Proz (protein Z, vitamin K-dependent plasma glycoprotein) - Rat Genome Database

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Gene: Proz (protein Z, vitamin K-dependent plasma glycoprotein) Rattus norvegicus
Analyze
Symbol: Proz
Name: protein Z, vitamin K-dependent plasma glycoprotein
RGD ID: 1308666
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein); PARTICIPATES IN coagulation cascade pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC306608; vitamin K-dependent protein Z
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,150,104 - 83,165,688 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1683,152,152 - 83,165,619 (-)EnsemblGRCr8
mRatBN7.21676,450,013 - 76,463,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,450,013 - 76,463,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1681,730,561 - 81,744,028 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,183,138 - 85,196,605 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,432,639 - 80,445,876 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,784,348 - 81,797,889 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,784,348 - 81,797,815 (-)Ensemblrn6Rnor6.0
Rnor_5.01681,269,715 - 81,283,268 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41681,311,405 - 81,321,986 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1674,256,045 - 74,269,512 (-)NCBICelera
RGSC_v3.11681,311,007 - 81,322,132 (-)NCBI
Cytogenetic Map16q12.5NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protein Z, an anticoagulant protein with expanding role in reproductive biology. Almawi WY, etal., Reproduction. 2013 Jun 27;146(2):R73-80. doi: 10.1530/REP-13-0072. Print 2013 Aug.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Protein Z influences the prothrombotic phenotype in Factor V Leiden patients. Kemkes-Matthes B, etal., Thromb Res. 2002 May 15;106(4-5):183-5.
5. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Lichy C, etal., Stroke 2004 Jan;35(1):40-5. Epub 2003 Dec 11.
6. Protein Z in ischemic stroke and its etiologic subtypes. McQuillan AM, etal., Stroke. 2003 Oct;34(10):2415-9. Epub 2003 Sep 11.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Decreased protein Z concentrations complicating the hypercoagulable state of Behcet's disease. Ozturk MA, etal., Clin Appl Thromb Hemost. 2003 Jul;9(3):259-63.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke. Staton J, etal., Stroke. 2005 Jun;36(6):1123-7. Epub 2005 May 5.
12. Prothrombotic phenotype of protein Z deficiency. Yin ZF, etal., Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6734-8.
Additional References at PubMed
PMID:12477932   PMID:19056867   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Proz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,150,104 - 83,165,688 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1683,152,152 - 83,165,619 (-)EnsemblGRCr8
mRatBN7.21676,450,013 - 76,463,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,450,013 - 76,463,480 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1681,730,561 - 81,744,028 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,183,138 - 85,196,605 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,432,639 - 80,445,876 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,784,348 - 81,797,889 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,784,348 - 81,797,815 (-)Ensemblrn6Rnor6.0
Rnor_5.01681,269,715 - 81,283,268 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41681,311,405 - 81,321,986 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1674,256,045 - 74,269,512 (-)NCBICelera
RGSC_v3.11681,311,007 - 81,322,132 (-)NCBI
Cytogenetic Map16q12.5NCBI
PROZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,158,648 - 113,172,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,158,622 - 113,172,387 (+)Ensemblhg38GRCh38
GRCh3713113,812,962 - 113,826,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,860,969 - 112,874,695 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3413112,860,968 - 112,874,695NCBI
Celera1394,638,628 - 94,652,355 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,251,393 - 94,264,909 (+)NCBIHuRef
CHM1_113113,781,985 - 113,795,462 (+)NCBICHM1_1
T2T-CHM13v2.013112,406,247 - 112,424,058 (+)NCBIT2T-CHM13v2.0
Proz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,110,583 - 13,126,026 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,110,914 - 13,126,026 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38813,060,584 - 13,076,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,060,914 - 13,076,026 (+)Ensemblmm10GRCm38
MGSCv37813,060,908 - 13,075,006 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36813,060,885 - 13,074,983 (+)NCBIMGSCv36mm8
Celera813,228,680 - 13,241,944 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
Proz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404646,841 - 657,262 (-)Ensembl
ChiLan1.0NW_004955404647,217 - 657,256 (-)NCBIChiLan1.0ChiLan1.0
PROZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214114,660,438 - 114,676,729 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,345,218 - 113,363,802 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,294,846 - 94,314,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,363,530 - 113,383,010 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,364,280 - 113,383,010 (+)EnsemblpanPan2panpan1.1
PROZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,156,880 - 91,171,333 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl391,157,307 - 91,171,042 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604648,193,308 - 48,207,312 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Proz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793745,579 - 755,059 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624793745,490 - 757,886 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Proz
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11370,614,505 - 70,626,102 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Proz
84 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:153
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000026666, ENSRNOT00000064694
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat

Markers in Region
RH142502  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,452,295 - 76,452,405 (+)MAPPERmRatBN7.2
Rnor_6.01681,786,631 - 81,786,740NCBIRnor6.0
Rnor_5.01681,271,998 - 81,272,107UniSTSRnor5.0
RGSC_v3.41681,310,699 - 81,310,808UniSTSRGSC3.4
Celera1674,258,328 - 74,258,437UniSTS
RH 3.4 Map8582.2UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 10 31 95 91 90 59 87 59 6 296 142 3 78 77 53 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000026666   ⟹   ENSRNOP00000026666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1683,152,152 - 83,165,619 (-)Ensembl
mRatBN7.2 Ensembl1676,450,013 - 76,463,480 (-)Ensembl
Rnor_6.0 Ensembl1681,784,348 - 81,797,815 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,790,946 - 81,791,511 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098453   ⟹   ENSRNOP00000086614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,450,013 - 76,463,480 (-)Ensembl
RefSeq Acc Id: NM_001309433   ⟹   NP_001296362
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,152,152 - 83,165,619 (-)NCBI
mRatBN7.21676,450,013 - 76,463,480 (-)NCBI
Rnor_6.01681,784,348 - 81,797,815 (-)NCBI
Celera1674,256,045 - 74,269,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600160   ⟹   XP_017455649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,150,104 - 83,165,688 (-)NCBI
mRatBN7.21676,452,151 - 76,463,558 (-)NCBI
Rnor_6.01681,784,348 - 81,797,889 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001296362 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455649 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI60868 (Get FASTA)   NCBI Sequence Viewer  
  EDM08871 (Get FASTA)   NCBI Sequence Viewer  
  EDM08872 (Get FASTA)   NCBI Sequence Viewer  
  EDM08873 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026666
  ENSRNOP00000026666.8
RefSeq Acc Id: NP_001296362   ⟸   NM_001309433
- Peptide Label: precursor
- UniProtKB: B1H253 (UniProtKB/TrEMBL),   G3V8K8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455649   ⟸   XM_017600160
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2L4 (UniProtKB/TrEMBL),   B1H253 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026666   ⟸   ENSRNOT00000026666
Ensembl Acc Id: ENSRNOP00000086614   ⟸   ENSRNOT00000098453
Protein Domains
EGF-like   Gla   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8K8-F1-model_v2 AlphaFold G3V8K8 1-406 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700236
Promoter ID:EPDNEW_R10759
Type:initiation region
Name:Proz_1
Description:protein Z, vitamin K-dependent plasma glycoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01681,797,818 - 81,797,878EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308666 AgrOrtholog
BioCyc Gene G2FUF-10699 BioCyc
Ensembl Genes ENSRNOG00000019700 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026666 ENTREZGENE
  ENSRNOT00000026666.11 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325485 IMAGE-MGC_LOAD
InterPro Coagulation_fac_subgr_Gla_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/TrEMBL
  Peptidase_S1_coag_factors UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
KEGG Report rno:306608 UniProtKB/TrEMBL
MGC_CLONE MGC:188233 IMAGE-MGC_LOAD
NCBI Gene 306608 ENTREZGENE
PANTHER COAGULATION FACTOR UniProtKB/TrEMBL
  VITAMIN K-DEPENDENT PROTEIN Z UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Gla UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PharmGKB PROZ RGD
PhenoGen Proz PhenoGen
PIRSF Factor_X UniProtKB/TrEMBL
PRINTS GLABLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019700 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
  VitK_dep_GLA UniProtKB/TrEMBL
UniProt A0A8I6A2L4 ENTREZGENE
  B1H253 ENTREZGENE, UniProtKB/TrEMBL
  G3V8K8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Proz  protein Z, vitamin K-dependent plasma glycoprotein   Proz_predicted  protein Z, vitamin K-dependent plasma glycoprotein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Proz_predicted  protein Z, vitamin K-dependent plasma glycoprotein (predicted)      Symbol and Name status set to approved 70820 APPROVED