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Gene: Upf2 (UPF2, regulator of nonsense mediated mRNA decay) Rattus norvegicus

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Symbol:

Upf2

Name:

UPF2, regulator of nonsense mediated mRNA decay

RGD ID:

1309178

Description:

Predicted to enable telomeric DNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to act upstream of or within animal organ regeneration and liver development. Predicted to be located in nucleus. Predicted to be part of exon-exon junction complex. Predicted to be active in cytoplasm. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay); PARTICIPATES IN mRNA decay pathway; RNA transport pathway; INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC361271; regulator of nonsense transcripts 2; UPF2 regulator of nonsense transcripts homolog; UPF2 regulator of nonsense transcripts homolog (yeast)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UPF2 (UPF2 regulator of nonsense mediated mRNA decay)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Upf2 (UPF2 regulator of nonsense transcripts homolog (yeast))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Upf2 (UPF2 regulator of nonsense mediated mRNA decay)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UPF2 (UPF2 regulator of nonsense mediated mRNA decay)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UPF2 (UPF2 regulator of nonsense mediated mRNA decay)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Upf2 (UPF2 regulator of nonsense mediated mRNA decay)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UPF2 (UPF2 regulator of nonsense mediated mRNA decay)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UPF2 (UPF2 regulator of nonsense mediated mRNA decay)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Upf2 (UPF2 regulator of nonsense mediated mRNA decay)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Upf2 (UPF2 regulator of nonsense mediated mRNA decay)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DNASE1L3 (deoxyribonuclease 1L3)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	UPF2 (UPF2 regulator of nonsense mediated mRNA decay)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Upf2 (UPF2 regulator of nonsense transcripts homolog (yeast))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	upf2 (UPF2 regulator of nonsense mediated mRNA decay)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NMD2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NMD2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Upf2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	smg-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	smg-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	upf2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	77,133,975 - 77,245,266 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	77,134,716 - 77,245,704 (-)	Ensembl				GRCr8
mRatBN7.2	17	72,224,575 - 72,335,896 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	72,225,316 - 72,335,855 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	75,733,527 - 75,843,307 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	79,554,976 - 79,664,754 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	73,605,249 - 73,715,022 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	76,176,379 - 76,287,246 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	76,175,643 - 76,287,186 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	77,816,922 - 77,925,240 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	83,350,525 - 83,377,185 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	71,679,973 - 71,791,085 (-)	NCBI		Celera
RGSC_v3.1	17	83,357,903 - 83,393,695 (-)	NCBI
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,4,6-tribromophenol (ISO)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

clotrimazole (EXP)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

cytochalasin D (ISO)

deoxynivalenol (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

jaspamide (ISO)

leflunomide (ISO)

methapyrilene (ISO)

methimazole (EXP)

methoxychlor (EXP)

nitrates (ISO)

paracetamol (ISO)

PCB138 (EXP)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

troglitazone (ISO)

tungsten (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ regeneration (ISO)

liver development (ISO)

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (IBA,IEA,ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

cytosol (IEA,ISO)

exon-exon junction complex (IBA,ISO)

nucleus (ISO)

perinuclear region of cytoplasm (IEA)

Molecular Function

protein binding (ISO)

RNA binding (IEA)

telomeric DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mRNA decay pathway (IEA)

RNA transport pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:14636577	PMID:16601204	PMID:17916692	PMID:18369367	PMID:20657840	PMID:21829167

Genomics

Comparative Map Data

Upf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	77,133,975 - 77,245,266 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	77,134,716 - 77,245,704 (-)	Ensembl				GRCr8
mRatBN7.2	17	72,224,575 - 72,335,896 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	72,225,316 - 72,335,855 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	75,733,527 - 75,843,307 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	79,554,976 - 79,664,754 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	73,605,249 - 73,715,022 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	76,176,379 - 76,287,246 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	76,175,643 - 76,287,186 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	77,816,922 - 77,925,240 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	83,350,525 - 83,377,185 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	71,679,973 - 71,791,085 (-)	NCBI		Celera
RGSC_v3.1	17	83,357,903 - 83,393,695 (-)	NCBI
Cytogenetic Map	17	q12.3	NCBI

UPF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	11,920,022 - 12,043,170 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	11,920,020 - 12,043,170 (-)	Ensembl			hg38	GRCh38
GRCh37	10	11,962,021 - 12,085,169 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	12,002,027 - 12,125,029 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	12,002,027 - 12,125,029	NCBI
Celera	10	11,890,782 - 12,013,775 (-)	NCBI		Celera
Cytogenetic Map	10	p14	NCBI
HuRef	10	11,879,153 - 12,002,622 (-)	NCBI		HuRef
CHM1_1	10	11,961,725 - 12,085,128 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	11,931,338 - 12,054,461 (-)	NCBI		T2T-CHM13v2.0

Upf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	5,956,218 - 6,061,514 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	5,956,280 - 6,061,514 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	5,951,447 - 6,056,703 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	5,951,469 - 6,056,703 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	5,872,515 - 5,977,749 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	5,868,741 - 5,973,975 (+)	NCBI		MGSCv36	mm8
Celera	2	5,891,444 - 5,996,766 (+)	NCBI		Celera
Cytogenetic Map	2	A1	NCBI
cM Map	2	3.62	NCBI

Upf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	27,861,958 - 27,952,835 (-)	Ensembl
ChiLan1.0	NW_004955421	27,867,663 - 27,962,809 (-)	NCBI	ChiLan1.0	ChiLan1.0

UPF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	24,446,477 - 24,569,667 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	24,451,809 - 24,574,999 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	11,924,483 - 12,047,617 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	11,916,893 - 12,028,126 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	11,916,893 - 12,020,760 (-)	Ensembl			panPan2	panpan1.1

UPF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	24,370,961 - 24,473,437 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	24,371,058 - 24,472,140 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	21,395,035 - 21,497,504 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	24,741,631 - 24,844,097 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	24,741,678 - 24,844,088 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	21,868,023 - 21,970,539 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	22,711,026 - 22,813,613 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	23,426,047 - 23,528,882 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Upf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	27,100,999 - 27,216,320 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	3,266,190 - 3,381,526 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	3,266,196 - 3,381,511 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UPF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	59,898,922 - 60,090,229 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	59,893,106 - 59,993,403 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

UPF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	11,967,294 - 12,094,120 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	11,967,269 - 12,093,709 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666051	17,469,821 - 17,596,515 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Upf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624775	7,142,411 - 7,249,637 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Upf2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	12,285,259 - 12,376,107 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Upf2
492 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	131
Count of miRNA genes:	101
Interacting mature miRNAs:	110
Transcripts:	ENSRNOT00000058070
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
631502	Cm26	Cardiac mass QTL 26	3.71		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	70613502	86062352	Rat
1354588	Bvd4	Brain ventricular dilatation QTL 4	5.31	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	58194064	87388164	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	33104645	78104645	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	65154872	93515804	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	33104645	78104645	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	68550040	93515804	Rat
7488963	Bp369	Blood pressure QTL 369		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	63697147	82818564	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	36045537	81045537	Rat
2302365	Gluco40	Glucose level QTL 40	4.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	64569820	86954580	Rat

Markers in Region

RH133224

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	17	77,245,785 - 77,246,190 (+)	Marker Load Pipeline
mRatBN7.2	17	72,336,426 - 72,336,832 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	76,287,818 - 76,288,222	NCBI	Rnor6.0
Rnor_5.0	17	77,925,812 - 77,926,216	UniSTS	Rnor5.0
RGSC_v3.4	17	83,377,757 - 83,378,161	UniSTS	RGSC3.4
Celera	17	71,791,657 - 71,792,061	UniSTS
RH 3.4 Map	17	717.6	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

BI278109

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	72,300,251 - 72,300,440 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	76,249,841 - 76,250,029	NCBI	Rnor6.0
Rnor_5.0	17	77,889,977 - 77,890,165	UniSTS	Rnor5.0
Celera	17	71,754,990 - 71,755,178	UniSTS
RH 3.4 Map	17	717.0	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001443838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000058070 ⟹ ENSRNOP00000054878

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	77,143,311 - 77,245,214 (-)	Ensembl
mRatBN7.2 Ensembl	17	72,233,740 - 72,335,855 (-)	Ensembl
Rnor_6.0 Ensembl	17	76,184,928 - 76,281,660 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092442 ⟹ ENSRNOP00000075770

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	17	76,175,643 - 76,188,979 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092452 ⟹ ENSRNOP00000075866

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	77,134,716 - 77,245,214 (-)	Ensembl
mRatBN7.2 Ensembl	17	72,225,316 - 72,335,855 (-)	Ensembl
Rnor_6.0 Ensembl	17	76,260,636 - 76,287,186 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092693 ⟹ ENSRNOP00000075795

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	77,134,716 - 77,245,214 (-)	Ensembl
mRatBN7.2 Ensembl	17	72,227,685 - 72,335,855 (-)	Ensembl
Rnor_6.0 Ensembl	17	76,198,959 - 76,250,537 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000132252 ⟹ ENSRNOP00000098717

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	77,134,716 - 77,245,704 (-)	Ensembl

RefSeq Acc Id:

NM_001108421 ⟹ NP_001101891

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,134,716 - 77,245,214 (-)	NCBI
mRatBN7.2	17	72,225,316 - 72,335,855 (-)	NCBI
Rnor_6.0	17	76,176,379 - 76,287,246 (-)	NCBI
Rnor_5.0	17	77,816,922 - 77,925,240 (-)	NCBI
RGSC_v3.4	17	83,350,525 - 83,377,185 (-)	RGD
Celera	17	71,679,973 - 71,791,085 (-)	RGD

Sequence:

show sequence

GGAAGGCGGGCCCTCGGCTGCGAGATAGGTGGGGGGAGGGGAGGGGAGAGCCCGAGCTCTGGAG
TTGGTGCTGGGAAACCCGGGGCTAATGTTGACAACAGGCACTAGATTGTCCTGGGTCACATAAT
GCCAGCTGAGCGGAAAAAGTCAGCAAGTATGGAGGAAAAAGAATCTTTACTAAACAACAAGGAA
AAAGACTGCAGTGAGAGGCGGCCAGTGAGCAGCAAGGAGAAATCAAAAGACGATCTCAAGATCA
CTGCCAAGAAGGAGGTCAGTAAGGTCCCAGAAGACAAAAAGAAGAAACTGGAAGAAGATAAGAG
AAAAAAGGAAGACAAGGAACGTAAGAAAAAAGAGGAAGAGAAGGTGAAGGCAGAGGAAGAGTTG
AAGAAGAAGGAAGAGGAAGAAAAGAAAAAACAGGAAGAGGAAGAGAGGAAAAAGCAGGAGGAGC
AGGCCAAGCGGCAGCAGGAAGAAGCAGCTGCCCAGCTGAAAGAGAAAGAAGAATCTCTTCAGCT
TCATCAGGAGGCGTGGGAACGCCATCAACTACGAAAGGAACTCCGTAGCAAAAACCAAAATGCT
CCAGACAACCGACCAGAGGAAAATTTCTTTAGCCGCCTAGATTCGAGCTTAAAGAAAAATACTG
CTTTTGTCAAGAAACTAAAAACAATTACAGAACAACAGAGAGACTCCTTGTCTCATGATTTTAA
TGGCCTGAATTTAAGCAAATATATTGGGGAAGCCGTAGCTTCCATTGTGGAAGCAAAATTAAAA
ATCTCTGACGTGAACTGTGCCGTGCACCTCTGCTCTCTCTTTCACCAGCGGTACGCTGACTTTG
CACCCTCACTTCTTCAGGTGTGGAAAAAACATTTTGAAGCAAGGAAAGAGGAGAAAACGCCCAA
CATTACCAAGCTAAGAACTGACTTGCGTTTCATTGCAGAATTGACAATAGTGGGAATCTTCACT
GACAAGGAAGGTCTTTCCTTAATCTATGAACAGCTAAAAAGTATTATTAATGCTGATCGAGAAT
CCCACACTCATGTGTCTGTGGTGATTAGTTTCTGTCGTCATTGTGGAGATGATATTGCTGGACT
TGTACCGAGGAAAGTAAAGAGTGCTGCAGAGAAGTTTAATTTGAACTTTCCTCCTAGTGAGATA
ATTAGCCCAGAGAAGCAGCAGCCTTTCCAGAATCTTTTAAAAGAGTACTTTACGTCTCTGACCA
AACACCTGAAAAGGGACCACAGGGAGCTTCAGAATACTGAGAGGCAAAACAGGCGTATTCTGCA
CTCTAAAGGCGAGCTAAGTGAAGACAGGCATAAACAGTATGAAGAGTTCGCCATGTCTTACCAG
AAGCTGCTGGCAAATTCTCAATCCTTAGCCGACCTTTTGGATGAAAATATGCCAGATCTTCCTC
AGGACAAACCGACACCAGAAGAGCATGGACCTGGAATCGATATATTTACACCTGGAAAACCTGG
AGAATATGACTTAGAAGGTGGCATATGGGAAGACGAAGACGCTCGGAATTTTTATGAAAACCTC
ATCGATTTGAAAGCATTTGTTCCAGCCATCTTGTTTAAAGACAATGAAAAAAGTCAGAACAAAG
ATTCTAGCAAAGATGATTCCAAAGAGGCAAAAGAACCAAAGGATAATAAGGAAGCATCAAGTCC
CGATGATTTGGAACTTGAGTTGGAGAATTTAGAAATTAATGATGACACACTGGAGTTAGAAGGT
GGAGATGAAGCTGAAGATCTTACAAAGAAACTCCTTGATGAACAAGAACAAGAAGATGAAGAAG
CCAGCACTGGATCTCACCTCAAACTCATAGTGGATGCTTTCCTCCAGCAGCTGCCCAACTGTGT
CAACCGAGACCTGATTGACAAGGCAGCCATGGACTTTTGCATGAACATGAACACAAAGGCAAAC
AGGAAGAAGTTGGTTCGGGCGCTCTTCATAGTTCCTAGGCAAAGGTTGGATTTGCTCCCATTTT
ATGCAAGATTGGTTGCTACATTGCATCCCTGCATGTCTGATGTAGCAGAGGATCTTTGTTCCAT
GCTGAGGGGGGATTTCAGATTTCATGTTCGAAAAAAGGACCAGATCAACATTGAAACAAAGAAT
AAAACTGTCCGTTTTATTGGAGAACTAACCAAGTTTAAGATGTTCACCAAAAATGATACACTGC
ATTGTCTAAAGATGCTTCTGTCAGACTTTTCTCATCATCATATTGAAATGGCATGTACCCTACT
GGAGACCTGTGGACGGTTTCTTTTCCGATCTCCAGAATCACACCTGAGGACCAGTGTGCTTTTG
GAGCAAATGATGAGAAAGAAGCAAGCAATGCACCTGGACGCGCGCTACGTTACAATGGTGGAGA
ACGCGTATTACTACTGCAACCCACCACCAGCCGAGAAGACAGTGAGAAGGAAGCGGCCTCCTCT
TCAGGAGTATGTCCGCAAACTTCTGTACAAGGATCTCTCTAAGGTCACCACGGAAAAGGTTTTG
AGACAGATGCGAAAGTTGCCCTGGCAGGACCAAGAAGTTAAAGACTATGTCATTTGTTGTATGA
TAAACATTTGGAATGTGAAATACAATAGTATTCACTGTGTAGCCAACCTCCTAGCAGGACTAGT
GCTTTACCAGGAGGATGTTGGGATCCACGTTGTGGACGGAGTACTTGAAGATATTCGATTGGGA
ATGGAGGTTAATCAACCTAAATTTAACCAGAGGCGCATCAGTAGTGCCAAGTTCTTAGGAGAAC
TTTATAATTACAGAATGGTCGAATCGGCTGTTATTTTCAGAACTCTTTATTCTTTTACTTCATT
TGGTGTCAACCCTGACGGGTCTCCAAGTTCCCTGGACCCTCCTGAGCATCTGTTTAGAATTAGA
CTAGTCTGCACTATTTTGGATACCTGTGGCCAGTACTTTGACAGAGGTTCCAGTAAAAGAAAAC
TTGACTGCTTCCTTGTATATTTTCAGCGTTATGTTTGGTGGAAGAAAAGTTTGGAGGTTTGGAC
AAAAGACCATCCATTTCCTATTGATATAGATTACATGATCAGTGATACACTAGAACTGCTAAGA
CCAAAGATCAAACTCTGTAATTCTCTGGAAGAATCCATCAGGCAGGTACAAGACTTGGAACGAG
AATTCTTAATAAAACTAGGCCTAGTAAATGACAAAGAGTCCAAAGATTCTATGACAGAAGGGGA
AAATCTTGAAGAGGATGAAGAAGAAGAAGAAGGAGGAGCTGAGACAGAGGAACAGTCTGGAAAT
GAGAGTGAAGTAAACGAGCCAGAAGAAGAAGAGGGTTCTGATGATGAAGACGAGGGAGAGGAGG
AGGAAGAAGAGAATACAGATTACCTCACAGATTCCAACAAGGAGAACGAGACTGATGAAGAGAA
TGCTGAGGTGATGATTAAGGGAGGCGGACTGAAGCATGTTCCTTGTGTAGAAGATGAGGACTTC
ATTCAAGCTCTGGACAAAATGATGCTAGAAAACCTTCAGCGAAGTGGTGAATCTGTGAAAGTAC
ACCAACTTGATGTTGCTATTCCTTTGCATCTCAAAAGCCAGCTGAGGAAAGGGCCCCCACTTGG
TGGTGGGGAAGGAGAGACAGAGTCTGCAGACACGATGCCGTTTGTCATGCTGACAAGGAAAGGC
AATAAACAGCAGTTTAAGATTCTCAATGTGCCCATGTCATCCCAACTTGCTGCAAATCACTGGA
ACCAGCAACAAGCAGAACAAGAGGAGAGGATGAGGATGAAAAAGCTCACCTTAGACATCAACGA
ACGACAAGAACAAGAAGATTATCAAGAAATGTTGCAGTCTCTCGCACAGCGCCCAGCTCCAGCG
AACACTAATCGTGAGCGGCGGCCTCGTTACCAACATCCAAAGGGAGCGCCTAATGCAGATCTAA
TCTTTAAGACTGGTGGGAGGAGACGTTGATCCAGCAGCACGTGTCATTTCATTAGGTCCTGTAT
CTGATGTTGTGGATAGTGGAGTCCTCCAGCAATTGAATGAGAGCAGCGGACACATCTCAGCATG
TCGGTCTAGAGAGTTGCGAATCTAAACCTGGGACAGGCTGGGGCCATGAGGCAGAAACACCAGC
CTCTGCCAACACCGGAACAAGCCGACGCTTCCAGACAAGGCAGAAAGGCCTTTTGTAATGGAAA
TCACGTGAGGGTTAATCTTCTCTTGAGAATGGCAGTCAAGAAATGAGAAGGTTCACTTGACTGC
TGAGAGCTACACCAGGAAGAGCGTCCGTGAGGTGACTGAGCCGGAGAGGAAACGGTTGAGATGG
GATGGTATGGGGGAAATGAACTTGAGTTTTAAACTTGATTTAAGTTACAGTGTCTCTGAATTGA
ACATCCCATGTTGGAAGAAGATACATTTGGGGGCTCCAGGACTACAGTAGAACAGTATAGAGCA
AGCAGTAAAATCTTCTAGTAAAACTTCCA

hide sequence

RefSeq Acc Id:

XM_039095923 ⟹ XP_038951851

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,133,975 - 77,245,266 (-)	NCBI
mRatBN7.2	17	72,224,575 - 72,335,896 (-)	NCBI

RefSeq Acc Id:

XM_039095924 ⟹ XP_038951852

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,133,975 - 77,245,259 (-)	NCBI
mRatBN7.2	17	72,224,575 - 72,335,856 (-)	NCBI

RefSeq Acc Id:

XM_039095926 ⟹ XP_038951854

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,133,975 - 77,242,493 (-)	NCBI
mRatBN7.2	17	72,224,575 - 72,333,150 (-)	NCBI

RefSeq Acc Id:

XM_039095928 ⟹ XP_038951856

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,143,311 - 77,245,245 (-)	NCBI
mRatBN7.2	17	72,233,910 - 72,335,896 (-)	NCBI

RefSeq Acc Id:

XM_039095929 ⟹ XP_038951857

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,133,975 - 77,231,075 (-)	NCBI
mRatBN7.2	17	72,224,575 - 72,321,713 (-)	NCBI

RefSeq Acc Id:

XM_039095930 ⟹ XP_038951858

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,192,006 - 77,245,245 (-)	NCBI
mRatBN7.2	17	72,282,641 - 72,335,896 (-)	NCBI

RefSeq Acc Id:

XM_063276631 ⟹ XP_063132701

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,133,975 - 77,244,490 (-)	NCBI

RefSeq Acc Id:

XM_063276632 ⟹ XP_063132702

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,133,975 - 77,245,020 (-)	NCBI

RefSeq Acc Id:

XM_063276633 ⟹ XP_063132703

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,133,975 - 77,245,207 (-)	NCBI

RefSeq Acc Id:

XM_063276634 ⟹ XP_063132704

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	77,180,777 - 77,245,245 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101891	(Get FASTA)	NCBI Sequence Viewer
	NP_001430767	(Get FASTA)	NCBI Sequence Viewer
	XP_038951851	(Get FASTA)	NCBI Sequence Viewer
	XP_038951852	(Get FASTA)	NCBI Sequence Viewer
	XP_038951854	(Get FASTA)	NCBI Sequence Viewer
	XP_038951856	(Get FASTA)	NCBI Sequence Viewer
	XP_038951857	(Get FASTA)	NCBI Sequence Viewer
	XP_038951858	(Get FASTA)	NCBI Sequence Viewer
	XP_063132701	(Get FASTA)	NCBI Sequence Viewer
	XP_063132702	(Get FASTA)	NCBI Sequence Viewer
	XP_063132703	(Get FASTA)	NCBI Sequence Viewer
	XP_063132704	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL78652	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000054878
	ENSRNOP00000054878.6
	ENSRNOP00000075795
	ENSRNOP00000075795.3
	ENSRNOP00000075866
	ENSRNOP00000075866.2
	ENSRNOP00000098717.1

RefSeq Acc Id:

NP_001101891 ⟸ NM_001108421

- Sequence:

show sequence

MPAERKKSASMEEKESLLNNKEKDCSERRPVSSKEKSKDDLKITAKKEVSKVPEDKKKKLEEDK
RKKEDKERKKKEEEKVKAEEELKKKEEEEKKKQEEEERKKQEEQAKRQQEEAAAQLKEKEESLQ
LHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSLKKNTAFVKKLKTITEQQRDSLSHDF
NGLNLSKYIGEAVASIVEAKLKISDVNCAVHLCSLFHQRYADFAPSLLQVWKKHFEARKEEKTP
NITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINADRESHTHVSVVISFCRHCGDDIAG
LVPRKVKSAAEKFNLNFPPSEIISPEKQQPFQNLLKEYFTSLTKHLKRDHRELQNTERQNRRIL
HSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQDKPTPEEHGPGIDIFTPGKP
GEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQNKDSSKDDSKEAKEPKDNKEASS
PDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKLIVDAFLQQLPNC
VNRDLIDKAAMDFCMNMNTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCS
MLRGDFRFHVRKKDQINIETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTL
LETCGRFLFRSPESHLRTSVLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRRKRPP
LQEYVRKLLYKDLSKVTTEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGL
VLYQEDVGIHVVDGVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTS
FGVNPDGSPSSLDPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVW
TKDHPFPIDIDYMISDTLELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEG
ENLEEDEEEEEGGAETEEQSGNESEVNEPEEEEGSDDEDEGEEEEEENTDYLTDSNKENETDEE
NAEVMIKGGGLKHVPCVEDEDFIQALDKMMLENLQRSGESVKVHQLDVAIPLHLKSQLRKGPPL
GGGEGETESADTMPFVMLTRKGNKQQFKILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDIN
ERQEQEDYQEMLQSLAQRPAPANTNRERRPRYQHPKGAPNADLIFKTGGRRR

hide sequence

Ensembl Acc Id:

ENSRNOP00000075795 ⟸ ENSRNOT00000092693

Ensembl Acc Id:

ENSRNOP00000075866 ⟸ ENSRNOT00000092452

Ensembl Acc Id:

ENSRNOP00000075770 ⟸ ENSRNOT00000092442

Ensembl Acc Id:

ENSRNOP00000054878 ⟸ ENSRNOT00000058070

RefSeq Acc Id:	XP_038951851 ⟸ XM_039095923
- Peptide Label:	isoform X1
- UniProtKB:	A0A0U1RRY8 (UniProtKB/TrEMBL), A0A0U1RRS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038951852 ⟸ XM_039095924
- Peptide Label:	isoform X1
- UniProtKB:	A0A0U1RRY8 (UniProtKB/TrEMBL), A0A0U1RRS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038951854 ⟸ XM_039095926
- Peptide Label:	isoform X1
- UniProtKB:	A0A0U1RRY8 (UniProtKB/TrEMBL), A0A0U1RRS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038951857 ⟸ XM_039095929
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038951856 ⟸ XM_039095928
- Peptide Label:	isoform X2
- UniProtKB:	A0A0U1RRS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038951858 ⟸ XM_039095930
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063132703 ⟸ XM_063276633
- Peptide Label:	isoform X1
- UniProtKB:	A0A0U1RRY8 (UniProtKB/TrEMBL), A0A0U1RRS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063132702 ⟸ XM_063276632
- Peptide Label:	isoform X1
- UniProtKB:	A0A0U1RRY8 (UniProtKB/TrEMBL), A0A0U1RRS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063132701 ⟸ XM_063276631
- Peptide Label:	isoform X1
- UniProtKB:	A0A0U1RRY8 (UniProtKB/TrEMBL), A0A0U1RRS6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063132704 ⟸ XM_063276634
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000098717 ⟸ ENSRNOT00000132252

Protein Domains

MIF4G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZT03-F1-model_v2	AlphaFold	D3ZT03	1-1272	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700569

Promoter ID:

EPDNEW_R11090

Type:

initiation region

Name:

Upf2_1

Description:

UPF2, regulator of nonsense mediated mRNA decay

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	76,287,193 - 76,287,253	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309178	AgrOrtholog
BioCyc Gene	G2FUF-8710	BioCyc
Ensembl Genes	ENSRNOG00000023593	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000058070	ENTREZGENE
	ENSRNOT00000058070.6	UniProtKB/TrEMBL
	ENSRNOT00000092452	ENTREZGENE
	ENSRNOT00000092452.3	UniProtKB/TrEMBL
	ENSRNOT00000092693	ENTREZGENE
	ENSRNOT00000092693.3	UniProtKB/TrEMBL
	ENSRNOT00000132252.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.180	UniProtKB/TrEMBL
	4.10.80.160	UniProtKB/TrEMBL
	6.10.250.770	UniProtKB/TrEMBL
InterPro	ARM-type_fold	UniProtKB/TrEMBL
	MIF4G-like_typ-3	UniProtKB/TrEMBL
	Nmd2/UPF2	UniProtKB/TrEMBL
	Upf2/Nmd2_C	UniProtKB/TrEMBL
KEGG Report	rno:361271	UniProtKB/TrEMBL
NCBI Gene	361271	ENTREZGENE
PANTHER	PTHR12839	UniProtKB/TrEMBL
	REGULATOR OF NONSENSE TRANSCRIPTS 2	UniProtKB/TrEMBL
Pfam	MIF4G	UniProtKB/TrEMBL
	Upf2	UniProtKB/TrEMBL
PhenoGen	Upf2	PhenoGen
RatGTEx	ENSRNOG00000023593	RatGTEx
SMART	MIF4G	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48371	UniProtKB/TrEMBL
UniProt	A0A0U1RRS6	ENTREZGENE, UniProtKB/TrEMBL
	A0A0U1RRY8	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L3P4_RAT	UniProtKB/TrEMBL
	A6JLX5_RAT	UniProtKB/TrEMBL
	D3ZT03_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-05-24	Upf2	UPF2, regulator of nonsense mediated mRNA decay	Upf2	UPF2 regulator of nonsense transcripts homolog (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Upf2	UPF2 regulator of nonsense transcripts homolog (yeast)	Upf2_predicted	UPF2 regulator of nonsense transcripts homolog (yeast) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Upf2_predicted	UPF2 regulator of nonsense transcripts homolog (yeast) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)