Malt1 (MALT1 paracaspase) - Rat Genome Database

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Gene: Malt1 (MALT1 paracaspase) Rattus norvegicus
Analyze
Symbol: Malt1
Name: MALT1 paracaspase
RGD ID: 1309195
Description: Predicted to enable several functions, including endopeptidase activator activity; identical protein binding activity; and protease binding activity. Predicted to contribute to kinase activator activity. Predicted to be involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of immune response. Predicted to act upstream of or within several processes, including B-1 B cell differentiation; T cell proliferation; and regulation of T cell receptor signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be part of CBM complex and polkadots. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase); PARTICIPATES IN nuclear factor kappa B signaling pathway; B cell receptor signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307366; mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase 1; paracaspase-1; Pcasp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,212,290 - 61,266,272 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1861,212,317 - 61,266,272 (+)EnsemblGRCr8
mRatBN7.21858,942,282 - 58,996,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)EnsemblmRatBN7.2
Rnor_6.01861,108,712 - 61,162,446 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,109,069 - 61,162,445 (+)Ensemblrn6Rnor6.0
Rnor_5.01860,305,085 - 60,358,786 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41861,708,388 - 61,760,004 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1857,070,977 - 57,125,050 (+)NCBICelera
RGSC_v3.11861,720,756 - 61,832,919 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium silicate  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metam  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
micafungin  (EXP,ISO)
o-anisidine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
CBM complex  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (IEA)
polkadots  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Akagi T, etal., Oncogene. 1999 Oct 14;18(42):5785-94.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Sanchez-Izquierdo D, etal., Blood. 2003 Jun 1;101(11):4539-46. Epub 2003 Jan 30.
Additional References at PubMed
PMID:12761501   PMID:12819136   PMID:14576442   PMID:14614861   PMID:14695475   PMID:15125833   PMID:16123224   PMID:16495340   PMID:16751776   PMID:16831874   PMID:16862125   PMID:18223652  
PMID:22158899   PMID:22267217   PMID:25282160   PMID:25762782   PMID:26377317   PMID:28628108   PMID:31961340   PMID:35913790   PMID:36527595   PMID:36603698   PMID:36692707   PMID:37146710  


Genomics

Comparative Map Data
Malt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,212,290 - 61,266,272 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1861,212,317 - 61,266,272 (+)EnsemblGRCr8
mRatBN7.21858,942,282 - 58,996,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)EnsemblmRatBN7.2
Rnor_6.01861,108,712 - 61,162,446 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,109,069 - 61,162,445 (+)Ensemblrn6Rnor6.0
Rnor_5.01860,305,085 - 60,358,786 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41861,708,388 - 61,760,004 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1857,070,977 - 57,125,050 (+)NCBICelera
RGSC_v3.11861,720,756 - 61,832,919 (+)NCBI
Cytogenetic Map18q12.1NCBI
MALT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381858,671,465 - 58,754,477 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1858,671,426 - 58,754,477 (+)Ensemblhg38GRCh38
GRCh371856,338,697 - 56,421,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361854,489,598 - 54,568,350 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341854,489,597 - 54,568,350NCBI
Celera1853,055,193 - 53,133,688 (+)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1853,046,774 - 53,125,499 (+)NCBIHuRef
CHM1_11856,333,855 - 56,412,584 (+)NCBICHM1_1
T2T-CHM13v2.01858,872,604 - 58,955,588 (+)NCBIT2T-CHM13v2.0
Malt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391865,564,010 - 65,612,138 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1865,564,009 - 65,612,138 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381865,430,939 - 65,478,888 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,430,938 - 65,479,067 (+)Ensemblmm10GRCm38
MGSCv371865,590,651 - 65,638,446 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361865,556,366 - 65,604,161 (+)NCBIMGSCv36mm8
Celera1866,699,207 - 66,748,598 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1838.56NCBI
Malt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540242,911,649 - 42,972,429 (+)Ensembl
ChiLan1.0NW_00495540242,919,480 - 42,968,873 (+)NCBIChiLan1.0ChiLan1.0
MALT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21776,210,829 - 76,295,818 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11861,903,645 - 61,988,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01852,060,878 - 52,141,985 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11855,395,462 - 55,473,574 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1855,395,462 - 55,473,574 (+)EnsemblpanPan2panpan1.1
MALT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1117,351,458 - 17,412,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl117,354,926 - 17,403,927 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha118,335,003 - 18,396,343 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0117,231,245 - 17,291,704 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl117,232,316 - 17,291,990 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1117,292,714 - 17,350,173 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.1117,272,403 - 17,281,013 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,187,356 - 17,248,249 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,455,416 - 17,516,194 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Malt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,615,326 - 30,665,178 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364975,853,870 - 5,904,266 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364975,854,361 - 5,910,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MALT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,076,955 - 162,144,880 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11162,076,933 - 162,144,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,571,906 - 179,706,232 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MALT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11820,984,985 - 21,064,198 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1820,985,819 - 21,054,554 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660604,506,132 - 4,584,611 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Malt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247924,148,453 - 4,217,548 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247924,148,258 - 4,223,431 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Malt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11565,788,873 - 65,840,575 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Malt1
281 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:134
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000023146, ENSRNOT00000068418
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001419766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001060526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO556697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ607864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000068418   ⟹   ENSRNOP00000059281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1861,212,368 - 61,266,272 (+)Ensembl
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)Ensembl
Rnor_6.0 Ensembl1861,109,069 - 61,162,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094098   ⟹   ENSRNOP00000097032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1861,212,317 - 61,264,231 (+)Ensembl
mRatBN7.2 Ensembl1858,942,299 - 58,994,260 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164884   ⟹   ENSRNOP00000108631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1861,212,368 - 61,266,272 (+)Ensembl
RefSeq Acc Id: NM_001419765   ⟹   NP_001406694
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,212,368 - 61,266,272 (+)NCBI
mRatBN7.21858,942,354 - 58,996,265 (+)NCBI
RefSeq Acc Id: NM_001419766   ⟹   NP_001406695
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,212,368 - 61,266,272 (+)NCBI
mRatBN7.21858,942,354 - 58,996,265 (+)NCBI
RefSeq Acc Id: XM_006254888   ⟹   XP_006254950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,212,292 - 61,266,254 (+)NCBI
mRatBN7.21858,942,282 - 58,996,318 (+)NCBI
Rnor_6.01861,108,712 - 61,162,446 (+)NCBI
Rnor_5.01860,305,085 - 60,358,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097398   ⟹   XP_038953326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,232,885 - 61,266,254 (+)NCBI
mRatBN7.21858,967,394 - 58,996,318 (+)NCBI
RefSeq Acc Id: XM_039097399   ⟹   XP_038953327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,212,290 - 61,247,013 (+)NCBI
mRatBN7.21858,942,282 - 58,977,023 (+)NCBI
RefSeq Acc Id: XM_063277326   ⟹   XP_063133396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,212,292 - 61,266,254 (+)NCBI
RefSeq Acc Id: XR_005496483
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81861,212,291 - 61,257,448 (+)NCBI
mRatBN7.21858,942,282 - 58,987,441 (+)NCBI
RefSeq Acc Id: XP_006254950   ⟸   XM_006254888
- Peptide Label: isoform X1
- UniProtKB: A6IXQ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059281   ⟸   ENSRNOT00000068418
RefSeq Acc Id: XP_038953327   ⟸   XM_039097399
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038953326   ⟸   XM_039097398
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000097032   ⟸   ENSRNOT00000094098
RefSeq Acc Id: NP_001406694   ⟸   NM_001419765
- Peptide Label: isoform 1
- UniProtKB: D4A980 (UniProtKB/TrEMBL),   A6IXQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406695   ⟸   NM_001419766
- Peptide Label: isoform 2
- UniProtKB: A0A8I6ARW3 (UniProtKB/TrEMBL),   A6IXQ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133396   ⟸   XM_063277326
- Peptide Label: isoform X2
- UniProtKB: A6IXQ3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108631   ⟸   ENSRNOT00000164884
Protein Domains
Caspase family p20   Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A980-F1-model_v2 AlphaFold D4A980 1-731 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309195 AgrOrtholog
BioCyc Gene G2FUF-7217 BioCyc
Ensembl Genes ENSRNOG00000017181 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068418 ENTREZGENE
  ENSRNOT00000068418.6 UniProtKB/TrEMBL
  ENSRNOT00000094098 ENTREZGENE
  ENSRNOT00000094098.2 UniProtKB/TrEMBL
  ENSRNOT00000164884 ENTREZGENE
  ENSRNOT00000164884.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.3360 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro Caspase-like_dom UniProtKB/TrEMBL
  Caspase-related_regulators UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  MALT1 UniProtKB/TrEMBL
  MALT1_Death UniProtKB/TrEMBL
  MALT1_Ig UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
NCBI Gene 307366 ENTREZGENE
PANTHER MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE UniProtKB/TrEMBL
  PTHR22576:SF40 UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  MALT1_Ig UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PhenoGen Malt1 PhenoGen
PROSITE CASPASE_P20 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017181 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A8I6ARW3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M1T3_RAT UniProtKB/TrEMBL
  A6IXQ3 ENTREZGENE, UniProtKB/TrEMBL
  D4A980 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-03 Malt1  MALT1 paracaspase  Malt1  mucosa associated lymphoid tissue lymphoma translocation gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Malt1  mucosa associated lymphoid tissue lymphoma translocation gene 1   Malt1_predicted  mucosa associated lymphoid tissue lymphoma translocation gene 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Malt1_predicted  mucosa associated lymphoid tissue lymphoma translocation gene 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED