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Gene: Tmem72 (transmembrane protein 72) Rattus norvegicus

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Symbol:

Tmem72

Name:

transmembrane protein 72

RGD ID:

1308850

Description:

Predicted to be located in early endosome membrane; nucleus; and plasma membrane. Orthologous to human TMEM72 (transmembrane protein 72); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; aflatoxin B1; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC362424; RGD1308850

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM72 (transmembrane protein 72)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tmem72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmem72 (transmembrane protein 72)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	IRF8 (interferon regulatory factor 8)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Tmem72 (transmembrane protein 72)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMEM72 (transmembrane protein 72)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem72 (transmembrane protein 72)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem72 (transmembrane protein 72)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14086	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG14086	Alliance	DIOPT (OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	tmem72	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	151,620,696 - 151,645,989 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	151,620,696 - 151,645,989 (-)	Ensembl				GRCr8
mRatBN7.2	4	149,946,296 - 149,973,550 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	149,948,257 - 149,973,550 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	156,189,817 - 156,215,098 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	151,973,859 - 151,999,140 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	150,596,754 - 150,622,035 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	148,819,906 - 148,845,199 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	148,817,514 - 148,845,267 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	214,757,519 - 214,782,812 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	153,036,955 - 153,062,248 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	138,823,892 - 138,849,161 (-)	NCBI		Celera
RGSC_v3.1	4	153,248,491 - 153,306,907 (-)	NCBI
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-palmitoylglycerol (ISO)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlorpyrifos (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

diiodine (ISO)

mono(2-ethylhexyl) phthalate (ISO)

permethrin (ISO)

quartz (EXP)

resveratrol (ISO)

sunitinib (ISO)

triptonide (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (ISO)

early endosome membrane (ISO)

nucleus (ISO)

plasma membrane (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Tmem72
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	151,620,696 - 151,645,989 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	151,620,696 - 151,645,989 (-)	Ensembl				GRCr8
mRatBN7.2	4	149,946,296 - 149,973,550 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	149,948,257 - 149,973,550 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	156,189,817 - 156,215,098 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	151,973,859 - 151,999,140 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	150,596,754 - 150,622,035 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	148,819,906 - 148,845,199 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	148,817,514 - 148,845,267 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	214,757,519 - 214,782,812 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	153,036,955 - 153,062,248 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	138,823,892 - 138,849,161 (-)	NCBI		Celera
RGSC_v3.1	4	153,248,491 - 153,306,907 (-)	NCBI
Cytogenetic Map	4	q42	NCBI

TMEM72
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	44,911,337 - 44,937,010 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	44,911,316 - 44,937,010 (+)	Ensembl			hg38	GRCh38
GRCh37	10	45,406,785 - 45,432,458 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	44,726,770 - 44,750,648 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	10	41,409,939 - 41,433,817 (+)	NCBI		Celera
Cytogenetic Map	10	q11.21	NCBI
HuRef	10	41,931,390 - 41,955,268 (+)	NCBI		HuRef
CHM1_1	10	45,445,747 - 45,469,622 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	45,792,055 - 45,818,001 (+)	NCBI		T2T-CHM13v2.0

Tmem72
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	116,668,500 - 116,693,943 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	116,656,024 - 116,693,874 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	116,691,539 - 116,716,982 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	116,679,063 - 116,716,913 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	116,642,743 - 116,666,776 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	116,658,344 - 116,682,377 (-)	NCBI		MGSCv36	mm8
Celera	6	118,534,797 - 118,558,809 (-)	NCBI		Celera
Cytogenetic Map	6	E3	NCBI
cM Map	6	53.84	NCBI

Tmem72
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955546	2,244,620 - 2,262,298 (+)	Ensembl
ChiLan1.0	NW_004955546	2,244,639 - 2,264,987 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMEM72
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	57,645,565 - 57,671,258 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	57,650,894 - 57,676,587 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	41,905,688 - 41,931,385 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	45,085,457 - 45,111,011 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	45,085,457 - 45,111,011 (+)	Ensembl			panPan2	panpan1.1

TMEM72
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	2,501,485 - 2,528,946 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	2,502,928 - 2,528,632 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	2,733,336 - 2,764,024 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	2,678,703 - 2,707,614 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	2,680,368 - 2,707,663 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	2,475,324 - 2,506,016 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	2,512,921 - 2,543,666 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	2,643,925 - 2,674,625 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmem72
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	82,078,653 - 82,106,466 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936617	4,677,484 - 4,706,280 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936617	4,677,546 - 4,705,317 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM72
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	91,144,938 - 91,169,812 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	91,144,938 - 91,170,178 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	99,622,285 - 99,643,433 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM72
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	40,534,937 - 40,561,808 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666056	45,842,627 - 45,868,361 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem72
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624982	3,683 - 21,626 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624982	7 - 21,431 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmem72
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	29,893,664 - 29,917,011 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmem72
310 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	295
Count of miRNA genes:	200
Interacting mature miRNAs:	239
Transcripts:	ENSRNOT00000037397
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	107346299	152346299	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	134095016	179095016	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	149763204	169799698	Rat
61446	Coreg2	Compensatory renal growth QTL 2	3.5		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	4	150095743	159267220	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	117737142	152833657	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	131384565	176384565	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	123870974	168870974	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	111383604	156383604	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	108206096	153206096	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	127263297	172263297	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	126334185	171334185	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	111383604	156383604	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82944895	154403548	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	134199006	168870974	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	148121375	176967367	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	148834094	168870974	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	6	56	146	53	50	28	22	28	6	231	101	3	130	81	65	22	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161866	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037397 ⟹ ENSRNOP00000035275

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	151,620,696 - 151,645,989 (-)	Ensembl
mRatBN7.2 Ensembl	4	149,948,257 - 149,973,550 (-)	Ensembl
Rnor_6.0 Ensembl	4	148,817,514 - 148,845,267 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000123093 ⟹ ENSRNOP00000111401

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	151,620,696 - 151,645,850 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000155038 ⟹ ENSRNOP00000108969

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	151,620,696 - 151,644,453 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000163830 ⟹ ENSRNOP00000105941

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	151,620,696 - 151,644,673 (-)	Ensembl

RefSeq Acc Id:

NM_001108643 ⟹ NP_001102113

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	151,620,696 - 151,645,989 (-)	NCBI
mRatBN7.2	4	149,948,257 - 149,973,550 (-)	NCBI
Rnor_6.0	4	148,819,906 - 148,845,199 (-)	NCBI
Rnor_5.0	4	214,757,519 - 214,782,812 (-)	NCBI
RGSC_v3.4	4	153,036,955 - 153,062,248 (-)	RGD
Celera	4	138,823,892 - 138,849,161 (-)	RGD

Sequence:

show sequence

TAATCAGCCTGATCTCAGGCAGCTACACAGGAGCCGAAGCAGCTCCAGGCTAGGCCAGGGCTGT
GTGGAGAGAGGAGAGCGTTCTTCCGAGATAATGATTAAACTGAGCAGCACTTGGCAAGGGCACC
CGCTGCTAAACTAAGGAGGTGAGCCCCATTCACACCTCAGCCAGGCTGTGGAGCCCGGAGCTAG
TTCATGGAGGCTGAGCTCAGAGGCCCAGGGGCCCCCAGCCAGCCCCTGTAGCCTTCTGCGCTTG
TGCGGAGCATCCAGAGCATCTCAGATACAGGGGAATCTTTGCAGCCTGCTCTTCTGGGACTCTG
TTCACACCCCCTGGCACCATGAAGCTCCAAGTATTCTGGACTGGACTGGAGTATACCTGCCGGC
TATTGGGCATCACCACGGCTGCAGTACTGATTGGAGTGGGCACTGAGACCTTCCTCCGGGGGCG
GTTCAAAAGCCTGGCCTTCTATCTGCTGTTTACAGGAGTCACCATCTCTGTGTGTGAAGGGACC
TACTTTGTGGCTCAACTGTTGGCCATCTGCTTCAAGTGTCAGCCGGGGTCTCTGGCACACAGAG
CAAAGGAGAAGGCCCACTGGCTGGGCTGCTTCCAGAAGTTCCTCGCCTACATGCTGCTGTCAGT
GGCCTGTTTCCTCCACCCTGTTCTGGTCTGGCATGTGACCATACCAGGCTCCATGCTAATCATC
ACTGGCCTGGCCTACTTCCTGCTGAGCAAACGGAAGAAAAAAAAGGCTGCCCCAGAGGTGATGC
CCCCCACGGAGCAGTACAGGGACCCTTCCAGCAGCATTGTGAGTACCACAGGCTCTGGGGACAC
TGAGCAAACCTATACTTTCCATGAGGCCTTCAAGGAGGGGCCCAGCTCATTCCTCATCCACATG
AAGAGCATCCTGAAGGGGACCAAGAAGCCACGTGTCCTGCAGGCCCAAGATACCCTAATGGAAC
TGGCTCTAGAGCCAGCTGACTCCTTGGCCAAGAAAAAGCAGGTACACTTTGAAGACAATGTGGT
CAGAATCATCCCATCGCTCACTGAAGGTCTAGGTGATAGTGACAGTGGGCCAGAGGAAACCAGT
TCTGACACAACCCCCATCATCCCTCCCTCCCAGACCCCACTCTTTCTGCCTTCTCTCATGGCCA
CTGACCTGTTCTGAGCTTCTCAGCTAGAGGTCTACAGATGGACGGACCTGCCAGAAGATTCCTA
ATAGTCACAGTTCCTACAGGGAACTCAGGGTCTCTGTTGGTCAGCTACTCACATCCTCGTGGTG
TCTGGGCACTCAGAACAATGACATAGTGTACCAAGTGTACCAAGACTGTGGTGACCTCCAGCAA
GGCACAAATGAAGCTTTGCCATGTGGCATCAACACAGGCTCCTTCTTGGCAAGGGGTAGTGAAA
GAGACCATGGCTTCATTCTCCACGAGGCTGCTGACCCAACTTTCTAAGCCCTAAAGGAACAGAA
AACATGAGTTCACCCCTGCACCCAACAAAGGGTTCAGCCTTCAGTAAGAACTCTATGGGACGTT
TTGCTTGTGATTAAGCCTACTGGTGCCAAAGGCCAAGGGCTATACTGGCAGCATAATCGAGATT
GCTCAGAGGACATATGAGAAAGGAAGACTTGGCTCTCAGTTGAGAACAGCCTGGCAGTGGGCTA
CATTCTCAGCATACTCTGGGACCGGGCTGGGCAGCAGGCATTTCAGAATCTCCCAGGAAAACAA
TAGCTCTCTGTGCTCCCTGCCAGACAAGCTGACCAGAAGAGCATCTCTCATTCCTGAAGGCTAG
CTCAGAGCTTCCTGCCCTCCCCTCATCTAACCCCCATCCAACTGTGTGGGCAACGTTCAGAGTC
CAAGTAGACGGTGTAGATGGTTCACTATAAGAGAGTCTGAGAGCCTGTGGGCATCTGTAGCAGA
AATGGCTAGGACATCGCATGGAATAGTCATTGTAGTTCAGGTTCCAAGGGACTGTCCCCAGAGA
GCCACATGGCACAGGAAGTACCTCTGCCATGCTTAGATACCTGGGAGAAGAACCTCTGATAAGG
AGATGATCACTCAAAATAGACAGGAGGGGAGAAAGCAGAGGGAAGGGGAGAGGGTTGTGGGCAG
CCAGGCATGGCTGCATCCTGGAGTTACAGAGGTGGCAGTGAATTTGATTTAGATATTTCTCAGA
GAAAAGATTAGCAAGACACTTTGTAATTCTAAATAGTATGTTTAGTCCACAGGATTACTGCCAG
GAAAAAGAGACATGTTATTCTTCATAGCTAACACCCAGCATGTGAGCAACAATGAATTGAGAGT
CCTATATCTTGTGTCTGAGGAGGGGACCTGTTTCAGGGCCCTCTGATGGGTAAGCCTCATAGCA
TTTATAGTCTAGATAAAGAACGTGTTTATTGTATAATGATCAGTGCCTATGAGATTTTTTTGTT
TTTGTTTTGCTTGGTTTGGTTTTGGAAACACGTAGACATGAGGCAACCTAGAAGTCAGTATTAG
CCTGGTACTTAGCACAGCCAGCAACCCAGATGGACAGAACATGTTTTGCAATAGAGAATGTGTT
TGCTAAGACTGTGAGGAGTGAAGGCAGGAAGCAAGCCAGGGGGCCTGGAGTAAGTAGGCATGGC
CTACTCAACTCATCCAAAGATCTACGTCTGATGGATGACCACGGGGGTATTTAAACTGTTTCTT
TGACTTTTCCAATGGAGGATGTTGGATAGTGCAGTCAGGGGAAAATAAAATATATGGAATATAG
GGGAATGTCCCCATTACTATGGGGACCTGACAGTGAGGAAGAACAAGAGAGCACCACCATGACA
CTGAATTTGTGTAAGGCAAGGCCAGTGCAGACCCAGGAGGTGACTCTTAACTCCAGATTGCAAG
GCTGGAACTCAGGGAGCAGAGCTTGCAGCCTGACTGAGGCCAAGGGCCAGAGGGAAGAAATCCC
TTAACCAAGAGGAGCCAGGTACTCTCTCTGAGTCTCTGTATTCATTACTTTCTGACACTGAGAT
AAAATACCATGGACAAAAGCCACTTAAGGAAGAGACAGTGTATGTGGCTGACAGTTCCAGAGAG
CTAGAGTCCGTGATAACAGAGACGACCTGGCATGCAGCCGGAGATAGAAGCCAGCCGGTCACAT
TTCATCCACACACGGGAAATGAGGGAGAATGGGGAGGGCAATGTGACATGAGGCTGTGAACCCT
CAAAGCCCACCCCCACGGATGCACTTCCTCCAGCAAGGCTGCACCCCGTAAAGCTCCCATAACT
TCCCCAAACAGTGTCACTAACTGGATGAGTGACTGACATTTTTCACCCAAACCACTGCAGTCTC
TCATCAGCTTGTACAGTGCTAGAAATCGGTGGCTCCTGGT

hide sequence

RefSeq Acc Id:

XM_039107864 ⟹ XP_038963792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	151,621,660 - 151,629,899 (-)	NCBI
mRatBN7.2	4	149,946,296 - 149,957,464 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102113	(Get FASTA)	NCBI Sequence Viewer
	XP_038963792	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM02111	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035275
	ENSRNOP00000035275.4
	ENSRNOP00000105941.1
	ENSRNOP00000108969.1
	ENSRNOP00000111401.1

RefSeq Acc Id:

NP_001102113 ⟸ NM_001108643

- UniProtKB:

D4A2U6 (UniProtKB/TrEMBL), A6IL28 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKLQVFWTGLEYTCRLLGITTAAVLIGVGTETFLRGRFKSLAFYLLFTGVTISVCEGTYFVAQL
LAICFKCQPGSLAHRAKEKAHWLGCFQKFLAYMLLSVACFLHPVLVWHVTIPGSMLIITGLAYF
LLSKRKKKKAAPEVMPPTEQYRDPSSSIVSTTGSGDTEQTYTFHEAFKEGPSSFLIHMKSILKG
TKKPRVLQAQDTLMELALEPADSLAKKKQVHFEDNVVRIIPSLTEGLGDSDSGPEETSSDTTPI
IPPSQTPLFLPSLMATDLF

hide sequence

Ensembl Acc Id:

ENSRNOP00000035275 ⟸ ENSRNOT00000037397

RefSeq Acc Id:	XP_038963792 ⟸ XM_039107864
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000108969 ⟸ ENSRNOT00000155038

Ensembl Acc Id:

ENSRNOP00000105941 ⟸ ENSRNOT00000163830

Ensembl Acc Id:

ENSRNOP00000111401 ⟸ ENSRNOT00000123093

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A2U6-F1-model_v2	AlphaFold	D4A2U6	1-275	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308850	AgrOrtholog
BioCyc Gene	G2FUF-43278	BioCyc
Ensembl Genes	ENSRNOG00000023340	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037397	ENTREZGENE
	ENSRNOT00000037397.7	UniProtKB/TrEMBL
	ENSRNOT00000123093.1	UniProtKB/TrEMBL
	ENSRNOT00000155038.1	UniProtKB/TrEMBL
	ENSRNOT00000163830.1	UniProtKB/TrEMBL
InterPro	TMEM72	UniProtKB/TrEMBL
KEGG Report	rno:362424	UniProtKB/TrEMBL
NCBI Gene	362424	ENTREZGENE
PANTHER	PTHR28474	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 72	UniProtKB/TrEMBL
Pfam	TMEM72	UniProtKB/TrEMBL
PhenoGen	Tmem72	PhenoGen
RatGTEx	ENSRNOG00000023340	RatGTEx
UniProt	A0ABK0LQJ5_RAT	UniProtKB/TrEMBL
	A0ABK0LSH0_RAT	UniProtKB/TrEMBL
	A0ABK0LY39_RAT	UniProtKB/TrEMBL
	A6IL28	ENTREZGENE, UniProtKB/TrEMBL
	D4A2U6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-09	Tmem72	transmembrane protein 72	RGD1308850	LOC362424	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1308850	LOC362424	RGD1308850_predicted	LOC362424 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1308850_predicted	LOC362424 (predicted)	LOC362424_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC362424_predicted	LOC362424 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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