Tmc1 (transmembrane channel-like 1) - Rat Genome Database

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Gene: Tmc1 (transmembrane channel-like 1) Rattus norvegicus
Analyze
Symbol: Tmc1
Name: transmembrane channel-like 1
RGD ID: 1308682
Description: Predicted to enable mechanosensitive monoatomic ion channel activity and voltage-gated calcium channel activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and vestibular reflex. Predicted to act upstream of or within several processes, including auditory receptor cell development; calcium ion transmembrane transport; and sensory perception of sound. Predicted to be located in external side of plasma membrane and stereocilium tip. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to human TMC1 (transmembrane channel like 1); INTERACTS WITH bisphenol A; furan; N,N-diethyl-m-toluamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361739; transmembrane channel-like gene family 1; transmembrane channel-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,701,781 - 227,872,534 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,701,781 - 227,872,534 (-)EnsemblGRCr8
mRatBN7.21218,275,249 - 218,446,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,276,417 - 218,445,955 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1226,704,373 - 226,886,796 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,640,940 - 233,823,358 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,458,957 - 226,641,395 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,336,919 - 238,525,792 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,336,919 - 238,441,500 (-)Ensemblrn6Rnor6.0
Rnor_5.01245,706,178 - 245,816,628 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01245,633,195 - 245,678,137 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,911,499 - 224,108,034 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1215,544,754 - 215,710,467 (-)NCBICelera
RGSC_v3.11224,075,517 - 224,193,990 (-)NCBI
Cytogenetic Map1q51NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function. Kurima K, etal., Nat Genet. 2002 Mar;30(3):277-84. Epub 2002 Feb 19.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16455951   PMID:22105175   PMID:23871232   PMID:24981230  


Genomics

Comparative Map Data
Tmc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,701,781 - 227,872,534 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,701,781 - 227,872,534 (-)EnsemblGRCr8
mRatBN7.21218,275,249 - 218,446,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,276,417 - 218,445,955 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1226,704,373 - 226,886,796 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,640,940 - 233,823,358 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,458,957 - 226,641,395 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,336,919 - 238,525,792 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,336,919 - 238,441,500 (-)Ensemblrn6Rnor6.0
Rnor_5.01245,706,178 - 245,816,628 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01245,633,195 - 245,678,137 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,911,499 - 224,108,034 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1215,544,754 - 215,710,467 (-)NCBICelera
RGSC_v3.11224,075,517 - 224,193,990 (-)NCBI
Cytogenetic Map1q51NCBI
TMC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38972,521,608 - 72,838,297 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl972,521,608 - 72,838,297 (+)Ensemblhg38GRCh38
GRCh37975,136,524 - 75,453,213 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,326,537 - 74,641,087 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34972,366,270 - 72,680,821NCBI
Celera945,709,595 - 46,024,123 (+)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef944,959,937 - 45,274,606 (+)NCBIHuRef
CHM1_1975,283,347 - 75,597,903 (+)NCBICHM1_1
T2T-CHM13v2.0984,672,507 - 84,989,215 (+)NCBIT2T-CHM13v2.0
Tmc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,760,820 - 20,931,566 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,760,822 - 20,931,566 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381920,783,456 - 21,037,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,783,458 - 20,954,202 (-)Ensemblmm10GRCm38
MGSCv371920,857,948 - 21,028,692 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361920,851,751 - 21,021,299 (-)NCBIMGSCv36mm8
Celera1921,504,691 - 21,681,769 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.98NCBI
Tmc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955434398,829 - 529,810 (-)Ensembl
ChiLan1.0NW_004955434398,734 - 500,378 (-)NCBIChiLan1.0ChiLan1.0
TMC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,709,074 - 72,028,283 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1971,715,008 - 72,034,211 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0951,974,326 - 52,200,228 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1971,310,247 - 71,620,858 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,400,783 - 71,620,858 (+)EnsemblpanPan2panpan1.1
TMC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,041,039 - 85,159,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,041,574 - 85,187,369 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha185,506,885 - 85,601,896 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0185,491,047 - 85,586,140 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,491,544 - 85,637,265 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,259,912 - 85,354,773 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,963,710 - 85,058,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,722,917 - 85,817,907 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,346,646 - 132,503,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365038,719,540 - 8,825,795 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365038,669,465 - 8,826,340 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,929,109 - 226,109,469 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11225,714,601 - 226,111,045 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,241,161 - 252,655,554 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11283,672,786 - 83,883,985 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1283,735,988 - 83,877,251 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603872,127,719 - 72,312,549 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473694,840 - 203,597 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473693,146 - 563,264 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1220,883,240 - 21,046,161 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmc1
1394 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1227535119233480676Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1221820316234540296Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1223964326236074012Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 6 16 111 52 49 22 29 22 2 155 63 1 100 50 86 27 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000076393   ⟹   ENSRNOP00000068461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,701,781 - 227,872,534 (-)Ensembl
mRatBN7.2 Ensembl1218,276,417 - 218,445,955 (-)Ensembl
Rnor_6.0 Ensembl1238,337,357 - 238,376,841 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1238,411,449 - 238,441,500 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077601   ⟹   ENSRNOP00000075695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1218,276,417 - 218,445,955 (-)Ensembl
Rnor_6.0 Ensembl1238,336,919 - 238,381,871 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106339   ⟹   ENSRNOP00000095251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,701,781 - 227,729,698 (-)Ensembl
mRatBN7.2 Ensembl1218,276,417 - 218,303,130 (-)Ensembl
RefSeq Acc Id: NM_001415991   ⟹   NP_001402920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,701,781 - 227,872,534 (-)NCBI
mRatBN7.21218,275,249 - 218,446,013 (-)NCBI
RefSeq Acc Id: XM_039084312   ⟹   XP_038940240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,703,120 - 227,825,450 (-)NCBI
mRatBN7.21218,275,262 - 218,398,927 (-)NCBI
RefSeq Acc Id: XM_063268475   ⟹   XP_063124545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,703,120 - 227,825,450 (-)NCBI
Ensembl Acc Id: ENSRNOP00000075695   ⟸   ENSRNOT00000077601
Ensembl Acc Id: ENSRNOP00000068461   ⟸   ENSRNOT00000076393
RefSeq Acc Id: XP_038940240   ⟸   XM_039084312
- Peptide Label: isoform X1
- UniProtKB: A0A096MKC4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095251   ⟸   ENSRNOT00000106339
RefSeq Acc Id: NP_001402920   ⟸   NM_001415991
RefSeq Acc Id: XP_063124545   ⟸   XM_063268475
- Peptide Label: isoform X2
- UniProtKB: A0A096MKC4 (UniProtKB/TrEMBL)
Protein Domains
TMC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KB87-F1-model_v2 AlphaFold A0A0G2KB87 1-519 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308682 AgrOrtholog
BioCyc Gene G2FUF-56177 BioCyc
Ensembl Genes ENSRNOG00000051262 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076393.3 UniProtKB/TrEMBL
  ENSRNOT00000106339.2 UniProtKB/TrEMBL
InterPro TMC UniProtKB/TrEMBL
  TMC UniProtKB/TrEMBL
NCBI Gene 361739 ENTREZGENE
PANTHER PTHR23302 UniProtKB/TrEMBL
  TRANSMEMBRANE CHANNEL-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam TMC UniProtKB/TrEMBL
PhenoGen Tmc1 PhenoGen
RatGTEx ENSRNOG00000051262 RatGTEx
UniProt A0A096MKC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A7D4XD71_RAT UniProtKB/TrEMBL
  A0A8I6GL27_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Tmc1  transmembrane channel-like 1  Tmc1  transmembrane channel-like gene family 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-25 Tmc1  transmembrane channel-like gene family 1  Tmc1  transmembrane channel-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Tmc1  transmembrane channel-like 1  Tmc1  transmembrane channel-like gene family 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tmc1  transmembrane channel-like gene family 1  Tmc1_predicted  transmembrane channel-like 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Tmc1_predicted  transmembrane channel-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED