Htra2 (HtrA serine peptidase 2) - Rat Genome Database

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Gene: Htra2 (HtrA serine peptidase 2) Rattus norvegicus
Analyze
Symbol: Htra2
Name: HtrA serine peptidase 2
RGD ID: 1308906
Description: Enables serine-type peptidase activity. Involved in several processes, including ceramide metabolic process; pentacyclic triterpenoid metabolic process; and response to herbicide. Predicted to be located in several cellular components, including chromatin; cytoplasmic side of plasma membrane; and mitochondrial intermembrane space. Predicted to be part of CD40 receptor complex and serine-type endopeptidase complex. Predicted to be active in mitochondrion. Used to study transient cerebral ischemia. Biomarker of asphyxia neonatorum; cryptorchidism; middle cerebral artery infarction; and status epilepticus. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2); PARTICIPATES IN intrinsic apoptotic pathway; Parkinson's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; clofibric acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: high temperature requirement protein A2; LOC297376; protease, serine, 25; Prss25; serine protease HTRA2, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,114,631 - 117,117,793 (-)NCBIGRCr8
mRatBN7.24115,556,914 - 115,560,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,556,916 - 115,560,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,033,497 - 121,036,659 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,808,694 - 116,811,856 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,423,257 - 115,426,420 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,883,671 - 113,886,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,883,670 - 113,886,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,568,771 - 178,571,933 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,262,206 - 117,265,368 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,506,685 - 117,509,829 (-)NCBI
Celera4104,551,592 - 104,554,754 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
3-phenylprop-2-enal  (ISO)
4-hydroxy-TEMPO  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
LGK974  (ISO)
lonidamine  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
okadaic acid  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phlorizin  (ISO)
potassium chromate  (ISO)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-nitrosoglutathione  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
testosterone  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion. Althaus J, etal., Neurochem Int. 2007 Jan;50(1):172-80. Epub 2006 Sep 15.
2. Inhibition of HtrA2/Omi ameliorates heart dysfunction following ischemia/reperfusion injury in rat heart in vivo. Bhuiyan MS and Fukunaga K, Eur J Pharmacol. 2007 Feb 28;557(2-3):168-77. Epub 2006 Nov 14.
3. Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease. Bogaerts V, etal., Hum Mutat. 2008 Jun;29(6):832-40.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. HtrA2 is up-regulated in the rat testis after experimental cryptorchidism. Hayashi T, etal., Int J Urol. 2006 Feb;13(2):157-64.
7. Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia. Hu XY, etal., APMIS. 2006 Dec;114(12):893-8.
8. Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat. Hu Y, etal., Int Immunopharmacol. 2013 May;16(1):108-13. doi: 10.1016/j.intimp.2013.03.019. Epub 2013 Apr 2.
9. [Effects of Ucf-101 on expression of Omi/HtrA2 in kidneys of postasphyxial neonatal rats]. Hua B, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Aug;12(8):658-61.
10. Minocycline prevents paraquat-induced cell death through attenuating endoplasmic reticulum stress and mitochondrial dysfunction. Huang CL, etal., Toxicol Lett. 2012 Mar 25;209(3):203-10. Epub 2012 Jan 10.
11. Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. Inagaki R, etal., Eur J Neurosci. 2008 Jul;28(1):30-40.
12. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Jones JM, etal., Nature. 2003 Oct 16;425(6959):721-7. Epub 2003 Oct 8.
13. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging. Kang S, etal., Cell Death Differ. 2013 Feb;20(2):259-69. doi: 10.1038/cdd.2012.117. Epub 2012 Sep 14.
14. Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer. Lee SH, etal., APMIS. 2003 May;111(5):586-90.
15. Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria. Lin CH, etal., Hum Genet. 2011 Dec;130(6):817-27. Epub 2011 Jun 24.
16. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Liu HR, etal., Circulation. 2005 Jan 4;111(1):90-6. Epub 2004 Dec 20.
17. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Martins LM, etal., Mol Cell Biol. 2004 Nov;24(22):9848-62.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer. Narkiewicz J, etal., Clin Biochem. 2008 May;41(7-8):561-9. Epub 2008 Jan 16.
20. Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer. Narkiewicz J, etal., Oncol Rep. 2009 Jun;21(6):1529-37.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain. Rami A, etal., Neurochem Res. 2010 Dec;35(12):2199-207. Epub 2010 Dec 4.
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1. Saito A, etal., Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):89-95.
27. Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls. Simon-Sanchez J and Singleton AB, Hum Mol Genet. 2008 Jul 1;17(13):1988-93. Epub 2008 Mar 25.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Strauss KM, etal., Hum Mol Genet. 2005 Aug 1;14(15):2099-111. Epub 2005 Jun 16.
30. UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats. Su D, etal., Anat Rec (Hoboken). 2009 Jun;292(6):854-61. doi: 10.1002/ar.20910.
31. Genetic variations of Omi/HTRA2 in Chinese patients with Parkinson's disease. Wang CY, etal., Brain Res. 2011 Apr 18;1385:293-7. Epub 2011 Feb 19.
32. Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death : Omi/HtrA2 and aged heart injury. Wang K, etal., Age (Dordr). 2013 Jun;35(3):733-46. doi: 10.1007/s11357-012-9406-x. Epub 2012 Apr 26.
33. Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease. Westerlund M, etal., FASEB J. 2011 Apr;25(4):1345-52. Epub 2010 Dec 16.
34. Asiatic acid protects primary neurons against C(2)-ceramide-induced apoptosis. Zhang X, etal., Eur J Pharmacol. 2012 Mar 15;679(1-3):51-9. Epub 2012 Jan 24.
35. Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer. Zurawa-Janicka D, etal., Int J Mol Sci. 2020 May 31;21(11). pii: ijms21113947. doi: 10.3390/ijms21113947.
Additional References at PubMed
PMID:8325640   PMID:10971580   PMID:11583623   PMID:11602612   PMID:11604410   PMID:11967569   PMID:14651853   PMID:15044455   PMID:15574596   PMID:17266347   PMID:17292393   PMID:17297443  
PMID:18614015   PMID:20125124   PMID:20614026   PMID:21198825   PMID:23413020   PMID:24270810   PMID:24657776   PMID:24709290   PMID:24798695   PMID:25118933   PMID:25931508   PMID:27998213  
PMID:29581019   PMID:30286467   PMID:31505169   PMID:32945404   PMID:34677809  


Genomics

Comparative Map Data
Htra2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,114,631 - 117,117,793 (-)NCBIGRCr8
mRatBN7.24115,556,914 - 115,560,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,556,916 - 115,560,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,033,497 - 121,036,659 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,808,694 - 116,811,856 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,423,257 - 115,426,420 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,883,671 - 113,886,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,883,670 - 113,886,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,568,771 - 178,571,933 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,262,206 - 117,265,368 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,506,685 - 117,509,829 (-)NCBI
Celera4104,551,592 - 104,554,754 (-)NCBICelera
Cytogenetic Map4q34NCBI
HTRA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,529,405 - 74,533,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,529,596 - 74,533,350 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,756,532 - 74,760,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,610,040 - 74,614,191 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,668,186 - 74,672,098NCBI
Celera274,587,640 - 74,591,791 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,492,793 - 74,496,944 (+)NCBIHuRef
CHM1_1274,685,928 - 74,690,079 (+)NCBICHM1_1
T2T-CHM13v2.0274,537,971 - 74,542,122 (+)NCBIT2T-CHM13v2.0
Htra2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,028,247 - 83,031,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,028,247 - 83,032,254 (-)EnsemblGRCm39 Ensembl
GRCm38683,051,266 - 83,054,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,051,266 - 83,055,273 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,001,260 - 83,004,565 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,016,940 - 83,020,229 (-)NCBIMGSCv36mm8
Celera685,033,853 - 85,037,160 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Htra2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,255,756 - 11,259,170 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,255,756 - 11,259,170 (-)NCBIChiLan1.0ChiLan1.0
HTRA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,856,074 - 51,859,242 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,858,033 - 51,861,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,596,020 - 74,599,790 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,102,240 - 76,106,169 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,102,240 - 76,106,152 (+)Ensemblpanpan1.1panPan2
HTRA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,610,408 - 48,613,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,610,408 - 48,613,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,252,304 - 48,255,295 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,469,859 - 49,472,851 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,467,050 - 49,472,864 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,487,009 - 48,490,000 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,553,751 - 48,556,744 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,111,429 - 49,114,422 (-)NCBIUU_Cfam_GSD_1.0
Htra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,992,054 - 9,996,178 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556741,718 - 749,090 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556741,718 - 746,016 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTRA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,516,500 - 68,519,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,516,666 - 68,520,025 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,688,452 - 71,690,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTRA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,745,436 - 32,749,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,743,708 - 32,748,577 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,422,108 - 79,425,985 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htra2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,980,362 - 28,983,869 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,980,375 - 28,983,719 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Htra2
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:43
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000037333
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat

Markers in Region
RH128117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,557,124 - 115,557,444 (+)MAPPERmRatBN7.2
Rnor_6.04113,883,880 - 113,884,199NCBIRnor6.0
Rnor_5.04178,568,980 - 178,569,299UniSTSRnor5.0
RGSC_v3.44117,262,415 - 117,262,734UniSTSRGSC3.4
Celera4104,551,801 - 104,552,120UniSTS
Cytogenetic Map4q34UniSTS
RH124966  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,561,661 - 115,561,745 (+)MAPPERmRatBN7.2
Rnor_6.04113,888,419 - 113,888,502NCBIRnor6.0
Rnor_5.04178,573,519 - 178,573,602UniSTSRnor5.0
RGSC_v3.44117,266,954 - 117,267,037UniSTSRGSC3.4
Celera4104,556,340 - 104,556,423UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000037333   ⟹   ENSRNOP00000030076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,556,916 - 115,560,095 (-)Ensembl
Rnor_6.0 Ensembl4113,883,670 - 113,886,994 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095148   ⟹   ENSRNOP00000094104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,557,105 - 115,560,061 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112194   ⟹   ENSRNOP00000092442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,557,105 - 115,560,095 (-)Ensembl
RefSeq Acc Id: NM_001106599   ⟹   NP_001100069
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,114,631 - 117,117,793 (-)NCBI
mRatBN7.24115,556,916 - 115,560,078 (-)NCBI
Rnor_6.04113,883,671 - 113,886,833 (-)NCBI
Rnor_5.04178,568,771 - 178,571,933 (-)NCBI
RGSC_v3.44117,262,206 - 117,265,368 (-)RGD
Celera4104,551,592 - 104,554,754 (-)RGD
Sequence:
RefSeq Acc Id: XM_063285788   ⟹   XP_063141858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,115,081 - 117,117,769 (-)NCBI
RefSeq Acc Id: XR_005503189
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,114,926 - 117,117,769 (-)NCBI
mRatBN7.24115,556,916 - 115,560,202 (-)NCBI
RefSeq Acc Id: XR_010065625
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,115,837 - 117,117,769 (-)NCBI
RefSeq Acc Id: XR_010065626
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,115,887 - 117,117,769 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100069 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141858 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58761 (Get FASTA)   NCBI Sequence Viewer  
  EDL91109 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030076.4
  ENSRNOP00000092442.1
  ENSRNOP00000094104.1
RefSeq Acc Id: NP_001100069   ⟸   NM_001106599
- UniProtKB: B0BNB9 (UniProtKB/TrEMBL),   F7FLZ6 (UniProtKB/TrEMBL),   A0A8I6AYW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030076   ⟸   ENSRNOT00000037333
Ensembl Acc Id: ENSRNOP00000094104   ⟸   ENSRNOT00000095148
Ensembl Acc Id: ENSRNOP00000092442   ⟸   ENSRNOT00000112194
RefSeq Acc Id: XP_063141858   ⟸   XM_063285788
- Peptide Label: isoform X1
Protein Domains
PDZ   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNB9-F1-model_v2 AlphaFold B0BNB9 1-458 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308906 AgrOrtholog
BioCyc Gene G2FUF-44034 BioCyc
Ensembl Genes ENSRNOG00000022448 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037333.6 UniProtKB/TrEMBL
  ENSRNOT00000095148.1 UniProtKB/TrEMBL
  ENSRNOT00000112194.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/TrEMBL
  2.40.10.10 UniProtKB/TrEMBL
  2.40.10.120 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103492 IMAGE-MGC_LOAD
  IMAGE:7320067 IMAGE-MGC_LOAD
InterPro PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1C UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
KEGG Report rno:297376 UniProtKB/TrEMBL
MGC_CLONE MGC:105779 IMAGE-MGC_LOAD
  MGC:187990 IMAGE-MGC_LOAD
NCBI Gene 297376 ENTREZGENE
PANTHER SERINE PROTEASE FAMILY S1C HTRA-RELATED UniProtKB/TrEMBL
  SERINE PROTEASE HTRA2, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam PDZ_6 UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
  Trypsin_2 UniProtKB/TrEMBL
PhenoGen Htra2 PhenoGen
PRINTS PROTEASES2C UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022448 RatGTEx
SMART PDZ UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A0A8I6AI60_RAT UniProtKB/TrEMBL
  A0A8I6AYW8 ENTREZGENE, UniProtKB/TrEMBL
  B0BNB9 ENTREZGENE, UniProtKB/TrEMBL
  F7FLZ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Htra2  HtrA serine peptidase 2  Prss25  protease, serine, 25  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Prss25  protease, serine, 25  Prss25_predicted  protease, serine, 25 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Prss25_predicted  protease, serine, 25 (predicted)      Symbol and Name status set to approved 70820 APPROVED