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Gene: Dipk2a (divergent protein kinase domain 2A) Rattus norvegicus

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Symbol:

Dipk2a

Name:

divergent protein kinase domain 2A

RGD ID:

1309079

Description:

Predicted to be involved in cardiac muscle cell proliferation and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within negative regulation of smooth muscle cell apoptotic process. Predicted to be located in COPI-coated vesicle; Golgi membrane; and extracellular space. Predicted to be part of COPI vesicle coat. Orthologous to human DIPK2A (divergent protein kinase domain 2A); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ab2-095; deleted in autism protein 1; hypothetical protein LOC315891; LOC315891; RGD1309079; similar to Ab2-095; uncharacterized protein LOC315891

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DIPK2A (divergent protein kinase domain 2A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Dipk2a (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dipk2a (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DIPK2A (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DIPK2A (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dipk2a (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DIPK2A (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DIPK2A (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dipk2a (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dipk2a (divergent protein kinase domain 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Dipk2a (divergent protein kinase domain 2A)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dipk2a (divergent protein kinase domain 2A)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DIPK2A (divergent protein kinase domain 2A)	Alliance	DIOPT (HGNC\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DIPK2A (divergent protein kinase domain 2A)	Alliance	DIOPT (HGNC\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11170	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG11170	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Danio rerio (zebrafish):	dipk2aa	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dipk2aa	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dipk2ab	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dipk2ab	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dipk2a	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dipk2a	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	103,950,345 - 103,969,461 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	103,909,931 - 103,969,461 (-)	Ensembl				GRCr8
mRatBN7.2	8	95,070,695 - 95,089,815 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	95,030,279 - 95,089,815 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	100,732,006 - 100,751,133 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	98,931,302 - 98,950,428 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	96,776,976 - 96,796,133 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	102,140,713 - 102,159,828 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	102,088,505 - 102,159,828 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	101,571,619 - 101,642,666 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	99,571,924 - 99,591,067 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	94,546,476 - 94,565,667 (-)	NCBI		Celera
RGSC_v3.1	8	99,544,806 - 99,753,225 (-)	NCBI
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-diaminodiphenylmethane (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

dibutyl phthalate (EXP)

dimethyl sulfoxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

fenvalerate (EXP)

furan (EXP)

methylisothiazolinone (ISO)

mono(2-ethylhexyl) phthalate (EXP)

Muraglitazar (EXP)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodimethylamine (EXP)

nickel dichloride (EXP)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

potassium chromate (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

thiram (ISO)

triphenyl phosphate (EXP)

troglitazone (EXP)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cardiac muscle cell proliferation (ISO)

negative regulation of smooth muscle cell apoptotic process (ISO)

positive regulation of protein kinase C activity (ISO)

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

Cellular Component

COPI vesicle coat (ISO)

COPI-coated vesicle (ISO)

extracellular region (IEA,ISO)

extracellular space (ISO)

Golgi membrane (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:18651652	PMID:19587158	PMID:23784961	PMID:24269490

Genomics

Comparative Map Data

Dipk2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	103,950,345 - 103,969,461 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	103,909,931 - 103,969,461 (-)	Ensembl				GRCr8
mRatBN7.2	8	95,070,695 - 95,089,815 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	95,030,279 - 95,089,815 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	100,732,006 - 100,751,133 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	98,931,302 - 98,950,428 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	96,776,976 - 96,796,133 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	102,140,713 - 102,159,828 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	102,088,505 - 102,159,828 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	101,571,619 - 101,642,666 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	99,571,924 - 99,591,067 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	94,546,476 - 94,565,667 (-)	NCBI		Celera
RGSC_v3.1	8	99,544,806 - 99,753,225 (-)	NCBI
Cytogenetic Map	8	q31	NCBI

DIPK2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	143,971,798 - 143,992,368 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	143,971,823 - 144,048,719 (+)	Ensembl			hg38	GRCh38
GRCh37	3	143,690,640 - 143,711,210 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	145,173,603 - 145,193,895 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	3	142,113,447 - 142,133,972 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI
HuRef	3	141,062,432 - 141,083,248 (+)	NCBI		HuRef
CHM1_1	3	143,654,076 - 143,674,614 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	146,718,429 - 146,738,995 (+)	NCBI		T2T-CHM13v2.0

Dipk2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	94,399,917 - 94,420,134 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	94,399,917 - 94,420,134 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	94,517,864 - 94,538,081 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	94,517,864 - 94,538,081 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	94,418,283 - 94,438,500 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	94,328,875 - 94,347,162 (-)	NCBI		MGSCv36	mm8
Celera	9	94,068,306 - 94,088,285 (-)	NCBI		Celera
Cytogenetic Map	9	E3.3	NCBI
cM Map	9	49.03	NCBI

Dipk2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955508	1,953,923 - 1,975,842 (-)	Ensembl
ChiLan1.0	NW_004955508	1,954,600 - 1,975,842 (-)	NCBI	ChiLan1.0	ChiLan1.0

DIPK2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	141,871,779 - 141,894,520 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	141,879,055 - 141,899,251 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	140,999,699 - 141,019,908 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	148,589,849 - 148,610,055 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	148,590,378 - 148,607,520 (+)	Ensembl			panPan2	panpan1.1

DIPK2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	39,472,090 - 39,496,000 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	39,325,698 - 39,356,305 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	39,996,628 - 40,027,211 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	40,002,035 - 40,027,206 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	39,679,985 - 39,710,607 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	39,760,410 - 39,791,001 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	39,999,406 - 40,030,000 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dipk2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	78,745,609 - 78,767,205 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936519	10,966,619 - 10,988,352 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936519	10,966,822 - 10,988,311 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DIPK2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	84,634,777 - 84,657,371 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	84,634,716 - 84,656,112 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	92,370,409 - 92,390,845 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DIPK2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	46,616,961 - 46,643,784 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	46,616,961 - 46,643,583 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	19,540,683 - 19,567,490 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dipk2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	20,633,816 - 20,655,815 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dipk2a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	86,021,236 - 86,040,383 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dipk2a
226 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	574
Count of miRNA genes:	264
Interacting mature miRNAs:	324
Transcripts:	ENSRNOT00000011263
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
8693654	Alc32	Alcohol consumption QTL 32	2	0.755	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	8	97492344	116428905	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	103375781	129871912	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

RH130719

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	95,071,001 - 95,071,187 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	102,141,020 - 102,141,205	NCBI	Rnor6.0
Rnor_5.0	8	101,623,830 - 101,624,015	UniSTS	Rnor5.0
RGSC_v3.4	8	99,572,231 - 99,572,416	UniSTS	RGSC3.4
Celera	8	94,546,783 - 94,546,968	UniSTS
RH 3.4 Map	8	1058.2	UniSTS
Cytogenetic Map	8	q31	UniSTS

RH139956

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	95,091,821 - 95,092,019 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	102,161,835 - 102,162,032	NCBI	Rnor6.0
Rnor_5.0	8	101,644,673 - 101,644,870	UniSTS	Rnor5.0
RGSC_v3.4	8	99,593,074 - 99,593,271	UniSTS	RGSC3.4
Celera	8	94,567,674 - 94,567,871	UniSTS
RH 3.4 Map	8	1057.7	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY325189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011263 ⟹ ENSRNOP00000011263

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	103,909,931 - 103,959,545 (-)	Ensembl
mRatBN7.2 Ensembl	8	95,030,279 - 95,079,898 (-)	Ensembl
Rnor_6.0 Ensembl	8	102,088,505 - 102,149,912 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000086491 ⟹ ENSRNOP00000071903

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	103,950,345 - 103,969,461 (-)	Ensembl
mRatBN7.2 Ensembl	8	95,070,695 - 95,089,815 (-)	Ensembl
Rnor_6.0 Ensembl	8	102,140,713 - 102,159,828 (-)	Ensembl

RefSeq Acc Id:

NM_001134472 ⟹ NP_001127944

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	103,950,345 - 103,969,461 (-)	NCBI
mRatBN7.2	8	95,070,695 - 95,089,815 (-)	NCBI
Rnor_6.0	8	102,140,713 - 102,159,828 (-)	NCBI
Rnor_5.0	8	101,571,619 - 101,642,666 (-)	NCBI
RGSC_v3.4	8	99,571,924 - 99,591,067 (-)	RGD
Celera	8	94,546,476 - 94,565,667 (-)	RGD

Sequence:

show sequence

GGAGTCGGAGGGCGGGGAGCTCGGAGGAGGGCGCCCGGAGTTGTGGAGACAGCCGATCGGGAAG
TCGCCGCGCTTGGCCGGCGCAGCCCGTTCTCGGGCTTCTTCGCTGCCGCCCTCCGTCTGCGCCG
CGGGCCTCGGCGCCGTGGGGCGGCCCGGGGTGCGCTCGCCCGCCCCGGCCCCGGCCACTGCCGC
GCGCGGGCGGGATGTGGCGCCTGGTGCCCCTGAAGCTGGGCCGCCTGTCCCGTGCACTGAAGCT
GGCGGCGCTCGGCAGCCTGTTGGTGCTGATGCTGCTGCACTCGCCGTCGCTGCTCGCCTCTTGG
CAGCGCAACGAGCTCGCCGACCGGCGTTTCCTGCAGCTCAATAAGTGCCCGGCGTGCTTCGGCA
CGAGCTGGTGCCGCCGTTTCCTCAACGGCCAGGTGGGCTTCGAGACGTGGGGCCGCCTGCGCCT
GCTGGACTTCCTCAACGTGAAGAACGTGTACTTCGCGCAGTACGGCGAGCCCCGCGAGGGCGGC
CGCCGGCGCGTGGTGCTCAAGCGCCTGGGTTCGCAGCGCGAGCTGGCGCAGCTCGACCAGAGCA
TCTGCAAGCGGGCCACCGGCCGGCCGCGCTGCGACCTGCTCCAGGCCATGCCCCGCACCGAGTT
CGCGCGTCTCAACGGCGACGTGCGGCTGCTCACGCCGGAGGCGGTGGAGGGTTGGTCAGACCTG
GTGCACTGCCCCTCGCAGCGCTTGCTGGACCGCCTGGTGCGCCGCTACGCCGAGACCAAGGACT
CGGGCAGTTTCCTGCTGCGCAACCTCAAGGACTCGGAGCGCATGCAGCTGCTGCTCACCCTGGC
CTTCAACCCCGAGCCGCTGGTGCTACAGAGTTTTCCATCTGATGAAGGTTGGCCATTTGCAAAG
TATCTCGGAGCTTGTGGAAGAATGGTGGCTGTAAATTACGTTGGAGAAGAACTGTGGAGTTATT
TTAATGCACCATGGGAGAAAAGAGTTGACCTTGCTTGGCAGTTAATGGAAATAGCAGAGCAGCT
TACAAACAATGACTTTGAATTTGCACTCTACCTCCTGGACGTCAGCTTTGACAATTTTGCAGTT
GGTCCAAGAGATGGGAAGGTAATCATTGTGGATGCTGAAAATGTTTTAGTTGCCGACAAAAGAT
TAATTAGACAAAATAAGCCTGAGAATTGGGATGTATGGTATGAGAGCAAGTTTGATGACTGTGA
CAAGGAGGCTTGCTTATCATTTTCGAAAGAAATCCTTTGTGCTCGTGTCACTGTGGACCACAAT
TACTATGCTGTTTGTCAAAACCTCTTATCTAGACATGCCACCTGGCGTGGCACTTCTGGAGGAC
TCCTTCATGATCCACCAAGTGAAATTGCCAAAGATGGCCGACTGGAGGCCTTGCTGGATGAGTG
CACCAACCCCAAGAAGCGCTATGGCCGATTCCAGGCTGCAAAAGAACTGCGAGGCTATCTAGCA
CAGTTAAGTCACAATGTGAGGTAGTCAGCAGTGATCTTTTCCTTTTCTTTGCTGAAATAGCACT
GGCAAAACTAAACCACCAAAAAACTGCCTAGAATAAACAAAGTGTGGAAGTATGGCATCAGAGG
ATGATGAACTTCTGGTAGATCTTACATTAACACCCGTCAAAATAAGACATTACTGTCCATCAAA
CTTCTCATGATGCTTCTGCAAGTCTGTTCTTCACTTTGGAGATTGGGATACCATTGACCGCTTT
TTCCCCTCCCCATACCTGAGTGGATGATACTGTTAAGCTATTGGAAAGGAGTCTGATAGTTACA
TGGCTTGTGTATCAAAGGGTACTTGGTACTTAGATTGCATTTCTATCATGATTTTGTGAATCTC
TTGCATTTACTTTGAATGTCAAGTTAGATTGGCCTGTTTTATAGGCCACATTTTCCTTCTGATG
TGTAAAATCATTTCCCATTTTTTAAAAGTTTTACACAACCAGGTTACTATAGGTATTCATTTAA
ATTTTAATATAAGTAGTTTTCATTCAGTGCTATGCGGTACATACTTAACTGTTAGGGCAGGACT
CCCAGGTTTACTGTTTTTACAGAGATCTTAGTATTTCATCATGTAAATAATTTACCTCTCCCTG
ACCTTCTATGCTTTACCATTGCATGATAATATCATTTCAGGTTATTTAAGAGTTAAATCCCTCA
ATGCCAGTAATTATAAGTATACACTGAACATGGCGTTCAGCATATGCTACAAAATGGCACTGTG
TCCTTTGCTAAAAGGCTTCAAGAATAATACACTAGCAGTCTACACTTCGATTGAAGAAACAATA
AAAGTCAATGTTTTTAATGCTAACTAGTCCAAGATAGTAATGCACATGCCAAAGAAATATTAAG
ACACATTCCTATGGTTAGGACTGAAAATAGAATTGGTCACCTTCTTATCCCACTTCAGTATTTT
AGCTGTCACTCTTAAATTAAGATCTACCTGTTCCTTTAATGCTGACAGTTGAGCTACTGCTGAT
ATTTAAAACGTGTATAACTTAAAGACCTTCGACTCTTTTATTCATTGGTAGTTTTTCCAAAATG
AATATGGTGATCACTGTTGGAATTTACTTAGGCATCAGAACCTTTTACTTACTGATACACTAGG
AACTTGTACTGTAAAGCTTGTCTGCCCATTGTGATCTTCTTTACCCAATTGCTAAATATCAGAA
CATCAAATTTAAATATGTGAGTAGAAAAATTAACAAATACTGTGTAAAAGTTTTGTCTATTTAA
AAGCTGTTCTTTGTAAAAAGTTGGCTCTCACTAGCACAGGTAACATTTTTCTGTTTGAAGTTGT
TTTTTTTTGTTTGCAGTAAAGTTTGGGGCAGTGGGTTCTGGGCTGACTTACTGAAATCAGAAAG
TGATTGAAACATGCACAACCAAAGCCAAGGTTTTCCTTTTCATTCATTTAGCAAATATGTGTTG
ATCCTCAAGCCCCATGCCAGGTGCATTTGTAGCTGCTATAAACCATCTGAACGTGACATGGTCA
AGTAACTGTCAACTGTGTCAGCATAGGTACTTCTTAAGTTGACATGCCATTATTTAGGATGCCT
CTTTCATGTTATTTGATTATTGTGATGGAAATTCTCTTTGTACCACCTTAAATTAGTTTGTTAA
TCCAAAGTGGAGGAAGACAGCAATAAAATGAATCCAAGTTTAAAAATGGGAAGACATAGGGTAA
GAGCTCTCTATTATAAAACTGATTGCATTGTGTTTCTTCTTACACATCAGTATATTGCATAGCT
CTCAATGAAACATTGACGAACTTGCTAAGCTTACTTTTTACAAACTCAAAAAATCCTTTAAAGG
GCATAGGAAAAAAAATCATTCAACAATAATACCCATTTGCTTCCTTAGAGCTATACTAAAGTAT
AGAATTTCAAAACAGGACACCCTTAGATTTTCCACCTATTCGTAACATGGACGCTGGAACTCAC
AGGAGAGCTGTCTGTGGTTCCACAAACATCATATTTTTTGGTGAGTGACTGTGGTTGTGATTAC
AGAGCAAGAAGTAAGGCTCTCCAGGCAGTGATGGCTACTTCAGGTATGACTACCATGAGAGACT
ATGTGGAATTTCTTTTATCTTTGGAGATGTTTGAGAAGCTAGTAAAAGAATTAGGAATTTAAAA
TTACAGGGAAAAATATGTATGTGAAAAGCAATAAGTATTTTGTTCTCTTTGCTATCCAGATGCT
CACACTCAGATATTTATTATACAGCAGCAGTCTATATTTTTAATCATTGCCCATTAATAGACGC
AGTGAAATATTTTTGAATCAAACATTTGGGGTTTGTATGTGCATTTAAATTGTCTTTTGTACTG
TATGTTACTGTTTAATTTGAATATTTTATCAGAACTGTCTCCCTGTGCCTTTATAATATAAAGT
TGTTTCTGCAACTTTTAATGATCTTAATAAAGAATACTTTAAGAACCATATTTTGCTAACTCTG
TCTTCAACTCTGCAAGTTTTTCTTGAGCAAAAAACAAATAAAAAATTAGTTAATT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001127944	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP92590	(Get FASTA)	NCBI Sequence Viewer
	EDL77527	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011263.6
	ENSRNOP00000071903
	ENSRNOP00000071903.1

RefSeq Acc Id:

NP_001127944 ⟸ NM_001134472

- UniProtKB:

A0A0G2K1M5 (UniProtKB/TrEMBL), A6I250 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWRLVPLKLGRLSRALKLAALGSLLVLMLLHSPSLLASWQRNELADRRFLQLNKCPACFGTSWC
RRFLNGQVGFETWGRLRLLDFLNVKNVYFAQYGEPREGGRRRVVLKRLGSQRELAQLDQSICKR
ATGRPRCDLLQAMPRTEFARLNGDVRLLTPEAVEGWSDLVHCPSQRLLDRLVRRYAETKDSGSF
LLRNLKDSERMQLLLTLAFNPEPLVLQSFPSDEGWPFAKYLGACGRMVAVNYVGEELWSYFNAP
WEKRVDLAWQLMEIAEQLTNNDFEFALYLLDVSFDNFAVGPRDGKVIIVDAENVLVADKRLIRQ
NKPENWDVWYESKFDDCDKEACLSFSKEILCARVTVDHNYYAVCQNLLSRHATWRGTSGGLLHD
PPSEIAKDGRLEALLDECTNPKKRYGRFQAAKELRGYLAQLSHNVR

hide sequence

Ensembl Acc Id:

ENSRNOP00000071903 ⟸ ENSRNOT00000086491

Ensembl Acc Id:

ENSRNOP00000011263 ⟸ ENSRNOT00000011263

Protein Domains

FAM69 protein-kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3J1-F1-model_v2	AlphaFold	D4A3J1	1-631	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696183

Promoter ID:

EPDNEW_R6708

Type:

initiation region

Name:

RGD1309079_1

Description:

similar to Ab2-095

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	102,159,830 - 102,159,890	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309079	AgrOrtholog
BioCyc Gene	G2FUF-29524	BioCyc
Ensembl Genes	ENSRNOG00000008519	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011263.8	UniProtKB/TrEMBL
	ENSRNOT00000086491	ENTREZGENE
	ENSRNOT00000086491.3	UniProtKB/TrEMBL
InterPro	FAM69_kinase_dom	UniProtKB/TrEMBL
	UPF0672	UniProtKB/TrEMBL
KEGG Report	rno:315891	UniProtKB/TrEMBL
NCBI Gene	315891	ENTREZGENE
PANTHER	DIVERGENT PROTEIN KINASE DOMAIN 2A	UniProtKB/TrEMBL
	PTHR32073	UniProtKB/TrEMBL
Pfam	PIP49_C	UniProtKB/TrEMBL
PhenoGen	Dipk2a	PhenoGen
RatGTEx	ENSRNOG00000008519	RatGTEx
UniProt	A0A0G2K1M5	ENTREZGENE, UniProtKB/TrEMBL
	A6I250	ENTREZGENE, UniProtKB/TrEMBL
	Q7TP59_RAT	UniProtKB/TrEMBL
UniProt Secondary	D4A3J1	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-10-18	Dipk2a	divergent protein kinase domain 2A	RGD1309079	similar to Ab2-095	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1309079	similar to Ab2-095	RGD1309079_predicted	similar to Ab2-095 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1309079_predicted	similar to Ab2-095 (predicted)	LOC315891_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC315891_predicted	similar to Ab2-095 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD