663,987 - 125,665,314 (-)NCBI
Rnor_5.01126,770,609 - 126,771,936 (-)NCBI
Celera1110,652,748 - 110,654,075 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001166998 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98730 (Get FASTA)   NCBI Sequence Viewer  
  EDM08399 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001166998   ⟸   NM_001173527
- UniProtKB: Q4KM72 (UniProtKB/TrEMBL),   A6JBM2 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
MAGE


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309206 AgrOrtholog
BioCyc Gene G2FUF-59064 BioCyc
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384787 IMAGE-MGC_LOAD
InterPro MAGE UniProtKB/TrEMBL
  MAGE UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
KEGG Report rno:309259 UniProtKB/TrEMBL
MGC_CLONE MGC:112722 IMAGE-MGC_LOAD
NCBI Gene 309259 ENTREZGENE
PANTHER NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 3 HOMOLOG UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
PhenoGen Nsmce3 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
SMART MAGE UniProtKB/TrEMBL
UniProt A6JBM2 ENTREZGENE, UniProtKB/TrEMBL
  Q4KM72 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Nsmce3  NSE3 component of SMC5/6 complex  Nsmce3  NSE3 homolog, SMC5-SMC6 complex component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-29 Nsmce3  NSE3 homolog, SMC5-SMC6 complex component  Ndnl2  necdin-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ndnl2  necdin-like 2  Ndnl2_predicted  necdin-like 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ndnl2_predicted  necdin-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED