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Gene: Brf2 (BRF2 general transcription factor 3B subunit) Rattus norvegicus

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Symbol:

Brf2

Name:

BRF2 general transcription factor 3B subunit (Ensembl:BRF2, RNA polymerase III transcription initiation factor subunit)

RGD ID:

1308817

Description:

Predicted to enable RNA polymerase II general transcription initiation factor activity; RNA polymerase III type 3 promoter sequence-specific DNA binding activity; and TBP-class protein binding activity. Predicted to be involved in cellular response to oxidative stress and regulation of transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human BRF2 (BRF2 general transcription factor IIIB subunit); PARTICIPATES IN RNA polymerase III transcription pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

B-related factor 2; BRF-2; BRF2, RNA polymerase III transcription initiation factor 50 subunit; BRF2, RNA polymerase III transcription initiation factor subunit; BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like; LOC306542; transcription factor IIIB 50 kDa subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	71,626,146 - 71,635,909 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	71,623,238 - 71,635,903 (+)	Ensembl				GRCr8
mRatBN7.2	16	64,928,334 - 64,933,057 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	64,928,300 - 64,933,059 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	70,211,909 - 70,216,635 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	73,618,242 - 73,622,968 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	68,863,717 - 68,868,440 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	69,089,955 - 69,094,678 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	69,089,955 - 69,094,680 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	68,763,911 - 68,768,633 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	69,250,416 - 69,255,138 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	62,847,875 - 62,852,598 (+)	NCBI		Celera
RGSC_v3.1	16	69,250,621 - 69,255,340 (+)	NCBI
Cytogenetic Map	16	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4-amino-2,6-dinitrotoluene (EXP)

5-aza-2'-deoxycytidine (ISO)

acrylamide (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol F (ISO)

bortezomib (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chlordecone (ISO)

cobalt atom (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dimethyl sulfoxide (ISO)

disulfiram (ISO)

diuron (EXP)

elemental selenium (ISO)

fenthion (ISO)

FR900359 (ISO)

genistein (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

selenium atom (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

thiram (ISO)

triptonide (ISO)

Tungsten carbide (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cellular response to oxidative stress (IEA,ISO,ISS)

DNA-templated transcription (IEA)

DNA-templated transcription initiation (IEA)

positive regulation of transcription by RNA polymerase III (IEA,ISO)

regulation of transcription by RNA polymerase III (IEA,ISO,ISS)

transcription by RNA polymerase II (IEA)

transcription preinitiation complex assembly (IEA)

Cellular Component

nucleolus (IEA,ISO)

nucleus (IBA,IEA)

transcription factor TFIIIB complex (IEA,ISO,ISS)

transcription preinitiation complex (IBA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II general transcription initiation factor activity (IBA)

RNA polymerase III type 3 promoter sequence-specific DNA binding (IEA,ISO,ISS)

TBP-class protein binding (IBA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase III transcription pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.	Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries.	Vannini A Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):258-64. doi: 10.1016/j.bbagrm.2012.09.009. Epub 2012 Sep 29.

Additional References at PubMed

PMID:12477932	PMID:26638071

Genomics

Comparative Map Data

Brf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	71,626,146 - 71,635,909 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	71,623,238 - 71,635,903 (+)	Ensembl				GRCr8
mRatBN7.2	16	64,928,334 - 64,933,057 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	64,928,300 - 64,933,059 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	70,211,909 - 70,216,635 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	73,618,242 - 73,622,968 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	68,863,717 - 68,868,440 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	69,089,955 - 69,094,678 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	69,089,955 - 69,094,680 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	68,763,911 - 68,768,633 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	69,250,416 - 69,255,138 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	62,847,875 - 62,852,598 (+)	NCBI		Celera
RGSC_v3.1	16	69,250,621 - 69,255,340 (+)	NCBI
Cytogenetic Map	16	q12.3	NCBI

BRF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	37,843,268 - 37,849,861 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	37,843,268 - 37,849,861 (-)	Ensembl			hg38	GRCh38
GRCh37	8	37,700,786 - 37,707,379 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	37,820,558 - 37,826,569 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	37,820,562 - 37,826,569	NCBI
Celera	8	36,652,978 - 36,659,011 (-)	NCBI		Celera
Cytogenetic Map	8	p11.23	NCBI
HuRef	8	36,235,927 - 36,241,960 (-)	NCBI		HuRef
CHM1_1	8	37,902,845 - 37,908,878 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	38,119,669 - 38,126,265 (-)	NCBI		T2T-CHM13v2.0

Brf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	27,613,367 - 27,618,743 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	27,613,392 - 27,618,708 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	27,123,339 - 27,128,715 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	27,123,364 - 27,128,680 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	28,234,304 - 28,239,104 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	28,589,768 - 28,594,568 (-)	NCBI		MGSCv36	mm8
Celera	8	28,613,490 - 28,618,293 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	15.91	NCBI

Brf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	13,547,071 - 13,554,277 (-)	Ensembl
ChiLan1.0	NW_004955463	13,549,571 - 13,553,946 (-)	NCBI	ChiLan1.0	ChiLan1.0

BRF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	56,404,884 - 56,410,953 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	32,122,595 - 32,128,045 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	37,144,341 - 37,150,371 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	34,321,741 - 34,327,625 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	34,321,746 - 34,327,622 (-)	Ensembl			panPan2	panpan1.1

BRF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	27,543,588 - 27,547,712 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	27,543,858 - 27,547,106 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	28,060,505 - 28,064,459 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	29,442,854 - 29,446,808 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	29,442,903 - 29,446,805 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	27,664,474 - 27,668,427 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	28,242,034 - 28,245,988 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	28,281,218 - 28,285,171 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Brf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	50,160,010 - 50,164,914 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936710	1,293,129 - 1,301,048 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936710	1,296,475 - 1,301,752 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BRF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	48,568,202 - 48,573,029 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	48,568,207 - 48,573,036 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	55,684,661 - 55,689,474 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BRF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	35,879,762 - 35,885,572 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	35,880,373 - 35,885,485 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666052	6,118,831 - 6,124,752 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Brf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	5,751,435 - 5,757,447 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624780	5,752,018 - 5,757,323 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Brf2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	59,387,505 - 59,392,216 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Brf2
82 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	78
Count of miRNA genes:	67
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000017324
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	44455123	89455123	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	36928782	81928782	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	41992064	86992064	Rat
2302057	Pia29	Pristane induced arthritis QTL 29	3.6	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	16	28468701	73468701	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	49099196	91442908	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	62414464	75736480	Rat
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	32361043	77361043	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	31058039	76058039	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	59428714	91442908	Rat
1298529	Arunc1	Aerobic running capacity QTL 1	4		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	34398294	79398294	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	31885271	76885271	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	44455123	89455123	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	59428714	91442908	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	59428714	91442908	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17730818	72536785	Rat

Markers in Region

BF390610

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	64,932,830 - 64,932,986 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	69,094,452 - 69,094,607	NCBI	Rnor6.0
Rnor_5.0	16	68,768,407 - 68,768,562	UniSTS	Rnor5.0
RGSC_v3.4	16	69,254,912 - 69,255,067	UniSTS	RGSC3.4
Celera	16	62,852,372 - 62,852,527	UniSTS
RH 3.4 Map	16	593.7	UniSTS
Cytogenetic Map	16	q12.4	UniSTS

RH141595

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	64,932,402 - 64,932,599 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	69,094,024 - 69,094,220	NCBI	Rnor6.0
Rnor_5.0	16	68,767,979 - 68,768,175	UniSTS	Rnor5.0
RGSC_v3.4	16	69,254,484 - 69,254,680	UniSTS	RGSC3.4
Celera	16	62,851,944 - 62,852,140	UniSTS
RH 3.4 Map	16	596.21	UniSTS
Cytogenetic Map	16	q12.4	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063275441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC113785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017324 ⟹ ENSRNOP00000017324

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	71,631,141 - 71,635,903 (+)	Ensembl
mRatBN7.2 Ensembl	16	64,928,300 - 64,933,059 (+)	Ensembl
Rnor_6.0 Ensembl	16	69,089,955 - 69,094,680 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092283

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	71,631,139 - 71,635,903 (+)	Ensembl
mRatBN7.2 Ensembl	16	64,928,339 - 64,932,633 (+)	Ensembl
Rnor_6.0 Ensembl	16	69,090,698 - 69,092,375 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092570

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	69,091,074 - 69,091,763 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000166641 ⟹ ENSRNOP00000108321

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	71,623,238 - 71,635,903 (+)	Ensembl

RefSeq Acc Id:

NM_001024773 ⟹ NP_001019944

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	71,631,184 - 71,635,907 (+)	NCBI
mRatBN7.2	16	64,928,334 - 64,933,057 (+)	NCBI
Rnor_6.0	16	69,089,955 - 69,094,678 (+)	NCBI
Rnor_5.0	16	68,763,911 - 68,768,633 (+)	NCBI
RGSC_v3.4	16	69,250,416 - 69,255,138 (+)	RGD
Celera	16	62,847,875 - 62,852,598 (+)	RGD

Sequence:

show sequence

CTGCTGACCAGTTATAAGTTCTTAGGAGTGGGTGTCTGGCCGTACTGCGGCACTTTACAAACGG
CGAGATGCCGAACGGAAGCCGCTGCCCAGACTGCGGCTCCTCTGAGCTGGTGGAAGATTCGCAT
TATTCGCAGAGCCAGCTGGTGTGCTCCGACTGCGGCTGCGTGGTCACCGAAGGGGTCCTTACTA
CTACCTTCAGCGACGAGGGCAACCTCAGAGAAGTGACGTATTCTCGAAGCACAGGGGAAAACGA
ACAAGTTAGCCGCAGCCAGCAACGAGATCTCCGTCGAGTAAGAGACCTGTGTCGAATTCTGAAG
TTGCCACTAACGTTCGAGGAAACCGCAGTCTCCTACTACCAAAAGGCGTATCAGCTGTCTGGCA
TCCGCGCTGCTAGGCTGCAGAAGAAGGAAGTGGTAGTCGGATGCTGTGTTTTAATCACCTGTCG
GCAACATAACTGGCCCCTCACCATGGGAGCCATCTGCACTCTGTTGTATGCAGATCTGGATGTG
TTTTCCAGCACCTACATGCAGATAGTGAAGCTTCTGGGGCTGGACGTGCCGTCCCTGTGCCTGG
CAGACTTGGTCAAGTCTTACTGCAGCAGCTTCAAACTGTTCCAAGCATCCCCATCCATGCCAGC
CAAATACGTGGAGGACAAAGACAAGATGCTGTCTCGAACCTTGCTGTTGGTGGAGCTGGCAAAT
GAGACGTGGCTAGTGACTGGACGGCATCCCCTGCCGATCATCACTGCAGCCACCTTCCTGGCAT
GGCAGTCTCTGCGGCCTTCAGACCGGCTGACCTGCTCTCTTGCCCGGTTTTGTAAATTGGCAAA
TGTGGACCTGCCCTACCCAGCTGCCTCCCGCCTGCAGGAGCTCCTGGCCGTGCTCCTTCAGATG
GCCAGCCAGCTGGCCTGGCTACAAGTGCTAAGACTTGATAAGCGGTCGGTGGTGAAACACATTG
GTGACCTTCTCCAGCACCGCCATATGCTGGTCCGAATGGCTTTTCAGGATGGAACAGCAGAAGT
GGAGACCAAGCAGCAGCAGCCGCAGGGACGAGGACAGCAGGAAGAGGTGGGGGACAGTACCTTC
GATTTGCCCAAGAGGAAACGTCCCGCCAGTCCTGCCCTCCTCCTCCCACCCTGCATGTTGAAGC
CCCCCAAGCGGACCCATACCATGCCCCCTGATTCTGTAGTGACTGGAGATGAGGACATTTCTGA
TAGTGAGATTGAGCAATATTTGCGTACCCCTCAGGAAGTTAGAGACTTTGAGAGAGCCCAAGCT
GCTAGCCGGGCAGCCATGAGTGTCCCTAACCCGCCATGATGCCCATTCTGGAAGGTGTGTTCAA
TTGTGACTGCAATCTCTAACAGGCCTGTTGTGTTGCATAAAGTGACGGTATGTGACCTTTGGAT
ATTTCTTTAAAGAAACCAAGAGTAGCTTGCAGTCTGTTAATGGACCCAAGGTCCTAGAGAAGGT
GGGAGGCAGGTGCGGTGTCTGTGGGGGACGTCCTGACCTTTGGTGCAGGTAACCAAGGATCCAA
GGATGGATTCTTCCTAAGACCGCTAAGGAATCTGTCCAGCTCTCTTCTACCCTAGTGTGCAGTA
AATGCATTGGTGTGAACAAGCTGGCATTTGAGCAGTATCCACCGTTCCATGACAGGAGCAGTTC
CTGGCCATGCCTGGCCTAGGCTCTAGTGGTTTCCAGTATTCATAAGCTCCTTTCCATCATTAAC
AAAAGGACCATGGGTGGACGACAGCTGTCGCTCAGAGAGTTCTGCAAGATTTTAATATATTAAA
ACAAAGAGGCATCTGCTGGAAAACATTCTATTGTATAAAACCAGAGCTTTTAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063275441 ⟹ XP_063131511

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	71,626,146 - 71,635,909 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001019944	(Get FASTA)	NCBI Sequence Viewer
	XP_063131511	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97435	(Get FASTA)	NCBI Sequence Viewer
	EDM09092	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017324
	ENSRNOP00000017324.4
GenBank Protein	Q4V8D6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001019944 ⟸ NM_001024773

- UniProtKB:

Q4V8D6 (UniProtKB/Swiss-Prot), A6IVY0 (UniProtKB/TrEMBL), A0A8I5ZJ74 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPNGSRCPDCGSSELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQ
VSRSQQRDLRRVRDLCRILKLPLTFEETAVSYYQKAYQLSGIRAARLQKKEVVVGCCVLITCRQ
HNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCLADLVKSYCSSFKLFQASPSMPAK
YVEDKDKMLSRTLLLVELANETWLVTGRHPLPIITAATFLAWQSLRPSDRLTCSLARFCKLANV
DLPYPAASRLQELLAVLLQMASQLAWLQVLRLDKRSVVKHIGDLLQHRHMLVRMAFQDGTAEVE
TKQQQPQGRGQQEEVGDSTFDLPKRKRPASPALLLPPCMLKPPKRTHTMPPDSVVTGDEDISDS
EIEQYLRTPQEVRDFERAQAASRAAMSVPNPP

hide sequence

Ensembl Acc Id:

ENSRNOP00000017324 ⟸ ENSRNOT00000017324

RefSeq Acc Id:	XP_063131511 ⟸ XM_063275441
- Peptide Label:	isoform X1
- UniProtKB:	Q4V8D6 (UniProtKB/Swiss-Prot), A6IVY0 (UniProtKB/TrEMBL), A0A8I5ZJ74 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000108321 ⟸ ENSRNOT00000166641

Protein Domains

BRF2-like C-terminal TFIIB-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V8D6-F1-model_v2	AlphaFold	Q4V8D6	1-416	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700153

Promoter ID:

EPDNEW_R10677

Type:

initiation region

Name:

Brf2_1

Description:

BRF2, RNA polymerase III transcription initiation factor subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	69,089,960 - 69,090,020	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308817	AgrOrtholog
BioCyc Gene	G2FUF-11033	BioCyc
Ensembl Genes	ENSRNOG00000012739	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000017324	ENTREZGENE
	ENSRNOT00000017324.7	UniProtKB/Swiss-Prot
Gene3D-CATH	2.20.25.10	UniProtKB/Swiss-Prot
	Cyclin-like	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7455454	IMAGE-MGC_LOAD
InterPro	BRF2-like_C	UniProtKB/Swiss-Prot
	Cyclin-like_sf	UniProtKB/Swiss-Prot
	TFIIB	UniProtKB/Swiss-Prot
	Znf_TFIIB	UniProtKB/Swiss-Prot
KEGG Report	rno:306542	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114485	IMAGE-MGC_LOAD
NCBI Gene	306542	ENTREZGENE
PANTHER	PTHR11618	UniProtKB/Swiss-Prot
	TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT	UniProtKB/Swiss-Prot
Pfam	BRF2-like_C_cyclin_rpt	UniProtKB/Swiss-Prot
	TF_Zn_Ribbon	UniProtKB/Swiss-Prot
PhenoGen	Brf2	PhenoGen
PROSITE	ZF_TFIIB	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000012739	RatGTEx
Superfamily-SCOP	SSF47954	UniProtKB/Swiss-Prot
	Zinc beta-ribbon	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZJ74	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LSX9_RAT	UniProtKB/TrEMBL
	A6IVY0	ENTREZGENE, UniProtKB/TrEMBL
	BRF2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-11-08	Brf2	BRF2 general transcription factor 3B subunit	Brf2	BRF2, RNA polymerase III transcription initiation factor subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-06-12	Brf2	BRF2, RNA polymerase III transcription initiation factor subunit	Brf2	BRF2, RNA polymerase III transcription initiation factor 50 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-06-05	Brf2	BRF2, RNA polymerase III transcription initiation factor 50 subunit	Brf2	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Brf2	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like	Brf2_predicted	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Brf2_predicted	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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