Tmc1 (transmembrane channel like 1) - Rat Genome Database

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Gene: Tmc1 (transmembrane channel like 1) Heterocephalus glaber
Analyze
Symbol: Tmc1
Name: transmembrane channel like 1
RGD ID: 18919633
Description: ENCODES a protein that exhibits mechanosensitive monoatomic ion channel activity (ortholog); INVOLVED IN auditory receptor cell development (ortholog); calcium ion transmembrane transport (ortholog); detection of mechanical stimulus involved in sensory perception of sound (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 36 (ortholog); autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 7 (ortholog); FOUND IN external side of plasma membrane (ortholog); stereocilium tip (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Transmembrane channel-like protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473694,840 - 203,597 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473693,146 - 563,264 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Tmc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473694,840 - 203,597 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473693,146 - 563,264 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TMC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38972,521,608 - 72,838,297 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl972,521,608 - 72,838,297 (+)EnsemblGRCh38hg38GRCh38
GRCh37975,136,524 - 75,453,213 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,326,537 - 74,641,087 (+)NCBINCBI36Build 36hg18NCBI36
Build 34972,366,270 - 72,680,821NCBI
Celera945,709,595 - 46,024,123 (+)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef944,959,937 - 45,274,606 (+)NCBIHuRef
CHM1_1975,283,347 - 75,597,903 (+)NCBICHM1_1
T2T-CHM13v2.0984,672,507 - 84,989,215 (+)NCBIT2T-CHM13v2.0
Tmc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,760,820 - 20,931,566 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1920,760,822 - 20,931,566 (-)EnsemblGRCm39 Ensembl
GRCm381920,783,456 - 21,037,126 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,783,458 - 20,954,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv371920,857,948 - 21,028,692 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361920,851,751 - 21,021,299 (-)NCBIMGSCv36mm8
Celera1921,504,691 - 21,681,769 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.98NCBI
Tmc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,701,781 - 227,872,534 (-)NCBIGRCr8
mRatBN7.21218,275,249 - 218,446,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,276,417 - 218,445,955 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1226,704,373 - 226,886,796 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,640,940 - 233,823,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01226,458,957 - 226,641,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,336,919 - 238,525,792 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,336,919 - 238,441,500 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,706,178 - 245,816,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01245,633,195 - 245,678,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,911,499 - 224,108,034 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11224,075,517 - 224,193,990 (-)NCBI
Celera1215,544,754 - 215,710,467 (-)NCBICelera
Cytogenetic Map1q51NCBI
Tmc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955434398,829 - 529,810 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955434398,734 - 500,378 (-)NCBIChiLan1.0ChiLan1.0
TMC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,709,074 - 72,028,283 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1971,715,008 - 72,034,211 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0951,974,326 - 52,200,228 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1971,310,247 - 71,620,858 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,400,783 - 71,620,858 (+)Ensemblpanpan1.1panPan2
TMC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,041,039 - 85,159,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,041,574 - 85,187,369 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,506,885 - 85,601,896 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,491,047 - 85,586,140 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,491,544 - 85,637,265 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,259,912 - 85,354,773 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0184,963,710 - 85,058,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,722,917 - 85,817,907 (-)NCBIUU_Cfam_GSD_1.0
Tmc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947132,346,646 - 132,503,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365038,719,540 - 8,825,795 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365038,669,465 - 8,826,340 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,929,109 - 226,109,469 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,714,601 - 226,111,045 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,241,161 - 252,655,554 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11283,672,786 - 83,883,985 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1283,735,988 - 83,877,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603872,127,719 - 72,312,549 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021252707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021252708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021252709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021252710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021252711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021252712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021252713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002392421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01012057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01012081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JH170982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000022421   ⟹   ENSHGLP00000022210
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473694,840 - 203,597 (-)Ensembl
RefSeq Acc Id: XM_021252707   ⟹   XP_021108366
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473693,146 - 213,792 (-)NCBI
RefSeq Acc Id: XM_021252708   ⟹   XP_021108367
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473693,146 - 563,264 (-)NCBI
RefSeq Acc Id: XM_021252709   ⟹   XP_021108368
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473693,146 - 563,264 (-)NCBI
RefSeq Acc Id: XM_021252710   ⟹   XP_021108369
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473693,146 - 452,724 (-)NCBI
RefSeq Acc Id: XM_021252711   ⟹   XP_021108370
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473693,146 - 213,792 (-)NCBI
RefSeq Acc Id: XM_021252712   ⟹   XP_021108371
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473693,146 - 213,792 (-)NCBI
RefSeq Acc Id: XM_021252713   ⟹   XP_021108372
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473693,146 - 213,519 (-)NCBI
RefSeq Acc Id: XR_002392421
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473698,288 - 213,792 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021108367   ⟸   XM_021252708
- Peptide Label: isoform X2
- UniProtKB: G5BLX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108368   ⟸   XM_021252709
- Peptide Label: isoform X2
- UniProtKB: G5BLX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108369   ⟸   XM_021252710
- Peptide Label: isoform X2
- UniProtKB: G5BLX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108370   ⟸   XM_021252711
- Peptide Label: isoform X3
- UniProtKB: G5BLX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108371   ⟸   XM_021252712
- Peptide Label: isoform X4
- UniProtKB: G5BLX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108366   ⟸   XM_021252707
- Peptide Label: isoform X1
- UniProtKB: G5BLX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108372   ⟸   XM_021252713
- Peptide Label: isoform X5
- UniProtKB: G5BLX8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000022210   ⟸   ENSHGLT00000022421


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015834 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000022421 ENTREZGENE
InterPro TMC UniProtKB/TrEMBL
  TMC_dom UniProtKB/TrEMBL
NCBI Gene Tmc1 ENTREZGENE
PANTHER TRANSMEMBRANE CHANNEL-LIKE PROTEIN 1 UniProtKB/TrEMBL
  TRANSMEMBRANE CHANNEL-RELATED UniProtKB/TrEMBL
Pfam TMC UniProtKB/TrEMBL
UniProt G5BLX8 ENTREZGENE, UniProtKB/TrEMBL